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1. 发明授权

US08808704B2 Non-coiled protective regions of pneumococcal surface proteins PspA and PspC 有权
标题翻译：肺炎球菌表面蛋白PspA和PspC的非卷曲保护区
公开(公告)号：US08808704B2
公开(公告)日：2014-08-19
申请号：US12162566
申请日：2007-02-01
申请人： Susan K. Hollingshead , David E. Briles
发明人： Susan K. Hollingshead , David E. Briles
IPC分类号： A61K39/09 , C12N15/09
CPC分类号： A61K39/092 , A61K2039/55505 , C07K14/3156 , C07K16/1275
摘要： The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
摘要翻译：本文描述的实施方案提供了肺炎链球菌表面蛋白A和缺乏α螺旋结构的表面蛋白C的免疫原性部分。

2. 发明授权

US08329195B2 Detoxified pneumococcal neuraminidase and uses thereof 有权
标题翻译：解毒型肺炎球菌神经氨酸酶及其用途
公开(公告)号：US08329195B2
公开(公告)日：2012-12-11
申请号：US12601233
申请日：2007-05-23
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： A61K39/09 , C07K14/315
CPC分类号： C12N9/2402 , A61K39/092 , C12Y302/01018
摘要： Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
摘要翻译：本文提供了旨在减少或预防球细胞感染，鼻运动，鼻腔定植和中枢神经系统侵袭的组合物。本文提供了包含包含SEQ ID NO：19的氨基酸序列的多肽或其可诱发抗神经氨酸酶免疫应答的变体的组合物。进一步提供制备和使用本文公开的组合物的方法。具体提供的是在受试者中产生抗体的方法，包括向受试者施用本文教导的试剂或组合物。还提供减少或预防受试者鼻腔运载或肺炎球菌感染的方法，包括向受试者施用本文教导的组合物。

3. 发明申请

US20100227341A1 Diagnosing Pneumococcal Pneumonia 有权
标题翻译：诊断肺炎球菌肺炎
公开(公告)号：US20100227341A1
公开(公告)日：2010-09-09
申请号：US12377440
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： G01N33/53
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10 , Y02A50/472
摘要： Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).
摘要翻译：描述了引起针对肺炎链球菌的免疫应答的组合物和方法。更具体地说，本公开内容涉及免疫原性PcpA多肽，包括PcpA及其变体的片段，以及编码多肽的核酸。本公开还涉及制备和使用免疫原性多肽的方法。还提供了通过从受试者获得生物样品并检测在入侵期间选择性表达的一种或多种肺炎球菌抗原（例如PcpA或其片段）来诊断受试者中的肺炎球菌感染（例如肺炎）的方法。

4. 发明申请

US20090170162A1 NON-COILED PROTECTIVE REGIONS OF PNEUMOCOCCAL SURFACE PROTEINS PSPA AND PSPC 有权
标题翻译：肺结核蛋白PSPA和PSPC的非卷曲保护区
公开(公告)号：US20090170162A1
公开(公告)日：2009-07-02
申请号：US12162566
申请日：2007-02-01
申请人： Susan K. Hollingshead , David E. Briles
发明人： Susan K. Hollingshead , David E. Briles
IPC分类号： C12P21/02 , C07K14/315 , C07H21/02 , C12N15/63 , C12N5/10 , A61K39/09 , A61P37/02
CPC分类号： A61K39/092 , A61K2039/55505 , C07K14/3156 , C07K16/1275
摘要： The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
摘要翻译：本文描述的实施方案提供了肺炎链球菌表面蛋白A和缺乏α螺旋结构的表面蛋白C的免疫原性部分。

5. 发明授权

US07189404B2 Strain selection of pneumococcal surface proteins 有权
标题翻译：肺炎球菌表面蛋白的菌株选择
公开(公告)号：US07189404B2
公开(公告)日：2007-03-13
申请号：US10674755
申请日：2003-09-30
申请人： Robert S. Becker , David E. Briles , Susan Hollingshead
发明人： Robert S. Becker , David E. Briles , Susan Hollingshead
IPC分类号： A61K39/09 , G01N33/569 , C07K1/00 , C07H21/04
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C07K14/7151 , C12Q1/689 , G01N33/56911
摘要： The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit greater than 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.
摘要翻译：本发明涉及包含选自至少一个家族的菌株的至少两种PspA的疫苗组合物，该家族由来自属于该家族的菌株的PspA定义，所述菌株的比对序列具有大于或等于50％的同源性 PspA的α螺旋区域的C-末端区域。另外，家族还包括进化枝，其中属于进化枝的菌株的PspA在PspA的α螺旋的C-末端区域的比对序列中表现出大于75％的序列同源性。本发明的疫苗组合物优选包含至少4个和最多6个表示单个进化枝的菌株，并且所述至少两个PspAs任选地是血清学的或广泛的交叉反应性的。

6. 发明授权

US06638516B1 Strain selection of pneumococcal surface proteins 失效
标题翻译：肺炎球菌表面蛋白的菌株选择
公开(公告)号：US06638516B1
公开(公告)日：2003-10-28
申请号：US09147875
申请日：1999-05-24
申请人： Robert S. Becker , David E. Briles , Susan Hollingshead
发明人： Robert S. Becker , David E. Briles , Susan Hollingshead
IPC分类号： A61K3909
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , C07K14/7151 , C12Q1/689 , G01N33/56911
摘要： The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit at least 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.
摘要翻译：本发明涉及包含选自至少一个家族的菌株的至少两种PspA的疫苗组合物，该家族由来自属于该家族的菌株的PspA定义，所述菌株的比对序列具有大于或等于50％的同源性 PspA的α螺旋区域的C-末端区域。此外，家族还包括进化枝，其中属于进化枝的菌株的PspAs在PspA的α螺旋的C-末端区域的比对序列中表现出至少75％的序列同源性。本发明的疫苗组合物优选包含至少4个和最多6个表示单个进化枝的菌株，并且所述至少两个PspAs任选地是血清学的或广泛的交叉反应性的。

7. 发明授权

US6027734A Mucosal administration of pneumococcal antigens 失效
标题翻译：粘膜给予肺炎球菌抗原
公开(公告)号：US6027734A
公开(公告)日：2000-02-22
申请号：US312949
申请日：1994-09-30
申请人： David E. Briles , Hong-Yin Wu
发明人： David E. Briles , Hong-Yin Wu
IPC分类号： A61K9/00 , A61K35/74 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/39 , A61P11/00 , A61P31/04 , C07K14/28 , C07K14/315 , C07K14/715 , C12N15/74 , C12Q1/68 , A01N63/00
CPC分类号： C07K14/28 , C07K14/3156 , C07K14/7151 , C12N15/74 , C12N15/746 , C12Q1/689 , A61K39/00 , C07K2319/00 , C07K2319/02
摘要： Mucosal administration, particularly intranasally, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with cholera toxin B subunit, provides protection in animals against pneumococcal colonization and systemic infection. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.
摘要翻译：特别是当与霍乱毒素B亚基一起施用时，粘膜给药，特别是鼻内杀死的全球肺炎球菌，肺炎球菌的裂解物和分离和纯化的PspA以及其免疫原性片段，在动物中提供了针对肺炎球菌定植和全身感染的保护作用。在宿主中引发针对肺炎球菌定居的保护的能力防止免疫个体携带，这可导致整体上消除人群的疾病。

8. 发明授权

US08252546B2 Diagnosing pneumococcal pneumonia 有权
标题翻译：诊断肺炎球菌肺炎
公开(公告)号：US08252546B2
公开(公告)日：2012-08-28
申请号：US12377440
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： G01N33/569
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10 , Y02A50/472
摘要： Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).
摘要翻译：描述了引起针对肺炎链球菌的免疫应答的组合物和方法。更具体地说，本公开内容涉及免疫原性PcpA多肽，包括PcpA及其变体的片段，以及编码多肽的核酸。本公开还涉及制备和使用免疫原性多肽的方法。还提供了通过从受试者获得生物样品并检测在入侵期间选择性表达的一种或多种肺炎球菌抗原（例如PcpA或其片段）来诊断受试者中的肺炎球菌感染（例如肺炎）的方法。

9. 发明申请

US20110002962A1 Immunogenic PcpA Polypeptides and Uses Thereof 审中-公开
标题翻译：免疫原性PcpA多肽及其用途
公开(公告)号：US20110002962A1
公开(公告)日：2011-01-06
申请号：US12377446
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead , Jeremy Yethon , Joe Wang
发明人： David E. Briles , Susan K. Hollingshead , Jeremy Yethon , Joe Wang
IPC分类号： A61K39/09 , C07K14/195 , A61K39/116 , A61P31/04
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PcpA and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译：本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。更具体地，组合物和方法涉及免疫原性多肽，包括PcpA及其变体的片段，以及编码或表达多肽的核酸，载体和转染的细胞。还描述了制备和使用免疫原性多肽的方法。

10. 发明授权

US07049419B2 Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor 有权
公开(公告)号：US07049419B2
公开(公告)日：2006-05-23
申请号：US10341201
申请日：2003-01-13
申请人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
发明人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12P21/06 , C12N15/09
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/51
摘要： Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.

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