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1. 发明申请

US20100004286A1 NOVEL ISOINDOLINONE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST T-TYPE CALCIUM CHANNEL AND METHOD FOR PREPARATION THEREOF 有权
标题翻译：具有抗T型钙通道的抑制活性的新型茚二酮衍生物及其制备方法
公开(公告)号：US20100004286A1
公开(公告)日：2010-01-07
申请号：US12256701
申请日：2008-10-23
申请人： Yong Seo CHO , Ae Nim PAE , Hyunah CHOO , Jae Kyun LEE , You Na OH , Hee Sup SHIN , Dong Jin KIM , Hoh Gyu HAHN , Kyung Il CHOI , Ghilsoo NAM , Kye Jung SHIN , Soon Bang KANG , Eun Joo ROH , Dong Yun SHIN , Seon Hee SEO , Hyewhon RHIM , Gyo Chang KEUM , Key-Sun KIM , Chan Seong CHEONG , Eunice Eun-Kyeong KIM , Cheolju LEE , Youngsoo KIM , Kee Hyun CHOI , Kee Dal NAM , Woong Seo PARK , Yong Koo KANG , Hye Jin CHUNG
发明人： Yong Seo CHO , Ae Nim PAE , Hyunah CHOO , Jae Kyun LEE , You Na OH , Hee Sup SHIN , Dong Jin KIM , Hoh Gyu HAHN , Kyung Il CHOI , Ghilsoo NAM , Kye Jung SHIN , Soon Bang KANG , Eun Joo ROH , Dong Yun SHIN , Seon Hee SEO , Hyewhon RHIM , Gyo Chang KEUM , Key-Sun KIM , Chan Seong CHEONG , Eunice Eun-Kyeong KIM , Cheolju LEE , Youngsoo KIM , Kee Hyun CHOI , Kee Dal NAM , Woong Seo PARK , Yong Koo KANG , Hye Jin CHUNG
IPC分类号： A61K31/454 , C07D401/12 , A61P35/00 , A61P9/12 , A61P25/08
CPC分类号： C07D401/12 , A61K31/454
摘要： Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. wherein R1˜R6 are as defined in the specification.
摘要翻译：公开了由化学式1表示的具有对T型钙通道的抑制活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法和包含其作为活性成分的药物组合物。其中R1〜R6如说明书中所定义。

2. 发明授权

US08492384B2 Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof 有权
标题翻译：咪唑烷基羰基衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US08492384B2
公开(公告)日：2013-07-23
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/496 , C07D233/64
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

3. 发明授权

US08088738B2 Thermostable alpha1-antitrypsin mutein with a disulfide bond and the method for preparing it 有权
标题翻译：具有二硫键的热稳定性α1-抗胰蛋白酶突变蛋白及其制备方法
公开(公告)号：US08088738B2
公开(公告)日：2012-01-03
申请号：US12743920
申请日：2007-11-22
申请人： Myeong-Hee Yu , Je-Hyun Baek , Cheolju Lee
发明人： Myeong-Hee Yu , Je-Hyun Baek , Cheolju Lee
IPC分类号： A61K38/55 , C07K14/00
CPC分类号： C07K14/8125
摘要： The present invention relates to a thermostable alpha-1-antitrypsin mutein with a disulfide bond and a preparation method of the same, more precisely an alpha-1-antitrypsin mutein with improved thermostability, compared with the conventional thermostable alpha-1-antitrypsin mutein (Korean Patent No. 133252), resulted from the process of substituting the 168th and 189th amino acids of the alpha-1-antitrypsin with cysteines which are then linked by a disulfide bond, with keeping its alpha-1-antitrypsin activity unchanged, and a preparing method of the same. The thermostable alpha-1-antitrypsin mutein with a disulfide bond of the invention can be effectively used for a protein based therapeutic agent which is very stable in vivo, and can be applied further in various fields including in the development of a diagnostic reagent and in the preparation of an affinity column.
摘要翻译：本发明涉及具有二硫键的热稳定性α-1-抗胰蛋白酶突变蛋白及其制备方法，更准确地说，与常规的热稳定性α-1-抗胰蛋白酶突变蛋白相比，具有改善的热稳定性的α-1-抗胰蛋白酶突变蛋白韩国专利133252）是由α-1-抗胰蛋白酶的第168位和第189位氨基酸用半胱氨酸取代的方法产生的，然后用二硫键连接，保持其α-1-抗胰蛋白酶活性不变，制备方法相同。具有本发明二硫键的热稳定性α-1-抗胰蛋白酶突变蛋白可有效地用于体内非常稳定的蛋白质治疗剂，并且可以进一步应用于各种领域，包括诊断试剂的开发和亲和柱的制备。

4. 发明申请

US20100248309A1 THERMOSTABLE ALPHA1-ANTITRYPSIN MUTEIN WITH A DISULFIDE BOND AND THE METHOD FOR PREPARING IT 有权
标题翻译：具有破乳粘结剂的可热稳定的ALPHA1-抗菌素MUTEIN及其制备方法
公开(公告)号：US20100248309A1
公开(公告)日：2010-09-30
申请号：US12743920
申请日：2007-11-22
申请人： Myeong-Hee Yu , Je-Hyun Baek , Cheolju Lee
发明人： Myeong-Hee Yu , Je-Hyun Baek , Cheolju Lee
IPC分类号： C07K14/435 , C07H21/04 , C12N15/63 , C12N1/21 , C12P21/00
CPC分类号： C07K14/8125
摘要： The present invention relates to a thermostable alpha-1-antitrypsin mutein with a disulfide bond and a preparation method of the same, more precisely an alpha-1-antitrypsin mutein with improved thermostability, compared with the conventional thermostable alpha-1-antitrypsin mutein (Korean Patent No. 133252), resulted from the process of substituting the 168th and 189th amino acids of the alpha-1-antitrypsin with cysteines which are then linked by a disulfide bond, with keeping its alpha-1-antitrypsin activity unchanged, and a preparing method of the same. The thermostable alpha-1-antitrypsin mutein with a disulfide bond of the invention can be effectively used for a protein based therapeutic agent which is very stable in vivo, and can be applied further in various fields including in the development of a diagnostic reagent and in the preparation of an affinity column.
摘要翻译：本发明涉及具有二硫键的热稳定性α-1-抗胰蛋白酶突变蛋白及其制备方法，更准确地说，与常规的热稳定性α-1-抗胰蛋白酶突变蛋白相比，具有改善的热稳定性的α-1-抗胰蛋白酶突变蛋白韩国专利133252）是由α-1-抗胰蛋白酶的第168位和第189位氨基酸用半胱氨酸取代的方法产生的，然后用二硫键连接，保持其α-1-抗胰蛋白酶活性不变，制备方法相同。具有本发明二硫键的热稳定性α-1-抗胰蛋白酶突变蛋白可有效地用于体内非常稳定的蛋白质治疗剂，并且可以进一步应用于各种领域，包括诊断试剂的开发和亲和柱的制备。

5. 发明申请

US20090325979A1 NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型咪唑啉酮衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US20090325979A1
公开(公告)日：2009-12-31
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/497 , C07D403/06 , C07D233/54
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

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