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1. 发明授权

US06602687B1 DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby 失效
标题翻译：编码人睫状神经营养因子的DNA及其制备方法
公开(公告)号：US06602687B1
公开(公告)日：2003-08-05
申请号：US07883630
申请日：1992-05-08
申请人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
发明人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
IPC分类号： C12N1516
CPC分类号： C07K16/22 , A61K38/1825 , A61K38/185 , C07K14/475 , A61K38/18 , A61K31/715 , A61K2300/00
摘要： The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treatment of a variety of neurological diseases and disorders, including Alzheimer's disease. In a specific embodiment of the invention, CNTF may be used to support the growth of spinal cord neurons, thereby providing a method of treating spinal cord damage caused by trauma infarction, infection, nutritional deficiency or toxic agents. The present invention also relates to a novel method for producing substantilly pure CNTF. The invention also relates to pharmaceutical compositions comprising effective amounts of CNTF gene products which may be used in the diagnosis and treatment of a variety of neurologial diseases and disorders. The present invention relates to the cloning sequencing and expression of CNTF and provides, for the first time, a means for producing human CNTF utilizing human CNTF-encoding nucleic acid sequences. Furthermore, the CNTF nucleic acid sequences of the invention may be utilized to identify nucleic acid sequences encoding CNTF or CNTF-homologous molecules in a variety of species and tissues.
摘要翻译：本发明涉及编码睫状神经营养因子（CNTF）的核酸序列以及由其产生的蛋白质，肽和衍生物。在本发明的各种实施方案中，本发明的核酸序列，蛋白质和肽可用于治疗各种神经疾病和病症，包括阿尔茨海默氏病。在本发明的一个具体实施方案中，CNTF可用于支持脊髓神经元的生长，从而提供治疗由创伤性梗塞，感染，营养缺乏或毒性剂引起的脊髓损伤的方法。本发明还涉及本发明还涉及包含有效量的可用于诊断和治疗多种神经系统疾病和病症的CNTF基因产物的药物组合物。本发明涉及克隆测序和表达的CNTF，并且首次提供了利用人CNTF编码核酸序列生产人CNTF的方法。此外，本发明的CNTF核酸序列可用于鉴定在各种物种和组织中编码CNTF或CNTF同源分子的核酸序列。

2. 发明授权

US08513300B2 Formulations for oral administration of cromolyn sodium 失效
标题翻译：口服色甘酸钠的配方
公开(公告)号：US08513300B2
公开(公告)日：2013-08-20
申请号：US12103821
申请日：2008-04-16
申请人： Richat Abbas , Ehud Arbit , Michael Goldberg , Vivien Wong , Donald J. Sarubbi
发明人： Richat Abbas , Ehud Arbit , Michael Goldberg , Vivien Wong , Donald J. Sarubbi
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： A61K31/352 , A61K9/4858 , A61K47/183
摘要： An oral dosage form comprises cromolyn sodium (sodium or disodium cromoglycate), and an acylated amino acid delivery agent.
摘要翻译：口服剂型包括色甘酸钠（色甘酸钠或二钠）和酰化氨基酸递送剂。

3. 发明申请

US20080194676A1 FORMULATIONS FOR ORAL ADMINISTRATION OF CROMOLYN SODIUM 失效
标题翻译： CROMOLYN SODIUM的口服药物制剂
公开(公告)号：US20080194676A1
公开(公告)日：2008-08-14
申请号：US12103821
申请日：2008-04-16
申请人： Richat Abbas , Ehud Arbit , Michael Goldberg , Vivien Wong , Donald J. Sarubbi
发明人： Richat Abbas , Ehud Arbit , Michael Goldberg , Vivien Wong , Donald J. Sarubbi
IPC分类号： A61K31/352 , A61P29/00 , A61P37/08
CPC分类号： A61K31/352 , A61K9/4858 , A61K47/183
摘要： An oral dosage form comprises cromolyn sodium (sodium or disodium cromoglycate), and an acylated amino acid delivery agent.
摘要翻译：口服剂型包括色甘酸钠（色甘酸钠或二钠）和酰化氨基酸递送剂。

4. 发明授权

US07429564B2 Oral insulin therapy 有权
标题翻译：口服胰岛素治疗
公开(公告)号：US07429564B2
公开(公告)日：2008-09-30
申请号：US10500822
申请日：2003-01-07
申请人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Cooper Woods , Steven Dinh , Vivien Wong
发明人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Cooper Woods , Steven Dinh , Vivien Wong
IPC分类号： A61K38/28
CPC分类号： A61K47/18 , A61K9/2013 , A61K9/4858 , A61K38/28 , A61K2300/00
摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.
摘要翻译：用于口服给予患者用于治疗糖尿病的药物剂型，其包含胰岛素和促进胰岛素以治疗有效量转运至血液并导致与重复施用胰岛素相关的血管疾病的较低发生率的递送剂被披露。还公开了一种减轻与慢性给药胰岛素相关的疾病的不期望的发病率的方法，其中通过口服给予胰岛素患者以及促进从患者的胃肠道吸收胰岛素的合适的递送剂治疗有效量，用于治疗糖尿病。

5. 发明授权

US07279907B2 Method of testing for power and ground continuity of a semiconductor device 有权
公开(公告)号：US07279907B2
公开(公告)日：2007-10-09
申请号：US11364792
申请日：2006-02-28
申请人： Wai Khuin Phoon , Vivien Wong , Wah Yew Tan
发明人： Wai Khuin Phoon , Vivien Wong , Wah Yew Tan
IPC分类号： G01R27/28
CPC分类号： G01R31/024
摘要： A method of testing for power and ground continuity of a semiconductor device having Input and Output (IO) pins and at least a pair of power and ground pins includes identifying the power and ground pins of the device. A victim pin is selected from the IO pins of the device for each pair of the power and ground pins, and an aggressor pin for each victim pin is selected from the remaining IO pins. The aggressor pins are toggled between a high state and a low state. A level of switching noise on each victim pin is measured, and the measured levels of switching noise are compared with predetermined data to determine power and ground continuity of the device.

6. 发明申请

US20060234913A1 Oral insulin therapy 有权
标题翻译：口服胰岛素治疗
公开(公告)号：US20060234913A1
公开(公告)日：2006-10-19
申请号：US10500822
申请日：2003-01-07
申请人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Woods , Steven Dinh , Vivien Wong
发明人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Woods , Steven Dinh , Vivien Wong
IPC分类号： A61K38/28 , A61K31/195
CPC分类号： A61K47/18 , A61K9/2013 , A61K9/4858 , A61K38/28 , A61K2300/00
摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.
摘要翻译：用于口服给予患者用于治疗糖尿病的药物剂型，其包含胰岛素和促进胰岛素以治疗有效量转运至血液并导致与重复施用胰岛素相关的血管疾病的较低发生率的递送剂被披露。还公开了一种减轻与慢性给药胰岛素相关的疾病的不期望的发病率的方法，其中通过口服给予胰岛素患者以及促进从患者的胃肠道吸收胰岛素的合适的递送剂治疗有效量，用于治疗糖尿病。

7. 发明申请

US20050218899A1 Load board with embedded relay tracker 有权
公开(公告)号：US20050218899A1
公开(公告)日：2005-10-06
申请号：US10805954
申请日：2004-03-22
申请人： Vivien Wong , Wai Phoon
发明人： Vivien Wong , Wai Phoon
IPC分类号： G01R31/02 , G01R31/327
CPC分类号： G01R31/3278
摘要： A load board includes an embedded relay tracker circuit that counts and stores relay clicks to measure relay usage. Having accurate relay usage data reduces maintenance costs. The relay tracker circuit includes a controller with a counter for counting relay clicks of the load board relays and wires or conductive traces connecting the controller to the relays. Each time a relay switches, a signal is transmitted from the relay to the controller and the controller increments the counter. The count information then is stored in a memory connected to the counter.

8. 发明申请

US20080269185A1 Methods Of Treating Oral Mucositis 有权
标题翻译：治疗口腔粘膜炎的方法
公开(公告)号：US20080269185A1
公开(公告)日：2008-10-30
申请号：US11871848
申请日：2007-10-12
申请人： David M. Rothstein , Chris Murphy , Vivien Wong , Glenn Kazo
发明人： David M. Rothstein , Chris Murphy , Vivien Wong , Glenn Kazo
IPC分类号： A61K31/555 , A61P29/00 , A61P35/00
CPC分类号： A61K31/555
摘要： Methods and kits for treating oral mucositis are disclosed. The treatment comprises administering to a patient in need thereof a Reactive Oxygen Species scavenger in a pharmaceutically acceptable formulation.
摘要翻译：公开了用于治疗口腔粘膜炎的方法和试剂盒。治疗包括向有需要的患者施用药学上可接受的制剂中的活性氧清除剂。

9. 发明申请

US20070200586A1 Method of testing for power and ground continuity of a semiconductor device 有权
标题翻译：测试半导体器件的功率和接地连续性的方法
公开(公告)号：US20070200586A1
公开(公告)日：2007-08-30
申请号：US11364792
申请日：2006-02-28
申请人： Wai Phoon , Vivien Wong , Wah Tan
发明人： Wai Phoon , Vivien Wong , Wah Tan
IPC分类号： G01R31/26
CPC分类号： G01R31/024
摘要： A method of testing for power and ground continuity of a semiconductor device having Input and Output (IO) pins and at least a pair of power and ground pins includes identifying the power and ground pins of the device. A victim pin is selected from the IO pins of the device for each pair of the power and ground pins, and an aggressor pin for each victim pin is selected from the remaining IO pins. The aggressor pins are toggled between a high state and a low state. A level of switching noise on each victim pin is measured, and the measured levels of switching noise are compared with predetermined data to determine power and ground continuity of the device.
摘要翻译：一种测试具有输入和输出（IO）引脚和至少一对电源和接地引脚的半导体器件的功率和接地连续性的方法，包括识别器件的电源和接地引脚。从每个电源和接地引脚的器件的IO引脚中选择受害器引脚，并从其余的IO引脚中选择每个受害引脚的引脚。侵略者引脚在高状态和低状态之间切换。测量每个受害者引脚上的开关噪声水平，并将测量的开关噪声电平与预定数据进行比较，以确定器件的功率和接地连续性。

10. 发明授权

US09855279B2 Methods of treating oral mucositis 有权
公开(公告)号：US09855279B2
公开(公告)日：2018-01-02
申请号：US11871848
申请日：2007-10-12
申请人： David M. Rothstein , Chris Murphy , Vivien Wong , Glenn Kazo
发明人： David M. Rothstein , Chris Murphy , Vivien Wong , Glenn Kazo
IPC分类号： A61K31/555
CPC分类号： A61K31/555
摘要： Methods and kits for treating oral mucositis are disclosed. The treatment comprises administering to a patient in need thereof a Reactive Oxygen Species scavenger in a pharmaceutically acceptable formulation.

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