专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09598496B2 Antibody capable of specifically recognizing transferrin receptor 有权
公开(公告)号：US09598496B2
公开(公告)日：2017-03-21
申请号：US14116714
申请日：2012-05-07
申请人： Yoshikazu Kurosawa , Kazuhiro Morishita , Lilin Zhang , Gene Kurosawa , Katsuyuki Mitomo , Yukio Sudo , Fumiko Nomura , Yoshinori Ukai
发明人： Yoshikazu Kurosawa , Kazuhiro Morishita , Lilin Zhang , Gene Kurosawa , Katsuyuki Mitomo , Yukio Sudo , Fumiko Nomura , Yoshinori Ukai
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： C07K16/30 , C07K16/2881
摘要： An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).

2. 发明申请

US20140114054A1 ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR 有权
标题翻译：特异性识别转铁蛋白受体的抗体
公开(公告)号：US20140114054A1
公开(公告)日：2014-04-24
申请号：US14116714
申请日：2012-05-07
申请人： Yoshikazu Kurosawa , Kazuhiro Morishita , Lilin Zhang , Gene Kurosawa , Katsuyuki Mitomo , Yukio Sudo , Fumiko Nomura , Yoshinori Ukai
发明人： Yoshikazu Kurosawa , Kazuhiro Morishita , Lilin Zhang , Gene Kurosawa , Katsuyuki Mitomo , Yukio Sudo , Fumiko Nomura , Yoshinori Ukai
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , C07K16/2881
摘要： An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).
摘要翻译：本发明的目的是提供一种完全人抗TfR抗体，其特异性识别人TfR，抑制高表达TfR的癌细胞的存活或生长，并且对人类没有免疫原性。本发明提供与人TfR特异性反应的抗体，其中所述抗体包含SEQ ID NO： 31-33,37-39,43-45,49-51,55-57,61-63,67-69,73-75,79-81,85-87,91-93,97-99,103- 105，109-111和115-117，作为重链第一互补决定区（VH CDR1），重链第二互补决定区（VH CDR2）和重链第三互补决定区（VH CDR3）。

3. 发明申请

US20120046451A1 ANTI-lgSF4 ANTIBODY AND UTILIZATION OF THE SAME 审中-公开
标题翻译：抗-IgSF4抗体及其应用
公开(公告)号：US20120046451A1
公开(公告)日：2012-02-23
申请号：US13238096
申请日：2011-09-21
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/42
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

4. 发明授权

US08048992B2 Anti-IgSF4 antibody and utilization of the same 失效
标题翻译：抗IgSF4抗体与利用相同
公开(公告)号：US08048992B2
公开(公告)日：2011-11-01
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/00
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

5. 发明申请

US20090053243A1 Anti-IgSF4 Antibody and Utilization of the Same 失效
标题翻译：抗IgSF4抗体及其利用
公开(公告)号：US20090053243A1
公开(公告)日：2009-02-26
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , A61P31/00 , C12N5/06 , G01N33/574
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

6. 发明授权

US09023343B2 Phosphorylation-inhibiting agent or dephosphorylating agent for PTEN 有权
标题翻译： PTEN的磷酸化抑制剂或去磷酸化剂
公开(公告)号：US09023343B2
公开(公告)日：2015-05-05
申请号：US13263876
申请日：2010-03-26
申请人： Kazuhiro Morishita , Shingo Nakahata , Makoto Hamasaki
发明人： Kazuhiro Morishita , Shingo Nakahata , Makoto Hamasaki
IPC分类号： A61K38/46 , C12N15/00 , G01N33/53 , C12Q1/48 , A61K31/223 , A61K31/7088 , C07K16/40 , C07K16/44 , C12N9/12 , C12N9/18 , A61K48/00
CPC分类号： C12Q1/485 , A61K31/223 , A61K31/7088 , A61K48/005 , C07K16/40 , C07K16/44 , C07K2317/34 , C12N9/12 , C12N9/18 , G01N2500/00 , A61K2300/00
摘要： Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g., an antibody against the phosphorylation-inhibiting or dephosphorylating agent for PTEN obtained above, is also obtained.
摘要翻译：提供预防性，进展抑制剂或疾病的补救方法，其原因之一是激活P13K / AKT信号传导途径，反之亦然。一种磷酸化抑制剂和/或去磷酸化剂，其至少在选自T382，T383和S380的PTEN蛋白的磷酸化位点之一处抑制磷酸化和/或使其去磷酸化的作用，准备好了或者，通过包括以下方法筛选用于PTEN的磷酸化抑制剂或去磷酸化剂，所述方法包括用于确认测试物质至少在PTEN蛋白的一个磷酸化位点抑制磷酸化的能力的步骤，所述磷酸化位点选自T382， T383和S380或其去磷酸化能力。然后，也可获得具有与抑制PTEN磷酸化或其去磷酸化作用相反的作用的物质，例如针对上述获得的PTEN的磷酸化抑制或去磷酸化剂的抗体。

7. 发明授权

US06657239B1 Power-switching semiconductor device 有权
标题翻译：电源开关半导体器件
公开(公告)号：US06657239B1
公开(公告)日：2003-12-02
申请号：US09784451
申请日：2001-02-27
申请人： Kazuhiro Morishita , Katsumi Satoh
发明人： Kazuhiro Morishita , Katsumi Satoh
IPC分类号： H01L2945
CPC分类号： H01L29/41716 , H01L29/42308
摘要： In order to reduce a turn-on time of a power switching semiconductor device at a low cost, a first main electrode divided into a plurality of segments forming segment rows of a multi-concentric circle and a control electrode surrounding the segments are formed on a front major surface of a semiconductor substrate, and a second electrode is formed on a rear major surface thereof, and a turn-on operation is performed between the first main electrode and the second main electrode with a control signal inputted from the control electrode, specifying a relationship between a width of a segment and a distance between adjacent segments, and others.
摘要翻译：为了以低成本降低功率开关半导体器件的导通时间，分割成形成多同心圆的段行的多个段的第一主电极和围绕该段的控制电极形成在半导体衬底的前主表面和第二电极形成在其后主表面上，并且利用从控制电极输入的控制信号在第一主电极和第二主电极之间进行导通操作，指定片段的宽度与相邻片段之间的距离之间的关系等。

8. 发明授权

US06624448B2 Semiconductor device with multiple supporting points 有权
标题翻译：具有多个支撑点的半导体器件
公开(公告)号：US06624448B2
公开(公告)日：2003-09-23
申请号：US09822342
申请日：2001-04-02
申请人： Kazunori Taguchi , Kazuhiro Morishita , Kenji Oota
发明人： Kazunori Taguchi , Kazuhiro Morishita , Kenji Oota
IPC分类号： H01L2974
CPC分类号： H01L24/72 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01015 , H01L2924/01019 , H01L2924/01033 , H01L2924/1301 , H01L2924/14 , H01L2924/19041 , H01L2924/30107 , H01L2924/00
摘要： A semiconductor device having a supporting member that reduces a resonance phenomenon. A pair of reinforcing members is fixed on a gate drive substrate with spacers interposed there between and upright portions of the pair of reinforcing members are fastened with screws on a side wall of a cathode flange. A spacer is fixed on the gate drive substrate and a projection of the spacer is inserted in an engaging member fixed on the bottom of the cathode fin electrode and thus fixed on the bottom of the cathode fin electrode. The pair of upright portions as the first and second supporting points and the projection of the spacer as the third supporting point stably support the gate drive substrate on the cathode fin electrode without freedom of rotation at the three positions arranged to surround an opening.
摘要翻译：一种具有减少共振现象的支撑构件的半导体器件。一对加强构件固定在栅极驱动基板上，其间隔着间隔件，一对加强构件的直立部分用螺钉紧固在阴极凸缘的侧壁上。间隔件固定在栅极驱动基板上，并且间隔件的突起插入固定在阴极鳍电极的底部上的接合构件中，并因此固定在阴极鳍电极的底部。作为第一支撑点和第二支撑点的一对直立部分和作为第三支撑点的间隔件的突出部在围绕开口的三个位置处稳定地支撑阴极鳍电极上的栅极驱动基板，而不会旋转自如。

9. 发明授权

US06521918B2 Semiconductor device and driving method thereof 有权
公开(公告)号：US06521918B2
公开(公告)日：2003-02-18
申请号：US09566738
申请日：2000-05-09
申请人： Kenji Oota , Kazuhiro Morishita , Katsumi Satoh
发明人： Kenji Oota , Kazuhiro Morishita , Katsumi Satoh
IPC分类号： H01L31111
CPC分类号： H01L29/0692 , H01L29/742 , H01L29/744
摘要： To make it possible to control turn-off operation even after switch over to transistor operation after commutation of the main current from cathode electrode to gate electrode in turn-off operation, a semiconductor device according to the invention comprises a first electrode, a first region of first conduction type provided on the first electrode, a second region of second conduction type provided on the first region, a third region and a fourth region of first conduction type respectively provided on the second region with a predetermined distance from each other to allow formation of a channel region on the second region, a fifth region of second conduction type provided on the third region, a second electrode provided on the fifth region, a gate electrode established in contact with the fourth region and a control electrode provided on a separate region between the third and fourth regions on the second region to control the channel region through an insulation layer.

10. 发明授权

US06227500B1 Meter mounting structure and meter mounting method 有权
标题翻译：仪表安装结构和仪表安装方法
公开(公告)号：US06227500B1
公开(公告)日：2001-05-08
申请号：US09281070
申请日：1999-03-09
申请人： Shigemitsu Inaba , Kazuhiro Morishita
发明人： Shigemitsu Inaba , Kazuhiro Morishita
IPC分类号： G12B900
CPC分类号： B60K37/06 , B60K37/02 , B60K2350/941 , B60K2350/946 , G01D11/30
摘要： A meter is mounted to an instrument panel. The meter has an engaging portion in the form of a projection-like rotation shaft and projections located on the side walls of the meter. The instrument panel has a support groove and guide grooves. The meter is inserted into the instrument panel so that the projection-like rotation portion engages with the support groove of the panel. The meter is rotated about the projection-like rotation portion while the projections on the side wall of the meter engage with the guide grooves of the instrument panel.
摘要翻译：仪表安装在仪表板上。仪表具有呈突起状旋转轴的形式的接合部分和位于仪表侧壁上的凸起。仪表板具有支撑槽和引导槽。仪表被插入到仪表板中，使得突起状旋转部分与面板的支撑槽接合。仪表在突出状旋转部分周围旋转，同时仪表侧壁上的突起与仪表板的导向槽接合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式