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1. 发明授权

US07538241B2 Hsp90 family protein inhibitors 失效
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07538241B2
公开(公告)日：2009-05-26
申请号：US10584234
申请日：2004-12-24
申请人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
发明人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
IPC分类号： C07C225/00 , C07C211/00 , C07C69/76
CPC分类号： C07C311/21 , C07C39/367 , C07C43/178 , C07C43/21 , C07C43/23 , C07C49/245 , C07C49/248 , C07C49/83 , C07C59/56 , C07C65/105 , C07C69/732 , C07C69/734 , C07C69/736 , C07C215/52 , C07C217/08 , C07C217/76 , C07C233/25 , C07C233/75 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/42 , C07C235/44 , C07C235/46 , C07C235/80 , C07C251/40 , C07C251/48 , C07C275/32 , C07C307/02 , C07C309/65 , C07C311/08 , C07C2601/14 , C07D203/10 , C07D207/27 , C07D211/16 , C07D211/58 , C07D213/30 , C07D213/36 , C07D213/40 , C07D213/85 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/18 , C07D263/32 , C07D263/34 , C07D271/113 , C07D277/24 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/12 , C07D307/42 , C07D307/52 , C07D307/54 , C07D307/68 , C07D307/91 , C07D309/06 , C07D317/20 , C07D317/54 , C07D333/16 , C07D405/12
摘要： (wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
摘要翻译：（其中n为0至10的整数; R 1表示取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的环烷基，取代或未取代的低级烷氧基羰基，取代或未取代的杂环 - 烷基，取代或未取代的芳基，-CONR 7 R 8 ，-NR9R10等; R2表示取代或未取代的芳基或取代或未取代的杂环基等; R3和R5可以相同或不同，分别表示氢原子，取代或未取代的低级烷基等; R4 R 6可以相同或不同，各自表示氢原子，卤素，取代或未取代的低级烷基等）。提供一种Hsp90家族蛋白质抑制剂，其包含作为活性成分的式（I）的苯衍生物或其前药或其药学上可接受的盐等

2. 发明申请

US20070155813A1 Hsp90 family protein inhibitors 失效
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20070155813A1
公开(公告)日：2007-07-05
申请号：US10584234
申请日：2004-12-24
申请人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
发明人： Yushi Kitamura , Shinji Nara , Hiroshi Nakagawa , Rieko Nakatsu , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Yukimasa Shiotsu , Yutaka Kanda
IPC分类号： A61K31/4152 , A61K31/277 , A61K31/138
CPC分类号： C07C311/21 , C07C39/367 , C07C43/178 , C07C43/21 , C07C43/23 , C07C49/245 , C07C49/248 , C07C49/83 , C07C59/56 , C07C65/105 , C07C69/732 , C07C69/734 , C07C69/736 , C07C215/52 , C07C217/08 , C07C217/76 , C07C233/25 , C07C233/75 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/42 , C07C235/44 , C07C235/46 , C07C235/80 , C07C251/40 , C07C251/48 , C07C275/32 , C07C307/02 , C07C309/65 , C07C311/08 , C07C2601/14 , C07D203/10 , C07D207/27 , C07D211/16 , C07D211/58 , C07D213/30 , C07D213/36 , C07D213/40 , C07D213/85 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/18 , C07D263/32 , C07D263/34 , C07D271/113 , C07D277/24 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/12 , C07D307/42 , C07D307/52 , C07D307/54 , C07D307/68 , C07D307/91 , C07D309/06 , C07D317/20 , C07D317/54 , C07D333/16 , C07D405/12
摘要： wherein n is an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, —CONR7R8, —NR9R10, etc.; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; R3 and R5 may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R4 and R6 may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.
摘要翻译：其中n为0至10的整数; R 1表示取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的环烷基，取代或未取代的低级烷氧基羰基，取代或未取代的杂环 - 烷基，取代或未取代的芳基，-CONR R 8，R 9，R 10等; R 2表示取代或未取代的芳基或取代或未取代的杂环基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R 4和R 6可以相同或不同，各自表示氢原子，卤素，取代或未取代的低级烷基等）。提供的是Hsp90家族蛋白抑制剂包含作为活性成分的式（I）的苯衍生物或其前药或其药学上可接受的盐等。

3. 发明申请

US20090247522A1 Hsp90 FAMILY PROTEIN INHIBITORS 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20090247522A1
公开(公告)日：2009-10-01
申请号：US12427847
申请日：2009-04-22
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A61K31/5377 , A61K31/12 , A61K31/216 , A61K31/165 , A61K31/44 , A61K31/495 , A61K31/445 , A61K31/40 , A61K31/496 , A61K31/47 , A61K31/5375 , A61P35/00
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上所述苯甲酰化合物或所述前药的可接受的盐。

4. 发明授权

US07767693B2 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07767693B2
公开(公告)日：2010-08-03
申请号：US12427847
申请日：2009-04-22
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A01N43/40 , C07D211/22 , C07C49/303
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上所述苯甲酰化合物或所述前药的可接受的盐。

5. 发明授权

US07538224B2 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07538224B2
公开(公告)日：2009-05-26
申请号：US10561415
申请日：2004-06-10
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： C07D211/22 , C07C49/303
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含作为活性成分的通式（I）表示的苯甲酰基化合物：（其中n表示0〜10的整数; R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR7R8等; R2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R3和R5可相同或不同，分别表示氢原子，取代或未取代的低级烷基，取代或未取代的未取代的低级烯基等;以及可以相同或不同的R 4和R 6各自表示氢原子，卤素，取代或未取代的低级烷基，取代或未取代的芳基等）或其前药，或药学上所述苯甲酰化合物或所述前药的可接受的盐。

6. 发明申请

US20070032532A1 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20070032532A1
公开(公告)日：2007-02-08
申请号：US10561415
申请日：2004-06-10
申请人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A61K31/4192 , A61K31/22 , A61K31/195 , A61K31/165
CPC分类号： C07D211/42 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/40 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C49/84 , C07C69/738 , C07C205/45 , C07C235/78 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/22 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/08 , C07D295/088 , C07D295/185 , C07D307/46 , C07D307/52 , C07D307/54 , C07D317/60 , C07D333/22 , C07D333/24 , C07D409/10
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白质抑制剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示0〜10的整数，R 1表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基，取代或未取代的芳族杂环基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的低级链烯基等; R 4和R 6和R 6可以相同或不同，分别表示氢原子，卤素，取代或未取代的低级烷基，被取代的或未取代的芳基等）或其前药，或所述苯甲酰基化合物或所述前药的药学上可接受的盐。

7. 发明申请

US20090042883A1 ANTITUMOR AGENT 审中-公开
标题翻译：抗菌剂
公开(公告)号：US20090042883A1
公开(公告)日：2009-02-12
申请号：US11816736
申请日：2006-02-21
申请人： Yutaka Kanda , Shiro Soga , Takayuki Nakashima , Shinji Nara , Hiroshi Nakagawa , Yukimasa Shiotsu
发明人： Yutaka Kanda , Shiro Soga , Takayuki Nakashima , Shinji Nara , Hiroshi Nakagawa , Yukimasa Shiotsu
IPC分类号： A61K31/05 , C07C39/04 , C07D211/70 , C07D241/04 , A61K31/4406 , A61K31/496 , A61K31/5377 , A61P35/00 , A61K31/5375 , A61K31/495 , C07D403/04 , C07D265/30 , C07D413/04
CPC分类号： A61K31/12 , A61K31/165 , A61K31/216 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4406 , A61K31/445 , A61K31/4535 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C235/78 , C07D207/09 , C07D207/24 , C07D207/27 , C07D211/22 , C07D211/42 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/18 , C07D295/088 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/46 , C07D307/52 , C07D317/60 , C07D333/22
摘要： The present invention provides a therapeutic agent for a tumor selected from a hematopoietic tumor and a solid tumor which comprises, as an active ingredient, a benzoyl compound represented by General Formula (I): (wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R3 and R5 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like), a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种选自造血肿瘤和实体肿瘤的肿瘤治疗剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示1〜5的整数; R1 表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基或取代或未取代的芳族杂环基; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R4表示氢原子，羟基或卤素; R6表示氢原子，卤素，取代或未取代的低级烷基等），其前药或其药学上可接受的盐。

8. 发明申请

US20100098690A1 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：US20100098690A1
公开(公告)日：2010-04-22
申请号：US12529380
申请日：2008-03-05
申请人： Shiro Soga , Toshihiko Ishii , Takayuki Nakashima , Yukimasa Shiotsu , Shiro Akinaga
发明人： Shiro Soga , Toshihiko Ishii , Takayuki Nakashima , Yukimasa Shiotsu , Shiro Akinaga
IPC分类号： A61K31/122 , A61K31/216 , A61K31/135 , A61K31/495 , A61K31/445 , A61K31/47 , A61K31/5375 , A61K31/44 , A61K31/075 , A61K31/165 , A61K31/05 , A61K31/5377 , A61K39/395 , A61K31/4965 , A61P35/00
CPC分类号： A61K31/5375 , A61K31/198 , A61K31/337 , A61K31/5377 , A61K39/39558 , A61K45/06 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising a combination of an Hsp 90 family protein inhibitor and at least one compound, the said pharmaceutical composition wherein the Hsp 90 family protein inhibitor is a benozoyl compound represented by formula (I): [wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkyl, CONR7R8 (wherein R7 and R8, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like; R2 represents substituted or unsubstituted aryl, or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like], or a prodrug thereof; or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译：本发明提供了包含Hsp90家族蛋白抑制剂和至少一种化合物的组合的药物组合物，所述药物组合物，其中Hsp 90家族蛋白抑制剂是由式（I）表示的新戊酰化合物：[其中n表示 1〜5的整数; R1表示取代或未取代的低级烷基CONR7R8（其中R7和R8可相同或不同，各自表示氢原子，取代或未取代的低级烷基等）等; R2表示取代或未取代的芳基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R4表示氢原子，羟基或卤素; R6代表氢原子，卤素，取代或未取代的低级烷基等]或其前药; 或其药学上可接受的盐等。

9. 发明授权

US07781485B2 Hsp90 family protein inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US07781485B2
公开(公告)日：2010-08-24
申请号：US11718079
申请日：2005-11-09
申请人： Yushi Kitamura , Yutaka Kanda , Takayuki Nakashima
发明人： Yushi Kitamura , Yutaka Kanda , Takayuki Nakashima
IPC分类号： A61K31/24 , A61K31/235
CPC分类号： C07C235/64 , C07C69/88 , C07C235/60 , C07D213/40 , C07D295/192
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoic acid derivative represented by General Formula (I): [wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted aroyl, or the like; R2 represents —NR14R15 (wherein R14 and R15 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R3 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; and R4 and R6 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like] or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoic acid derivative or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白抑制剂，其包含通式（I）表示的苯甲酸衍生物作为活性成分：[其中，n表示0〜10的整数， R 1表示取代或未取代的低级烷氧基羰基，取代或未取代的芳酰基等; R2表示-NR14R15（其中R14和R15可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基等）; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; 并且R 4和R 6可以相同或不同，并且各自表示氢原子，卤素，取代或未取代的低级烷基等]或其前药，或所述苯甲酸衍生物或所述前药的药学上可接受的盐。

10. 发明申请

US20070265268A1 Hsp90 Family protein Inhibitors 有权
标题翻译： Hsp90家族蛋白抑制剂
公开(公告)号：US20070265268A1
公开(公告)日：2007-11-15
申请号：US11718079
申请日：2005-11-09
申请人： Yushi Kitamura , Yutaka Kanda , Takayuki Nakashima
发明人： Yushi Kitamura , Yutaka Kanda , Takayuki Nakashima
IPC分类号： A61K31/166 , A61K31/235 , A61K31/24 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C229/34 , C07C235/44 , C07C69/84 , C07D207/08 , C07D213/04 , C07D265/30 , C07D295/14
CPC分类号： C07C235/64 , C07C69/88 , C07C235/60 , C07D213/40 , C07D295/192
摘要： The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoic acid derivative represented by General Formula (I): [wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted aroyl, or the like; R2 represents —NR14R15 (wherein R14 and R15 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R3 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; and R4 and R6 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like] or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoic acid derivative or said prodrug.
摘要翻译：本发明提供Hsp90家族蛋白抑制剂，其包含通式（I）表示的苯甲酸衍生物作为活性成分：[其中，n表示0〜10的整数， R 1表示取代或未取代的低级烷氧基羰基，取代或未取代的芳酰基等; R 2表示-NR 14 R 15（其中R 14和R 15）可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基等）; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R 4和R 6可以相同或不同，各自表示氢原子，卤素，取代或未取代的低级烷基等]或其前药，或所述苯甲酸衍生物或所述前药的药学上可接受的盐。

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