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1. 发明申请

US20110287408A1 Preparation of Micro-Porous Crystals and Conjugates Thereof 失效
标题翻译：微孔多晶体及其结合体的制备
公开(公告)号：US20110287408A1
公开(公告)日：2011-11-24
申请号：US13099577
申请日：2011-05-03
申请人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
发明人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
IPC分类号： C12Q1/70 , C07F19/00 , C12Q1/02
CPC分类号： G01N33/533 , G01N33/582
摘要： A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
摘要翻译：公开了包含染料标记的微孔结晶，停止旋塞部分并与其共价结合的亲和力结合剂的缀合物。染料标记的微孔结晶是沸石晶体，例如沸石L晶体，其内部具有大量通道，染料加载到其中。停止旋塞部分可以与可以连接羧基酯基团的氨基官能化。亲和力结合剂允许结合生物部分。该部分的缀合物可用于体内和/或体外成像应用。

2. 发明授权

US08445214B2 Preparation of micro-porous crystals and conjugates thereof 失效
标题翻译：微孔结晶及其共轭物的制备
公开(公告)号：US08445214B2
公开(公告)日：2013-05-21
申请号：US13099577
申请日：2011-05-03
申请人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
发明人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
IPC分类号： G01N33/53
CPC分类号： G01N33/533 , G01N33/582
摘要： A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
摘要翻译：公开了包含染料标记的微孔结晶，停止旋塞部分并与其共价结合的亲和力结合剂的缀合物。染料标记的微孔结晶是沸石晶体，例如沸石L晶体，其内部具有大量通道，染料加载到其中。停止旋塞部分可以与可以连接羧基酯基团的氨基官能化。亲和力结合剂允许结合生物部分。该部分的缀合物可用于体内和/或体外成像应用。

3. 发明授权

US07960124B2 Preparation of micro-porous crystals and conjugates thereof 有权
标题翻译：微孔结晶及其结合物的制备
公开(公告)号：US07960124B2
公开(公告)日：2011-06-14
申请号：US11824416
申请日：2007-06-29
申请人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
发明人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
IPC分类号： G01N33/53
CPC分类号： G01N33/533 , G01N33/582
摘要： A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
摘要翻译：公开了包含染料标记的微孔结晶，停止旋塞部分并与其共价结合的亲和力结合剂的缀合物。染料标记的微孔结晶是沸石晶体，例如沸石L晶体，其内部具有大量通道，染料加载到其中。停止旋塞部分可以与可以连接羧基酯基团的氨基官能化。亲和力结合剂允许结合生物部分。该部分的缀合物可用于体内和/或体外成像应用。

4. 发明申请

US20080138914A1 Preparation of micro-porous crystals and conjugates thereof 有权
标题翻译：微孔结晶及其结合物的制备
公开(公告)号：US20080138914A1
公开(公告)日：2008-06-12
申请号：US11824416
申请日：2007-06-29
申请人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
发明人： Zoran Popovic , Manuel Matthias Tsotsalas , Michael Busby , Luisa De Cola , Gion Calzaferri , Hans-Peter Josel
IPC分类号： G01N33/536 , C01B39/02 , C07F7/02 , C07H21/00 , C07K16/00 , C07K14/42 , C07K2/00
CPC分类号： G01N33/533 , G01N33/582
摘要： A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
摘要翻译：公开了包含染料标记的微孔结晶，停止旋塞部分并与其共价结合的亲和力结合剂的缀合物。染料标记的微孔结晶是沸石晶体，例如沸石L晶体，其内部具有大量通道，染料加载到其中。停止旋塞部分可以与可以连接羧基酯基团的氨基官能化。亲和力结合剂允许结合生物部分。该部分的缀合物可用于体内和/或体外成像应用。

5. 发明授权

US08173041B2 Method for intercalating chromophores into zeolite-L nanochannels and products thereof 失效
标题翻译：将发色团插入沸石-L纳米通道及其产物的方法
公开(公告)号：US08173041B2
公开(公告)日：2012-05-08
申请号：US12361616
申请日：2009-01-29
申请人： Gion Calzaferri , Luisa De Cola , Michael Busby , Christian Blum , Vinod Subramaniam
发明人： Gion Calzaferri , Luisa De Cola , Michael Busby , Christian Blum , Vinod Subramaniam
IPC分类号： C09K11/06 , H01L31/00
CPC分类号： C01B39/026
摘要： The present invention discloses a method for the intercalation of a chromophore within channels of a zeolite L crystal. The intercalated chromophores exhibit J type aggregation of the chromophores within the channels of the zeolite L crystals. The invention discloses method parameters which lead to the J type aggregation of the chromophores within the channels of the zeolite L crystals. The J type aggregation of the chromophores affords unique florescent properties rendering the intercalated zeolite L crystals as a material for use in novel optoelectronic devices.
摘要翻译：本发明公开了一种在沸石L晶体的通道内插入发色团的方法。插层发色团在沸石L晶体的通道内显示发色团的J型聚集体。本发明公开了导致沸石L晶体通道内发色团的J型聚集的方法参数。发色团的J型聚集提供了独特的荧光性质，使嵌入的沸石L晶体作为用于新型光电子器件的材料。

6. 发明申请

US20100003188A1 METHOD FOR INTERCALATING CHROMOPHORES INTO ZEOLITE-L NANOCHANNELS AND PRODUCTS THEREOF 失效
标题翻译：将染料与ZEOLITE-L纳米通道及其制品交联的方法
公开(公告)号：US20100003188A1
公开(公告)日：2010-01-07
申请号：US12361616
申请日：2009-01-29
申请人： Gion CALZAFERRI , Luisa De Cola , Michael Busby , Christian Blum , Vinod Subramaniam
发明人： Gion CALZAFERRI , Luisa De Cola , Michael Busby , Christian Blum , Vinod Subramaniam
IPC分类号： C01B39/04 , C07D473/04 , C07D471/02
CPC分类号： C01B39/026
摘要： The present invention discloses a method for the intercalation of a chromophore within channels of a zeolite L crystal. The intercalated chromophores exhibit J type aggregation of the chromophores within the channels of the zeolite L crystals. The invention discloses method parameters which lead to the J type aggregation of the chromophores within the channels of the zeolite L crystals. The J type aggregation of the chromophores affords unique florescent properties rendering the intercalated zeolite L crystals as a material for use in novel optoelectronic devices.
摘要翻译：本发明公开了一种在沸石L晶体的通道内插入发色团的方法。插层发色团在沸石L晶体的通道内显示发色团的J型聚集体。本发明公开了导致沸石L晶体通道内发色团的J型聚集的方法参数。发色团的J型聚集提供了独特的荧光性质，使嵌入的沸石L晶体作为用于新型光电子器件的材料。

7. 发明授权

US5957982A Method and system for space navigation 失效
标题翻译：空间导航方法和系统
公开(公告)号：US5957982A
公开(公告)日：1999-09-28
申请号：US135884
申请日：1998-08-18
申请人： George C. Hughes , Michael J. Wehner , Mark L. Hanson , D. Hobson Lane , Paul A. Lavoie , Warren H. Taylor , Bryan H. Kang , Paul Steiner , Arnold J. Galloway , Michael Busby
发明人： George C. Hughes , Michael J. Wehner , Mark L. Hanson , D. Hobson Lane , Paul A. Lavoie , Warren H. Taylor , Bryan H. Kang , Paul Steiner , Arnold J. Galloway , Michael Busby
IPC分类号： G06F17/10 , G06F15/00
CPC分类号： G06F17/10
摘要： A method that allows a space vehicle to determine navigation information represented by the contents of a state vector. The method includes the steps of intermittently receiving navigation signals, initializing the state vector with an estimate of the navigation information, and generating a predicted state vector that represents the predicted values for the navigation information after a predetermined time increment in the future. The method further determines whether a navigation signal has been received within a predetermined window of time from a navigation beacon. If a navigation signal has been received, the method updates the state vector and the contents of the state vector are propagated forward in time to provide an estimate of the navigation information after a predetermined time increment. In some instances, however, a navigation signal is not received within the predetermined window of time. In such situations, the method simply propagates the contents of the predicted state vector forward in time. Thus, the predicted state vector maintains an estimate of the current navigation information even in the absence of a navigation signal.
摘要翻译：一种允许航天器确定由状态向量的内容表示的导航信息的方法。该方法包括以下步骤：间歇地接收导航信号，利用导航信息的估计来初始化状态向量，并且在将来经过预定的时间增量之后生成表示导航信息的预测值的预测状态向量。该方法还确定在导航信标的预定窗口内是否已经接收到导航信号。如果已经接收到导航信号，则该方法更新状态向量，并且状态向量的内容在时间上向前传播，以在预定时间增量之后提供对导航信息的估计。然而，在一些情况下，在预定的时间窗口内没有接收到导航信号。在这种情况下，该方法简单地将预测状态向量的内容及时传播。因此，即使在不存在导航信号的情况下，预测状态矢量也保持当前导航信息的估计。

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