专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5439932A Substituted amine derivatives having anti-hyperlipemia activity 失效
标题翻译：具有抗高血脂活性的取代的胺衍生物
公开(公告)号：US5439932A
公开(公告)日：1995-08-08
申请号：US26692
申请日：1993-03-04
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/38 , A61K31/495 , C07D409/02 , C07D409/14
CPC分类号： C07D213/30 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/10 , C07D417/12
摘要： Substituted amine derivatives represented by the general formula ##STR1## wherein Q is --C--D--E--F--G--M-- or --N--H--I--J--K--L-- [C, D, E, F, G, H, I, J, K and L are each O, S, a carbonyl group, --CHR.sup.a --, --R.sup.b .dbd. or --NR.sup.c -- (R.sup.a, R.sup.b and R.sup.c are each H or a lower alkyl group), M and N are each an aromatic ring of 5-6 members optionally having a halogen, OH, LN, a lower alkyl group or a lower alkoxy group, provided that L is not O, S, or --NR.sup.c --]; R is a heterocyclic ring of 5-6 members; R.sup.1 is H, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group, a lower alkynyl group or a cycloalkyl group; R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are each H, a halogen or a lower alkyl group or two of them denote a single bond; R.sup.8 and R.sup.9 are each F, CF.sub.3 or a lower alkyl group or are a cycloalkane in combination thereof; and R.sup.10 is H, F, CF.sub.3 an acetoxy group, a lower alkyl group or a lower alkoxy group. These compounds inhibit biosynthesis of cholesterol in mammals by inhibiting their squalene epoxidase, and thereby lower their blood cholesterol values. Therefore, these compounds are expected to be effective as an agent for treatment and prophylaxis of diseases caused by excess of cholesterol, for example, obesity, hyperlipemia and arteriosclerosis and heart and encephalic diseases accompanying them.
摘要翻译：由通式[IMAGE] [I]表示的取代的胺衍生物，其中Q是-_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ，_F，_G，_H，_I，_J，_K和_L各自为O，S，羰基，-CHR a - ，-R b =或-NR c - （R a，R b和R c各自为H或低级烷基） M和N各自为任选具有卤素，OH，LN，低级烷基或低级烷氧基的5-6个成员的芳环，条件是_L不是O，S或-NRc-]; R是5-6个成员的杂环; R1是H，低级烷基，低级卤代烷基，低级烯基，低级炔基或环烷基; R2，R3，R4，R5，R6和R7各自为H，卤素或低级烷基，或两个表示单键; R8和R9各自为F，CF3或低级烷基，或其组合为环烷烃; R 10为H，F，CF 3为乙酰氧基，低级烷基或低级烷氧基。这些化合物通过抑制它们的角鲨烯环氧酶抑制哺乳动物胆固醇的生物合成，从而降低它们的血液中胆固醇值。因此，预期这些化合物作为用于治疗和预防由胆固醇过量引起的疾病，例如肥胖症，高脂血症和动脉硬化以及与其伴随的心脏和脑病有关的药剂。

2. 发明授权

US5306728A Substituted amine derivatives having antihyperlipemia activity 失效
标题翻译：具有抗高血脂活性的取代的胺衍生物
公开(公告)号：US5306728A
公开(公告)日：1994-04-26
申请号：US26120
申请日：1993-03-04
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/38 , A01N43/06 , C07D333/10 , C07D411/10
CPC分类号： C07D213/30 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/10 , C07D417/12
摘要： Substituted amine derivatives represented by the general formula ##STR1## wherein Q is -C-D-E- F-G-M- or -N-H-I-J-K-L- [C, D, E, F, G, H, I, J, K and L are each O, S, a carbonyl group, -CHR.sup.2 -, -R.sup.b = or -NR.sup.c - (R.sup.a, R.sup.b and R.sup.c are each H or a lower alkyl group), M and N are each an aromatic ring of 5-6 members optionally having a halogen, OH, LN, a lower alkyl group or a lower alkoxy group, provided that L is not O, S, or -NR.sup.c -]; R is a heterocyclic ring of 5-6 members; R.sup.1 is H, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group, a lower alkynyl group or a cycloalkyl group; R.sup.2, R.sup.3, R.sup.4, R.sup.5 R.sup.6 and R.sup.7 are each H, a halogen or a lower alkyl group or two of them denote a single bond; R.sup.8 and R.sup.9 are each F, CF.sub.3 or a lower alkyl group or are a cycloalkane in combination thereof; and R.sup.10 is H, F, CF.sub. 3 an acetoxy group, a lower alkyl group or a lower alkoxy group. These compounds inhibit biosynthesis of cholesterol in mammals by inhibiting their squalene epoxidase, and thereby lower their blood cholesterol values. Therefore, these compounds are expected to be effective as an agent for treatment and prophylaxis of diseases caused by excess of cholesterol, for example, obesity, hyperlipemia and arteriosclerosis and heart and encephalic diseases accompanying them.
摘要翻译：其中Q为-CDE-FGM-或-NHIJKL- [C，D，E，F，G，H，I，J，K和L各自为O， S，羰基，-CHR 2 - ，-R b =或-NR c - （R a，R b和R c各自为H或低级烷基），M和N各自为任选具有卤素的5-6个成员的芳香环，OH，LN，低级烷基或低级烷氧基，条件是L不是O，S或-NRc-]; R是5-6个成员的杂环; R1是H，低级烷基，低级卤代烷基，低级烯基，低级炔基或环烷基; R2，R3，R4，R5 R6和R7各自为H，卤素或低级烷基，或两个表示单键; R8和R9各自为F，CF3或低级烷基，或其组合为环烷烃; R 10为H，F，CF 3为乙酰氧基，低级烷基或低级烷氧基。这些化合物通过抑制它们的角鲨烯环氧酶抑制哺乳动物胆固醇的生物合成，从而降低它们的血液中胆固醇值。因此，预期这些化合物作为用于治疗和预防由胆固醇过量引起的疾病，例如肥胖症，高脂血症和动脉硬化以及与其伴随的心脏和脑病有关的药剂。

3. 发明授权

US07915263B2 Aminopyridine derivatives having aurora A selective inhibitory action 有权
标题翻译：具有极光A的选择性抑制作用的氨基吡啶衍生物
公开(公告)号：US07915263B2
公开(公告)日：2011-03-29
申请号：US11897272
申请日：2007-08-29
申请人： Yoshikazu Iwasawa , Tetsuya Kato , Nobuhiko Kawanishi , Kouta Masutani , Takashi Mita , Katsumasa Nonoshita , Mitsuru Ohkubo
发明人： Yoshikazu Iwasawa , Tetsuya Kato , Nobuhiko Kawanishi , Kouta Masutani , Takashi Mita , Katsumasa Nonoshita , Mitsuru Ohkubo
IPC分类号： C07D401/12 , A61K31/4439
CPC分类号： C07D413/14 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to a compound of formula I: wherein: R1 is a hydrogen atom, F, CN, etc.; R1′ is a hydrogen atom or lower alkyl which may be substituted; R2 is O, S, SO, SO2, etc.; R3 is a phenyl which may be substituted; X1, X2, and X3 each independently CH, N, etc. provided, however, that among X1, X2 and X3, the number of nitrogen is 0 or 1; W is the following residue: wherein: W1, W2, and W3 each independently CH, N, etc., or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及式I化合物：其中：R1是氢原子，F，CN等; R1'是氢原子或可被取代的低级烷基; R2是O，S，SO，SO2等; R3是可被取代的苯基; X1，X2和X3各自独立地为CH，N等，但X1，X2和X3之间的氮数为0或1。 W是以下残基：其中：W1，W2和W3各自独立地为CH，N等，或其药学上可接受的盐或酯。

4. 发明申请

US20100016335A1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION 审中-公开
标题翻译：具有选择性抑制作用的新型氨基吡啶衍生物
公开(公告)号：US20100016335A1
公开(公告)日：2010-01-21
申请号：US12310307
申请日：2007-08-29
申请人： Yoshikazu Iwasawa , Tetsuya Kato , Nobuhiko Kawanishi , Kouta Masutani , Takashi Mita , Katsumasa Nonoshita , Mitsuru Ohkubo
发明人： Yoshikazu Iwasawa , Tetsuya Kato , Nobuhiko Kawanishi , Kouta Masutani , Takashi Mita , Katsumasa Nonoshita , Mitsuru Ohkubo
IPC分类号： A61K31/497 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/506 , C07D403/04
CPC分类号： C07D413/14 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to a compound of formula I: wherein: R1 is a hydrogen atom, F, CN, etc.; R1′ is a hydrogen atom or lower alkyl which may be substituted; R2 is O, S, SO, SO2, etc.; R3 is a phenyl which may be substituted; X1, X2, and X3 each independently CH, N, etc. provided, however, that among X1, X2 and X3, the number of nitrogen is 0 or 1; W is the following residue: wherein: W1, W2, and W3 each independently CH, N, etc., or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及式I化合物：其中：R1是氢原子，F，CN等; R1'是氢原子或可被取代的低级烷基; R2是O，S，SO，SO2等; R3是可被取代的苯基; X1，X2和X3各自独立地为CH，N等，但X1，X2和X3之间的氮数为0或1。 W是以下残基：其中：W1，W2和W3各自独立地为CH，N等，或其药学上可接受的盐或酯。

5. 发明申请

US20120029004A1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION 有权
标题翻译：具有选择性抑制作用的新型氨基吡啶衍生物
公开(公告)号：US20120029004A1
公开(公告)日：2012-02-02
申请号：US13258748
申请日：2010-03-12
申请人： Hayley Binch , Masaya Hashimoto , Toshiharu Iwama , Nobuhiko Kawanishi , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
发明人： Hayley Binch , Masaya Hashimoto , Toshiharu Iwama , Nobuhiko Kawanishi , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
IPC分类号： A61K31/506 , A61P35/00 , C07D403/14
CPC分类号： C07D403/14
摘要： The present invention relates to a compound of Formula (I): wherein: R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10; R5 is H, hydroxy, C1-2 alkyl, or OCH3; and R10 is F or Cl, or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及式（I）的化合物：其中：R 1是H或C 1-2烷基; R2是H或C1-3烷基; R 3和R 4各自独立地为H或C 1-2烷基，其中烷基可以被一至三个相同或不同的选自R 10的取代基取代; R5是H，羟基，C1-2烷基或OCH3; R 10为F或Cl，或其药学上可接受的盐或酯。

6. 发明授权

US07491720B2 Aminopyridine derivatives having Aurora A selective inhibitory action 有权
标题翻译：具有极光A的氨基吡啶衍生物选择性抑制作用
公开(公告)号：US07491720B2
公开(公告)日：2009-02-17
申请号：US11258447
申请日：2005-10-25
申请人： Mitsuru Ohkubo , Tetsuya Kato , Nobuhiko Kawanishi , Takashi Mita , Toshiyasu Shimomura
发明人： Mitsuru Ohkubo , Tetsuya Kato , Nobuhiko Kawanishi , Takashi Mita , Toshiyasu Shimomura
IPC分类号： C07D241/00 , C07D241/02 , A01N43/58 , A61K31/50
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/14
摘要： The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).
摘要翻译：本发明涉及由通式（I）表示的化合物：其中m1和m2为1,2或3; n1和n2为0或1; 我是1到m1中任何一个的整数; j为1〜m2的整数， R是芳基，杂芳基或环烷基，其中任一个可以被取代; Rai和Rai'是氢原子等，Rbj和Rbj'是氢原子等; Rc，Rd和Re为氢原子等; X1是CH，CX1a或N; X2是CH，N等; X3是CH，N等; X4是CH或N; Y1，Y2和Y3各自独立地为CH或N; Z1和Z2各自独立地为CH或N; W是5元芳族杂环基，例如吡唑基，噻唑基等，或其药学上可接受的盐或酯; 含有它们的药物组合物或抗肿瘤剂; 以及抗肿瘤剂与其它抗肿瘤剂的组合。

7. 发明申请

US20080027042A1 Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action 审中-公开
标题翻译：具有极光选择性抑制作用的新型氨基吡啶衍生物
公开(公告)号：US20080027042A1
公开(公告)日：2008-01-31
申请号：US11666531
申请日：2005-10-25
申请人： Mitsuru Ohkubo , Tetsuya Kato , Nobuhiko Kawanishi , Takashi Mita , Toshiyasu Shimomura
发明人： Mitsuru Ohkubo , Tetsuya Kato , Nobuhiko Kawanishi , Takashi Mita , Toshiyasu Shimomura
IPC分类号： A61K31/496 , A61K31/425 , A61K31/497 , A61K31/5513 , C07D211/72 , C07D243/14 , C07D295/00 , C07D277/04 , C07D241/04 , A61P43/00 , A61K31/5355 , A61K31/44
CPC分类号： A61K38/21 , A61K31/282 , A61K31/337 , A61K31/407 , A61K31/4745 , A61K31/475 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7076 , A61K33/24 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12 , A61K2300/00
摘要： The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).
摘要翻译：本发明涉及由通式（I）表示的化合物：其中m 1和m 2是1,2或3; n 1和n 2是0或1; i是1〜m1的任一个的整数; j为1〜m 2的整数; R是芳基，杂芳基或环烷基，其中任一个可以被取代; R a a和R a'是氢原子等，R bj和R b'是氢原子等等 R c，R d和R e是氢原子等; X 1是CH，CX 1a，或N; X 2是CH，N等; X 3是CH，N等; X 4是CH或N; Y 1，Y 2和Y 3各自独立地为CH或N; Z 1和Z 2各自独立地为CH或N; W是5元芳族杂环基，例如吡唑基，噻唑基等，或其药学上可接受的盐或酯; 含有它们的药物组合物或抗肿瘤剂; 以及抗肿瘤剂与其它抗肿瘤剂的组合。

8. 发明授权

US07053219B2 Isoxazolopyridone derivatives and their use 失效
标题翻译：异恶唑吡啶酮衍生物及其用途
公开(公告)号：US07053219B2
公开(公告)日：2006-05-30
申请号：US10732988
申请日：2003-12-10
申请人： Masayuki Nakamura , Hideki Kurihara , Mitsuru Ohkubo , Naohiro Tsukamoto
发明人： Masayuki Nakamura , Hideki Kurihara , Mitsuru Ohkubo , Naohiro Tsukamoto
IPC分类号： C07D471/22 , A61K31/44
CPC分类号： C07D498/04
摘要： The invention relates to isoxazolopyridone derivatives of a formula (I-a): wherein R1a represents an optionally-substituted heteroaryl or phenyl group, R2a represents an optionally-substituted phenyl or heteroaryl group, and R3a represents a methyl group, provided that, (1) when R1a is an unsubstituted phenyl group, then R2a must not be a para-substituted phenyl group of which the substituent is any of a methoxy group, a chloro group, a methyl group, a trifluoromethyl group, a fluoro group, a bromomethyl group or a dimethylaminomethyl group, and R2a must not be an unsubstituted heteroaryl group, and (2) when R1a is a 4-tolyl group or a 4-fluorophenyl group, then R2a must not be an unsubstituted phenyl group, a 4-methoxyphenyl group or a 4-fluorophenyl group, or their pharmaceutically-acceptable salts. The isoxazolopyridone derivatives or their pharmaceutically-acceptable salts of the invention have a metabotropic glutamic acid receptor-antagonistic effect, and are useful for remedy of, for example, anxiety disorders, psychosomatic disorders, obsessive-compulsive neurosis, bipolar disorders, melancholia, eating disorders, schizophrenia, multi-infarct dementia, Alzheimer disease, epilepsy, Parkinson disease, Huntington's chorea, pain or retrograde neurosis.
摘要翻译：本发明涉及式（Ia）的异恶唑吡啶酮衍生物：其中R 1a表示任选取代的杂芳基或苯基，R 2a表示任选取代的苯基或杂芳基基团，且R 3a表示甲基，条件是（1）当R 1a为未取代的苯基时，R 2a必须不是取代基是甲氧基，氯基，甲基，三氟甲基，氟基，溴甲基或二甲基氨基甲基中的任何一个的对位取代的苯基，R 2a， / SUP>不能是未取代的杂芳基，和（2）当R 1a是4-甲苯基或4-氟苯基时，R 2a不能为未取代的苯基，4-甲氧基苯基或4-氟苯基，或其药学上可接受的盐。本发明的异恶唑吡啶酮衍生物或其药学上可接受的盐具有代谢型谷氨酸受体拮抗作用，并且可用于治疗例如焦虑症，心理障碍，强迫性神经症，双相情感障碍，忧郁症，进食障碍，精神分裂症，多发性梗塞性痴呆，阿尔茨海默病，癫痫，帕金森病，亨廷顿舞蹈病，疼痛或逆行神经症。

9. 发明授权

US08492397B2 Aminopyridine derivatives having Aurora A selective inhibitory action 有权
标题翻译：具有极光A的氨基吡啶衍生物选择性抑制作用
公开(公告)号：US08492397B2
公开(公告)日：2013-07-23
申请号：US13258748
申请日：2010-03-12
申请人： Hayley Binch , Masaya Hashimoto , Toshiharu Iwama , Nobuhiko Kawanishi , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
发明人： Hayley Binch , Masaya Hashimoto , Toshiharu Iwama , Nobuhiko Kawanishi , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
IPC分类号： C07D403/14 , A61K31/535
CPC分类号： C07D403/14
摘要： The present invention relates to a compound of Formula (I): wherein R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10; R5 is H, hydroxy, C1-2 alkyl, or OCH3; and R10 is F or Cl, or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及式（I）的化合物：其中R 1是H或C 1-2烷基; R2是H或C1-3烷基; R 3和R 4各自独立地为H或C 1-2烷基，其中烷基可以被一至三个相同或不同的选自R 10的取代基取代; R5是H，羟基，C1-2烷基或OCH3; R 10为F或Cl，或其药学上可接受的盐或酯。

10. 发明申请

US20120015940A1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION 有权
标题翻译：具有选择性抑制作用的新型氨基吡啶衍生物
公开(公告)号：US20120015940A1
公开(公告)日：2012-01-19
申请号：US13258782
申请日：2010-03-15
申请人： Toshiharu Iwama , Nobuhiko Kawanishi , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
发明人： Toshiharu Iwama , Nobuhiko Kawanishi , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
IPC分类号： A61K31/5383 , A61P35/00 , A61K31/506 , C07D487/04 , C07D498/04
CPC分类号： C07D471/04 , C07D498/04
摘要： The present invention relates to a compound of Formula (I): wherein: n is 0 or 1; X is O or CH2; R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10 R5 is H or OCH3; R10 is F or Cl; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及式（I）的化合物：其中：n为0或1; X是O或CH2; R1是H或C1-2烷基; R2是H或C1-3烷基; R 3和R 4各自独立地为H或C 1-2烷基，其中烷基可被一至三个相同或不同的选自R 10的取代基取代，R 5为H或OCH 3; R10为F或Cl; 或其药学上可接受的盐或酯。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式