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1. 发明授权

US5439932A Substituted amine derivatives having anti-hyperlipemia activity 失效
标题翻译：具有抗高血脂活性的取代的胺衍生物
公开(公告)号：US5439932A
公开(公告)日：1995-08-08
申请号：US26692
申请日：1993-03-04
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/38 , A61K31/495 , C07D409/02 , C07D409/14
CPC分类号： C07D213/30 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/10 , C07D417/12
摘要： Substituted amine derivatives represented by the general formula ##STR1## wherein Q is --C--D--E--F--G--M-- or --N--H--I--J--K--L-- [C, D, E, F, G, H, I, J, K and L are each O, S, a carbonyl group, --CHR.sup.a --, --R.sup.b .dbd. or --NR.sup.c -- (R.sup.a, R.sup.b and R.sup.c are each H or a lower alkyl group), M and N are each an aromatic ring of 5-6 members optionally having a halogen, OH, LN, a lower alkyl group or a lower alkoxy group, provided that L is not O, S, or --NR.sup.c --]; R is a heterocyclic ring of 5-6 members; R.sup.1 is H, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group, a lower alkynyl group or a cycloalkyl group; R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are each H, a halogen or a lower alkyl group or two of them denote a single bond; R.sup.8 and R.sup.9 are each F, CF.sub.3 or a lower alkyl group or are a cycloalkane in combination thereof; and R.sup.10 is H, F, CF.sub.3 an acetoxy group, a lower alkyl group or a lower alkoxy group. These compounds inhibit biosynthesis of cholesterol in mammals by inhibiting their squalene epoxidase, and thereby lower their blood cholesterol values. Therefore, these compounds are expected to be effective as an agent for treatment and prophylaxis of diseases caused by excess of cholesterol, for example, obesity, hyperlipemia and arteriosclerosis and heart and encephalic diseases accompanying them.
摘要翻译：由通式[IMAGE] [I]表示的取代的胺衍生物，其中Q是-_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ，_F，_G，_H，_I，_J，_K和_L各自为O，S，羰基，-CHR a - ，-R b =或-NR c - （R a，R b和R c各自为H或低级烷基） M和N各自为任选具有卤素，OH，LN，低级烷基或低级烷氧基的5-6个成员的芳环，条件是_L不是O，S或-NRc-]; R是5-6个成员的杂环; R1是H，低级烷基，低级卤代烷基，低级烯基，低级炔基或环烷基; R2，R3，R4，R5，R6和R7各自为H，卤素或低级烷基，或两个表示单键; R8和R9各自为F，CF3或低级烷基，或其组合为环烷烃; R 10为H，F，CF 3为乙酰氧基，低级烷基或低级烷氧基。这些化合物通过抑制它们的角鲨烯环氧酶抑制哺乳动物胆固醇的生物合成，从而降低它们的血液中胆固醇值。因此，预期这些化合物作为用于治疗和预防由胆固醇过量引起的疾病，例如肥胖症，高脂血症和动脉硬化以及与其伴随的心脏和脑病有关的药剂。

2. 发明授权

US5306728A Substituted amine derivatives having antihyperlipemia activity 失效
标题翻译：具有抗高血脂活性的取代的胺衍生物
公开(公告)号：US5306728A
公开(公告)日：1994-04-26
申请号：US26120
申请日：1993-03-04
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Masahiro Hayashi , Yoshikazu Iwasawa , Hitoshi Masaki , Mitsuru Ohkubo , Yumiko Sakuma , Yasufumi Nagata , Toshihiko Satoh , Toshio Kamei
IPC分类号： C07D213/30 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/38 , A01N43/06 , C07D333/10 , C07D411/10
CPC分类号： C07D213/30 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D277/24 , C07D333/16 , C07D333/18 , C07D333/20 , C07D333/24 , C07D333/32 , C07D409/12 , C07D413/10 , C07D417/12
摘要： Substituted amine derivatives represented by the general formula ##STR1## wherein Q is -C-D-E- F-G-M- or -N-H-I-J-K-L- [C, D, E, F, G, H, I, J, K and L are each O, S, a carbonyl group, -CHR.sup.2 -, -R.sup.b = or -NR.sup.c - (R.sup.a, R.sup.b and R.sup.c are each H or a lower alkyl group), M and N are each an aromatic ring of 5-6 members optionally having a halogen, OH, LN, a lower alkyl group or a lower alkoxy group, provided that L is not O, S, or -NR.sup.c -]; R is a heterocyclic ring of 5-6 members; R.sup.1 is H, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group, a lower alkynyl group or a cycloalkyl group; R.sup.2, R.sup.3, R.sup.4, R.sup.5 R.sup.6 and R.sup.7 are each H, a halogen or a lower alkyl group or two of them denote a single bond; R.sup.8 and R.sup.9 are each F, CF.sub.3 or a lower alkyl group or are a cycloalkane in combination thereof; and R.sup.10 is H, F, CF.sub. 3 an acetoxy group, a lower alkyl group or a lower alkoxy group. These compounds inhibit biosynthesis of cholesterol in mammals by inhibiting their squalene epoxidase, and thereby lower their blood cholesterol values. Therefore, these compounds are expected to be effective as an agent for treatment and prophylaxis of diseases caused by excess of cholesterol, for example, obesity, hyperlipemia and arteriosclerosis and heart and encephalic diseases accompanying them.
摘要翻译：其中Q为-CDE-FGM-或-NHIJKL- [C，D，E，F，G，H，I，J，K和L各自为O， S，羰基，-CHR 2 - ，-R b =或-NR c - （R a，R b和R c各自为H或低级烷基），M和N各自为任选具有卤素的5-6个成员的芳香环，OH，LN，低级烷基或低级烷氧基，条件是L不是O，S或-NRc-]; R是5-6个成员的杂环; R1是H，低级烷基，低级卤代烷基，低级烯基，低级炔基或环烷基; R2，R3，R4，R5 R6和R7各自为H，卤素或低级烷基，或两个表示单键; R8和R9各自为F，CF3或低级烷基，或其组合为环烷烃; R 10为H，F，CF 3为乙酰氧基，低级烷基或低级烷氧基。这些化合物通过抑制它们的角鲨烯环氧酶抑制哺乳动物胆固醇的生物合成，从而降低它们的血液中胆固醇值。因此，预期这些化合物作为用于治疗和预防由胆固醇过量引起的疾病，例如肥胖症，高脂血症和动脉硬化以及与其伴随的心脏和脑病有关的药剂。

3. 发明授权

US06871994B2 Light diffusion sheet and backlight unit using the same 有权
标题翻译：光扩散片和使用其的背光单元
公开(公告)号：US06871994B2
公开(公告)日：2005-03-29
申请号：US10639979
申请日：2003-08-13
申请人： Kenichi Harada , Hitoshi Masaki
发明人： Kenichi Harada , Hitoshi Masaki
IPC分类号： G02B5/02 , F21V3/04 , F21V8/00 , G02B6/00 , G02F1/1335 , G02F1/13357 , F21V5/00
CPC分类号： G02B6/0051 , F21V3/04 , G02B6/0065
摘要： A light diffusion sheet comprising a transparent base material sheet; a light diffusion layer laminated on a surface of the base material sheet and containing beads dispersed within a binder; and a sticking-inhibiting layer laminated on a rear face of the base material sheet, wherein the binder of the light diffusion layer contains a thermosetting resin and the sticking-inhibiting layer is a resin layer containing an ionizing radiation curable resin. In the light diffusion sheet of the invention, which employs an ionizing radiation curable resin for the binder of the sticking-inhibiting layer, the cross-linking density of the binder can be increased, whereby the wear resistance of the sticking-inhibiting layer as well as the wear resistance of the rear face of the light diffusion sheet can be increased. Further, possible occurrence of scratches in the sticking-inhibiting layer, which is attributable to the contact between the sticking-inhibiting layer and the beads of the light diffusion layer, can be effectively avoided.
摘要翻译：一种光扩散片，包括透明基材片; 光扩散层，层叠在基材片的表面上，并含有分散在粘合剂中的珠粒; 以及层叠在基材片的背面上的粘着抑制层，其中，所述光扩散层的粘合剂含有热固性树脂，所述粘着抑制层是含有电离辐射固化性树脂的树脂层。在本发明的光扩散片中，使用电离辐射固化树脂作为粘着抑制层的粘结剂，可以提高粘合剂的交联密度，从而防粘层的耐磨性也因为可以增加光扩散片的背面的耐磨性。此外，可以有效地避免由于粘着抑制层与光扩散层的珠粒之间的接触引起的粘附抑制层中的划痕的可能发生。

4. 发明授权

US06709143B2 Light diffusion sheet and backlight unit using the same 有权
公开(公告)号：US06709143B2
公开(公告)日：2004-03-23
申请号：US10080460
申请日：2002-02-22
申请人： Kenichi Harada , Hitoshi Masaki
发明人： Kenichi Harada , Hitoshi Masaki
IPC分类号： F21V1116
CPC分类号： G02B6/0051 , F21V3/04 , G02B6/0065
摘要： A light diffusion sheet comprising a transparent base material sheet; a light diffusion layer laminated on a surface of the base material sheet and containing beads dispersed within a binder; and a sticking-inhibiting layer laminated on a rear face of the base material sheet, wherein the binder of the light diffusion layer contains a thermosetting resin and the sticking-inhibiting layer is a resin layer containing an ionizing radiation curable resin. In the light diffusion sheet of the invention, which employs an ionizing radiation curable resin for the binder of the sticking-inhibiting layer, the cross-linking density of the binder can be increased, whereby the wear resistance of the sticking-inhibiting layer as well as the wear resistance of the rear face of the light diffusion sheet can be increased. Further, possible occurrence of scratches in the sticking-inhibiting layer, which is attributable to the contact between the sticking-inhibiting layer and the beads of the light diffusion layer, can be effectively avoided.

5. 发明申请

US20050068628A1 Optical sheet and backlight unit using the same 审中-公开
标题翻译：光学片和背光单元使用相同
公开(公告)号：US20050068628A1
公开(公告)日：2005-03-31
申请号：US10950723
申请日：2004-09-27
申请人： Hitoshi Masaki
发明人： Hitoshi Masaki
IPC分类号： C08J5/18 , C08F20/12 , C08L33/10 , G02B5/02 , G02F1/13357 , G03G15/04 , G02B13/20
CPC分类号： G02B5/0226 , G02B5/0242 , G02B5/0278
摘要： An object of the present invention is to provide optical sheets having excellent heat resistance, moisture resistance, thermal dimensional stability and weather resistance, which hardly give rise to bending, yellowing and the like even though they receive generated heat from a lamp and ultraviolet ray irradiation, and to provide backlight units in which reduction of the occurrence of lack in uniformity of the brightness and lowering of the brightness is achieved using the optical sheet. The optical sheet of the present invention has a transparent substrate layer, and an optical layer overlaid to the front face side of the substrate layer. This optical layer includes a light diffusing agent in the binder. This binder is formed from a polymer composition containing (A) a copolymer and (B) a fine inorganic filler. This copolymer (A) includes at least one of a recurring unit derived from a (meth)acrylic ester having a cycloalkyl group, a recurring unit derived from an iso-butyl (meth)acrylate or a recurring unit derived from a tert-butyl (meth)acrylate.
摘要翻译：本发明的目的是提供即使从灯中产生的热量和紫外线照射也难以产生弯曲，变黄等优良的耐热性，耐湿性，热尺寸稳定性和耐候性优异的光学片并且提供背光单元，其中使用光学片实现亮度均匀性的缺乏的发生的减少和亮度的降低。本发明的光学片具有透明基板层和覆盖在基板层的正面侧的光学层。该光学层包括粘合剂中的光漫射剂。该粘合剂由含有（A）共聚物和（B）无机填料的聚合物组合物形成。该共聚物（A）包括来源于具有环烷基的（甲基）丙烯酸酯的重复单元，来自（甲基）丙烯酸异丁酯的重复单元或由（甲基）丙烯酸叔丁酯甲基）丙烯酸酯。

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