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1. 发明授权

US4055589A 20-Alkoxy-16-alkyl prostadienoic acid derivatives 失效
标题翻译： 20-烷氧基-16-烷基前列腺素衍生物
公开(公告)号：US4055589A
公开(公告)日：1977-10-25
申请号：US640497
申请日：1975-12-15
申请人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
发明人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
IPC分类号： C07C405/00 , C07D307/935 , C07D309/12 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12
摘要： A 20-alkoxy-16-alkyl-prostadienoic acid derivative shown by the formula ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group,And the pharmacologically acceptable nontoxic salts thereof.The compounds have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..
摘要翻译：其中A表示R和R 5可以相同或不同，表示氢原子或低级烷基的式“IMAGE”所示的20-烷氧基-16-烷基 - 前列腺二烯酸衍生物。并且可以相同或不同的R 1和R 4各自表示低级烷基，并且其药理学上可接受的非共价键。

2. 发明授权

US4246280A 20-Alkoxy-16-alkyl-prostadienoic acid derivatives 失效
标题翻译： 20-烷氧基-16-烷基 - 前列腺烯酸衍生物
公开(公告)号：US4246280A
公开(公告)日：1981-01-20
申请号：US16070
申请日：1979-02-28
申请人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
发明人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
IPC分类号： C07C405/00 , C07D307/935 , C07D309/12 , A61K31/557
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12
摘要： There are disclosed 20-alkoxy-16-alkyl-prostadienoic acid derivatives of the formula: ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group, and the pharmaceutically acceptable non-toxic salts thereof. These compounds have excellent pharmacological effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..
摘要翻译：公开了下式的20-烷氧基-16-烷基 - 前列腺烯酸衍生物：其中A表示R和R 5可以相同或不同，各自表示氢原子或低级烷基; 和可以相同或不同的R 1和R 4各自表示低级烷基及其药学上可接受的无毒盐。这些化合物具有优异的药理作用，如前列腺素E2和前列腺素F2α。

3. 发明授权

US4908454A Process of producing guanidinothiazole derivatives 失效
标题翻译：制备胍啶噻唑衍生物的方法
公开(公告)号：US4908454A
公开(公告)日：1990-03-13
申请号：US300760
申请日：1989-01-23
申请人： Yoshio Ishii , Isao Yanagisawa
发明人： Yoshio Ishii , Isao Yanagisawa
IPC分类号： C07D277/20 , C07D277/48
CPC分类号： C07D277/48
摘要： A process is provided for producing a guanidinothiazole compound represented by the formula: ##STR1## wherein, R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen or an alkyl group having 1 to 3 carbon atoms; m represents 1 or 2; and n represents 2, 3 or 4. The process comprises reacting an aminothiazole compound of the formula: ##STR2## with a cyanamide or an amidinopyrazole, the compounds are useful as intermediates in the preparation of a gastric acid secretion inhibitor.
摘要翻译：提供了用于制备由下式表示的胍基噻唑化合物的方法：其中，R 1和R 2可以相同或不同，各自表示氢或具有1至3个碳原子的烷基; m表示1或2; 并且n表示2,3或4.该方法包括使下式的氨基噻唑化合物与氨腈或脒基吡唑反应，该化合物可用作制备胃酸分泌抑制剂的中间体。

4. 发明授权

US4283408A Guanidinothiazole compounds, process for preparation and gastric inhibiting compositions containing them 失效
标题翻译：胍基噻唑化合物，制备方法和含有它们的胃抑制组合物
公开(公告)号：US4283408A
公开(公告)日：1981-08-11
申请号：US107629
申请日：1979-12-27
申请人： Yasufumi Hirata , Isao Yanagisawa , Yoshio Ishii , Shinichi Tsukamoto , Noriki Ito , Yasuo Isomura , Masaaki Takeda
发明人： Yasufumi Hirata , Isao Yanagisawa , Yoshio Ishii , Shinichi Tsukamoto , Noriki Ito , Yasuo Isomura , Masaaki Takeda
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61P1/00 , A61P1/04 , A61P43/00 , C07D277/40 , C07D277/48 , C07D277/38
CPC分类号： C07D277/48 , C07D277/40
摘要： Novel guanidinothiazole compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a lower alkyl group, R.sub.1 represents an amino group, a lower alkyl group, a halogeno lower alkyl group, a substituted- or unsubstituted-aryl group, a mono- or di-lower alkylamino group, an arylamino group or an aralkylamino group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, Y represents a sulfur atom or a methylene group, m and n, each represents an integer of 1-3, and the pharmacologically acceptable acid addition salts thereof, they are useful as gastric acid secretion inhibitors.
摘要翻译：新型的胍基噻唑化合物，其通式为：其中R表示氢原子或低级烷基，R1表示氨基，低级烷基，卤代低级烷基，取代或未取代的芳基，单 - 或二 - 低级烷基氨基，芳基氨基或芳烷基氨基，R 2表示氢原子，低级烷基，低级烯基或低级炔基，Y表示硫原子或亚甲基，m和n 各自表示1-3的整数，其药理学上可接受的酸加成盐可用作胃酸分泌抑制剂。

5. 发明授权

US4058665A Novel 3,15-dilower alkyl PGE.sub.2 derivatives 失效
标题翻译：新型3,15-二烯烷基PGE {HD 2 {B衍生物
公开(公告)号：US4058665A
公开(公告)日：1977-11-15
申请号：US629568
申请日：1975-11-06
申请人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Tetsuya Shizaoki , Kenichi Tomioka , Tokuichi Takagi
发明人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Tetsuya Shizaoki , Kenichi Tomioka , Tokuichi Takagi
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00
摘要： 3,15-Dilower alkyl prostaglandin E.sub.2 derivatives and 3,15-dilower alkyl prostaglandin D.sub.2 derivatives are disclosed. These compounds have antigastric ulcer activity without undesirable side effects to intestinal organs.
摘要翻译：公开了3,15-二烷基前列腺素E2衍生物和3,15-二代烷基前列腺素D2衍生物。这些化合物具有抗胃溃疡活性，对肠器官无不良副作用。

6. 发明授权

US4362736A Guanidinothiazole compounds, and medical compositions containing them 失效
标题翻译：胍基噻唑化合物和含有它们的医药组合物
公开(公告)号：US4362736A
公开(公告)日：1982-12-07
申请号：US127902
申请日：1980-03-06
申请人： Yasufumi Hirata , Isao Yanagisawa , Yoshio Ishii , Masaaki Takeda
发明人： Yasufumi Hirata , Isao Yanagisawa , Yoshio Ishii , Masaaki Takeda
IPC分类号： C07D277/38 , C07D277/46 , C07D277/48 , C07D277/20 , A61K31/425
CPC分类号： C07D277/48 , C07D277/46
摘要： Novel guanidinothiazole compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represents an integer of 1-3, A represents the group shown by ##STR2## (wherein R.sub.1 represents a hydrogen atom, a cyano group, a carbamoyl group, a ureido group, a hydroxyl group, a lower alkoxy group, a lower acyl group, an acylamino group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cyano group or a lower acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group or a sulfamoyl group), and the pharmacologically acceptable acid addition salts thereof; these compounds are useful as gastric acid secretion inhibitors.
摘要翻译：新颖的通式为“IMAGE”的胍基噻唑化合物，其中R表示氢原子或低级烷基，Y表示硫原子或亚甲基，m和n各自表示1-3的整数，A表示由（其中R 1表示氢原子，氰基，氨基甲酰基，脲基，羟基，低级烷氧基，低级酰基，酰氨基，芳基氨磺酰基，芳烷基或羧甲基，芳基氨磺酰基，芳烷基或羧甲基，R2表示氢原子，低级烷基，低级烯基，低级炔基，氰基或低级酰基，R3表示氢原子，低级烷基，羟基或氨磺酰基）及其药理学上可接受的酸加成盐; 这些化合物可用作胃酸分泌抑制剂。

7. 发明授权

US4026927A Novel prostaglandin derivatives 失效
标题翻译：新型前列腺素衍生物
公开(公告)号：US4026927A
公开(公告)日：1977-05-31
申请号：US508252
申请日：1974-09-23
申请人： Masuo Murakami , Noriyoshi Inukai , Hidenori Iwamoto , Toshinari Tamura , Isao Yanagisawa , Osamu Hasegawa , Yoshio Ishii , Hideya Matsuda , Tetsuya Shiozaki , Kenichi Tomioka
发明人： Masuo Murakami , Noriyoshi Inukai , Hidenori Iwamoto , Toshinari Tamura , Isao Yanagisawa , Osamu Hasegawa , Yoshio Ishii , Hideya Matsuda , Tetsuya Shiozaki , Kenichi Tomioka
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00
摘要： Novel prostaglandin derivatives are provided having the formula: ##STR1## wherein A represents ##STR2## one of R.sub.3 and R.sub.4 represents a hydrogen atom and the other of them represents a lower alkyl group; one of R.sub.5 and R.sub.6 represents a hydrogen atom and the other of them represents a hydroxyl group; and one of R.sub.7 and R.sub.8 represents a hydrogen atom and the other of them represents a lower alkyl group.The compounds of this invention have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.sub..alpha..
摘要翻译：提供了具有下式的新型前列腺素衍生物：其中A表示R 3中的一个，R 4表示氢原子，另一个表示低级烷基; R5和R6之一表示氢原子，另一个表示羟基; R 7和R 8中的一个表示氢原子，另一个表示低级烷基。

8. 发明授权

US07816064B2 Image-forming method using heat-sensitive transfer system 失效
标题翻译：使用热敏转印系统的成像方法
公开(公告)号：US07816064B2
公开(公告)日：2010-10-19
申请号：US11711696
申请日：2007-02-28
申请人： Kazuaki Oguma , Yoshio Ishii , Hisashi Mikoshiba , Hiroshi Takehara , Yoshihisa Tsukada
发明人： Kazuaki Oguma , Yoshio Ishii , Hisashi Mikoshiba , Hiroshi Takehara , Yoshihisa Tsukada
IPC分类号： G03C8/00 , G03F7/00 , B41M5/20 , B41M5/24
CPC分类号： B41M5/52 , B41M5/385 , B41M5/3852 , B41M5/3854 , B41M5/39 , B41M5/44 , B41M2205/02
摘要： An image-forming method, containing the steps of: superposing a heat-sensitive transfer sheet on a heat-sensitive transfer image-receiving sheet so that the following receptor layer can be contacted with the following thermal transfer layer; and providing thermal energy in accordance with image signals, thereby to form a thermal transfer image;in which the heat-sensitive transfer image-receiving sheet comprises, on a support, a receptor layer containing a polymer latex, and a heat insulation layer containing hollow polymer particles, and the heat-sensitive transfer sheet comprises, on a support, a thermal transfer layer containing any one of compounds represented by formulas (1) to (7): in which, one of Z1 and Z2 represents ═N— and the other represents ═C(R95)—; Z3 and Z4 each independently represents ═N— or ═C(R96)—; R51 to R114 each independently represent a substituent, or a hydrogen atom or a substituent; n8 to n18 each independently represent an integer of 0 to 5, 0 to 4 or 0 to 2.
摘要翻译：一种图像形成方法，包括以下步骤：将热敏转印片材叠加在热敏转印图像接收片材上，使得随后的受体层可以与以下热转印层接触; 并根据图像信号提供热能，从而形成热转印图像; 其中所述热敏转印图像接收片材在载体上包含含有聚合物胶乳的受体层和包含中空聚合物颗粒的隔热层，并且所述热敏转印片材在载体上包含热含有式（1）〜（7）表示的化合物中的任一种的转印层：其中，Z1和Z2中的一个表示= N-，另一个表示= C（R95） - ; Z3和Z4各自独立地表示= N-或= C（R96） - ; R 51〜R 114各自独立地表示取代基，或氢原子或取代基。 n8〜n18各自独立地表示0〜5，0〜4或0〜2的整数。

9. 发明申请

US20070213217A1 Image-forming method using thermal transfer system 失效
标题翻译：使用热转印系统的成像方法
公开(公告)号：US20070213217A1
公开(公告)日：2007-09-13
申请号：US11711622
申请日：2007-02-28
申请人： Kazuaki Oguma , Yoshio Ishii , Yoshihisa Tsukada , Hiroshi Takehara , Yoshihiko Fujie
发明人： Kazuaki Oguma , Yoshio Ishii , Yoshihisa Tsukada , Hiroshi Takehara , Yoshihiko Fujie
IPC分类号： B41M5/50
CPC分类号： B41M5/52 , B41M5/385 , B41M5/388 , B41M5/39 , B41M5/44 , B41M2205/02 , B41M2205/22 , B41M2205/32
摘要： An image-forming method, containing the steps of: superposing a heat-sensitive transfer sheet on a heat-sensitive transfer image-receiving sheet so that the following at least one receptor layer of the heat-sensitive transfer image-receiving sheet can be contacted with the following thermal transfer layer of the heat-sensitive transfer sheet; and providing thermal energy in accordance with image signals, thereby to form a thermal transfer image; in which the heat-sensitive transfer image-receiving sheet comprises, on a support, at least one receptor layer containing a polymer latex, and at least one heat insulation layer containing hollow polymer particles but free of any resins having poor resistance to an organic solvent except for the hollow polymer particles, and the heat-sensitive transfer sheet comprises, on a support, a thermal transfer layer containing at least any one of a compound represented by formula (Y), a compound represented by formula (M) and a compound represented by formula (C): in which, in formulas (Y), (M) and (C), X, Y and Z each independently represents =C(D13)— or a nitrogen atom, and D1 to D23 each independently represent a hydrogen atom or a substituent, such as an alkyl group.
摘要翻译：一种图像形成方法，包括以下步骤：将热敏转印片材叠加在热敏转印图像接收片材上，使得可以接触热敏转印图像接收片材的以下至少一个受体层具有热敏转印片的以下热转印层; 并根据图像信号提供热能，从而形成热转印图像; 其中所述热敏转印图像接收片材在载体上包含至少一个含有聚合物胶乳的受体层，以及至少一个含有中空聚合物颗粒但不含有机溶剂耐受性差的树脂的隔热层除了中空聚合物颗粒之外，热敏转印片在载体上包含含有式（Y）表示的化合物，式（M）表示的化合物和式（M）表示的化合物和化合物由式（C）表示：其中，在式（Y），（M）和（C）中，X，Y和Z各自独立地表示= C（D 13） - 或氮原子和D 1〜D 2各自独立地表示氢原子或取代基，例如烷基。

10. 发明申请

US20070202277A1 Heat-sensitive transfer image receiving sheet and method for producing heat-sensitive transfer image-receiving sheet 失效
标题翻译：热敏转印图像接收片材和热敏转印图像接收片材的制造方法
公开(公告)号：US20070202277A1
公开(公告)日：2007-08-30
申请号：US11711788
申请日：2007-02-28
申请人： Takuya Arai , Yoshio Ishii , Yoshihisa Tsukada , Toshihide Yoshitani
发明人： Takuya Arai , Yoshio Ishii , Yoshihisa Tsukada , Toshihide Yoshitani
IPC分类号： B41M5/40
CPC分类号： B41M5/42 , B41M5/52 , B41M5/5254 , B41M2205/32 , Y10S430/142
摘要： A heat-sensitive transfer image-receiving sheet comprising at least one receiving layer containing a polymer latex and at least one heat insulating layer containing a hollow polymer on a support, wherein the polymer latex contained in the receiving layer comprises two or more dyable polymers having different glass transition temperatures.
摘要翻译：一种热敏转印图像接受片，其包含至少一个包含聚合物胶乳的接收层和在支持体上含有中空聚合物的至少一个绝热层，其中所述接收层中包含的聚合物胶乳包含两种或更多种可染色聚合物，不同的玻璃化转变温度。

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