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1. 发明申请

US20150282779A1 Treating an Ischemic Stroke 审中-公开
标题翻译：治疗缺血性中风
公开(公告)号：US20150282779A1
公开(公告)日：2015-10-08
申请号：US14243374
申请日：2014-04-02
申请人： Yu Deuerling-Zheng , Klaus Klingenbeck
发明人： Yu Deuerling-Zheng , Klaus Klingenbeck
IPC分类号： A61B6/00 , A61M5/00 , A61B6/03
CPC分类号： A61B6/504 , A61B6/032 , A61B6/4441 , A61B6/501 , A61B6/5205 , A61B6/5217 , A61B6/5235
摘要： Systems and methods for treating an ischemic stroke are provided. In one aspect, a non-contrast scan is performed on a patient with a C-arm computed tomography (CT) imaging device in an interventional suite. A contrast agent is injected into the patient. A plurality of contrast scans is performed on the patient with the C-arm CT imaging device. Three-dimensional vascular images are reconstructed using the non-contrast scan and the plurality of contrast scans. A location of an ischemic stroke is determined from the reconstructed three-dimensional data sets and calculation of cerebral blood flow, mass transit time, time to peak, or a combination thereof. The ischemic stroke is treated in the interventional suite.
摘要翻译：提供了治疗缺血性卒中的系统和方法。在一个方面，在介入套件中的具有C臂计算机断层摄影（CT）成像装置的患者上执行非对比度扫描。将造影剂注射到患者体内。使用C臂CT成像装置对患者进行多次造影扫描。使用非对比度扫描和多个对比度扫描重建三维血管图像。从重建的三维数据集和脑血流量，体积传播时间，时间到峰值或其组合来确定缺血性卒中的位置。缺血性卒中在介入组中进行治疗。

2. 发明授权

US10390782B2 Device and method for ascertaining at least one individual fluid-dynamic characteristic parameter of a stenosis in a vascular segment having serial stenoses 有权
公开(公告)号：US10390782B2
公开(公告)日：2019-08-27
申请号：US15451575
申请日：2017-03-07
申请人： Klaus Klingenbeck , Thomas Redel , Michael Scheuering , Michael Wiets
发明人： Klaus Klingenbeck , Thomas Redel , Michael Scheuering , Michael Wiets
IPC分类号： A61B6/00 , G06T7/11 , A61B6/03 , G06T7/00 , G16H50/50 , A61B34/10 , A61B5/02
摘要： The disclosure relates to a device and a method for ascertaining at least one individual fluid-dynamic characteristic parameter of a stenosis in a vascular segment having a plurality of serial stenoses, wherein angiography image data of the vascular segment is received from an angiography recording device, geometry data of the vascular segment is ascertained by an analysis device based on the angiography image data and combined into a segment model. At least one division point located between two of the stenoses respectively is ascertained by a dividing device in the segment model, the segment model is subdivided into subsegment models at each of the at least one division points, and the respective fluid-dynamic characteristic parameter is ascertained by a simulation device for at least one of the subsegment models based on respective geometry data of the subsegment model.

3. 发明授权

US08213565B2 Method for correcting truncated projection data 有权
标题翻译：用于校正截断的投影数据的方法
公开(公告)号：US08213565B2
公开(公告)日：2012-07-03
申请号：US12891849
申请日：2010-09-28
申请人： Jan Boese , Klaus Klingenbeck
发明人： Jan Boese , Klaus Klingenbeck
IPC分类号： A61B6/00
CPC分类号： A61B6/5241 , A61B6/032 , A61B6/4441 , A61B6/4458 , G06T11/005 , G06T2211/432
摘要： A method for correcting truncated projection data of a rotation for a reconstruction technique for computed tomography scans with truncated projection data in the computed tomography images produced by a C-arm is proposed. At least one truncated projection is recorded. The truncated portions prior to acquisition of the rotation for the at least one truncated projection is captured. The truncated projection and the truncated portions are assembled into at least one complete projection. Truncated projection data is acquired during the rotation. The truncated data is estimated based on a model of the patient geometry from the at least one complete projection. A reconstruction technique is performed on the basis of the acquired and the estimated data.
摘要翻译：提出了一种通过C臂产生的计算机断层图像中的截断的投影数据来校正用于计算机断层摄影扫描的重建技术的旋转的截断投影数据的方法。至少记录一个截断的投影。捕获用于至少一个截断投影的旋转获取之前的截断部分。截头突起和截头部分组装成至少一个完整的突起。在旋转期间获取截断的投影数据。基于来自至少一个完整投影的患者几何形状的模型来估计截断的数据。基于获取的和估计的数据执行重建技术。

4. 发明授权

US08068581B2 Method for representing interventional instruments in a 3D data set of an anatomy to be examined as well as a reproduction system for performing the method 有权
标题翻译：用于表示要检查的解剖结构的3D数据集中的介入仪器的方法以及用于执行该方法的再现系统
公开(公告)号：US08068581B2
公开(公告)日：2011-11-29
申请号：US12507343
申请日：2009-07-22
申请人： Jan Boese , Klaus Klingenbeck
发明人： Jan Boese , Klaus Klingenbeck
IPC分类号： G01N23/04
CPC分类号： A61B5/06 , A61B5/745 , A61B6/12 , A61B6/4458 , A61B6/4464 , A61B6/466 , A61B6/5229 , A61B6/5241 , A61B34/20 , A61B90/37 , A61B2090/366 , A61B2090/367 , A61B2090/376 , G06F19/00
摘要： The invention relates to a method for presenting interventional instruments in a 3D data set of an anatomy to be treated. A 3D data set of the anatomy is recorded before introduction of an interventional instrument. Once the interventional instrument has been applied, the spatial position of the instrument is determined by x-ray fluoroscopy from images created at two different angulations. A 3D model of the instrument is formed from the x-ray images. The 3D model of the instrument is fused with the 3D data set of the anatomy. A 3D hologram is reproduced from the fused 3D data set. The 3D hologram is repeatedly reproduced in real time to follow the application of the instrument in the presentation.
摘要翻译：本发明涉及一种用于在待治疗的解剖结构的3D数据集中呈现介入器械的方法。在引入介入仪器之前记录解剖结构的3D数据集。一旦介入仪器被应用，仪器的空间位置就是通过X射线荧光透视法确定的，这些图像是以两个不同角度产生的图像。仪器的3D模型由X射线图像形成。仪器的3D模型与解剖结构的3D数据集融合。从融合的3D数据集再现3D全息图。 3D全息图在实时中反复再现，以便在演示中遵循仪器的应用。

5. 发明授权

US08693758B2 Imaging method for enhanced visualization of vessels in an examination region of a patient and medical system for performing the method 有权
标题翻译：用于在用于执行该方法的患者和医疗系统的检查区域中增强血管可视化的成像方法
公开(公告)号：US08693758B2
公开(公告)日：2014-04-08
申请号：US13094855
申请日：2011-04-27
申请人： Klaus Klingenbeck
发明人： Klaus Klingenbeck
IPC分类号： G06K9/00
CPC分类号： A61B6/481 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B5/489 , A61B5/7425 , A61B6/4417 , A61B6/4441 , A61B6/4458 , A61B6/4464 , A61B6/485 , A61B6/504 , A61B6/507 , A61B6/5247 , A61B8/0816 , A61B8/0891 , A61B8/4416 , A61B8/5238 , A61B90/36 , A61B2090/364
摘要： An imaging method for enhanced visualization of vessels in an examination region of a patient, in particular during an intervention, is proposed. A 3D reconstruction image of the examination region is generated using a preoperatively recorded 3D image dataset of the examination region. At least one current 2D fluorescence image of the examination region is recorded by a fluorescence angiography. The vessels are identified. The 3D image dataset with the image dataset of the 2D fluorescence or ultrasound image is registered based on the result of the identification. The 3D reconstruction image and the 2D image are overplayed. The overlaid images are 3D played back.
摘要翻译：提出了一种用于在患者的检查区域，特别是在干预期间增强血管视觉的成像方法。使用检查区域的术前记录的3D图像数据集来生成检查区域的3D重建图像。通过荧光血管造影记录检查区域的至少一个当前2D荧光图像。识别船只。基于识别结果登记具有2D荧光或超声图像的图像数据集的3D图像数据集。 3D重建图像和2D图像被显示。重叠的图像是3D回放的。

6. 发明申请

US20120087563A1 Method and System for Intraoperative Guidance Using Physiological Image Fusion 有权
标题翻译：使用生理图像融合进行术中指导的方法和系统
公开(公告)号：US20120087563A1
公开(公告)日：2012-04-12
申请号：US13267662
申请日：2011-10-06
申请人： Razvan Ioan Ionasec , Ingmar Voigt , Bogdan Georgescu , Yefeng Zheng , Jan Boese , Klaus Klingenbeck , Dorin Comaniciu
发明人： Razvan Ioan Ionasec , Ingmar Voigt , Bogdan Georgescu , Yefeng Zheng , Jan Boese , Klaus Klingenbeck , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06T19/006 , G06T7/344 , G06T17/00 , G06T2207/10072 , G06T2207/10121 , G06T2207/10136 , G06T2207/30048 , G16H50/50
摘要： A method and system for intraoperative guidance in an off-pump mitral valve repair procedure is disclosed. A plurality of patient-specific models of the mitral valve are generated, each from pre-operative image data obtained using a separate imaging modality. The pre-operative image data from the separate imaging modalities are fused into a common coordinate system by registering the plurality of patient-specific models. A model of the mitral valve is estimated in real-time in intraoperative image data using a fused physiological prior resulting from the registering of the plurality of patient-specific models.
摘要翻译：公开了一种用于非抽血二尖瓣修复手术中术中引导的方法和系统。产生多个患者特异性二尖瓣模型，每个来自使用单独成像模态获得的术前图像数据。来自分开的成像模态的手术前图像数据通过登记多个患者特定模型而融合到公共坐标系中。使用由多个患者特定模型的登记产生的融合生理学先验在实际的术中图像数据中估计二尖瓣的模型。

7. 发明申请

US20110268333A1 Imaging method for enhanced visualization of vessels in an examination region of a patient and medical system for performing the method 有权
标题翻译：用于在用于执行该方法的患者和医疗系统的检查区域中增强血管可视化的成像方法
公开(公告)号：US20110268333A1
公开(公告)日：2011-11-03
申请号：US13094855
申请日：2011-04-27
申请人： Klaus Klingenbeck
发明人： Klaus Klingenbeck
IPC分类号： G06K9/00
CPC分类号： A61B6/481 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B5/489 , A61B5/7425 , A61B6/4417 , A61B6/4441 , A61B6/4458 , A61B6/4464 , A61B6/485 , A61B6/504 , A61B6/507 , A61B6/5247 , A61B8/0816 , A61B8/0891 , A61B8/4416 , A61B8/5238 , A61B90/36 , A61B2090/364
摘要： An imaging method for enhanced visualization of vessels in an examination region of a patient, in particular during an intervention, is proposed. A 3D reconstruction image of the examination region is generated using a preoperatively recorded 3D image dataset of the examination region. At least one current 2D fluorescence image of the examination region is recorded by a fluorescence angiography. The vessels are identified. The 3D image dataset with the image dataset of the 2D fluorescence or ultrasound image is registered based on the result of the identification. The 3D reconstruction image and the 2D image are overplayed. The overlaid images are 3D played back.
摘要翻译：提出了一种用于在患者的检查区域，特别是在干预期间增强血管视觉的成像方法。使用检查区域的术前记录的3D图像数据集来生成检查区域的3D重建图像。通过荧光血管造影记录检查区域的至少一个当前2D荧光图像。识别船只。基于识别结果登记具有2D荧光或超声图像的图像数据集的3D图像数据集。 3D重建图像和2D图像被显示。重叠的图像是3D回放的。

8. 发明授权

US09031295B2 Angiographic method for examining a vascular system 有权
标题翻译：用于检查血管系统的血管造影方法
公开(公告)号：US09031295B2
公开(公告)日：2015-05-12
申请号：US13963265
申请日：2013-08-09
申请人： Klaus Klingenbeck
发明人： Klaus Klingenbeck
IPC分类号： G06K9/00 , A61B6/00 , A61B6/03
CPC分类号： A61B6/486 , A61B6/032 , A61B6/4441 , A61B6/4458 , A61B6/504 , A61B6/507 , A61B6/5217
摘要： An angiographic method is provided. The method includes: identification of a relevant part in acquired angiography 4D sequences which exhibit a vascular disorder or change; determination of a centerline for the part; ascertainment of lines parallel and surrounding the centerline; specification of perpendicular cross-sections; determination of voxels; ascertainment of bolus curves as a function of time for each voxel; which intersects one of the cross-sections; determination of a time for each voxel; measurement of the true Euclidean distance between voxels at the positions along the centerline and the parallel lines; division of the measured distance by the time difference; determination of second speed components, running transversely, proportional to the relative change in mass for each voxel; and calculation of the blood flow in the relevant part of the vascular system on the basis of the speed components.
摘要翻译：提供血管造影方法。该方法包括：鉴定显示血管病变或变化的获得性血管造影4D序列中的相关部分; 确定零件的中心线; 确定线平行并围绕中心线; 垂直截面规格; 体素的确定确定推注曲线作为每个体素的时间函数; 其与横截面之一相交; 确定每个体素的时间; 在沿着中心线和平行线的位置处的体素之间的真欧几里德距离的测量; 测量距离除以时差; 确定二速组件，横向运行，与每个体素的质量相对变化成比例; 并根据速度分量计算血管系统相关部位的血流量。

9. 发明授权

US08885908B2 Method for acquiring a 3D image dataset for an image object 有权
标题翻译：用于获取图像对象的3D图像数据集的方法
公开(公告)号：US08885908B2
公开(公告)日：2014-11-11
申请号：US13527843
申请日：2012-06-20
申请人： Klaus Klingenbeck , Ernst-Peter Rührnschopf , Bernhard Scholz
发明人： Klaus Klingenbeck , Ernst-Peter Rührnschopf , Bernhard Scholz
IPC分类号： G06K9/00 , G06T11/00
CPC分类号： G06T11/006 , G06T2211/416 , G06T2211/424
摘要： A method for acquiring a 3D image dataset for an image object based on a plurality of 2D image datasets relating to the image object is proposed. A scattered radiation is taken into account in an acquisition operator used in the method for the optimum reconstruction of the 3D image dataset. The acquisition operator should be as close as possible to the real mapping operator.
摘要翻译：提出了一种基于与图像对象相关的多个2D图像数据集获取图像对象的3D图像数据集的方法。在用于3D图像数据集的最佳重建的方法中使用的采集算子中考虑散射辐射。采集操作员应尽可能靠近真实的映射运算符。

10. 发明申请

US20130237815A1 METHOD FOR DETERMINING A FOUR-DIMENSIONAL ANGIOGRAPHY DATASET DESCRIBING THE FLOW OF CONTRAST AGENT 审中-公开
标题翻译：用于确定描述对比剂流动的四维血管造影数据的方法
公开(公告)号：US20130237815A1
公开(公告)日：2013-09-12
申请号：US13784914
申请日：2013-03-05
申请人： Klaus Klingenbeck
发明人： Klaus Klingenbeck
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B6/4014 , A61B6/4441 , A61B6/481 , A61B6/487 , A61B6/501 , A61B6/503 , A61B6/507 , A61B6/5235
摘要： A method for determining a four-dimensional angiography dataset describing the flow of contrast agent over time through a blood vessel system of the body of a patient is provided. Four-dimensional flow information is obtained from two-dimensional images captured in a capture time period in different projection directions using a biplanar x-ray device in an inflow phase and/or an outflow phase of the contrast agent by back projection of the images. A three-dimensional reconstruction dataset is determined from the projection of the images depending on the flow information during a filling phase in which the contrast agent is present evenly distributed in the blood vessel system. The three-dimensional reconstruction dataset is animated in order to determine the angiography dataset. The capture time periods for the inflow phase and/or the outflow phase are determined from images captured of a test bolus.
摘要翻译：提供了一种通过患者身体的血管系统确定描述造影剂随时间流动的四维血管造影数据集的方法。通过背景投影的造影剂的流入相和/或流出相中的双平面x射线装置，在不同投影方向的捕获时间段内捕获的二维图像获得四维流动信息。根据在血浆系统中均匀分布的造影剂的填充期间的流动信息，从图像的投影确定三维重建数据集。为了确定血管造影数据集，三维重建数据集被动画化。流入阶段和/或流出阶段的捕获时间段是从测试团块捕获的图像中确定的。

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