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1. 发明申请

WO2005005640A1 A YEAST MODEL FOR AMYLOIDOGENIC PROTEIN TOXICITY 审中-公开
标题翻译：用于蛋白质蛋白毒性的YEAST模型
公开(公告)号：WO2005005640A1
公开(公告)日：2005-01-20
申请号：PCT/BE2004/000102
申请日：2004-07-09
申请人： reMYND NV , GRIFFIOEN, Gerard , DUHAMEL, Hein , VAN DAMME, Nele , WINDERICKX, Joris , WERA, Stefaan
发明人： GRIFFIOEN, Gerard , DUHAMEL, Hein , VAN DAMME, Nele , WINDERICKX, Joris , WERA, Stefaan
IPC分类号： C12N15/81
CPC分类号： C12N15/81 , C07K14/395
摘要： The present invention relates to an engineered yeast strain, comprising a transgene encoding one or more amyloidogenic proteins or mutant(s) thereof, characterised in that it lacks one or more functional genes responsive to oxidative stress. The invention further relates to the use of this yeast strain for pharmaceutical screening, for modelling of neurodegenerative diseases and for cellular modelling of biochemistry of the amyloidogenic proteins involved therein.
摘要翻译：本发明涉及工程改造的酵母菌株，其包含编码一种或多种淀粉样蛋白形成蛋白质或其突变体的转基因，其特征在于其缺少一种或多种对氧化应激有响应的功能基因。本发明还涉及这种酵母菌株用于药物筛选，神经变性疾病的建模和涉及其中的淀粉样蛋白形成蛋白的生物化学的细胞建模的用途。

2. 发明申请

WO2012007531A2 METHODS AND COMPOSITIONS FOR DIAGNOSING MEDICAL CONDITIONS 审中-公开
标题翻译：用于诊断医学条件的方法和组合物
公开(公告)号：WO2012007531A2
公开(公告)日：2012-01-19
申请号：PCT/EP2011/062006
申请日：2011-07-13
申请人： MADEO, Frank , EISENBERG, Tobias , PIEBER, Thomas , MAGNES, Christoph , SINNER, Frank , WINDERICKX, Joris , VAN DEN BERGHE, Gret , GUNST, Jan
发明人： MADEO, Frank , EISENBERG, Tobias , PIEBER, Thomas , MAGNES, Christoph , SINNER, Frank , WINDERICKX, Joris , VAN DEN BERGHE, Gret , GUNST, Jan
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2800/042
摘要： The present invention relates to a method for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop a non-infectious medical condition, comprising detecting and/or analyzing in a test sample derived from the subject one or more polyamines or one or more salts or derivatives thereof, wherein the presence of any one of the polyamines or the salts or derivatives thereof in the test sample is indicative of the medical condition or a predisposition to develop the medical condition. In particular embodiments, the method further comprises quantifying the levels of the one or more polyamines or the one or more salts or derivatives thereof in the test sample, wherein an altered level of any one the polyamines or the salts or derivatives thereof in the test sample as compared to a reference is indicative of the non-infectious medical condition or a predisposition to develop such condition. The present invention is also directed to a kit-of-parts for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop such condition, comprising means for detecting and/or analyzing one or more polyamines or one or more salts or derivatives thereof, as defined herein, as well as to the use of one or more polyamines or one or more salts or derivatives thereof, as defined herein, as a panel of molecular markers for diagnosing a non-infectious medical condition or a predisposition to develop such condition.
摘要翻译：本发明涉及用于诊断和/或监测受试者非传染性医学状况或倾向于发展非感染性医学病症的方法，包括在来自受试者的测试样品中检测和/或分析样品，或更多的多胺或其一种或多种盐或其衍生物，其中在测试样品中多胺或其盐或衍生物中的任何一种的存在表示医学状况或发展医学病症的倾向。在具体实施方案中，该方法还包括定量测试样品中一种或多种多胺或其一种或多种盐或衍生物的含量，其中测试样品中多胺或其盐或衍生物中任何一种的改变水平与参考文献相比，表示非传染性医学状况或发展这种病症的倾向。本发明还涉及用于诊断和/或监测受试者的非感染性医学病症或倾向于开发这种病症的试剂盒，其包括用于检测和/或分析一种或多种多胺或一种或多种多胺或其更多的盐或衍生物，以及本文定义的一种或多种多胺或其一种或多种盐或其衍生物作为诊断非感染性医学病症的分子标记物的一组或发展这种状况的倾向。

3. 发明申请

WO2010081862A3 METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS WITH A POLYAMINE (E.G. SPERMINE, SPERMIDINE) 审中-公开
公开(公告)号：WO2010081862A3
公开(公告)日：2010-07-22
申请号：PCT/EP2010/050426
申请日：2010-01-14
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D , UNIVERSITY OF GRAZ , JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH , WINDERICKX, Joris , VAN DEN BERGHE, Greet , GUNST, Jan , VANHOREBEEK, Ilse , LANGOUCHE, Lies , EISENBERG, Tobias , MADEO, Frank , MAGNES, Christophe , SINNER, Frank
发明人： WINDERICKX, Joris , VAN DEN BERGHE, Greet , GUNST, Jan , VANHOREBEEK, Ilse , LANGOUCHE, Lies , EISENBERG, Tobias , MADEO, Frank , MAGNES, Christophe , SINNER, Frank
IPC分类号： A61K31/132 , A61K31/198 , A61K45/06 , A61P3/00 , A61P21/00 , A61P43/00
摘要： The present invention relates to the use of a polyamine or a salt, solvate, or derivative thereof, such as spermine or spermidine for the treatment or prevention of a life threatening condition, such as multiple organ failure, in a critically ill patient with a non-infectuous disorder.

4. 发明申请

WO2013007839A1 ANTIBODIES TO PHOSPHORYLATED TAU AGGREGATES 审中-公开
标题翻译：抗菌剂对磷酸化聚集体的影响
公开(公告)号：WO2013007839A1
公开(公告)日：2013-01-17
申请号：PCT/EP2012/063924
申请日：2012-07-16
申请人： ADX NEUROSCIENCES NV , KATHOLIEKE UNIVERSITEIT LEUVEN , WINDERICKX, Joris , VANMECHELEN, Eugeen , VAN LEUVEN, Fred
发明人： WINDERICKX, Joris , VANMECHELEN, Eugeen , VAN LEUVEN, Fred
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K14/4711 , C07K2317/56 , C07K2317/565 , G01N33/566
摘要： This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates.
摘要翻译：本发明涉及tau蛋白的寡聚形式的亲和力工具。它涉及到神经退行性疾病，特别是与tau相关的疾病和tau蛋白病的领域。本发明提供了新颖的tau抗体和抗体片段，编码此类抗体和抗体片段的核酸，产生此类抗体的细胞系和抗体片段，抗体组合物和用于检测聚集的tau和用于诊断涉及聚集的tau的疾病的试剂盒。本发明还提供了用于检测聚集的tau的方法，用于诊断涉及聚集的tau的疾病，以及用于鉴定干扰tau聚集体的形成和/或稳定性的组合物。

5. 发明申请

WO2009021295A2 ALPHA SYNUCLEIN TOXICITY 审中-公开
标题翻译： ALPHA SYNUCLEIN毒性
公开(公告)号：WO2009021295A2
公开(公告)日：2009-02-19
申请号：PCT/BE2008/000062
申请日：2008-08-07
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN , UNIVERSITY OF GRAZ , BAEKELANDT, Veerle , BUETTNER, Sabrina , MADEO, Frank , WINDERICKX, Joris
发明人： BAEKELANDT, Veerle , BUETTNER, Sabrina , MADEO, Frank , WINDERICKX, Joris
IPC分类号： C07K16/00
CPC分类号： A61K39/3955 , A61K31/713 , A61K38/005 , A61K2039/505 , C07K16/40 , C12N15/1137 , C12N2310/14
摘要： Present inventions demonstrates that alpha synculein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of the endonuclease G apoptotic pathway attenuates or counteracts such alpha synuclein toxicity. The present invention compositions and methods for inhibition of α-synuclein toxicity. The inhibiting α-synuclein toxicity can be used in methods of treatment of synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA) and the manufacture of medicaments for such treatment. In particular The subject matter provided in herein relates to a pharmaceutical compositions containing inhibitors of endonuclease G, and their use in the treatment of synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, and multiple system atrophy and the manufacture of medicaments for such treatment. Furthermore the present invention relates to a method for the identification of compounds attenuating the synuclein toxicity, said method comprising evaluating the inhibitory action of said compound on the endonuclease G dependent apoptosis.
摘要翻译：本发明证明α-突触素毒性如α-突触核蛋白介导的细胞死亡，α突触核蛋白在细胞中诱导活性氧（ROS）需要促凋亡内切酶G，并且内切核酸酶G的缺失或内切核酸酶G凋亡通路的抑制减弱或抵抗这种α突触核蛋白毒性。本发明的组合物和抑制α-突触核蛋白毒性的方法。抑制性α-突触核蛋白毒性可用于治疗突触核蛋白病，如帕金森病（PD），路易体痴呆（DLB），纯自主神经功能衰竭（PAF）和多系统萎缩（MSA）药物用于治疗。特别地，本文提供的主题涉及含有内切核酸酶G抑制剂的药物组合物及其在治疗突触核蛋白病（例如帕金森病，路易体痴呆，纯粹的自主神经衰竭和多系统萎缩）中的用途，以及制造药物用于治疗。此外，本发明涉及鉴定减毒突触核蛋白毒性的化合物的方法，所述方法包括评价所述化合物对核酸内切酶G依赖性凋亡的抑制作用。

6. 发明申请

WO2010081204A2 ACTIVATORS OF THE AUTOPHAGIC PATHWAY 审中-公开
标题翻译：自动途径的激活者
公开(公告)号：WO2010081204A2
公开(公告)日：2010-07-22
申请号：PCT/BE2010/000002
申请日：2010-01-14
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN , WINDERICKX, Joris , EISENBERG, Tobias , KROEMER, Guido , MADEO, Frank , MINOIS, Nadege , ROCKENFELLER, Patrick
发明人： WINDERICKX, Joris , EISENBERG, Tobias , KROEMER, Guido , MADEO, Frank , MINOIS, Nadege , ROCKENFELLER, Patrick
CPC分类号： A61K31/132
摘要： By present invention it has been clearly demonstrated that polyamine compounds of the groups consisting of putrescine, spermine, spermidine, cholesteryl spermine, spermidine trihydrochloride, spermidine phosphate hexahydrate, spermidine phosphate hexahydrate and 1,4-butanediamine N-(3-aminopropyl)-monohydrochloride or derivatives thereof or combinations thereof can induce deacetylation or can maintain a condition of hypoacetylation of histone H3 and can activate autophagy and can be used in a treatment to activate or reinstate a normal autophagic pathway.
摘要翻译：通过本发明，已经清楚地证明，由腐胺，精胺，亚精胺，胆固醇精胺，亚精胺三盐酸盐，亚精胺磷酸六水合物，亚精胺磷酸盐六水合物和1,4-丁二胺N-（3-氨基丙基） - 单盐酸盐组成的组中的多胺化合物或其衍生物或其组合可以诱导脱乙酰化或可以维持组蛋白H3的低乙酰化状态，并且可以活化自噬，并且可用于治疗以激活或恢复正常自噬途径。

7. 发明申请

WO2002068663A1 TAU-OPATHY MODEL 审中-公开
标题翻译： TAO-OPATHY MODEL
公开(公告)号：WO2002068663A1
公开(公告)日：2002-09-06
申请号：PCT/BE2002/000022
申请日：2002-02-25
申请人： K.U. LEUVEN RESEARCH & DEVELOPMENT , VAN LEUVEN, Freddy , WINDERICKX, Joris
发明人： VAN LEUVEN, Freddy , WINDERICKX, Joris
IPC分类号： C12N15/81
CPC分类号： G01N33/6896 , C07K14/4711 , C12N15/81 , C12Q1/025 , G01N2500/00 , G01N2800/28
摘要： The present invention relates to cell models of Alzheimer's disease. Transgenic yeast cells are described as models for the tau-opathy in Alzheimer's disease. These cell models comprise recombinant DNA constructs comprising control sequences and a cDNA sequence encoding a human tau-isoform and another similar construct comprising a protein kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-associated protein tau. The transgenic cells are useful for high-throughput testing for potential therapeutic agents for Alzheimer's disease and other neurodegenerative disorders.
摘要翻译：本发明涉及阿尔茨海默氏病的细胞模型。转基因酵母细胞被描述为阿尔茨海默病中tau蛋白病的模型。这些细胞模型包含重组DNA构建体，其包含控制序列和编码人tau同工型的cDNA序列，以及包含直接或间接调节微管相关蛋白tau磷酸化的蛋白激酶的另一类似构建体。转基因细胞可用于对阿尔茨海默氏病和其他神经变性疾病的潜在治疗剂的高通量测试。

8. 发明公开

EP1644505A1 A YEAST MODEL FOR AMYLOIDOGENIC PROTEIN TOXICITY 有权
标题翻译：酵母模型毒性淀粉样变蛋白
公开(公告)号：EP1644505A1
公开(公告)日：2006-04-12
申请号：EP04737685.0
申请日：2004-07-09
申请人： reMynd NV
发明人： GRIFFIOEN, Gerard , DUHAMEL, Hein , VAN DAMME, Nele , WINDERICKX, Joris , WERA, Stefaan
IPC分类号： C12N15/81 , C12N9/64 , C07K14/395 , C07K14/47 , G01N33/68
CPC分类号： C12N15/81 , C07K14/395
摘要： The present invention relates to an engineered yeast strain, comprising a transgene encoding one or more amyloidogenic proteins or mutant(s) thereof, characterised in that it lacks one or more functional genes responsive to oxidative stress. The invention further relates to the use of this yeast strain for pharmaceutical screening, for modelling of neurodegenerative diseases and for cellular modelling of biochemistry of the amyloidogenic proteins involved therein.

9. 发明授权

EP1644505B1 A YEAST MODEL FOR AMYLOIDOGENIC PROTEIN TOXICITY 有权
标题翻译：酵母模型毒性淀粉样变蛋白
公开(公告)号：EP1644505B1
公开(公告)日：2008-04-23
申请号：EP04737685.0
申请日：2004-07-09
申请人： reMynd NV
发明人： GRIFFIOEN, Gerard , DUHAMEL, Hein , VAN DAMME, Nele , WINDERICKX, Joris , WERA, Stefaan
IPC分类号： C12N15/81 , C12N9/64 , C07K14/395 , C07K14/47 , G01N33/68
CPC分类号： C12N15/81 , C07K14/395
摘要： The present invention relates to an engineered yeast strain, comprising a transgene encoding one or more amyloidogenic proteins or mutant(s) thereof, characterised in that it lacks one or more functional genes responsive to oxidative stress. The invention further relates to the use of this yeast strain for pharmaceutical screening, for modelling of neurodegenerative diseases and for cellular modelling of biochemistry of the amyloidogenic proteins involved therein.

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