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    • 9. 发明授权
    • Combined neural stimulation and cardiac resynchronization therapy
    • 组合神经刺激和心脏再同步治疗
    • US08131362B2
    • 2012-03-06
    • US12543654
    • 2009-08-19
    • Julia MoffittSophia WangBruce H. KenKnightImad Libbus
    • Julia MoffittSophia WangBruce H. KenKnightImad Libbus
    • A61N1/00
    • A61N1/3627A61N1/056A61N1/0587A61N1/36114A61N1/3962
    • Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
    • 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗(RCT),并且进一步被编程以通过递送神经刺激来递送抗重塑疗法(ART) 与RCT结合抑制交感神经活动。 本文提供了其他实施例。