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1. 发明申请

US20080027039A1 Method for treating a motor neuron disease 失效
标题翻译：治疗运动神经元疾病的方法
公开(公告)号：US20080027039A1
公开(公告)日：2008-01-31
申请号：US11707883
申请日：2007-02-20
申请人： Yoshihiro Arakawa , Makoto Miyazaki
发明人： Yoshihiro Arakawa , Makoto Miyazaki
IPC分类号： A61K31/5415 , A61K31/15 , A61K31/164 , A61K31/445 , A61K31/55 , A61K31/554 , A61P25/00 , A61K31/551 , A61K31/4523 , A61K31/496 , A61K31/519
CPC分类号： A61K31/15 , A61K31/164 , A61K31/445 , A61K31/4523 , A61K31/496 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554
摘要： According to the present invention, there is provided a method for treating a motor neuron disease, comprising the step of administering a therapeutically effective amount of a compound having serotonin receptor antagonist activity or its pharmacologically acceptable salt or their solvate optionally together with a pharmaceutically acceptable carrier to a mammal for which the treatment of said disease is indicated.
摘要翻译：根据本发明，提供了一种治疗运动神经元疾病的方法，包括以下步骤：将治疗有效量的具有5-羟色胺受体拮抗剂活性的化合物或其药理学上可接受的盐或其溶剂合物任选与药学上可接受的载体涉及对其表示所述疾病的治疗的哺乳动物。

2. 发明授权

US07541371B2 Method for treating a motor neuron disease 失效
标题翻译：治疗运动神经元疾病的方法
公开(公告)号：US07541371B2
公开(公告)日：2009-06-02
申请号：US11707883
申请日：2007-02-20
申请人： Yoshihiro Arakawa , Makoto Miyazaki
发明人： Yoshihiro Arakawa , Makoto Miyazaki
IPC分类号： A61K31/445
CPC分类号： A61K31/15 , A61K31/164 , A61K31/445 , A61K31/4523 , A61K31/496 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554
摘要： According to the present invention, there is provided a method for treating a motor neuron disease, comprising the step of administering a therapeutically effective amount of a compound having serotonin receptor antagonist activity or its pharmacologically acceptable salt or their solvate optionally together with a pharmaceutically acceptable carrier to a mammal for which the treatment of said disease is indicated.
摘要翻译：根据本发明，提供了一种治疗运动神经元疾病的方法，包括以下步骤：将治疗有效量的具有5-羟色胺受体拮抗剂活性的化合物或其药理学上可接受的盐或其溶剂合物任选与药学上可接受的载体涉及对其表示所述疾病的治疗的哺乳动物。

3. 发明授权

US4551273A Analgesic peptide and process for the preparation thereof 失效
标题翻译：止痛肽及其制备方法
公开(公告)号：US4551273A
公开(公告)日：1985-11-05
申请号：US575804
申请日：1984-01-31
申请人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
发明人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
IPC分类号： C07K14/655 , A61K38/00 , A61P25/04 , C07C231/02 , C07K7/08 , C07K14/575 , C07K14/665 , C07C103/52
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
摘要： A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.
摘要翻译：具有一级结构的新型肽：N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH2（其中D. Ile和D.Leu分别表示D-Ile和D-Leu残基，氨基酸的其它缩写代表每个L-氨基酸残基，Me表示甲基），其在外周施用时显示出显着的镇痛作用。还公开了通过固相法制备其方法。

4. 发明授权

US4707468A Polypeptide 失效
公开(公告)号：US4707468A
公开(公告)日：1987-11-17
申请号：US796390
申请日：1985-11-08
申请人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
发明人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
IPC分类号： C07K1/14 , A61K38/00 , A61K38/08 , A61P25/04 , C07K7/06 , C07K14/665 , C07K14/675 , C07K7/12
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl or lower alkenyl group, A represents a D-amino acid, Gly or Sar provided that when the D-amino acid is D-Cys, it is bonded with L-Cys or D-Cys in position 5 through a S--S bond to effect intramolecular ring closure, B represents L-Phe or D-Phe in which the benzene ring may be substituted or an .alpha.-N-alkyl derivative thereof, C represents an L-amino acid, D-Cys or an .alpha.-N-alkyl derivative thereof, D and E each represent an L- or D-basic amino acid or an .alpha.-N-alkyl derivative thereof, F represents a group of the formula --OR.sup.3 (in which R.sup.3 is H or a lower alkyl group), a group of the formula: ##STR2## (in which R.sup.4 and R.sup.5 are the same or different and each represents H or a lower alkyl group), a group of the formula: --G--OR.sup.6 (in which G is an L- or D-amino acid or Gly or an .alpha.-N-alkyl derivative thereof and R.sup.6 represents H or a lower alkyl group), a group of the formula: ##STR3## (in which G is as defined above and R.sup.7 and R.sup.8 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--L--Arg--OR.sup.9 or --G--D--Arg--OR.sup.9 (in which G is as defined above and R.sup.9 represents H or a lower alkyl group or a group of the formula: ##STR4## (in which G is as defined above and R.sup.10 and R.sup.11 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--J--OR.sup.12 in which G is defined as above, J is a neutral amono acid group or an acidic amino acid group and R.sup.12 is hydrogen or a lower alkyl group; or a group of the formula: --G--Arg--M--OR.sup.13 in which M is D-amino acid group and R.sup.13 is hydrogen or a lower alkyl group, provided that all of the amino acids constituting the polypeptide of the above formula do not represent at the same time an L-amino acid of the general formula: ##STR5## (in which R represents a group corresponding to a structural formula of an amino acid deprived of a group of the formula: ##STR6## or pharmacologically acceptable salts of them.

5. 发明申请

US20110033365A1 PROCESS AND APPARATUS FOR PRODUCING CARBONACEOUS FILM 审中-公开
标题翻译：生产碳膜的方法和装置
公开(公告)号：US20110033365A1
公开(公告)日：2011-02-10
申请号：US12517887
申请日：2007-12-07
申请人： Hiroyuki Kousaka , Hiroyuki Koizumi , Eri Hamajima , Noritsugu Umehara , Yoshihiro Arakawa
发明人： Hiroyuki Kousaka , Hiroyuki Koizumi , Eri Hamajima , Noritsugu Umehara , Yoshihiro Arakawa
IPC分类号： H05H1/50 , H05H1/48 , C23C16/513 , D01F9/14
CPC分类号： C23C16/26 , C23C16/4485 , C23C16/503
摘要： This invention provides a process and apparatus for producing a carbonaceous film such as a DLC film using a solid raw material without the need to supply a high energy radiation such as a laser beam. The process comprises providing a solid organic material as a raw material, applying a discharge energy to the material to form plasma, and depositing the plasma onto a base material to form a carbonaceous film. This process is preferably carried out by using a film production apparatus (1) comprising discharge means (10). The discharge means (10) comprises a pair of electrodes (a raw material holder) (12, 14) for holding a raw material (50) and voltage applying means (20) for applying voltage across the electrodes.
摘要翻译：本发明提供一种使用固体原料生产碳质膜如DLC膜的方法和装置，而不需要提供诸如激光束的高能量辐射。该方法包括提供作为原料的固体有机材料，向材料施加放电能量以形成等离子体，以及将等离子体沉积到基底材料上以形成碳质膜。该方法优选通过使用包括排出装置（10）的薄膜制造装置（1）来进行。放电装置（10）包括用于保持原料（50）的一对电极（原料保持器）（12,14）和用于在电极两端施加电压的电压施加装置（20）。

6. 发明授权

US3979641A Vertical deflection output circuitry for television receiver 失效
标题翻译：电视接收机的垂直偏转输出电路
公开(公告)号：US3979641A
公开(公告)日：1976-09-07
申请号：US474025
申请日：1974-05-28
申请人： Yoshihiro Arakawa , Akio Nakashima , Shunji Iwabuchi , Kenji Ando
发明人： Yoshihiro Arakawa , Akio Nakashima , Shunji Iwabuchi , Kenji Ando
IPC分类号： H04N3/16 , H03K4/69 , H01J29/70
CPC分类号： H03K4/696
摘要： A vertical deflection output circuitry for a television receiver wherein two transistors are connected in single ended and push-pull relation, and the output junction point of the two transistors is connected, to a D.C. power source for supplying a higher voltage than that of a power source for the vertical deflection output circuitry, through a switch which is turned off during the vertical scan period and turned on during the vertical retrace period.
摘要翻译：一种用于电视接收机的垂直偏转输出电路，其中两个晶体管以单端和推挽关系连接，并且两个晶体管的输出连接点连接到用于提供比功率更高的电压的DC电源通过在垂直扫描周期期间关闭并在垂直回扫期间接通的开关，垂直偏转输出电路的源极。

7. 发明授权

US06745731B2 Valve driving device of an internal combustion engine 有权
标题翻译：内燃机的阀驱动装置
公开(公告)号：US06745731B2
公开(公告)日：2004-06-08
申请号：US10437848
申请日：2003-05-14
申请人： Tsuneo Tanaka , Akihiko Minato , Yoshihiro Arakawa
发明人： Tsuneo Tanaka , Akihiko Minato , Yoshihiro Arakawa
IPC分类号： F01L902
CPC分类号： F01L9/02
摘要： A valve driving device reduces the volume of the pressure chamber and decreases the energy supplied during driving to open the main valve. As a result of this initial energy, the main valve is lifted by inertial motion. When the main valve is opened (lifted), a first actuating valve is opened, and high-pressure actuating fluid is supplied to the pressure chamber. When in this process the pressure in the pressure chamber falls below the pressure of a low-pressure chamber, a second actuating valve opens independently, and low-pressure actuating fluid is introduced into the pressure chamber. By this means negative pressure in the pressure chamber can be prevented, and the main valve can be held in a lift position equivalent to the initial energy. When the main valve is to be closed, an actuator forcibly opens the second actuating valve. Then, high-pressure actuating fluid in the pressure chamber passes through the second actuating valve, presses and opens a third actuating valve on the downstream side, and is discharged to a path.
摘要翻译：阀驱动装置减小了压力室的体积，并降低了在打开主阀时在驱动期间供应的能量。由于这种初始能量，主阀由惯性运动提升。当主阀打开（提起）时，第一致动阀打开，高压致动流体被供应到压力室。当在这个过程中压力室中的压力低于低压室的压力时，第二个致动阀独立打开，低压致动流体被引入压力室。由此，能够防止压力室的负压，能够将主阀保持在与初期能量相当的提升位置。当主阀关闭时，执行器强制打开第二个致动阀。然后，压力室中的高压致动流体通过第二致动阀，在下游侧按压并打开第三致动阀，并将其排出到路径上。

8. 发明授权

US06602687B1 DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby 失效
标题翻译：编码人睫状神经营养因子的DNA及其制备方法
公开(公告)号：US06602687B1
公开(公告)日：2003-08-05
申请号：US07883630
申请日：1992-05-08
申请人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
发明人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
IPC分类号： C12N1516
CPC分类号： C07K16/22 , A61K38/1825 , A61K38/185 , C07K14/475 , A61K38/18 , A61K31/715 , A61K2300/00
摘要： The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treatment of a variety of neurological diseases and disorders, including Alzheimer's disease. In a specific embodiment of the invention, CNTF may be used to support the growth of spinal cord neurons, thereby providing a method of treating spinal cord damage caused by trauma infarction, infection, nutritional deficiency or toxic agents. The present invention also relates to a novel method for producing substantilly pure CNTF. The invention also relates to pharmaceutical compositions comprising effective amounts of CNTF gene products which may be used in the diagnosis and treatment of a variety of neurologial diseases and disorders. The present invention relates to the cloning sequencing and expression of CNTF and provides, for the first time, a means for producing human CNTF utilizing human CNTF-encoding nucleic acid sequences. Furthermore, the CNTF nucleic acid sequences of the invention may be utilized to identify nucleic acid sequences encoding CNTF or CNTF-homologous molecules in a variety of species and tissues.
摘要翻译：本发明涉及编码睫状神经营养因子（CNTF）的核酸序列以及由其产生的蛋白质，肽和衍生物。在本发明的各种实施方案中，本发明的核酸序列，蛋白质和肽可用于治疗各种神经疾病和病症，包括阿尔茨海默氏病。在本发明的一个具体实施方案中，CNTF可用于支持脊髓神经元的生长，从而提供治疗由创伤性梗塞，感染，营养缺乏或毒性剂引起的脊髓损伤的方法。本发明还涉及本发明还涉及包含有效量的可用于诊断和治疗多种神经系统疾病和病症的CNTF基因产物的药物组合物。本发明涉及克隆测序和表达的CNTF，并且首次提供了利用人CNTF编码核酸序列生产人CNTF的方法。此外，本发明的CNTF核酸序列可用于鉴定在各种物种和组织中编码CNTF或CNTF同源分子的核酸序列。

9. 发明授权

US5398040A Adaptive crosshatch signal generator 失效
标题翻译：自适应交叉影线信号发生器
公开(公告)号：US5398040A
公开(公告)日：1995-03-14
申请号：US359270
申请日：1989-05-31
申请人： Masanori Ogino , Takeo Yamada , Miyuki Ikeda , Yoshihiro Arakawa
发明人： Masanori Ogino , Takeo Yamada , Miyuki Ikeda , Yoshihiro Arakawa
IPC分类号： H04N17/00 , G09G1/00 , G09G1/14 , G09G1/16 , H04N3/23
CPC分类号： G09G1/143
摘要： An adaptive crosshatch signal generator includes a frequency detector for detecting a horizontal scanning frequency, a square calculator supplied with the detected output of the frequency detector, and a variable pulse width multivibrator controlled to have an output pulse width substantially in inverse proportion to the squared output. Longitudinal lines of a crosshatch signal are formed by the output pulses of the multivibrator. The crosshatch signal has a longitudinal line width which is always substantially equivalent to the distance between adjacent scanning lines and is generated by using a simplified configuration irrespective of input signal format.
摘要翻译：自适应交叉影线信号发生器包括用于检测水平扫描频率的频率检测器，提供有频率检测器的检测输出的平方运算器以及被控制为具有与输出平方成反比的输出脉冲宽度的可变脉宽多谐振荡器。交叉阴影信号的纵向线由多谐振荡器的输出脉冲形成。交叉阴影线信号具有总是基本上等于相邻扫描线之间的距离的纵向线宽，并且通过使用简化的配置而与输入信号格式无关地产生。

10. 发明授权

US4980614A Convergence correction circuit 失效
标题翻译：收敛校正电路
公开(公告)号：US4980614A
公开(公告)日：1990-12-25
申请号：US194305
申请日：1988-05-16
申请人： Takeo Yamada , Miyuki Ikeda , Toshiyuki Kimoto , Masanori Ogino , Tsuneo Fujikura , Yoshihiro Arakawa
发明人： Takeo Yamada , Miyuki Ikeda , Toshiyuki Kimoto , Masanori Ogino , Tsuneo Fujikura , Yoshihiro Arakawa
IPC分类号： H04N3/23 , H04N3/27 , H04N9/28
CPC分类号： H04N9/28
摘要： A convergence correction circuit according to the present invention has a phased locked loop including a programmable counter. The programmable counter has programmable count start and end points. The output of the programmable counter is supplied to a memory storing convergence distortion correcting data therein. As the horizontal screen size is increased, a value closer to the lower limit 0 of the start point as compared with that taken when the horizontal size is small is set as the count start point of the programmable counter, and a value closer to the upper limit (2.sup.7 -1) of the end point as compared with that taken when the horizontal size is small is set as the count end point. In accordance with the horizontal screen size, the count start and end points of the programmable counter are changed. Correct convergence correction is performed even if the horizontal screen size is changed.
摘要翻译：根据本发明的会聚校正电路具有包括可编程计数器的定相锁相环。可编程计数器具有可编程计数开始和结束点。可编程计数器的输出被提供给存储其中的会聚失真校正数据的存储器。随着水平画面尺寸的增加，与水平尺寸较小时相比，开始点的下限值越小，可设定为可编程计数器的计数开始点，越接近上限值与水平尺寸较小时相比，终点的极限（27-1）被设定为计数终点。根据水平屏幕尺寸，可编程计数器的计数开始和结束点被更改。即使水平画面尺寸发生变化，也可进行正确的会聚校正。

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