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1. 发明申请

US20100027751A1 Method for the production of angiography recordings 有权
标题翻译：生产血管造影记录的方法
公开(公告)号：US20100027751A1
公开(公告)日：2010-02-04
申请号：US12507818
申请日：2009-07-23
申请人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
发明人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
IPC分类号： H05G1/64 , G06K9/00
CPC分类号： A61B6/504 , A61B5/055 , A61B6/4458 , A61B6/481 , A61B6/488 , A61B6/541
摘要： The invention relates to a method for the production of angiography recordings. First, a mask image is recorded with a first modality. A contrast medium is injected after the first recording. A control image is recorded with a second modality after the injection of the contrast medium. A spreading of the contrast medium is determined based on the images and the control of subsequent recordings is analyzed. A recording criterion is checked to determine whether the recording criterion has been achieved. If it has not been achieved, the control image is repeatedly recorded for repeatedly determining the spreading of the contrast medium. If it has been achieved, a contrast image is recorded with the first modality and the mask image and the contrast image are processed and analyzed.
摘要翻译：本发明涉及一种生产血管造影记录的方法。首先，以第一模式记录掩模图像。在第一次记录之后注射造影剂。在注射造影剂之后，以第二模态记录控制图像。基于图像确定造影剂的扩展，并分析后续记录的控制。检查记录标准以确定是否已经实现了记录标准。如果还没有实现，则重复记录控制图像以重复确定造影剂的扩展。如果已经实现，则用第一模态记录对比度图像，并且处理和分析掩模图像和对比度图像。

2. 发明授权

US08054941B2 Method for the production of angiography recordings 有权
标题翻译：生产血管造影记录的方法
公开(公告)号：US08054941B2
公开(公告)日：2011-11-08
申请号：US12507818
申请日：2009-07-23
申请人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
发明人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
IPC分类号： H05G1/64 , H05G1/60 , H05G1/58 , G01N23/083
CPC分类号： A61B6/504 , A61B5/055 , A61B6/4458 , A61B6/481 , A61B6/488 , A61B6/541
摘要： The invention relates to a method for the production of angiography recordings. First, a mask image is recorded with a first modality. A contrast medium is injected after the first recording. A control image is recorded with a second modality after the injection of the contrast medium. A spreading of the contrast medium is determined based on the images and the control of subsequent recordings is analyzed. A recording criterion is checked to determine whether the recording criterion has been achieved. If it has not been achieved, the control image is repeatedly recorded for repeatedly determining the spreading of the contrast medium. If it has been achieved, a contrast image is recorded with the first modality and the mask image and the contrast image are processed and analyzed.
摘要翻译：本发明涉及一种生产血管造影记录的方法。首先，以第一模式记录掩模图像。在第一次记录之后注射造影剂。在注射造影剂之后，以第二模态记录控制图像。基于图像确定造影剂的扩展，并分析后续记录的控制。检查记录标准以确定是否已经实现了记录标准。如果还没有实现，则重复记录控制图像以重复确定造影剂的扩展。如果已经实现，则用第一模态记录对比度图像，并且处理和分析掩模图像和对比度图像。

3. 发明授权

US08488861B2 System and method of automatic estimation of arterial input function for evaluation of blood flow 有权
标题翻译：自动估计动脉输入功能评估血流量的系统和方法
公开(公告)号：US08488861B2
公开(公告)日：2013-07-16
申请号：US12245373
申请日：2008-10-03
申请人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
发明人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
IPC分类号： G06K9/60 , G06K9/78 , G06K9/80 , H05G1/60
CPC分类号： A61B6/481 , A61B5/055 , A61B6/4441 , A61B6/504 , A61B6/507
摘要： A system and method of determining hemodynamic parameters of a patient is described. A background image data set is obtained prior to the administration of a contrast agent. A series of image data sets is obtained during the first passage of the bolus through a parenchymal volume. The pre-contrast-agent image is subtracted from image data sets obtained during the first passage of the contrast agent bolus, so that the amount of contrast agent in the volume may be determined. The time series of the amount of contrast agent is computed to determine the arterial input function (AIF) which may be used to determine a tissue impulse response, and hemodynamic parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT).
摘要翻译：描述了确定患者的血液动力学参数的系统和方法。在施用造影剂之前获得背景图像数据集。在推注通过实质体积的第一次通过期间获得一系列图像数据集。在造影剂推注的第一次通过期间获得的图像数据集中减去预造影剂图像，从而可以确定体积中造影剂的量。计算造影剂量的时间序列以确定可用于确定组织脉冲响应的动脉输入功能（AIF），以及血液动力学参数，例如脑血流量（CBF），脑血容量（CBV）和平均通行时间（MTT）。

4. 发明申请

US20090092308A1 SYSTEM AND METHOD OF AUTOMATIC ESTIMATION OF ARTERIAL INPUT FUNCTION FOR EVALUATION OF BLOOD FLOW 有权
标题翻译：用于评估血液流动的输入函数的自动估计系统和方法
公开(公告)号：US20090092308A1
公开(公告)日：2009-04-09
申请号：US12245373
申请日：2008-10-03
申请人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
发明人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
IPC分类号： A61B6/00 , G06K9/00 , A61B5/055
CPC分类号： A61B6/481 , A61B5/055 , A61B6/4441 , A61B6/504 , A61B6/507
摘要： A system and method of determining hemodynamic parameters of a patient is described. A background image data set is obtained prior to the administration of a contrast agent. A series of image data sets is obtained during the first passage of the bolus through a parenchymal volume. The pre-contrast-agent image is subtracted from image data sets obtained during the first passage of the contrast agent bolus, so that the amount of contrast agent in the volume may be determined. The time series of the amount of contrast agent is computed to determine the arterial input function (AIF) which may be used to determine a tissue impulse response, and hemodynamic parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT).
摘要翻译：描述了确定患者的血液动力学参数的系统和方法。在施用造影剂之前获得背景图像数据集。在推注通过实质体积的第一次通过期间获得一系列图像数据集。在造影剂推注的第一次通过期间获得的图像数据集中减去预造影剂图像，从而可以确定体积中造影剂的量。计算造影剂量的时间序列以确定可用于确定组织脉冲响应的动脉输入功能（AIF），以及血液动力学参数，例如脑血流量（CBF），脑血容量（CBV）和平均通行时间（MTT）。

5. 发明申请

US20100246916A1 Method and apparatus for generating a functional data set of a perfused region of the human or animal body 有权
标题翻译：用于产生人或动物体的灌注区域的功能数据集的方法和装置
公开(公告)号：US20100246916A1
公开(公告)日：2010-09-30
申请号：US12729269
申请日：2010-03-23
申请人： Yu Deuerling-Zheng , Thomas Redel , Michael Zellerhoff
发明人： Yu Deuerling-Zheng , Thomas Redel , Michael Zellerhoff
IPC分类号： G06K9/00 , G01N23/04
CPC分类号： A61B6/504 , A61B6/481 , A61B6/507 , A61B6/5235 , A61B2090/364
摘要： A method and apparatus for generating at least one functional data set of a perfused region of the human or animal body are proposed. A first image data set is supplied comprising at least two images of the perfused region recorded at different times before and after an injection of contrast agent into a first artery supplying the region. A second image data set is supplied comprising at least two images of the perfused region recorded at different times before and after an injection of contrast agent into a second artery supplying the region. A first functional data set is generated by pixel-based calculation of at least one perfusion parameter from the first image data set. A second functional data set is generated by pixel-based calculation of at least one perfusion parameter from the second image data set.
摘要翻译：提出了一种用于产生人体或动物身体的灌注区域的至少一个功能数据集的方法和装置。提供第一图像数据组，其包括在将造影剂注射到供应该区域的第一动脉之前和之后的不同时间记录的灌注区域的至少两个图像。提供第二图像数据集，其包括在将造影剂注射到供应该区域的第二动脉之前和之后的不同时间记录的灌注区域的至少两个图像。通过基于来自第一图像数据集的至少一个灌注参数的基于像素的计算来生成第一功能数据集。通过基于来自第二图像数据集的至少一个灌注参数的基于像素的计算来生成第二功能数据集。

6. 发明申请

US20080240338A1 Evaluation method for mapping the myocardium of a patient 有权
标题翻译：用于绘制患者心肌的评估方法
公开(公告)号：US20080240338A1
公开(公告)日：2008-10-02
申请号：US12079142
申请日：2008-03-25
申请人： Jan Boese , Yu Deuerling-Zheng
发明人： Jan Boese , Yu Deuerling-Zheng
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/4441 , A61B6/503 , A61B6/504 , A61B6/507 , G06T5/50 , G06T7/0012 , G06T2207/10116 , G06T2207/30048
摘要： The invention relates to an evaluation method for mapping the myocardium of a patient, in particular the automated, functional evaluation, for instance the heart perfusion, in angiographic series with the steps: recording a series of angiographic recordings directly after administering a contrast agent to the patient; determining a reference area in an angiographic recording; determining a trend pattern of the contrast agent as a reference curve within the reference area from the series of angiographic recordings; obtaining trend patterns of the contrast agent from all areas of the angiographic recordings; determining the correlation between the trend patterns and the reference curve as a measure for the interrelationship between statistical variables, comparison with stored reference curve; comparison of the correlation coefficient with a threshold value; and reproduction of a marker identifying the myocardium.
摘要翻译：本发明涉及用于映射患者心肌的评估方法，特别是血管造影系列中的自动功能评估（例如心脏灌注），其步骤为：在将造影剂施用于患者之后直接记录一系列血管造影记录患者; 确定血管造影记录中的参考区域; 确定造影剂的趋势图案作为来自该系列血管造影记录的参考区域内的参考曲线; 从血管造影记录的所有区域获得造影剂的趋势图; 确定趋势模式和参考曲线之间的相关性，作为统计变量之间相互关系的度量，与存储的参考曲线进行比较; 相关系数与阈值的比较; 以及识别心肌的标记物的繁殖。

7. 发明授权

US08023707B2 Evaluation method for mapping the myocardium of a patient 有权
标题翻译：用于绘制患者心肌的评估方法
公开(公告)号：US08023707B2
公开(公告)日：2011-09-20
申请号：US12079142
申请日：2008-03-25
申请人： Jan Boese , Yu Deuerling-Zheng
发明人： Jan Boese , Yu Deuerling-Zheng
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B6/481 , A61B6/4441 , A61B6/503 , A61B6/504 , A61B6/507 , G06T5/50 , G06T7/0012 , G06T2207/10116 , G06T2207/30048
摘要： The invention relates to an evaluation method for mapping the myocardium of a patient, in particular the automated, functional evaluation, for instance the heart perfusion, in angiographic series with the steps: recording a series of angiographic recordings directly after administering a contrast agent to the patient; determining a reference area in an angiographic recording; determining a trend pattern of the contrast agent as a reference curve within the reference area from the series of angiographic recordings; obtaining trend patterns of the contrast agent from all areas of the angiographic recordings; determining the correlation between the trend patterns and the reference curve as a measure for the interrelationship between statistical variables, comparison with stored reference curve; comparison of the correlation coefficient with a threshold value; and reproduction of a marker identifying the myocardium.
摘要翻译：本发明涉及用于映射患者心肌的评估方法，特别是血管造影系列中的自动功能评估（例如心脏灌注），其步骤为：在将造影剂施用于患者之后直接记录一系列血管造影记录患者; 确定血管造影记录中的参考区域; 确定造影剂的趋势图案作为来自该系列血管造影记录的参考区域内的参考曲线; 从血管造影记录的所有区域获得造影剂的趋势图; 确定趋势模式和参考曲线之间的相关性，作为统计变量之间相互关系的度量，与存储的参考曲线进行比较; 相关系数与阈值的比较; 以及识别心肌的标记物的繁殖。

8. 发明授权

US08755583B2 Method and apparatus for generating a functional data set of a perfused region of the human or animal body 有权
标题翻译：用于产生人或动物体的灌注区域的功能数据集的方法和装置
公开(公告)号：US08755583B2
公开(公告)日：2014-06-17
申请号：US12729269
申请日：2010-03-23
申请人： Yu Deuerling-Zheng , Thomas Redel , Michael Zellerhoff
发明人： Yu Deuerling-Zheng , Thomas Redel , Michael Zellerhoff
IPC分类号： G01N23/04 , G06K9/00 , H05G1/08
CPC分类号： A61B6/504 , A61B6/481 , A61B6/507 , A61B6/5235 , A61B2090/364
摘要： A method and apparatus for generating at least one functional data set of a perfused region of the human or animal body are proposed. A first image data set is supplied comprising at least two images of the perfused region recorded at different times before and after an injection of contrast agent into a first artery supplying the region. A second image data set is supplied comprising at least two images of the perfused region recorded at different times before and after an injection of contrast agent into a second artery supplying the region. A first functional data set is generated by pixel-based calculation of at least one perfusion parameter from the first image data set. A second functional data set is generated by pixel-based calculation of at least one perfusion parameter from the second image data set.
摘要翻译：提出了一种用于产生人体或动物身体的灌注区域的至少一个功能数据集的方法和装置。提供第一图像数据组，其包括在将造影剂注射到供应该区域的第一动脉之前和之后的不同时间记录的灌注区域的至少两个图像。提供第二图像数据集，其包括在将造影剂注射到供应该区域的第二动脉之前和之后的不同时间记录的灌注区域的至少两个图像。通过基于来自第一图像数据集的至少一个灌注参数的基于像素的计算来生成第一功能数据集。通过基于来自第二图像数据集的至少一个灌注参数的基于像素的计算来生成第二功能数据集。

9. 发明申请

US20130129172A1 COMPUTED-TOMOGRAPHY SYSTEM AND METHOD FOR DETERMINING VOLUME INFORMATION FOR A BODY 有权
标题翻译：用于确定身体体积信息的计算机图像系统和方法
公开(公告)号：US20130129172A1
公开(公告)日：2013-05-23
申请号：US13680318
申请日：2012-11-19
申请人： Jan Boese , Yu Deuerling-Zheng , Sabine Heiland , Martin Wagner
发明人： Jan Boese , Yu Deuerling-Zheng , Sabine Heiland , Martin Wagner
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T11/003
摘要： A tomogram of a body is provided. Projection-image data obtained by a radiation-based projection method is used for providing the tomogram. Initial voxel data are first specified for a plurality of voxels of the body. Synthetic projection-image data are generated based upon a projection rule modeling a course of the projection method. Projection-error data is determined by comparing the synthetic projection-image data with the real projection-image data. The projection-error data are imaged on the basis of a back-projection rule dependent on the projection rule so that voxel-error data are produced. Correction data is generated from the voxel-error data by a gradient-based optimizing algorithm, wherein corrected voxel data are generated using the correction data.
摘要翻译：提供身体的断层图像。使用基于辐射的投影方法获得的投影图像数据用于提供断层图像。首先为身体的多个体素指定初始体素数据。基于对投影方法的投影方法建模的投影规则生成合成投影图像数据。通过将合成投影图像数据与实际投影图像数据进行比较来确定投影误差数据。基于取决于投影规则的反投影规则对投影误差数据进行成像，从而产生体元错误数据。通过基于梯度的优化算法从体元错误数据生成校正数据，其中使用校正数据生成校正的体素数据。

10. 发明申请

US20150282779A1 Treating an Ischemic Stroke 审中-公开
标题翻译：治疗缺血性中风
公开(公告)号：US20150282779A1
公开(公告)日：2015-10-08
申请号：US14243374
申请日：2014-04-02
申请人： Yu Deuerling-Zheng , Klaus Klingenbeck
发明人： Yu Deuerling-Zheng , Klaus Klingenbeck
IPC分类号： A61B6/00 , A61M5/00 , A61B6/03
CPC分类号： A61B6/504 , A61B6/032 , A61B6/4441 , A61B6/501 , A61B6/5205 , A61B6/5217 , A61B6/5235
摘要： Systems and methods for treating an ischemic stroke are provided. In one aspect, a non-contrast scan is performed on a patient with a C-arm computed tomography (CT) imaging device in an interventional suite. A contrast agent is injected into the patient. A plurality of contrast scans is performed on the patient with the C-arm CT imaging device. Three-dimensional vascular images are reconstructed using the non-contrast scan and the plurality of contrast scans. A location of an ischemic stroke is determined from the reconstructed three-dimensional data sets and calculation of cerebral blood flow, mass transit time, time to peak, or a combination thereof. The ischemic stroke is treated in the interventional suite.
摘要翻译：提供了治疗缺血性卒中的系统和方法。在一个方面，在介入套件中的具有C臂计算机断层摄影（CT）成像装置的患者上执行非对比度扫描。将造影剂注射到患者体内。使用C臂CT成像装置对患者进行多次造影扫描。使用非对比度扫描和多个对比度扫描重建三维血管图像。从重建的三维数据集和脑血流量，体积传播时间，时间到峰值或其组合来确定缺血性卒中的位置。缺血性卒中在介入组中进行治疗。

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