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    • 1. 发明授权
    • Indazole derivatives
    • 吲唑衍生物
    • US07919517B2
    • 2011-04-05
    • US12275614
    • 2008-11-21
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • A61K31/416C07D231/56
    • C07D231/56
    • The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].
    • 本发明提供由式(I)表示的化合物:[其中R1表示CONR1aR1b(其中R1a和R1b可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的 芳基或取代或未取代的杂环基,或者R1a和R1b与相邻的氮原子一起形成取代或未取代的杂环基)等,R2表示氢原子,CONR2aR2b(其中R2a和R2b可以是 各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳基或取代或未取代的杂环基,或者R 2a和R 2b与相邻的氮原子一起形成取代基 或未取代的杂环基),NR2cR2d(其中R2c和R2d可以相同或不同 取代或未取代的杂芳酰基,取代或未取代的芳酰基,取代或未取代的低级烷基磺酰基或取代或未取代的低级芳基磺酰基)等,其中R 1表示氢原子,取代或未取代的低级烷基,取代或未取代的低级烷酰基,取代或未取代的芳酰基, 。
    • 2. 发明申请
    • Indazole derivatives
    • 吲唑衍生物
    • US20070117856A1
    • 2007-05-24
    • US10548475
    • 2004-07-30
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • A61K31/416C07D231/56
    • C07D231/56
    • The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].
    • 本发明提供由式(I)表示的化合物:[其中R 1表示CONR 1a 1b 1b(其中R 1a) R 1b和R 1b可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳烷基或取代或未取代的杂环基, 或R 1a和R 1b与相邻的氮原子一起形成取代或未取代的杂环基)等,R 2 O, >表示氢原子,其中R 2a,R 2b和R 2b可以相同或不同, 各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳烷基或取代或未取代的杂环基,或R 2b和R 2b >与t结合在一起 它与氮原子相邻以形成取代或未取代的杂环基),NR 2c R 2d(其中R 2c和R 2d) 取代或未取代的低级烷酰基,取代或未取代的芳酰基,取代或未取代的杂芳酰基,取代或未取代的芳烷基,取代或未取代的低级烷基磺酰基或 取代或未取代的低级芳基磺酰基等)。
    • 3. 发明申请
    • INDAZOLE DERIVATIVES
    • 吲哚衍生物
    • US20090082348A1
    • 2009-03-26
    • US12275614
    • 2008-11-21
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • A61K31/5377A61K31/416A61K31/496A61K31/454A61K31/506A61K31/4439A61P35/00
    • C07D231/56
    • The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].
    • 本发明提供由式(I)表示的化合物:[其中R1表示CONR1aR1b(其中R1a和R1b可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的 芳基或取代或未取代的杂环基,或者R1a和R1b与相邻的氮原子一起形成取代或未取代的杂环基)等,R2表示氢原子,CONR2aR2b(其中R2a和R2b可以是 各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳基或取代或未取代的杂环基,或者R 2a和R 2b与相邻的氮原子一起形成取代基 或未取代的杂环基),NR2cR2d(其中R2c和R2d可以相同或不同 取代或未取代的芳酰基,取代或未取代的芳酰基,取代或未取代的低级烷基磺酰基或取代或未取代的低级芳基磺酰基)等。 。
    • 4. 发明授权
    • Indazole derivatives
    • 吲唑衍生物
    • US07470717B2
    • 2008-12-30
    • US10548475
    • 2004-07-30
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • Yoshihisa OhtaFumihiko KanaiShinji NaraYutaka KandaHiroshi UmeharaYukimasa ShiotsuTomoki NaoeHitoshi KiyoiKeiko KawashimaHiromi AndoMotoki Miyama
    • A61K31/416C07D231/56
    • C07D231/56
    • The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].
    • 本发明提供由式(I)表示的化合物:[其中R1表示CONR1aR1b(其中R1a和R1b可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的 芳烷基或取代或未取代的杂环基,或者R1a和R1b与相邻的氮原子一起形成取代或未取代的杂环基)等,R2表示氢原子,CONR2aR2b(其中R2a和R2b可以是 各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的芳烷基或取代或未取代的杂环基,或R 2a和R 2b与相邻的氮原子一起形成取代基 或未取代的杂环基),NR2cR2d(其中R2c和R2d可以相同或不同 取代或未取代的杂芳酰基,取代或未取代的芳烷基,取代或未取代的低级烷基磺酰基或取代或未取代的低级芳基磺酰基)等,其中R 1代表氢原子,取代或未取代的低级烷基,取代或未取代的低级烷酰基,取代或未取代的芳酰基, 。
    • 9. 发明申请
    • AURORA INHIBITORS
    • AURORA抑制剂
    • US20090209537A1
    • 2009-08-20
    • US12305120
    • 2007-06-29
    • Yukimasa ShiotsuKenichi IshiiHiroshi Umehara
    • Yukimasa ShiotsuKenichi IshiiHiroshi Umehara
    • A61K31/5377A61P35/00
    • C07D403/10A61K31/416A61K31/4439A61K31/454A61K31/496A61K31/5377C07D231/56C07D401/06
    • The present invention provides an Aurora inhibitor which comprises, as an active ingredient, an indazole derivative represented by Formula (I) (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group) or a pharmaceutically acceptable salt thereof, an Aurora inhibitor which comprises, as an active ingredient, an indazole derivative represented by Formula (Ia) [wherein R2 represents CONR4aR4b (wherein R4a and R4b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like, or R4a and R4b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, and R3 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like] or a pharmaceutically acceptable salt thereof, and the like.
    • 本发明提供一种Aurora抑制剂,其包含作为活性成分的由式(I)表示的吲唑衍生物(其中R 1表示取代或未取代的芳基或取代或未取代的杂环基)或其药学上可接受的盐,极光抑制剂 其包含作为活性成分的由式(Ia)表示的吲唑衍生物[其中R2表示CONR4aR4b(其中R4a和R4b可以相同或不同,各自表示氢原子,取代或未取代的低级烷基等, 或R4a和R4b与相邻的氮原子一起形成取代或未取代的杂环基)等,R 3表示氢原子,取代或未取代的低级烷基等]或其药学上可接受的盐, 等等。
    • 10. 发明授权
    • Magnetic recording and reproducing apparatus with selective loading of
different sized magnetic tapes
    • 具有选择性加载不同尺寸磁带的磁记录和再现装置
    • US4866550A
    • 1989-09-12
    • US171746
    • 1988-03-22
    • Keiichi OhashiHiroshi UmeharaHajime Nagahashi
    • Keiichi OhashiHiroshi UmeharaHajime Nagahashi
    • H02M7/219G11B15/665G11B15/675G11B25/06
    • G11B15/6653G11B15/67544G11B15/67565G11B25/066
    • A magnetic recording and reproducing apparatus which enables selective loading of a plurality of kinds of magnetic tape cassettes of different sizes, including a slider which receives a large magnetic tape cassette horizontally from an insertion position of the large magnetic tape cassette so as to displace the large magnetic tape cassette horizontally and then, lowers the large magnetic tape cassette vertically and an adapter chassis into which a small magnetic tape cassette is fitted so as to be locked thereto. Upon detection of fitting of the small magnetic tape cassette into the adapter chassis, a magnetic tape is drawn from the small magnetic tape cassette by first and second tape drawing arms mounted on the adapter chassis and upon detection of a state in which the magnetic tape has been drawn from the small magnetic tape cassette and the slider has been displaced to a position for performing recording and reproduction, the adapter chassis is loaded onto the slider located at the position for performing recording and reproduction.
    • 一种磁记录和再现装置,其能够选择性地装载多种不同尺寸的磁带盒(1,3),包括滑块(6),滑块(6)从大的磁带盒(3)的水平插入位置 使大型磁带盒(3)水平移位,然后使大型磁带盒(3)垂直移动,并将适配器底盘(14)放入小型磁带盒(1)中, )被装配以便被锁定在其上。 在检测到小型磁带盒(1)装配到适配器底座(14)中时,通过第一和第二带状拉伸臂(22,23)从小型磁带盒(1)中抽出磁带(1a) 安装在适配器底盘(14)上,并且在检测到磁带(1a)已经从小型磁带盒(1)中被拉出并且滑块(6)已经移位到位置(6P)的状态下 执行记录和再现时,适配器底盘(14)被加载到位于位置(6P)处的用于执行记录和再现的滑块(6)上。