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1. 发明授权

US08054941B2 Method for the production of angiography recordings 有权
标题翻译：生产血管造影记录的方法
公开(公告)号：US08054941B2
公开(公告)日：2011-11-08
申请号：US12507818
申请日：2009-07-23
申请人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
发明人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
IPC分类号： H05G1/64 , H05G1/60 , H05G1/58 , G01N23/083
CPC分类号： A61B6/504 , A61B5/055 , A61B6/4458 , A61B6/481 , A61B6/488 , A61B6/541
摘要： The invention relates to a method for the production of angiography recordings. First, a mask image is recorded with a first modality. A contrast medium is injected after the first recording. A control image is recorded with a second modality after the injection of the contrast medium. A spreading of the contrast medium is determined based on the images and the control of subsequent recordings is analyzed. A recording criterion is checked to determine whether the recording criterion has been achieved. If it has not been achieved, the control image is repeatedly recorded for repeatedly determining the spreading of the contrast medium. If it has been achieved, a contrast image is recorded with the first modality and the mask image and the contrast image are processed and analyzed.
摘要翻译：本发明涉及一种生产血管造影记录的方法。首先，以第一模式记录掩模图像。在第一次记录之后注射造影剂。在注射造影剂之后，以第二模态记录控制图像。基于图像确定造影剂的扩展，并分析后续记录的控制。检查记录标准以确定是否已经实现了记录标准。如果还没有实现，则重复记录控制图像以重复确定造影剂的扩展。如果已经实现，则用第一模态记录对比度图像，并且处理和分析掩模图像和对比度图像。

2. 发明申请

US20100027751A1 Method for the production of angiography recordings 有权
标题翻译：生产血管造影记录的方法
公开(公告)号：US20100027751A1
公开(公告)日：2010-02-04
申请号：US12507818
申请日：2009-07-23
申请人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
发明人： Jan Boese , Yu Deuerling-Zheng , Michael Zellerhoff
IPC分类号： H05G1/64 , G06K9/00
CPC分类号： A61B6/504 , A61B5/055 , A61B6/4458 , A61B6/481 , A61B6/488 , A61B6/541
摘要： The invention relates to a method for the production of angiography recordings. First, a mask image is recorded with a first modality. A contrast medium is injected after the first recording. A control image is recorded with a second modality after the injection of the contrast medium. A spreading of the contrast medium is determined based on the images and the control of subsequent recordings is analyzed. A recording criterion is checked to determine whether the recording criterion has been achieved. If it has not been achieved, the control image is repeatedly recorded for repeatedly determining the spreading of the contrast medium. If it has been achieved, a contrast image is recorded with the first modality and the mask image and the contrast image are processed and analyzed.
摘要翻译：本发明涉及一种生产血管造影记录的方法。首先，以第一模式记录掩模图像。在第一次记录之后注射造影剂。在注射造影剂之后，以第二模态记录控制图像。基于图像确定造影剂的扩展，并分析后续记录的控制。检查记录标准以确定是否已经实现了记录标准。如果还没有实现，则重复记录控制图像以重复确定造影剂的扩展。如果已经实现，则用第一模态记录对比度图像，并且处理和分析掩模图像和对比度图像。

3. 发明授权

US08488861B2 System and method of automatic estimation of arterial input function for evaluation of blood flow 有权
标题翻译：自动估计动脉输入功能评估血流量的系统和方法
公开(公告)号：US08488861B2
公开(公告)日：2013-07-16
申请号：US12245373
申请日：2008-10-03
申请人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
发明人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
IPC分类号： G06K9/60 , G06K9/78 , G06K9/80 , H05G1/60
CPC分类号： A61B6/481 , A61B5/055 , A61B6/4441 , A61B6/504 , A61B6/507
摘要： A system and method of determining hemodynamic parameters of a patient is described. A background image data set is obtained prior to the administration of a contrast agent. A series of image data sets is obtained during the first passage of the bolus through a parenchymal volume. The pre-contrast-agent image is subtracted from image data sets obtained during the first passage of the contrast agent bolus, so that the amount of contrast agent in the volume may be determined. The time series of the amount of contrast agent is computed to determine the arterial input function (AIF) which may be used to determine a tissue impulse response, and hemodynamic parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT).
摘要翻译：描述了确定患者的血液动力学参数的系统和方法。在施用造影剂之前获得背景图像数据集。在推注通过实质体积的第一次通过期间获得一系列图像数据集。在造影剂推注的第一次通过期间获得的图像数据集中减去预造影剂图像，从而可以确定体积中造影剂的量。计算造影剂量的时间序列以确定可用于确定组织脉冲响应的动脉输入功能（AIF），以及血液动力学参数，例如脑血流量（CBF），脑血容量（CBV）和平均通行时间（MTT）。

4. 发明申请

US20090092308A1 SYSTEM AND METHOD OF AUTOMATIC ESTIMATION OF ARTERIAL INPUT FUNCTION FOR EVALUATION OF BLOOD FLOW 有权
标题翻译：用于评估血液流动的输入函数的自动估计系统和方法
公开(公告)号：US20090092308A1
公开(公告)日：2009-04-09
申请号：US12245373
申请日：2008-10-03
申请人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
发明人： Yu Deuerling-Zheng , Jan Boese , Michael Zellerhoff
IPC分类号： A61B6/00 , G06K9/00 , A61B5/055
CPC分类号： A61B6/481 , A61B5/055 , A61B6/4441 , A61B6/504 , A61B6/507
摘要： A system and method of determining hemodynamic parameters of a patient is described. A background image data set is obtained prior to the administration of a contrast agent. A series of image data sets is obtained during the first passage of the bolus through a parenchymal volume. The pre-contrast-agent image is subtracted from image data sets obtained during the first passage of the contrast agent bolus, so that the amount of contrast agent in the volume may be determined. The time series of the amount of contrast agent is computed to determine the arterial input function (AIF) which may be used to determine a tissue impulse response, and hemodynamic parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT).
摘要翻译：描述了确定患者的血液动力学参数的系统和方法。在施用造影剂之前获得背景图像数据集。在推注通过实质体积的第一次通过期间获得一系列图像数据集。在造影剂推注的第一次通过期间获得的图像数据集中减去预造影剂图像，从而可以确定体积中造影剂的量。计算造影剂量的时间序列以确定可用于确定组织脉冲响应的动脉输入功能（AIF），以及血液动力学参数，例如脑血流量（CBF），脑血容量（CBV）和平均通行时间（MTT）。

5. 发明授权

US08023707B2 Evaluation method for mapping the myocardium of a patient 有权
标题翻译：用于绘制患者心肌的评估方法
公开(公告)号：US08023707B2
公开(公告)日：2011-09-20
申请号：US12079142
申请日：2008-03-25
申请人： Jan Boese , Yu Deuerling-Zheng
发明人： Jan Boese , Yu Deuerling-Zheng
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B6/481 , A61B6/4441 , A61B6/503 , A61B6/504 , A61B6/507 , G06T5/50 , G06T7/0012 , G06T2207/10116 , G06T2207/30048
摘要： The invention relates to an evaluation method for mapping the myocardium of a patient, in particular the automated, functional evaluation, for instance the heart perfusion, in angiographic series with the steps: recording a series of angiographic recordings directly after administering a contrast agent to the patient; determining a reference area in an angiographic recording; determining a trend pattern of the contrast agent as a reference curve within the reference area from the series of angiographic recordings; obtaining trend patterns of the contrast agent from all areas of the angiographic recordings; determining the correlation between the trend patterns and the reference curve as a measure for the interrelationship between statistical variables, comparison with stored reference curve; comparison of the correlation coefficient with a threshold value; and reproduction of a marker identifying the myocardium.
摘要翻译：本发明涉及用于映射患者心肌的评估方法，特别是血管造影系列中的自动功能评估（例如心脏灌注），其步骤为：在将造影剂施用于患者之后直接记录一系列血管造影记录患者; 确定血管造影记录中的参考区域; 确定造影剂的趋势图案作为来自该系列血管造影记录的参考区域内的参考曲线; 从血管造影记录的所有区域获得造影剂的趋势图; 确定趋势模式和参考曲线之间的相关性，作为统计变量之间相互关系的度量，与存储的参考曲线进行比较; 相关系数与阈值的比较; 以及识别心肌的标记物的繁殖。

6. 发明申请

US20080240338A1 Evaluation method for mapping the myocardium of a patient 有权
标题翻译：用于绘制患者心肌的评估方法
公开(公告)号：US20080240338A1
公开(公告)日：2008-10-02
申请号：US12079142
申请日：2008-03-25
申请人： Jan Boese , Yu Deuerling-Zheng
发明人： Jan Boese , Yu Deuerling-Zheng
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/4441 , A61B6/503 , A61B6/504 , A61B6/507 , G06T5/50 , G06T7/0012 , G06T2207/10116 , G06T2207/30048
摘要： The invention relates to an evaluation method for mapping the myocardium of a patient, in particular the automated, functional evaluation, for instance the heart perfusion, in angiographic series with the steps: recording a series of angiographic recordings directly after administering a contrast agent to the patient; determining a reference area in an angiographic recording; determining a trend pattern of the contrast agent as a reference curve within the reference area from the series of angiographic recordings; obtaining trend patterns of the contrast agent from all areas of the angiographic recordings; determining the correlation between the trend patterns and the reference curve as a measure for the interrelationship between statistical variables, comparison with stored reference curve; comparison of the correlation coefficient with a threshold value; and reproduction of a marker identifying the myocardium.
摘要翻译：本发明涉及用于映射患者心肌的评估方法，特别是血管造影系列中的自动功能评估（例如心脏灌注），其步骤为：在将造影剂施用于患者之后直接记录一系列血管造影记录患者; 确定血管造影记录中的参考区域; 确定造影剂的趋势图案作为来自该系列血管造影记录的参考区域内的参考曲线; 从血管造影记录的所有区域获得造影剂的趋势图; 确定趋势模式和参考曲线之间的相关性，作为统计变量之间相互关系的度量，与存储的参考曲线进行比较; 相关系数与阈值的比较; 以及识别心肌的标记物的繁殖。

7. 发明申请

US20130129172A1 COMPUTED-TOMOGRAPHY SYSTEM AND METHOD FOR DETERMINING VOLUME INFORMATION FOR A BODY 有权
标题翻译：用于确定身体体积信息的计算机图像系统和方法
公开(公告)号：US20130129172A1
公开(公告)日：2013-05-23
申请号：US13680318
申请日：2012-11-19
申请人： Jan Boese , Yu Deuerling-Zheng , Sabine Heiland , Martin Wagner
发明人： Jan Boese , Yu Deuerling-Zheng , Sabine Heiland , Martin Wagner
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T11/003
摘要： A tomogram of a body is provided. Projection-image data obtained by a radiation-based projection method is used for providing the tomogram. Initial voxel data are first specified for a plurality of voxels of the body. Synthetic projection-image data are generated based upon a projection rule modeling a course of the projection method. Projection-error data is determined by comparing the synthetic projection-image data with the real projection-image data. The projection-error data are imaged on the basis of a back-projection rule dependent on the projection rule so that voxel-error data are produced. Correction data is generated from the voxel-error data by a gradient-based optimizing algorithm, wherein corrected voxel data are generated using the correction data.
摘要翻译：提供身体的断层图像。使用基于辐射的投影方法获得的投影图像数据用于提供断层图像。首先为身体的多个体素指定初始体素数据。基于对投影方法的投影方法建模的投影规则生成合成投影图像数据。通过将合成投影图像数据与实际投影图像数据进行比较来确定投影误差数据。基于取决于投影规则的反投影规则对投影误差数据进行成像，从而产生体元错误数据。通过基于梯度的优化算法从体元错误数据生成校正数据，其中使用校正数据生成校正的体素数据。

8. 发明申请

US20090092225A1 Method for the three-dimensional representation of a moving structure by a tomographic method 有权
标题翻译：通过断层摄影法对移动结构进行三维表示的方法
公开(公告)号：US20090092225A1
公开(公告)日：2009-04-09
申请号：US12221938
申请日：2008-08-07
申请人： Jan Boese , Wolfgang Harer , Michael Zellerhoff
发明人： Jan Boese , Wolfgang Harer , Michael Zellerhoff
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B6/025 , A61B6/027 , A61B6/4441 , A61B6/466 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , G06T11/006 , G06T2211/404 , G06T2211/412 , G06T2211/436
摘要： The invention relates to a method for a three-dimensional representation of a moving structure by a tomographic method, in which during one recording pass a series of projection recordings is registered by an imaging unit at different recording angles between a start position and an end position, it being possible to reconstruct three-dimensional image data from the projection recordings with the following steps: a) generation of tomosynthesis projection recordings along a tomosynthesis scanning path; b) interpolation of the data of the tomosynthesis projection recordings in accordance with an interpolation algorithm in order to generate a projection data set; c) use of a tomosynthesis reconstruction method on the projection data set in order to generate a tomosynthesis volume image; d) repetition of steps b) and c) for all times of interest, and e) display of tomosynthesis representations from the tomosynthesis volume images.
摘要翻译：本发明涉及一种用于通过断层摄影方法对运动结构进行三维表示的方法，其中在一次记录通过期间，成像单元以起始位置和结束位置之间的不同记录角度登记一系列投影记录可以通过以下步骤从投影记录重建三维图像数据：a）沿着断层合成扫描路径生成断层合成投影记录; b）根据插值算法对所述断层合成投影记录的数据进行插值，以生成投影数据集; c）在投影数据集上使用断层合成重建方法，以便产生断层合成体积图像; d）对所有感兴趣的时间重复步骤b）和c），以及e）从断层合成体积图像显示断层合成表示。

9. 发明授权

US07899152B2 Method for the three-dimensional representation of a moving structure by a tomographic method 有权
标题翻译：通过断层摄影法对移动结构进行三维表示的方法
公开(公告)号：US07899152B2
公开(公告)日：2011-03-01
申请号：US12221938
申请日：2008-08-07
申请人： Jan Boese , Wolfgang Härer , Michael Zellerhoff
发明人： Jan Boese , Wolfgang Härer , Michael Zellerhoff
IPC分类号： A61B6/00
CPC分类号： A61B6/025 , A61B6/027 , A61B6/4441 , A61B6/466 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , G06T11/006 , G06T2211/404 , G06T2211/412 , G06T2211/436
摘要： The invention relates to a method for a three-dimensional representation of a moving structure by a tomographic method, in which during one recording pass a series of projection recordings is registered by an imaging unit at different recording angles between a start position and an end position, it being possible to reconstruct three-dimensional image data from the projection recordings with the following steps: a) generation of tomosynthesis projection recordings along a tomosynthesis scanning path; b) interpolation of the data of the tomosynthesis projection recordings in accordance with an interpolation algorithm in order to generate a projection data set; c) use of a tomosynthesis reconstruction method on the projection data set in order to generate a tomosynthesis volume image; d) repetition of steps b) and c) for all times of interest, and e) display of tomosynthesis representations from the tomosynthesis volume images.
摘要翻译：本发明涉及一种用于通过断层摄影方法对运动结构进行三维表示的方法，其中在一次记录通过期间，成像单元以起始位置和结束位置之间的不同记录角度登记一系列投影记录可以通过以下步骤从投影记录重建三维图像数据：a）沿着断层合成扫描路径生成断层合成投影记录; b）根据插值算法对所述断层合成投影记录的数据进行插值，以生成投影数据集; c）在投影数据集上使用断层合成重建方法，以便产生断层合成体积图像; d）对所有感兴趣的时间重复步骤b）和c），以及e）从断层合成体积图像显示断层合成表示。

10. 发明授权

US10719986B2 Method and system for virtual percutaneous valve implantation 有权
公开(公告)号：US10719986B2
公开(公告)日：2020-07-21
申请号：US12975714
申请日：2010-12-22
申请人： Dominik Zaeuner , Razvan Ioan Ionasec , Bogdan Georgescu , Yefeng Zheng , Dorin Comaniciu , Ingmar Voigt , Jan Boese
发明人： Dominik Zaeuner , Razvan Ioan Ionasec , Bogdan Georgescu , Yefeng Zheng , Dorin Comaniciu , Ingmar Voigt , Jan Boese
IPC分类号： G06T17/00 , G06T19/00 , G16H50/50 , G06F19/00
摘要： A method and system for virtual percutaneous valve implantation is disclosed. A patient-specific anatomical model of a heart valve is estimated based on 3D cardiac medical image data and an implant model representing a valve implant is virtually deployed into the patient-specific anatomical model of the heart valve. A library of implant models, each modeling geometrical properties of a corresponding valve implant, is maintained. The implant models maintained in the library are virtually deployed into the patient specific anatomical model of the heart valve to select an implant type and size and deployment location and orientation for percutaneous valve implantation.

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