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1. 发明申请

WO2012007531A3 METHODS AND COMPOSITIONS FOR DIAGNOSING MEDICAL CONDITIONS 审中-公开
标题翻译：诊断医疗条件的方法和组合物
公开(公告)号：WO2012007531A3
公开(公告)日：2012-03-08
申请号：PCT/EP2011062006
申请日：2011-07-13
申请人： MADEO FRANK , EISENBERG TOBIAS , PIEBER THOMAS , MAGNES CHRISTOPH , SINNER FRANK , WINDERICKX JORIS , VAN DEN BERGHE GRET , GUNST JAN
发明人： MADEO FRANK , EISENBERG TOBIAS , PIEBER THOMAS , MAGNES CHRISTOPH , SINNER FRANK , WINDERICKX JORIS , VAN DEN BERGHE GRET , GUNST JAN
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2800/042
摘要： The present invention relates to a method for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop a non-infectious medical condition, comprising detecting and/or analyzing in a test sample derived from the subject one or more polyamines or one or more salts or derivatives thereof, wherein the presence of any one of the polyamines or the salts or derivatives thereof in the test sample is indicative of the medical condition or a predisposition to develop the medical condition. In particular embodiments, the method further comprises quantifying the levels of the one or more polyamines or the one or more salts or derivatives thereof in the test sample, wherein an altered level of any one the polyamines or the salts or derivatives thereof in the test sample as compared to a reference is indicative of the non-infectious medical condition or a predisposition to develop such condition. The present invention is also directed to a kit-of-parts for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop such condition, comprising means for detecting and/or analyzing one or more polyamines or one or more salts or derivatives thereof, as defined herein, as well as to the use of one or more polyamines or one or more salts or derivatives thereof, as defined herein, as a panel of molecular markers for diagnosing a non-infectious medical condition or a predisposition to develop such condition.
摘要翻译：本发明涉及用于在受试者中诊断和/或监测非感染性医学病症或发展非传染性医学病症的倾向的方法，包括检测和/或分析来自受试者的测试样品或更多的多胺或其一种或多种盐或衍生物，其中测试样品中任何一种多胺或其盐或衍生物的存在表明医学病症或发展医学病症的倾向。在具体的实施方案中，所述方法进一步包括定量测试样品中的一种或多种多胺或其一种或多种盐或衍生物的水平，其中测试样品中任何一种多胺或其盐或衍生物的水平改变与参考文献相比表明非传染性医学病症或发展这种病症的倾向。本发明还涉及用于在受试者中诊断和/或监测非感染性医学病症或发展这种病症的倾向的部分试剂盒，其包含用于检测和/或分析一种或多种多胺或一种或更多的盐或衍生物，以及本文定义的一种或多种多胺或其一种或多种盐或衍生物作为用于诊断非感染性医学病症的分子标志物组的使用或发展这种情况的倾向。

2. 发明申请

WO2012007531A2 METHODS AND COMPOSITIONS FOR DIAGNOSING MEDICAL CONDITIONS 审中-公开
标题翻译：用于诊断医学条件的方法和组合物
公开(公告)号：WO2012007531A2
公开(公告)日：2012-01-19
申请号：PCT/EP2011/062006
申请日：2011-07-13
申请人： MADEO, Frank , EISENBERG, Tobias , PIEBER, Thomas , MAGNES, Christoph , SINNER, Frank , WINDERICKX, Joris , VAN DEN BERGHE, Gret , GUNST, Jan
发明人： MADEO, Frank , EISENBERG, Tobias , PIEBER, Thomas , MAGNES, Christoph , SINNER, Frank , WINDERICKX, Joris , VAN DEN BERGHE, Gret , GUNST, Jan
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2800/042
摘要： The present invention relates to a method for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop a non-infectious medical condition, comprising detecting and/or analyzing in a test sample derived from the subject one or more polyamines or one or more salts or derivatives thereof, wherein the presence of any one of the polyamines or the salts or derivatives thereof in the test sample is indicative of the medical condition or a predisposition to develop the medical condition. In particular embodiments, the method further comprises quantifying the levels of the one or more polyamines or the one or more salts or derivatives thereof in the test sample, wherein an altered level of any one the polyamines or the salts or derivatives thereof in the test sample as compared to a reference is indicative of the non-infectious medical condition or a predisposition to develop such condition. The present invention is also directed to a kit-of-parts for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop such condition, comprising means for detecting and/or analyzing one or more polyamines or one or more salts or derivatives thereof, as defined herein, as well as to the use of one or more polyamines or one or more salts or derivatives thereof, as defined herein, as a panel of molecular markers for diagnosing a non-infectious medical condition or a predisposition to develop such condition.
摘要翻译：本发明涉及用于诊断和/或监测受试者非传染性医学状况或倾向于发展非感染性医学病症的方法，包括在来自受试者的测试样品中检测和/或分析样品，或更多的多胺或其一种或多种盐或其衍生物，其中在测试样品中多胺或其盐或衍生物中的任何一种的存在表示医学状况或发展医学病症的倾向。在具体实施方案中，该方法还包括定量测试样品中一种或多种多胺或其一种或多种盐或衍生物的含量，其中测试样品中多胺或其盐或衍生物中任何一种的改变水平与参考文献相比，表示非传染性医学状况或发展这种病症的倾向。本发明还涉及用于诊断和/或监测受试者的非感染性医学病症或倾向于开发这种病症的试剂盒，其包括用于检测和/或分析一种或多种多胺或一种或多种多胺或其更多的盐或衍生物，以及本文定义的一种或多种多胺或其一种或多种盐或其衍生物作为诊断非感染性医学病症的分子标记物的一组或发展这种状况的倾向。

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