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1. 发明申请

US20090247522A1 Hsp90 FAMILY PROTEIN INHIBITORS 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20090247522A1
公开(公告)日：2009-10-01
申请号：US12427847
申请日：2009-04-22
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A61K31/5377 , A61K31/12 , A61K31/216 , A61K31/165 , A61K31/44 , A61K31/495 , A61K31/445 , A61K31/40 , A61K31/496 , A61K31/47 , A61K31/5375 , A61P35/00
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上所述苯甲酰化合物或所述前药的可接受的盐。

2. 发明授权

US07767693B2 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07767693B2
公开(公告)日：2010-08-03
申请号：US12427847
申请日：2009-04-22
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A01N43/40 , C07D211/22 , C07C49/303
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上所述苯甲酰化合物或所述前药的可接受的盐。

3. 发明申请

US20070004674A1 Remedy for diseases associated with immunoglobulin gene translocation 审中-公开
标题翻译：与免疫球蛋白基因易位相关疾病的补救措施
公开(公告)号：US20070004674A1
公开(公告)日：2007-01-04
申请号：US10569090
申请日：2004-08-23
申请人： Yukimasa Shiotsu , Shiro Soga , Yutaka Kanda , Shiro Akinaga
发明人： Yukimasa Shiotsu , Shiro Soga , Yutaka Kanda , Shiro Akinaga
IPC分类号： A61K31/695 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/452 , A61K31/4433 , A61K31/4025 , A61K31/365
CPC分类号： A61K31/365 , A61K31/00 , C07D313/00
摘要： A medicament comprising a compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof as an active ingredient is used as a therapeutic agent for diseases associated with immunoglobulin gene translocations. In diseases associated with immunoglobulin gene translocations, abnormal enhancement of the expression of a partner gene in immunoglobulin gene translocation participates in the development of the diseases and the progress of the symptoms. By administering the compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof, degradation of protein encoded by the partner gene is promoted and the diseases can be treated.
摘要翻译：将包含对Hsp90或其药学上可接受的盐具有抑制作用的化合物作为活性成分的药物用作与免疫球蛋白基因易位相关的疾病的治疗剂。在与免疫球蛋白基因易位相关的疾病中，免疫球蛋白基因易位中伴侣基因表达的异常增强参与疾病的发展和症状的进展。通过施用对Hsp90具有抑制作用的化合物或其药学上可接受的盐，促进由配对基因编码的蛋白质的降解，并且可以治疗疾病。

4. 发明授权

US07538224B2 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07538224B2
公开(公告)日：2009-05-26
申请号：US10561415
申请日：2004-06-10
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： C07D211/22 , C07C49/303
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上所述苯甲酰化合物或所述前药的可接受的盐。

5. 发明申请

US20070032532A1 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20070032532A1
公开(公告)日：2007-02-08
申请号：US10561415
申请日：2004-06-10
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A61K31/4192 , A61K31/22 , A61K31/195 , A61K31/165
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示0〜10的整数，R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的低级链烯基等; R 4和R 6和R 6可以相同或不同，分别表示氢原子，卤素，取代或未取代的低级烷基，被取代的或未取代的芳基等）或其前药，或所述苯甲酰基化合物或所述前药的药学上可接受的盐。

6. 发明申请

US20060281789A1 Protein kinase inhibitors 审中-公开
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20060281789A1
公开(公告)日：2006-12-14
申请号：US10548592
申请日：2004-07-30
申请人： Yukimasa Shiotsu , Hiroshi Umehara , Fumihiko Kanai , Shinji Nara , Yoshihisa Ohta , Yutaka Kanda , Shiro Akinaga , Tomoki Naoe , Hitoshi Kiyoi , Tomoyuki Nakazato , Satoshi Tashiro
发明人： Yukimasa Shiotsu , Hiroshi Umehara , Fumihiko Kanai , Shinji Nara , Yoshihisa Ohta , Yutaka Kanda , Shiro Akinaga , Tomoki Naoe , Hitoshi Kiyoi , Tomoyuki Nakazato , Satoshi Tashiro
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D231/56
摘要： The present invention provides a protein kinase inhibitor (excluding c-Jun N-terminal kinase inhibitor) which comprises, as an active ingredient, an indazole derivative represented by Formula (I) (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种蛋白激酶抑制剂（不包括c-Jun N-末端激酶抑制剂），其包含作为活性成分的由式（I）表示的吲唑衍生物（其中R 1表示取代或未取代的芳基或取代或未取代的杂环基）或其药学上可接受的盐。

7. 发明申请

US20090042883A1 ANTITUMOR AGENT 审中-公开
标题翻译：抗菌剂
公开(公告)号：US20090042883A1
公开(公告)日：2009-02-12
申请号：US11816736
申请日：2006-02-21
申请人： Yutaka Kanda , Shiro Soga , Takayuki Nakashima , Shinji Nara , Hiroshi Nakagawa , Yukimasa Shiotsu
发明人： Yutaka Kanda , Shiro Soga , Takayuki Nakashima , Shinji Nara , Hiroshi Nakagawa , Yukimasa Shiotsu
IPC分类号： A61K31/05 , C07C39/04 , C07D211/70 , C07D241/04 , A61K31/4406 , A61K31/496 , A61K31/5377 , A61P35/00 , A61K31/5375 , A61K31/495 , C07D403/04 , C07D265/30 , C07D413/04
CPC分类号： A61K31/12 , A61K31/165 , A61K31/216 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4406 , A61K31/445 , A61K31/4535 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C235/78 , C07D207/09 , C07D207/24 , C07D207/27 , C07D211/22 , C07D211/42 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/18 , C07D295/088 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/46 , C07D307/52 , C07D317/60 , C07D333/22
摘要： The present invention provides a therapeutic agent for a tumor selected from a hematopoietic tumor and a solid tumor which comprises, as an active ingredient, a benzoyl compound represented by General Formula (I): (wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R3 and R5 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like), a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种选自造血肿瘤和实体肿瘤的肿瘤治疗剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示1〜5的整数; R1 表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基或取代或未取代的芳族杂环基; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R4表示氢原子，羟基或卤素; R6表示氢原子，卤素，取代或未取代的低级烷基等），其前药或其药学上可接受的盐。

8. 发明授权

US07538241B2 Hsp90 family protein inhibitors 失效
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07538241B2
公开(公告)日：2009-05-26
申请号：US10584234
申请日：2004-12-24
申请人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
发明人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
IPC分类号： C07C225/00 , C07C211/00 , C07C69/76
CPC分类号： C07C311/21 , C07C39/367 , C07C43/178 , C07C43/21 , C07C43/23 , C07C49/245 , C07C49/248 , C07C49/83 , C07C59/56 , C07C65/105 , C07C69/732 , C07C69/734 , C07C69/736 , C07C215/52 , C07C217/08 , C07C217/76 , C07C233/25 , C07C233/75 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/42 , C07C235/44 , C07C235/46 , C07C235/80 , C07C251/40 , C07C251/48 , C07C275/32 , C07C307/02 , C07C309/65 , C07C311/08 , C07C2601/14 , C07D203/10 , C07D207/27 , C07D211/16 , C07D211/58 , C07D213/30 , C07D213/36 , C07D213/40 , C07D213/85 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/18 , C07D263/32 , C07D263/34 , C07D271/113 , C07D277/24 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/12 , C07D307/42 , C07D307/52 , C07D307/54 , C07D307/68 , C07D307/91 , C07D309/06 , C07D317/20 , C07D317/54 , C07D333/16 , C07D405/12
摘要： (wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
摘要翻译：（其中n为0至10的整数; R 1表示取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的环烷基，取代或未取代的低级烷氧基羰基，取代或未取代的杂环 - 烷基，取代或未取代的芳基，-CONR 7 R 8 ，-NR9R10等; R2表示取代或未取代的芳基或取代或未取代的杂环基等; R3和R5可以相同或不同，分别表示氢原子，取代或未取代的低级烷基等; R4 R 6可以相同或不同，各自表示氢原子，卤素，取代或未取代的低级烷基等）。提供一种Hsp90家族蛋白质抑制剂，其包含作为活性成分的式（I）的苯衍生物或其前药或其药学上可接受的盐等

9. 发明申请

US20070155813A1 Hsp90 family protein inhibitors 失效
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20070155813A1
公开(公告)日：2007-07-05
申请号：US10584234
申请日：2004-12-24
申请人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
发明人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
IPC分类号： A61K31/4152 , A61K31/277 , A61K31/138
CPC分类号： C07C311/21 , C07C39/367 , C07C43/178 , C07C43/21 , C07C43/23 , C07C49/245 , C07C49/248 , C07C49/83 , C07C59/56 , C07C65/105 , C07C69/732 , C07C69/734 , C07C69/736 , C07C215/52 , C07C217/08 , C07C217/76 , C07C233/25 , C07C233/75 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/42 , C07C235/44 , C07C235/46 , C07C235/80 , C07C251/40 , C07C251/48 , C07C275/32 , C07C307/02 , C07C309/65 , C07C311/08 , C07C2601/14 , C07D203/10 , C07D207/27 , C07D211/16 , C07D211/58 , C07D213/30 , C07D213/36 , C07D213/40 , C07D213/85 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/18 , C07D263/32 , C07D263/34 , C07D271/113 , C07D277/24 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/12 , C07D307/42 , C07D307/52 , C07D307/54 , C07D307/68 , C07D307/91 , C07D309/06 , C07D317/20 , C07D317/54 , C07D333/16 , C07D405/12
摘要： wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
摘要翻译：其中n为0至10的整数; R 1表示取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的环烷基，取代或未取代的低级烷氧基羰基，取代或未取代的杂环 - 烷基，取代或未取代的芳基，-CONR R 8，R 9，R 10等; R 2表示取代或未取代的芳基或取代或未取代的杂环基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R 4和R 6可以相同或不同，各自表示氢原子，卤素，取代或未取代的低级烷基等）。提供的是Hsp90家族蛋白抑制剂包含作为活性成分的式（I）的苯衍生物或其前药或其药学上可接受的盐等。

10. 发明申请

US20070117856A1 Indazole derivatives 失效
标题翻译：吲唑衍生物
公开(公告)号：US20070117856A1
公开(公告)日：2007-05-24
申请号：US10548475
申请日：2004-07-30
申请人： Yoshihisa Ohta , Fumihiko Kanai , Shinji Nara , Yutaka Kanda , Hiroshi Umehara , Yukimasa Shiotsu , Tomoki Naoe , Hitoshi Kiyoi , Keiko Kawashima , Hiromi Ando , Motoki Miyama
发明人： Yoshihisa Ohta , Fumihiko Kanai , Shinji Nara , Yutaka Kanda , Hiroshi Umehara , Yukimasa Shiotsu , Tomoki Naoe , Hitoshi Kiyoi , Keiko Kawashima , Hiromi Ando , Motoki Miyama
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56
摘要： The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].
摘要翻译：本发明提供由式（I）表示的化合物：[其中R 1表示CONR 1a 1b 1b（其中R 1a） R 1b和R 1b可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基，或R 1a和R 1b与相邻的氮原子一起形成取代或未取代的杂环基）等，R 2 O， >表示氢原子，其中R 2a，R 2b和R 2b可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基，或R 2b和R 2b >与t结合在一起它与氮原子相邻以形成取代或未取代的杂环基），NR 2c R 2d（其中R 2c和R 2d）取代或未取代的低级烷酰基，取代或未取代的芳酰基，取代或未取代的杂芳酰基，取代或未取代的芳烷基，取代或未取代的低级烷基磺酰基或取代或未取代的低级芳基磺酰基等）。

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