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1. 发明申请

WO2012139148A1 ANTIOXIDANT COMPOSITION FOR TISSUE AND ORGAN PRESERVATION 审中-公开
标题翻译：用于组织和组织保存的抗氧化剂组合物
公开(公告)号：WO2012139148A1
公开(公告)日：2012-10-18
申请号：PCT/AT2012/050049
申请日：2012-04-16
申请人： MEDICAL UNIVERSITY OF GRAZ - MUG , UNIVERSITY OF GRAZ - KFUG , C.Y.L. PHARMAZEUTIKA GMBH - CYL , SCHWARZ, Michaela , GREILBERGER, Joachim , SANTOS, Robson , UNIVERSIDADE FEDERAL DE MINAS GERAIS INSTITUICAO DE ENSINO E PESQUISA , LAMACIE, Mariana , WINTERSTEIGER, Reinhold , MOSER, Peter , BÜCHERL-HARRER, Christian , KAGER, Ernst , RUBEN DARIO SINISTERRA, Millan
发明人： SCHWARZ, Michaela , GREILBERGER, Joachim , SANTOS, Robson , LAMACIE, Mariana , WINTERSTEIGER, Reinhold , MOSER, Peter , BÜCHERL-HARRER, Christian , KAGER, Ernst , RUBEN DARIO SINISTERRA, Millan
IPC分类号： A01N1/02 , A61K38/08
CPC分类号： A01N1/0226 , A61K31/11 , A61K31/191 , A61K31/194 , A61K31/198 , A61K31/7004 , A61K31/715 , A61K33/04 , A61K38/085 , A61K2300/00
摘要： The present invention relates to an antioxidant composition, comprising a combination of at least one carbonic acid selected from the group of mono- and polycarbonic acids, at least one mono- or polysaccharides derivatized heterolytic aldehyde, at least one selenium-compound such as seleniummethionine, seleniumcysteine, or selenite, at least one compound selected from the group of sulfur-, disulfide- or sulfhydryl-containing amino acids such as N-acetyl- L-methionine and N-acetyl-l-cysteine, and aminosulfonic acids such as taurine, at least one carbohydrate, and at least one Mas receptor agonist such as angiotensines. The invention further relates to a pharmaceutical composition comprising such an antioxidant composition and a pharmaceutically acceptable carrier. The invention is particularly useful in a solution for preserving organs and tissue, particularly during the process of transplantation.
摘要翻译：本发明涉及抗氧化剂组合物，其包含至少一种选自单羧酸和聚碳酸的碳酸，至少一种单糖或多糖衍生的异解性醛，至少一种硒化合物如硒代甲硫氨酸，硒代半胱氨酸或亚硒酸盐，至少一种选自硫代，二硫化物或巯基的氨基酸如N-乙酰基-L-甲硫氨酸和N-乙酰基-1-半胱氨酸的化合物，以及氨基磺酸如牛磺酸，至少一种碳水化合物和至少一种Mas受体激动剂如血管紧张素。本发明还涉及包含这种抗氧化组合物和药学上可接受的载体的药物组合物。本发明在用于保存器官和组织的解决方案中特别有用，特别是在移植过程中。

2. 发明专利

CA2811064A1 MUTATIONS IN SPTLC2 GENE ASSOCIATED WITH SENSORY NEUROPATHY 未知
公开(公告)号：CA2811064A1
公开(公告)日：2012-03-22
申请号：CA2811064
申请日：2011-09-19
申请人： VIB VZW , UNIV ANTWERPEN , UNIV ZUERICH , MEDICAL UNIVERSITY OF GRAZ
发明人： ROTTHIER ANNELIES , TIMMERMAN VINCENT , AUER-GRUMBACH MICHAELA , HORNEMANN THORSTEN
IPC分类号： C12Q1/68
摘要： The present invention relates to a method and kit for identifying a subject at risk of, or having, a sensory neuropathy related disease. In particular, the present invention is based on the determination of mutations in the SPTLC2 gene causing said sensory neuropathies.

3. 发明专利

AU2012272541A1 Hybrid polymeric materials for medical applications and preparation thereof 未知
公开(公告)号：AU2012272541A1
公开(公告)日：2014-01-30
申请号：AU2012272541
申请日：2012-06-20
申请人： UNIV GRAZ TECH , AUSTRIA TECH & SYSTEM TECH , HERAEUS MEDICAL GMBH , MEDICAL UNIVERSITY OF GRAZ MUG
发明人： WIESBROCK FRANK , EBNER CLEMENS , STELZER FRANZ , WEINBERG ANNELIE , KUHN KLAUS-DIETER
IPC分类号： A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , C08G63/685 , C08L67/00
摘要： The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azidoformate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.

4. 发明专利

CA2827506A1 BAP1 MUTATIONAL ANALYSIS IN DETERMINING SUSCEPTIBILITY TO, PROGNOSIS OF, AND TREATMENT OF MELANOCYTIC NEOPLASIA 未知
公开(公告)号：CA2827506A1
公开(公告)日：2013-07-18
申请号：CA2827506
申请日：2012-02-16
申请人： SLOAN KETTERING INST CANCER , MEDICAL UNIVERSITY OF GRAZ
发明人： WIESNER THOMAS , BASTIAN BORIS , SPEICHER MICHAEL R , KUTZNER HEINZ
IPC分类号： G01N33/48 , G01N33/53
摘要： Methods and compositions for diagnosing and prognosmg neoplasms, particularly malignant melanomas, and for identifying patients at high risk for melanocytic nevi and/or melanomas or other cancers are provided. Methods for distinguishing between nevi at high and low risk for malignant transformation and for characterizing or classifying lesions or nevi are also disclosed. Assays and kits for prognosis of melanoma in a human subject comprising assessment of BAP1 protein and/or BAP1 nucleic acid are provided.

5. 发明专利

CA2840115A1 HYBRID POLYMERIC MATERIALS FOR MEDICAL APPLICATIONS AND PREPARATION THEREOF 未知
公开(公告)号：CA2840115A1
公开(公告)日：2012-12-27
申请号：CA2840115
申请日：2012-06-20
申请人： UNIV GRAZ TECH , MEDICAL UNIVERSITY OF GRAZ MUG , HERAEUS MEDICAL GMBH
发明人： WIESBROCK FRANK , EBNER CLEMENS , STELZER FRANZ , WEINBERG ANNELIE , KUHN KLAUS-DIETER
IPC分类号： A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , C08G63/685 , C08L67/00
摘要： The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azidoformate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.

6. 发明专利

GB201015581D0 Mutations in SPTLC2 gene associated with sensory neuropathy 未知
公开(公告)号：GB201015581D0
公开(公告)日：2010-10-27
申请号：GB201015581
申请日：2010-09-17
申请人： VIB VZW , MEDICAL UNIVERSITY OF GRAZ , UNIV ANTWERPEN , UNIV ZUERICH

7. 发明公开

EP2529665A1 System and method of determining thickness of body tissue 审中-公开
标题翻译： System und Verfahren zur Bestimmung der Dicke vonKörpergewebe
公开(公告)号：EP2529665A1
公开(公告)日：2012-12-05
申请号：EP11450069.7
申请日：2011-05-30
申请人： University of Graz , Medical University of Graz
发明人： Müller, Wolfram , Horn, Martin , Ahammer, Helmut
IPC分类号： A61B8/08 , A61B5/107 , G06T7/00
CPC分类号： A61B8/0858 , A61B5/1075 , A61B8/469 , A61B8/486 , A61B8/5223 , G06T7/12 , G06T7/136 , G06T7/62 , G06T2207/10132 , G06T2207/30004
摘要： For the determining the thickness of a tissue layer based on an image recorded with an imaging process such as ultrasound imaging (11), an image describing spatial behavior of a measured quantity across at least one section through said tissue layer is recorded (13) and processed in a data processing apparatus, which calculates values of thickness for said image data. For this calculation, a plurality of section lines within the image is used, thickness value candidates for each of the section lines are determined (17), the thickness value candidates are sorted into distance classes (19), of which at least one is selected, and a value of thickness is calculated by averaging (21) the thickness value candidates within the distance class(es) selected. The individual distance values can also be used for analyses of patterns, e.g. subcutaneous fat patterning in the imaged part of the body.
摘要翻译：为了基于使用诸如超声成像（11）的成像处理记录的图像来确定组织层的厚度，记录描述穿过所述组织层的至少一个部分上的测量量的空间行为的图像（13）和在数据处理装置中进行处理，该数据处理装置计算所述图像数据的厚度值。对于该计算，使用图像内的多个截面线，确定每个截面线的厚度值候选（17），厚度值候选被分类为距离等级（19），其中选择至少一个，并且通过对所选择的距离等级（es）中的厚度值候选进行平均（21）来计算厚度值。单独的距离值也可以用于模式的分析，例如。在身体的成像部分的皮下脂肪图案化。

8. 发明公开

US20240245338A1 IDENTIFICATION OF TARGET SITES FOR VENTRICULAR TACHYCARDIA TREATMENT 审中-公开
公开(公告)号：US20240245338A1
公开(公告)日：2024-07-25
申请号：US18684351
申请日：2022-08-11
申请人： MEDICAL UNIVERSITY OF GRAZ , KING'S COLLEGE LONDON , NUMERICOR GmbH
发明人： Gernot PLANK , Martin BISHOP , Aurel NEIC , Fernando Otaviano CAMPOS
IPC分类号： A61B5/319 , G06F30/20 , G06T17/20
CPC分类号： A61B5/319 , G06F30/20 , G06T17/20 , G06T2210/41
摘要： A computer-implemented method of determining one or more target sites usable for treatment of ventricular tachycardia is proposed including receiving three-dimensional model data indicative of a cardiac model modelling an anatomy of a heart of a subject with fibrosis, wherein the cardiac model includes at least one myocardial segment associated with and/or modelled as electrically conducting myocardial tissue and at least one fibrotic segment associated with and/or modelled as insulating fibrotic tissue, simulating the evolution of a cardiac activation wave across the at least one myocardial segment and the at least one fibrotic segment, and determining at least one split location, at which an isosurface of the simulated wave is split into two or more sections, the at least one split location being indicative of a location for the simulated wave hitting a boundary between the at least one fibrotic segment and the at least one myocardial segment.

9. 发明授权

US10870887B2 Mutations in SPTLC2 gene associated with sensory neuropathy 有权
公开(公告)号：US10870887B2
公开(公告)日：2020-12-22
申请号：US15814766
申请日：2017-11-16
申请人： VIB VZW , UNIVERSITEIT ANTWERPEN , UNIVERSITY OF ZURICH , MEDICAL UNIVERSITY OF GRAZ
发明人： Annelies Rotthier , Vincent Timmerman , Michaela Auer-Grumbach , Thorsten Hornemann
IPC分类号： C12Q1/68 , C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Described are methods and kits for identifying a subject at risk of, or having, a sensory neuropathy related disease, such as sensory neuropathies. In particular, the disclosure is based on the determination of mutations in the SPTLC2 gene causing sensory neuropathies.

10. 发明申请

US20160106768A1 LYSOPHOSPHOLIPIDS AND LYSOPHOSPHOLIPID ANALOGUES AGAINST HONEYBEE BROOD DISEASES 有权
标题翻译：蜂毒EE OL IDS ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES
公开(公告)号：US20160106768A1
公开(公告)日：2016-04-21
申请号：US14892914
申请日：2014-05-22
申请人： UNIVERSITY OF GRAZ
发明人： Wolfgang SCHÜHLY , Ulrike RIESSBERGER-GALLÉ , Javier HERNÁNDEZ-LÓPEZ , Karl CRAILSHEIM
IPC分类号： A61K31/685 , A61K31/683 , A61K35/644 , A01K51/00
CPC分类号： A61K31/685 , A01K51/00 , A23K20/158 , A23K50/90 , A61K31/683 , A61K35/644 , A61K2300/00
摘要： The present invention refers to a compound selected from the group consisting of a lysophospholipid and a lysophospholipid analogue for use in the treatment or prophylaxis of honeybee brood diseases, in particular American foulbrood and European foulbrood. The invention also refers to a diet composition, a sprayable composition, a dipping solution for brood combs, a beeswax composition and liposomal and microsphere- or nanosphere-based compositions, comprising a compound according to the invention, for use in the treatment or prophylaxis of bee brood diseases.
摘要翻译：本发明涉及一种选自用于治疗或预防蜜蜂种类疾病的溶血磷脂和溶血磷脂类似物的化合物，特别是美国foulbrood和欧洲foulbrood。本发明还涉及一种饮食组合物，可喷雾组合物，用于梳子梳的浸渍溶液，蜂蜡组合物和脂质体和微球或纳米球基组合物，其包含根据本发明的化合物，用于治疗或预防蜜蜂疾病

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