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1. 发明授权

US5663411A (+)2-benzoyl-3-[(prop-2(S)-yl)amino]acrylate derivatives and a method for the preparation of the same 失效
标题翻译：（+）2-苯甲酰基-3 - [（丙-2（S） - 基）氨基]丙烯酸酯衍生物及其制备方法
公开(公告)号：US5663411A
公开(公告)日：1997-09-02
申请号：US321359
申请日：1994-10-11
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07C229/24 , C07C229/34 , C07D498/06 , C07C205/06
CPC分类号： C07C229/34
摘要： There are disclosed (+)2-benzoyl-3-[prop-2(S)-yl)amino] acrylate derivatives of following the formula and a method for the preparation of the same; ##STR1## wherein X is a halogen; X.sub.1 and X.sub.2 are independently selected from a halogen and a nitro; and R and R.sub.1 each is an alkyl group containing 1 to 4 carbon atoms.
摘要翻译：公开了下列通式的（+）2-苯甲酰基-3- [丙-2（S） - 基）氨基]丙烯酸酯衍生物及其制备方法：其中X是卤素; X1和X2独立地选自卤素和硝基; R和R 1各自为含有1〜4个碳原子的烷基。

2. 发明授权

US5952494A Method for the preparation of pyrido benzoxazine derivatives 失效
标题翻译：吡啶并苯并恶嗪衍生物的制备方法
公开(公告)号：US5952494A
公开(公告)日：1999-09-14
申请号：US443884
申请日：1995-05-26
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07D498/06
CPC分类号： C07D498/06
摘要： There is disclosed a method for the preparation of pyrido benzoxazine derivative having the following formula I, that is improved in both production coat and yield.The method comprises reacting a compound of the following general formula II with tetraalkyl ammonium fluoride or with a mixture of tetraalkyl ammonium halide and metal fluoride in an organic solvent at a reaction temperature of about 30 to about 100.degree. C. for 1 to 3 hours under stirring; and reacting the resulting solution with a metal hydroxide or a metal carboxylate dissolved in water or in a mixture of water and alcohol, for 1 to 3 hours under heat. ##STR1## wherein X is a fluorine or chlorine atom and X.sub.1 and X.sub.2 each is a halogen atom or a nitro group, R is an alkyl group containing 1 to 4 carbon atoms and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is an alkyd group or allyl group containing 1 to 8 carbon atoms.
摘要翻译：公开了制备具有下式I的吡啶并苯并恶嗪衍生物的方法，其在生产涂层和产率方面都得到改善。该方法包括将下列通式II的化合物与四烷基氟化铵或四烷基卤化铵和金属氟化物的混合物在有机溶剂中在约30至约100℃的反应温度下反应1-3小时，搅拌并将所得溶液与溶于水中或在水和醇的混合物中的金属氢氧化物或金属羧酸酯反应1至3小时。其中X为氟或氯原子，X 1和X 2各自为卤原子或硝基，R为含有1至4个碳原子的烷基，R 1，R 2，R 3和R 4各自为醇酸基或含烯丙基 1至8个碳原子。

3. 发明授权

US5539110A Method for the preparation of (-)piperazine benzoxazine derivatives 失效
标题翻译：（ - ）哌嗪苯并恶嗪衍生物的制备方法
公开(公告)号：US5539110A
公开(公告)日：1996-07-23
申请号：US321360
申请日：1994-10-11
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07D498/06
CPC分类号： C07D498/06
摘要： There is disclosed a method for the preparation of the antibacterial (-) piperazine benzoxazine derivative having formula I comprising the steps of reacting (+)2-aminomethylene-3-oxo-3-phenylpropionate derivative of formula II with a base in an organic polar solvent, to give a (-) benzoxazine derivative of formula III: and reacting the (-) benzoxazine derivative of formula III with a piperazine derivative of formula IV in an organic polar solvent. ##STR1##
摘要翻译：公开了制备具有式I的抗菌（ - ）哌嗪苯并恶嗪衍生物的方法，包括使式II的（+）2-氨基亚甲基-3-氧代-3-苯基丙酸酯衍生物与有机极性的碱反应的步骤溶剂，得到式III的（ - ）苯并恶嗪衍生物，并使式III的（ - ）苯并恶嗪衍生物与式Ⅳ的哌嗪衍生物在有机极性溶剂中反应。（一）图像（二）<图像>（三）

4. 发明授权

US5516926A (+) 2-benzoyl-3-(silyloxyprop-2(S)-yl)aminoacrylate derivatives and a method for preparing the same 失效
标题翻译：（+）2-苯甲酰基-3-（silyloxyprop-2（S） - 基）氨基丙烯酸酯衍生物及其制备方法
公开(公告)号：US5516926A
公开(公告)日：1996-05-14
申请号：US452167
申请日：1995-05-26
申请人： Youseung Kim , Soon Bang Kang , Seonhee Park
发明人： Youseung Kim , Soon Bang Kang , Seonhee Park
IPC分类号： C07F7/10 , C07F7/18
CPC分类号： C07F7/1852
摘要： (+)2-benzoyl-3-(silyloxyprop-2(S)-yl)aminoacrylate derivative of following formula I which can be an useful starting material for producing a potent antibacterial compound and a method for the preparation of the same: ##STR1## wherein X is fluoro or chloro; X.sub.1 and X.sub.2 can be halogen or nitro; and R, R.sub.1, R.sub.2 and R.sub.3 each can be C.sub.1-8 alkyl group.
摘要翻译：可以作为制备有效抗菌化合物的有用原料的下式I的（+）2-苯甲酰基-3-（甲硅烷氧基-2（S） - 基）氨基丙烯酸酯衍生物及其制备方法（I）其中X是氟或氯; X1和X2可以是卤素或硝基; 并且R，R 1，R 2和R 3各自可以是C 1-8烷基。

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