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1. 发明专利

JP2003287368A Bean dryer 审中-公开
标题翻译：豆干
公开(公告)号：JP2003287368A
公开(公告)日：2003-10-10
申请号：JP2002091214
申请日：2002-03-28
申请人： Yoshimi Tsuchiya , 吉美土谷
发明人： TSUCHIYA YOSHIMI
IPC分类号： F26B11/04 , F26B21/00
摘要： PROBLEM TO BE SOLVED: To provide a simple bean dryer suitable for a bean grower to process gathered beans in a small scale by oneself, superior in drying efficiency, capable of drying even the beans in the pods, and capable of simultaneously removing the pods of the beans at drying time.
SOLUTION: This bean dryer has at least a drying object housing rotary drum 20 for arranging a large number of ventilation slits 23 in an outer shell, an atmospheric box 10 for arranging the rotary drum 20 inside so that a rotary shaft becomes the horizontal direction, a hot air means 30 for blowing off dry hot air from below the rotary drum 20 in the atmospheric box 10, and a ventilation adjusting cover 40 arranged in a ceiling part 11 of the atmospheric box 10.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种适合于豆类种植者的简单的豆干机，用于自己小规模处理收集的豆类，干燥效率优异，甚至可以干燥豆荚中的豆类，并且能够同时去除豆荚在干燥的时候。解决方案：该豆干燥器至少具有一个用于在外壳中布置大量通风狭缝23的旋转滚筒20的干燥物体，用于将旋转滚筒20布置在内部的大气箱10，使得旋转轴成为在大气箱10内从旋转鼓20的下方吹出干热空气的热风装置30以及设置在大气盒10的顶棚部11内的换气调整盖40.（COPYRIGHT：（ C）2004，JPO

2. 发明授权

US6040449A Fluorine-containing 1, 4-disubstituted piperidine derivatives 失效
标题翻译：含氟的1,4-二取代的哌啶衍生物
公开(公告)号：US6040449A
公开(公告)日：2000-03-21
申请号：US290607
申请日：1999-04-13
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
IPC分类号： C07D211/46 , C07D211/58 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D401/06 , C07D211/58 , C07D405/06 , C07D409/06
摘要： In the production of fluorine-containing 1,4-disubstituted piperidine derivatives by the reaction of a carboxylic acid of formula where Ar represents aryl or heteroaryl and R.sup.10 represents C.sub.3 -C.sub.6 cycloalkyl in which up to 4 hydrogen atoms are substituted with fluorine or C.sub.3 -C.sub.6 cycloalkyl having 1 to 2 protected or unprotected hydroxyl or oxo groups, or a reactive derivative thereof, with a piperidine derivative of formula [IV] as defined in the specification, especially useful results are obtained using 4-amino-1-(6-aminopyridin-2-ylmethyl)piperidine or a salt thereof, e.g., trihydrochloride, as the piperidine derivative.
摘要翻译：在通过下式的羧酸的反应制备含氟的1,4-二取代的哌啶衍生物时，其中Ar表示芳基或杂芳基，R10表示C3-C6环烷基，其中最多4个氢原子被氟或C3- 具有1至2个受保护或未保护的羟基或氧代基团的C 6环烷基或其活性衍生物与本说明书中定义的式[IV]哌啶衍生物特别有用的结果是使用4-氨基-1-（6- 氨基吡啶-2-基甲基）哌啶或其盐，例如三盐酸盐作为哌啶衍生物。

3. 发明授权

US5948792A Fluorine-containing 1,4-disubstituted piperidine derivatives 失效
标题翻译：含氟的1,4-二取代的哌啶衍生物
公开(公告)号：US5948792A
公开(公告)日：1999-09-07
申请号：US903768
申请日：1997-07-31
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
IPC分类号： C07D211/46 , C07D211/58 , C07D401/06 , C07D405/06 , C07D409/06 , A61K31/445
CPC分类号： C07D401/06 , C07D211/58 , C07D405/06 , C07D409/06
摘要： Novel fluorine-containing 1,4-disubstituted piperidine derivatives, represented by general formula �I! ##STR1## such as, for example, (2R)-N-�1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl!-2-�(1R)-3,3-difluorocyclopentyl!-2-hydroxy-2-phenylacetamide or pharmaceutically acceptable salt thereof, are potent and selective antagonists for muscarinic M.sub.3 receptors with little side effects. The compounds of formula �I! exhibit excellent oral activity, duration of activity and pharmacolkinetics. They are useful for treatment and prophylaxis of respiratory diseases, such as chronic obstructive pulmonary diseases; urinary diseases, such as urinary incontinence; and digestive diseases, such as irritable bowel syndrome, and motion sickness.
摘要翻译：由通式[I]表示的新型含氟1,4-二取代哌啶衍生物，例如（2R）-N- [1-（6-氨基吡啶-2-基甲基）哌啶-4-基] - 2 - [（1R）-3,3-二氟环戊基] -2-羟基-2-苯基乙酰胺或其药学上可接受的盐是毒副反应较少的毒蕈碱M3受体的有效和选择性拮抗剂。式[I]的化合物表现出优异的口服活性，活性持续时间和药物动力学。它们可用于治疗和预防呼吸系统疾病，如慢性阻塞性肺疾病; 尿病如尿失禁; 和消化系统疾病，如肠易激综合征，晕车等。

4. 发明授权

US4737494A 1,3-dithiole derivatives and pharmaceutical compositions 失效
标题翻译： 1,3-二硫杂衍生物和药物组合物
公开(公告)号：US4737494A
公开(公告)日：1988-04-12
申请号：US813583
申请日：1985-12-26
申请人： Mitsuo Yano , Yoshimi Tsuchiya , Yukio Hirayama , Kyoko Nakamichi , Junji Yoshizawa
发明人： Mitsuo Yano , Yoshimi Tsuchiya , Yukio Hirayama , Kyoko Nakamichi , Junji Yoshizawa
IPC分类号： A61K31/385 , A61P1/16 , C07D339/06 , C07D409/04 , C07D413/04 , C07D417/04 , A61K31/40 , A61K31/535
CPC分类号： C07D409/04 , C07D339/06 , C07D413/04 , C07D417/04
摘要： A 1,3-dithiole derivative having the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is a substituted or unsubstituted alkyl, cycloalkyl, lower alkenyl, lower alkynyl, aryl or aralkyl group or R.sup.1 and R.sup.2 together form a substituted or unsubstituted alkylene or alkenylene group having from 3 to 6 carbon atoms, which may contain a cycloalkylene group, an o-phenylene group or a hetero atom selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom which may have a substituent, and Q is an acid residue useful for the treatment of liver diseases.
摘要翻译：具有下式的1,3-二硫杂衍生物：其中R 1和R 2各自为取代或未取代的烷基，环烷基，低级烯基，低级炔基，芳基或芳烷基或R 1和R 2一起形成取代的或未取代的具有3至6个碳原子的亚烷基或亚烯基，其可以含有亚环烷基，邻亚苯基或选自氧原子，硫原子和氮原子的杂原子，其可以具有取代基，Q是可用于治疗肝脏疾病的酸残基。

5. 发明授权

US4155742A Water-soluble binder 失效
标题翻译：水溶性粘合剂
公开(公告)号：US4155742A
公开(公告)日：1979-05-22
申请号：US870414
申请日：1978-01-18
申请人： Akira Sakurai , Yoshimi Tsuchiya , Mikio Kanno
发明人： Akira Sakurai , Yoshimi Tsuchiya , Mikio Kanno
IPC分类号： C08L71/00 , A01N25/10 , A61K47/34 , A61L9/05 , B01J2/28 , C02F1/50 , C02F1/68 , C05B1/02 , C05G3/00 , C08G59/14 , C08G65/00 , C08G65/32 , C08L71/02 , C09K3/00 , C11D1/72 , C11D3/20 , C11D17/00 , A01N9/00 , A01N11/00
CPC分类号： C11D3/2068 , A01N25/10 , A61L9/05 , C02F1/50 , C02F1/688 , C05B1/02 , C05G3/0052 , C08G59/1444 , C11D1/72 , C11D17/0056 , Y10S71/904
摘要： A unit dosage form comprising one or more active ingredients and a water-soluble binder in which the water-soluble binder comprises, as a main component, a product obtained by condensing a polyoxyethylene alkyl, alkylphenyl or alkenyl ether having the following formula (I):r-o--(ch.sub.2 ch.sub.2 o).sub.n H (I)wherein R is alkyl or alkenyl having 8 to 22 carbon atoms or alkylphenyl group having 8 to 22 carbon atoms in the alkyl group, and n is an integer of from 50 to 500, with 1-epoxyethyl-3,4-epoxycyclohexane having the following formula (II): ##STR1## the molar ratio of the compound of the formula (II) to the compound of the formula (I) being in the range of from 0.05 to 2.5.
摘要翻译：包含一种或多种活性成分和水溶性粘合剂的单位剂量形式，其中所述水溶性粘合剂作为主要组分包含通过将具有下式（I）的聚氧乙烯烷基，烷基苯基或链烯基醚缩合得到的产物，：

6. 发明授权

US5234946A Substituted alkylamine derivatives 失效
标题翻译：取代的烷基胺衍生物
公开(公告)号：US5234946A
公开(公告)日：1993-08-10
申请号：US753611
申请日：1991-08-30
申请人： Hiroshi Takezawa , Masahiro Hayashi , Yoshikazu Iwasawa , Masaaki Hosoi , Yoshiaki Iida , Yoshimi Tsuchiya , Masahiro Horie , Toshio Kamei
发明人： Hiroshi Takezawa , Masahiro Hayashi , Yoshikazu Iwasawa , Masaaki Hosoi , Yoshiaki Iida , Yoshimi Tsuchiya , Masahiro Horie , Toshio Kamei
IPC分类号： C07C211/27 , C07C211/30 , C07C211/46 , C07C211/49 , C07C217/48 , C07C217/58 , C07C233/20 , C07C237/40 , C07C255/54 , C07C323/32 , C07D207/08 , C07D207/32 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D213/64 , C07D215/14 , C07D231/12 , C07D239/26 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/24 , C07D277/28 , C07D307/42 , C07D307/68 , C07D307/80 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D521/00
CPC分类号： C07D207/08 , C07C211/27 , C07C211/30 , C07C211/46 , C07C211/49 , C07C217/48 , C07C217/58 , C07C233/20 , C07C237/40 , C07C255/54 , C07C323/32 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D213/64 , C07D215/14 , C07D231/12 , C07D233/56 , C07D239/26 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/24 , C07D277/28 , C07D307/42 , C07D307/68 , C07D307/80 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04 , Y10S514/824
摘要： The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R.sup.1 represents (a) substituted or unsubstituted C.sub.2-6 alkenyl group, (b) substituted or unsubstituted C.sub.3-6 cycloalkenyl group, (c) substituted or unsubstituted C.sub.2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru.sup.11 -Ar wherein R.sup.11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; ##STR2## represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R.sup.7,X and Y are linking groups,R.sup.2 is H or lower alkyl,R.sup.3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl,R.sup.4 and R.sup.5 are independently hydrogen or halogen atoms,R.sup.6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.
摘要翻译：由式（I）表示的取代烷基胺衍生物其中R 1表示（a）取代或未取代的C 2-6烯基，（b）取代或未取代的C 3-6环烯基，（c）取代或未取代的C 2 -6炔基，（d）取代或未取代的芳基，（e）取代或未取代的杂环基，（f）可被取代的稠合杂环基，或（g）由式Ru11-Ar表示的基团，其中R11为杂环基和Ar是可以含有杂原子N，O或S原子并且可以被取代的5或6元芳环; 表示可含有杂原子N，O或S原子的5或6元芳环，可被R 7取代，X和Y为连接基团，R 2为H或低级烷基，R 3为氢，低级烷基，低级烯基，低级炔基或低级环烷基，R4和R5独立地是氢或卤素原子，R6表示（a）可以是不饱和的取代或未取代的无环烃基，（b）取代或未取代的环烷基，或（c ）取代或未取代的苯基，或其无毒盐。（E）-N-（6-6-二甲基-2-庚烯-4-炔基）-N-乙基-3- [4-（3-噻吩基）-2-噻吩-1-甲氧基]苄胺盐酸盐是一个代表性的例子。取代的烷基胺衍生物可用作药物，特别是用于治疗和预防高胆固醇血症，高脂血症和动脉硬化。

7. 发明授权

US4966915A L-dopa derivatives or their acid addition salts, process for producing same and their use 失效
标题翻译： L-多巴衍生物或其酸加成盐，其制备方法及其用途
公开(公告)号：US4966915A
公开(公告)日：1990-10-30
申请号：US245348
申请日：1988-09-16
申请人： Yoshimi Tsuchiya , Masahiro Hayashi , Hiroshi Takehana , Akihiro Hisaka , Yoshio Sawasaki , Masaki Ihara
发明人： Yoshimi Tsuchiya , Masahiro Hayashi , Hiroshi Takehana , Akihiro Hisaka , Yoshio Sawasaki , Masaki Ihara
IPC分类号： A61K31/215 , A61K20060101 , A61K31/165 , A61K31/265 , A61P25/00 , C07C227/16 , C07C229/36
CPC分类号： A61K31/165
摘要： An L-dopa derivative represented by formula (I) ##STR1## wherein one of R.sup.1 and R.sup.2 denotes a hydrogen atom and the other denotes a group of formula R--CO-- in which R denotes an alkyl, alkenyl, optionally substituted cycloalkyl, optionally substituted phenyl, optionally substituted aralkyl, lower alkoxy or optionally substituted aralkyloxy group,and its acid addition salt. The compounds are useful in the medical field, especially in the treatment of a series of diseases called Parkinson's disease or Parkinsonism.

8. 发明授权

US4414255A Water absorbing sheet assembly 失效
标题翻译：吸水片组装
公开(公告)号：US4414255A
公开(公告)日：1983-11-08
申请号：US141742
申请日：1980-04-18
申请人： Mitsuru Tokuyama , Yoshimi Tsuchiya , Hikotaro Kawaguchi , Masayuki Sagae , Kenji Ohki
发明人： Mitsuru Tokuyama , Yoshimi Tsuchiya , Hikotaro Kawaguchi , Masayuki Sagae , Kenji Ohki
IPC分类号： A61F13/472 , A61F13/15 , A61F13/49 , A61F13/53 , B29C63/00 , B32B5/24 , B32B27/00 , B32B27/10 , B32B37/00 , D21H27/30 , B32B3/28 , B32B29/00
CPC分类号： A61F13/533 , A61F13/15731 , A61F13/539 , B32B5/24 , A61F13/511 , A61F13/534 , A61F2013/15821 , A61F2013/51042 , A61F2013/51078 , A61F2013/530481 , A61F2013/53445 , A61F2013/53966 , Y10T156/1023 , Y10T428/24463 , Y10T428/24612 , Y10T428/24826 , Y10T428/24992 , Y10T428/254 , Y10T428/31982
摘要： A water-absorbing sheet assembly comprises two sheets, at least one of which is a water-permeable sheet, and a polymeric absorbent inserted between said two sheets, wherein at least a part of said two sheets are pressed and bonded to each other.
摘要翻译：吸水片组件包括两个片材，其中至少一个是透水片材，以及插入在所述两个片材之间的聚合物吸收剂，其中所述两个片材的至少一部分被压合并彼此结合。

9. 发明授权

US6140333A N-acyl cyclic amine derivatives 失效
标题翻译： N-酰基环胺衍生物
公开(公告)号：US6140333A
公开(公告)日：2000-10-31
申请号：US244985
申请日：1999-02-04
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
IPC分类号： C07D211/26 , C07D211/58 , C07D211/70 , C07D221/20 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , A61K31/505 , A61K31/445 , C07D211/30 , C07D219/00 , C07D409/00
CPC分类号： C07D221/20 , C07D211/26 , C07D211/58 , C07D211/70 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10
摘要： The invention relates to compounds represented by the general formula [I] ##STR1## [wherein Ar means an aryl group or a heteroaryl group which may have a substitutive group selected from a group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; R.sup.1 means a C.sub.3 -C.sub.6 cycloalkyl group which is substitutable with a fluorine atom; R.sup.2 and R.sup.4 mean hydrogen atoms, groups represented by --(A.sup.1).sub.m --NH--B or the like; R.sup.3 and R.sup.5 mean hydrogen atoms, C.sub.1 -C.sub.6 aliphatic hydrocarbon groups or the like which are substitutable with a lower alkyl group(s); n means 0 or 1; and X means an oxygen atom or a sulfur atom].Compounds according to the invention, since they not only have potent selective antagonistic activity against muscarinic M.sub.3 receptors but also exhibit excellent oral activity, durability of action and pharmacokinetics, are very useful as safe and effective remedies against respiratory, urinary and digestive diseases with little adverse side effects.
摘要翻译：本发明涉及由通式[I]表示的化合物[其中Ar表示可以具有选自卤素原子，低级烷基和低级烷氧基的取代基的芳基或杂芳基; R1表示可与氟原子取代的C3-C6环烷基; R2和R4表示氢原子，由 - （A1）m-NH-B等表示的基团; R3和R5表示可被低级烷基取代的氢原子，C1-C6脂族烃基等; n表示0或1; X表示氧原子或硫原子]。根据本发明的化合物，因为它们不仅对毒蕈碱M3受体具有有效的选择性拮抗活性，而且还表现出优异的口服活性，作用的耐久性和药代动力学，对于呼吸，尿和消化疾病的安全和有效的治疗方法是非常有用的副作用。

10. 发明授权

US5750540A 1,4-di-substituted piperidine derivatives 失效
标题翻译： 1,4-二取代的哌啶衍生物
公开(公告)号：US5750540A
公开(公告)日：1998-05-12
申请号：US682785
申请日：1996-07-31
申请人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
发明人： Yoshimi Tsuchiya , Takashi Nomoto , Hirokazu Ohsawa , Kumiko Kawakami , Kenji Ohwaki , Masaru Nishikibe
IPC分类号： C07D211/46 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/445 , A61K31/505
CPC分类号： C07D401/12 , C07D211/46 , C07D211/58 , C07D405/12 , C07D409/12 , C07D417/12
摘要： This invention provides novel 1,4-di-substituted piperidine derivatives of the general formula �I! ##STR1## and the pharmaceutically acceptable salts thereof, wherein: Ar represents a phenyl group or a five- or six-membered heteroaromatic group having one or two hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom in which one or two optional hydrogen atoms on the ring may be replaced by substituent groups selected from the group consisting of a halogen atom and a lower alkyl group; R.sup.1 represents a cycloalkyl group of 3 to 6 carbon atoms or a cycloalkenyl group of 3 to 6 carbon atoms; R.sup.2 represents a saturated or unsaturated aliphatic hydrocarbon radical of 5 to 15 carbon atoms; and X represents O or NH. These compounds have selective antagonistic activity against the muscarinic M.sub.3 receptors and can hence be used safely with a minimum of side effects.
摘要翻译： PCT No.PCT / JP96 / 01128 Sec。 371日期：1996年7月31日 102（e）1996年7月31日PCT PCT 1996年4月25日PCT公布。公开号WO96 / 33973 日期：1996年10月31日本发明提供通式[I]＆lt; IMAGE＆gt;的新型1,4-二取代哌啶衍生物及其药学上可接受的盐，其中：Ar表示苯基或五元或六元具有一个或两个选自氧原子，硫原子和氮原子的杂原子的杂芳族基团，其中环上的一个或两个任选的氢原子可以被选自卤素原子和低级烷基; R1表示3〜6个碳原子的环烷基或3〜6个碳原子的环烯基; R 2表示5至15个碳原子的饱和或不饱和脂族烃基; X表示O或NH。这些化合物对毒蕈碱M3受体具有选择性的拮抗作用，因此可以以最少的副作用安全使用。

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