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1. 发明授权

US4543254A Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient 失效
标题翻译：含有可可碱或茶碱衍生物作为活性成分的消炎/解热/止痛剂
公开(公告)号：US4543254A
公开(公告)日：1985-09-24
申请号：US471564
申请日：1983-03-02
申请人： Takeru Kaneko , Satoru Ozaki , Kimie Takizawa , Hachiro Sugimoto
发明人： Takeru Kaneko , Satoru Ozaki , Kimie Takizawa , Hachiro Sugimoto
IPC分类号： C07D473/08 , C07D473/10 , A61K31/33 , A61K31/495 , A61K31/52
CPC分类号： C07D473/10 , C07D473/08
摘要： Treatment methods are disclosed which utilize antiphlogistic/antipyretic/analgesic agents containing as active ingredient theobromine and theophylline derivatives represented by the general formula: ##STR1## wherein one of A and B is --CH.sub.3 and the other of A and B is ##STR2## wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formula ##STR3## wherein X.sub.1 and X.sub.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; or (3) a group of the formula: ##STR4## wherein Y.sub.1 and Y.sub.2 may be the same or different and Y.sub.1 and Y.sub.2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or >CH--, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that when (i) A is --CH.sub.3, m is 2, and (ii) when A is ##STR5## Z is not pyridyl and X is nitrogen, and acid addition salts thereof.
摘要翻译：公开了利用含有由以下通式表示的活性成分可可碱和茶碱衍生物的抗炎/解热/止痛剂的治疗方法：其中A和B之一为-CH 3，A和B中的一个为“IMAGE”，其中 R是氢原子或低级烷基，Z选自（1）式（1）的基团，其中X 1和X 2相同或不同，各自表示氢原子，低级烷基，低级烷氧基，三氟甲基或卤素原子; （2）吡啶基; 或（3）下式的基团：其中Y1和Y2可以相同或不同，Y1和Y2选自氢原子，低级烷基，低级烷氧基，三氟甲基基团和卤素原子，X为氮原子或> CH-，m为2或3，n为2至10的整数，条件是当（i）A为-CH 3时，m为2，和（ii）当A是Z时，Z不是吡啶基，X是氮，及其酸加成盐。

2. 发明授权

US5523307A Cyclic amine and pharmacological composition 失效
标题翻译：环胺和药理组成
公开(公告)号：US5523307A
公开(公告)日：1996-06-04
申请号：US258798
申请日：1994-06-07
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
IPC分类号： C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04 , C07D401/12 , A61K31/44 , A61K31/445 , A61K31/47
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --0--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat a mental symptoms associated with a cerebrovascular disease.
摘要翻译：环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ Y是-O - ， - CO-或-NH-，Z是苯基，萘基，吡啶基，烷基或环烷基。治疗与脑血管疾病相关的精神症状是有用的。

3. 发明授权

US4921863A Cyclic amine derivatives 失效
标题翻译：环胺衍生物
公开(公告)号：US4921863A
公开(公告)日：1990-05-01
申请号：US177662
申请日：1988-02-17
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizou Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizou Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu
IPC分类号： C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07D215/12 , C07D295/02 , C07D295/03 , C07D295/108 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D295/03 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07D215/12 , C07D295/108 , C07D401/06 , C07D405/06 , C07D409/06
摘要： Cyclic amine derivatives of the formula: ##STR1## or the pharmacologically acceptable salts thereof, wherein the symbols are as defined in the specification, as effective in relieving, curing or preventing mental symptoms due to cerebral vascular disorders.
摘要翻译： PCT No.PCT / JP86 / 00502 Sec。 371日期1988年2月17日 102（e）日期1988年2月17日PCT提交1986年9月30日PCT公布。公开号WO88 / 02365 日期：1988年4月7日。下式的环胺衍生物或其药理学上可接受的盐，其中符号如本说明书中所定义，有效缓解，治愈或预防由于脑血管病症引起的精神症状。

4. 发明授权

US08706857B2 Information processing apparatus, information processing method, data management server and data synchronization system 有权
标题翻译：信息处理装置，信息处理方法，数据管理服务器和数据同步系统
公开(公告)号：US08706857B2
公开(公告)日：2014-04-22
申请号：US12951983
申请日：2010-11-22
申请人： Seiji Esaka , Takeru Kaneko , Masayuki Takada , Shuhei Sonoda
发明人： Seiji Esaka , Takeru Kaneko , Masayuki Takada , Shuhei Sonoda
IPC分类号： G06F15/16
CPC分类号： G06F17/30581
摘要： There is provided an information processing apparatus that is connected to a server for managing data, the information processing apparatus including a data storage configured to store the data obtained from the server, a check unit configured to check a cumulative state of change history information indicating a change type of the data in the server stored in the server, and a data obtaining unit configured to use a check result of the check unit as a basis to determine an obtaining method by selecting either a first obtaining method of synchronizing the data stored in the data storage with the data managed by the server in accordance with the change history information or a second obtaining method of obtaining, from the server, data presence information indicating the data existing in the server to synchronize the data stored in the data storage and to obtain the data from the server.
摘要翻译：提供了一种连接到用于管理数据的服务器的信息处理设备，该信息处理设备包括：数据存储器，被配置为存储从服务器获得的数据;检查单元，被配置为检查表示变更历史信息的累积状态更改存储在服务器中的服务器中的数据的类型，以及数据获取单元，被配置为使用检查单元的检查结果作为基础，通过选择使存储在服务器中的数据同步的第一获取方法来确定获取方法数据存储与由服务器根据变更历史信息管理的数据，或第二获取方法从服务器获取指示服务器中存在的数据的数据存在信息，以使存储在数据存储器中的数据同步并获得来自服务器的数据。

5. 发明授权

US5196439A Piperidine compounds useful to treat cerebrovascular diseases 失效
标题翻译：可用于治疗脑血管疾病的哌啶化合物
公开(公告)号：US5196439A
公开(公告)日：1993-03-23
申请号：US825423
申请日：1992-01-24
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
IPC分类号： C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04 , C07D401/12
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --O--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat mental symptoms associated with a cerebrovascular disease.
摘要翻译：环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ ，Y为-O-，-CO-或-NH-，Z为苯基，萘基，吡啶基，烷基或环烷基。治疗与脑血管病相关的精神症状是有用的。

6. 发明授权

US4707468A Polypeptide 失效
公开(公告)号：US4707468A
公开(公告)日：1987-11-17
申请号：US796390
申请日：1985-11-08
申请人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
发明人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
IPC分类号： C07K1/14 , A61K38/00 , A61K38/08 , A61P25/04 , C07K7/06 , C07K14/665 , C07K14/675 , C07K7/12
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl or lower alkenyl group, A represents a D-amino acid, Gly or Sar provided that when the D-amino acid is D-Cys, it is bonded with L-Cys or D-Cys in position 5 through a S--S bond to effect intramolecular ring closure, B represents L-Phe or D-Phe in which the benzene ring may be substituted or an .alpha.-N-alkyl derivative thereof, C represents an L-amino acid, D-Cys or an .alpha.-N-alkyl derivative thereof, D and E each represent an L- or D-basic amino acid or an .alpha.-N-alkyl derivative thereof, F represents a group of the formula --OR.sup.3 (in which R.sup.3 is H or a lower alkyl group), a group of the formula: ##STR2## (in which R.sup.4 and R.sup.5 are the same or different and each represents H or a lower alkyl group), a group of the formula: --G--OR.sup.6 (in which G is an L- or D-amino acid or Gly or an .alpha.-N-alkyl derivative thereof and R.sup.6 represents H or a lower alkyl group), a group of the formula: ##STR3## (in which G is as defined above and R.sup.7 and R.sup.8 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--L--Arg--OR.sup.9 or --G--D--Arg--OR.sup.9 (in which G is as defined above and R.sup.9 represents H or a lower alkyl group or a group of the formula: ##STR4## (in which G is as defined above and R.sup.10 and R.sup.11 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--J--OR.sup.12 in which G is defined as above, J is a neutral amono acid group or an acidic amino acid group and R.sup.12 is hydrogen or a lower alkyl group; or a group of the formula: --G--Arg--M--OR.sup.13 in which M is D-amino acid group and R.sup.13 is hydrogen or a lower alkyl group, provided that all of the amino acids constituting the polypeptide of the above formula do not represent at the same time an L-amino acid of the general formula: ##STR5## (in which R represents a group corresponding to a structural formula of an amino acid deprived of a group of the formula: ##STR6## or pharmacologically acceptable salts of them.

7. 发明授权

US4551273A Analgesic peptide and process for the preparation thereof 失效
标题翻译：止痛肽及其制备方法
公开(公告)号：US4551273A
公开(公告)日：1985-11-05
申请号：US575804
申请日：1984-01-31
申请人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
发明人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
IPC分类号： C07K14/655 , A61K38/00 , A61P25/04 , C07C231/02 , C07K7/08 , C07K14/575 , C07K14/665 , C07C103/52
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
摘要： A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.
摘要翻译：具有一级结构的新型肽：N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH2（其中D. Ile和D.Leu分别表示D-Ile和D-Leu残基，氨基酸的其它缩写代表每个L-氨基酸残基，Me表示甲基），其在外周施用时显示出显着的镇痛作用。还公开了通过固相法制备其方法。

8. 发明授权

US4599337A Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient 失效
标题翻译：含有可可碱或茶碱衍生物作为活性成分的消炎/解热/止痛剂
公开(公告)号：US4599337A
公开(公告)日：1986-07-08
申请号：US755404
申请日：1985-07-16
申请人： Takeru Kaneko , Satoru Ozaki , Kimie Takizawa , Hachiro Sugimoto
发明人： Takeru Kaneko , Satoru Ozaki , Kimie Takizawa , Hachiro Sugimoto
IPC分类号： A61K9/00 , A61K35/74 , A61K31/52
CPC分类号： A61K9/2018 , A61K31/522 , A61K9/4858 , A61K9/1623
摘要： Treatment methods are disclosed which utilize antiphlogistic/antipyretic/analgesic agents containing as active ingredient theobromine and theophylline derivatives represented by the general formula: ##STR1## wherein one of A and B is --CH.sub.3 and the other of A and B is ##STR2## wherein R is a hydrogen atom or a lower alkyl group, Z is selected from the group consisting of (1) a group of the formula ##STR3## wherein X.sub.1 and X.sub.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group or a halogen atom; (2) a pyridyl group; or (3) a group of the formula: ##STR4## wherein Y.sub.1 and Y.sub.2 may be the same or different and Y.sub.1 and Y.sub.2 are selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxy group, a trifluoromethyl group and a halogen atom, X is a nitrogen atom or a carbon atom, m is 2 or 3, and n is an integer of from 2 to 10, with the provisos that when (i) A is --CH.sub.3, m is 2, and (ii) when A is ##STR5## Z is not pyridyl and X is nitrogen, and acid addition salts thereof.
摘要翻译：公开了利用含有由以下通式表示的活性成分可可碱和茶碱衍生物的抗炎/解热/止痛剂的治疗方法：其中A和B之一为-CH 3，A和B中的一个为“IMAGE”，其中 R是氢原子或低级烷基，Z选自（1）式（1）的基团，其中X 1和X 2相同或不同，各自表示氢原子，低级烷基，低级烷氧基，三氟甲基或卤素原子; （2）吡啶基; 或（3）下式的基团：其中Y1和Y2可以相同或不同，Y1和Y2选自氢原子，低级烷基，低级烷氧基，三氟甲基基团和卤原子，X为氮原子或碳原子，m为2或3，n为2至10的整数，条件是当（i）A为-CH 3时，m为2，和（ii）当A是Z时，Z不是吡啶基，X是氮，及其酸加成盐。

9. 发明授权

US4493837A Theobromine derivatives 失效
标题翻译：可可碱衍生物
公开(公告)号：US4493837A
公开(公告)日：1985-01-15
申请号：US435518
申请日：1982-10-20
申请人： Hachiro Sugimoto , Sachiyuki Hamano , Tadao Shoji , Takeru Kaneko , Takeshi Uzuo
发明人： Hachiro Sugimoto , Sachiyuki Hamano , Tadao Shoji , Takeru Kaneko , Takeshi Uzuo
IPC分类号： A61K31/52 , A61K31/522 , A61K31/55 , A61P9/08 , A61P25/00 , C07D473/10 , C07D491/10 , C07D519/00
CPC分类号： C07D491/10 , C07D473/10
摘要： There are disclosed theobromine derivatives wherein theobromine is substituted at the 1 position with substituted piperazino, homopiperazino and piperidino groups, and pharmacologically acceptable acid addition salts thereof. The compounds exhibit vasodilating and psychotropic and analgesic activities.
摘要翻译：公开了可可碱衍生物，其中可可碱在1位被取代的哌嗪子基，高哌嗪基和哌啶子基取代，以及其药理学上可接受的酸加成盐。化合物显示出血管扩张和精神活化和止痛活性。

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