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1. 发明授权

US5491251A 2-benzoyl-3-aminoacrylate derivatives and methods for the preparation of the same 失效
标题翻译： 2-苯甲酰基-3-氨基丙烯酸酯衍生物及其制备方法
公开(公告)号：US5491251A
公开(公告)日：1996-02-13
申请号：US321370
申请日：1994-10-11
申请人： You Seung Kim , Soon Bang Kang , Seon Hee Park
发明人： You Seung Kim , Soon Bang Kang , Seon Hee Park
IPC分类号： C07C229/24 , C07C229/34 , C07D498/06 , C07C205/06 , C07C229/30
CPC分类号： C07C229/34
摘要： 2-benzoyl-3-aminoacrylate derivatives of the following formula I and methods for the preparation of the same. ##STR1## wherein X is a halogen; X.sub.1 and X.sub.2 are independently selected from a halogen and a nitro; and R, R.sub.1 and R.sub.2 each is an alkyl group containing 1 to 4 carbon atoms. The compounds can be used as starting materials to synthesize benzoxazine derivatives, potent antibacterial compounds.
摘要翻译：下式I的2-苯甲酰基-3-氨基丙烯酸酯衍生物及其制备方法。其中X是卤素; X1和X2独立地选自卤素和硝基; R 1，R 2和R 2各自为含有1〜4个碳原子的烷基。该化合物可用作原料合成苯并恶嗪衍生物，有效的抗菌化合物。

2. 发明授权

US06759419B2 Pyrrolidinone derivatives, their preparation and pharmaceutical composition comprising the same 失效
标题翻译：吡咯烷酮衍生物，其制备方法和包含它们的药物组合物
公开(公告)号：US06759419B2
公开(公告)日：2004-07-06
申请号：US10273643
申请日：2002-10-18
申请人： Youseung Kim , Soon Bang Kang , Gyochang Keum , Min Seok Jang , Jae Yang Kong , Dae Young Jeong , Taeg-Su Jang
发明人： Youseung Kim , Soon Bang Kang , Gyochang Keum , Min Seok Jang , Jae Yang Kong , Dae Young Jeong , Taeg-Su Jang
IPC分类号： A61K31445
CPC分类号： C07D413/14
摘要： The present invention relates to substituted pyrrolidinone compounds of formula 1, wherein n is 0 or 1; Aza is a heterocycle optionally substituted with C1-4 alkyl, or C1-4 alkyl substituted with a heterocycle, which represents a saturated or unsaturated five- or six-membered ring having nitrogen(s) as a heteroatom, which are muscarinic acetylcholine receptor agonists and useful as nootropics and therapeutic agents for cerebral neural diseases such as Alzheimer's disease; and pharmaceutically acceptable salts thereof; processes for the preparation thereof; and pharmaceutical compositions comprising these compounds or salts.
摘要翻译：本发明涉及式1的取代吡咯烷酮化合物，其中n为0或1; 氮杂是任选被C 1-4烷基取代的杂环，或被杂环取代的C 1-4烷基，其表示饱和或不饱和的具有氮（S）杂原子的五元或六元环，它们是毒蕈碱性乙酰胆碱受体激动剂并且可用作脑神经疾病如阿尔茨海默病的神经调节剂和治疗剂; 及其药学上可接受的盐; 制备方法; 和包含这些化合物或盐的药物组合物。

3. 发明授权

US06716857B2 Tetrahydropyridine derivatives acting on muscarinic acetylcholine receptors 失效
标题翻译：作用于毒蕈碱乙酰胆碱受体的四氢吡啶衍生物
公开(公告)号：US06716857B2
公开(公告)日：2004-04-06
申请号：US10273630
申请日：2002-10-18
申请人： Youseung Kim , Soon Bang Kang , Gyochang Keum , Min Seok Jang , Jae Yang Kong , Dae Young Jeong
发明人： Youseung Kim , Soon Bang Kang , Gyochang Keum , Min Seok Jang , Jae Yang Kong , Dae Young Jeong
IPC分类号： A61K3144
CPC分类号： C07D401/06
摘要： The present invention relates to novel tetrahydropyridine derivatives of formula 1 having an appropriately substituted pyrrolidinone and oxime, wherein m is 0 or 1, n is 1 or 2, R1 is hydrogen, C1-4alkyl, C2-4 alkynyl or aryl, R3 is C1-4 alkyl, which show high efficacy, low cholinergic adverse effects and high affinity for muscarinic acetylcholine receptor; and pharmaceutically acceptable salts thereof; processes for the preparation thereof; and pharmaceutical compositions comprising these compounds or salts.
摘要翻译：本发明涉及具有适当取代的吡咯烷酮和肟的式1的新的四氢吡啶衍生物，其中m为0或1，n为1或2，R 1为氢，C 1-4烷基，C 2-4炔基或芳基， R 3是C 1-4烷基，其显示出高效力，低胆碱能不良反应和对毒蕈碱性乙酰胆碱受体的高亲和力; 及其药学上可接受的盐; 制备方法; 和包含这些化合物或盐的药物组合物。

4. 发明授权

US5952494A Method for the preparation of pyrido benzoxazine derivatives 失效
标题翻译：吡啶并苯并恶嗪衍生物的制备方法
公开(公告)号：US5952494A
公开(公告)日：1999-09-14
申请号：US443884
申请日：1995-05-26
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07D498/06
CPC分类号： C07D498/06
摘要： There is disclosed a method for the preparation of pyrido benzoxazine derivative having the following formula I, that is improved in both production coat and yield.The method comprises reacting a compound of the following general formula II with tetraalkyl ammonium fluoride or with a mixture of tetraalkyl ammonium halide and metal fluoride in an organic solvent at a reaction temperature of about 30 to about 100.degree. C. for 1 to 3 hours under stirring; and reacting the resulting solution with a metal hydroxide or a metal carboxylate dissolved in water or in a mixture of water and alcohol, for 1 to 3 hours under heat. ##STR1## wherein X is a fluorine or chlorine atom and X.sub.1 and X.sub.2 each is a halogen atom or a nitro group, R is an alkyl group containing 1 to 4 carbon atoms and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is an alkyd group or allyl group containing 1 to 8 carbon atoms.
摘要翻译：公开了制备具有下式I的吡啶并苯并恶嗪衍生物的方法，其在生产涂层和产率方面都得到改善。该方法包括将下列通式II的化合物与四烷基氟化铵或四烷基卤化铵和金属氟化物的混合物在有机溶剂中在约30至约100℃的反应温度下反应1-3小时，搅拌并将所得溶液与溶于水中或在水和醇的混合物中的金属氢氧化物或金属羧酸酯反应1至3小时。其中X为氟或氯原子，X 1和X 2各自为卤原子或硝基，R为含有1至4个碳原子的烷基，R 1，R 2，R 3和R 4各自为醇酸基或含烯丙基 1至8个碳原子。

5. 发明授权

US5756731A Process for preparation of (-)3(S)-methylbenzoxazine derivative 失效
标题翻译：（ - ）3（S） - 甲基苯并恶嗪衍生物的制备方法
公开(公告)号：US5756731A
公开(公告)日：1998-05-26
申请号：US613299
申请日：1996-03-11
申请人： Youseung Kim , Soon Bang Kang , Eu Jin Ahn
发明人： Youseung Kim , Soon Bang Kang , Eu Jin Ahn
IPC分类号： B01J23/40 , B01J23/42 , B01J23/44 , C07B43/04 , C07B53/00 , C07B55/00 , C07B61/00 , C07D265/36
CPC分类号： C07D265/36
摘要： A process for preparing (-)3(S)-methylbenzoxazine derivative of formula (I) comprising the steps of reacting the compound of formula (II) with benzoic acid, triphenylphosphine and diethyl azodicarboxylate in an organic solvent to obtain the compound of formula (III); hydrogenating the compound of formula (III) in the presence of a metallic catalyst to provide the compound of formula (IV); hydrolyzing the compound of formula (IV) to give the compound of formula (V); and reacting the compound of formula (V) with diethyl azodicarboxylate, triphenylphosphine, and zinc chloride in an organic solvent. The obtained (-)3(S)-methylbenzoxazine derivative is a useful intermediate for preparing an antibacterial agent which has a potent bacteriocidal effect. ##STR1##
摘要翻译：制备式（I）的（ - ）3（S） - 甲基苯并恶嗪衍生物的方法，包括使式（II）化合物与苯甲酸，三苯基膦和偶氮二羧酸二乙酯在有机溶剂中反应，得到式 III）; 在金属催化剂存在下氢化式（III）化合物，得到式（Ⅳ）化合物; 水解式（Ⅳ）化合物，得到式（Ⅴ）化合物; 并在有机溶剂中使式（Ⅴ）化合物与偶氮二羧酸二乙酯，三苯基膦和氯化锌反应。得到的（ - ）3（S） - 甲基苯并恶嗪衍生物是制备具有强效杀菌作用的抗菌剂的有用中间体。（I）（II）（III）（IV）（V）\！

6. 发明申请

US20090325979A1 NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型咪唑啉酮衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US20090325979A1
公开(公告)日：2009-12-31
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/497 , C07D403/06 , C07D233/54
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

7. 发明授权

US5539110A Method for the preparation of (-)piperazine benzoxazine derivatives 失效
标题翻译：（ - ）哌嗪苯并恶嗪衍生物的制备方法
公开(公告)号：US5539110A
公开(公告)日：1996-07-23
申请号：US321360
申请日：1994-10-11
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07D498/06
CPC分类号： C07D498/06
摘要： There is disclosed a method for the preparation of the antibacterial (-) piperazine benzoxazine derivative having formula I comprising the steps of reacting (+)2-aminomethylene-3-oxo-3-phenylpropionate derivative of formula II with a base in an organic polar solvent, to give a (-) benzoxazine derivative of formula III: and reacting the (-) benzoxazine derivative of formula III with a piperazine derivative of formula IV in an organic polar solvent. ##STR1##
摘要翻译：公开了制备具有式I的抗菌（ - ）哌嗪苯并恶嗪衍生物的方法，包括使式II的（+）2-氨基亚甲基-3-氧代-3-苯基丙酸酯衍生物与有机极性的碱反应的步骤溶剂，得到式III的（ - ）苯并恶嗪衍生物，并使式III的（ - ）苯并恶嗪衍生物与式Ⅳ的哌嗪衍生物在有机极性溶剂中反应。（一）图像（二）<图像>（三）

8. 发明授权

US5516926A (+) 2-benzoyl-3-(silyloxyprop-2(S)-yl)aminoacrylate derivatives and a method for preparing the same 失效
标题翻译：（+）2-苯甲酰基-3-（silyloxyprop-2（S） - 基）氨基丙烯酸酯衍生物及其制备方法
公开(公告)号：US5516926A
公开(公告)日：1996-05-14
申请号：US452167
申请日：1995-05-26
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07F7/10 , C07F7/18
CPC分类号： C07F7/1852
摘要： (+)2-benzoyl-3-(silyloxyprop-2(S)-yl)aminoacrylate derivative of following formula I which can be an useful starting material for producing a potent antibacterial compound and a method for the preparation of the same: ##STR1## wherein X is fluoro or chloro; X.sub.1 and X.sub.2 can be halogen or nitro; and R, R.sub.1, R.sub.2 and R.sub.3 each can be C.sub.1-8 alkyl group.
摘要翻译：可以作为制备有效抗菌化合物的有用原料的下式I的（+）2-苯甲酰基-3-（甲硅烷氧基-2（S） - 基）氨基丙烯酸酯衍生物及其制备方法（I）其中X是氟或氯; X1和X2可以是卤素或硝基; 并且R，R 1，R 2和R 3各自可以是C 1-8烷基。

9. 发明授权

US09422274B2 Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same 有权
标题翻译：用于预防或治疗丙型肝炎的恶唑烷酮衍生物和组合物
公开(公告)号：US09422274B2
公开(公告)日：2016-08-23
申请号：US14539472
申请日：2014-11-12
申请人： Sung Key Jang , Gyo Chang Keum , Eunice Eun-Kyeong Kim , Soon Bang Kang , Suyeon Yeom , Juhyeon Lee , SeungGi Lee , Hee Sun Kim
发明人： Sung Key Jang , Gyo Chang Keum , Eunice Eun-Kyeong Kim , Soon Bang Kang , Suyeon Yeom , Juhyeon Lee , SeungGi Lee , Hee Sun Kim
IPC分类号： C07D413/14 , A61K31/422
CPC分类号： C07D413/14
摘要： The present invention relates to oxazolidinone compounds represented by Chemical Formula 1, pharmaceutically acceptable salts thereof or hydrates, a method of preparing the same, and a pharmaceutical composition for preventing or treating Hepatitis C infection: Wherein R1, R7 and X are defined in the detailed description.
摘要翻译：本发明涉及由化学式1表示的恶唑烷酮化合物，其药学上可接受的盐或水合物，其制备方法和用于预防或治疗丙型肝炎感染的药物组合物：其中R1，R7和X定义在详细的描述。

10. 发明授权

US08492384B2 Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof 有权
标题翻译：咪唑烷基羰基衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US08492384B2
公开(公告)日：2013-07-23
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/496 , C07D233/64
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

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