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    • 3. 发明申请
    • PHARMACEUTICAL COMPOSITION USED IN PROPHYLAXIS OR TREATMENT OF HYPERPROLIFERATIVE SKIN CONDITIONS AND MALIGNANT MELANOMAS COMPRISING PACHASTRISSAMINE AS ACTIVE INGREDIENT
    • 用于预防或治疗包含PACHASTRISSAMINE作为主动成分的高增殖性皮肤病症和恶性肿瘤的药物组合物
    • US20120071424A1
    • 2012-03-22
    • US13236080
    • 2011-09-19
    • Dong Heon ShinTae Yoon Kim
    • Dong Heon ShinTae Yoon Kim
    • A61K31/7008A61P35/00A61P17/00A61P17/12A61P17/10A61P17/08C07H5/06A61P17/06
    • A61K31/341
    • Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle. Accordingly, the disclosed composition, a use, and the method can be used for preventing or treating various hyper-proliferative skin diseases such as skin cancer or psoriasis.
    • 披露了植物鞘氨醇的新用途。 更具体地,公开了一种用于预防或治疗高增殖性皮肤疾病的组合物,其包括作为活性成分的蓬曲沙胺,用于制备高增殖性皮肤疾病的预防/治疗剂的波多沙胺或其药学上可接受的盐的方法, 用于治疗对有需要的受试者施用有效量的多沙普坦或其药学上可接受的盐的增殖性皮肤病。 帕沙星可抑制FoxO3a蛋白的降解,增加FoxO3a蛋白的表达。 因此,本发明的药物组合物通过诱导高增殖细胞的细胞凋亡和抑制细胞周期来防止治疗对增殖性疾病的作用。 因此,所公开的组合物,用途和方法可用于预防或治疗各种高增殖性皮肤疾病如皮肤癌或牛皮癣。
    • 4. 发明申请
    • APPARATUS AND METHOD FOR DETECTING MOTION CHARACTERISTICS OF PARTICLES IN FLOW CHANNEL
    • 用于检测流通道中颗粒的运动特性的装置和方法
    • US20100025246A1
    • 2010-02-04
    • US12374092
    • 2007-07-16
    • Young-Ho ChoTae Yoon KimDong Woo Lee
    • Young-Ho ChoTae Yoon KimDong Woo Lee
    • G01N27/26
    • G01N15/1031G01N2015/1075
    • Disclosed herein is an apparatus and method for detecting the motion characteristics of particles in a flow channel. The apparatus of the present invention includes first and second electrode groups, each comprising a pair of electrodes, which are arranged to be spaced apart from each other in a flow channel, the pair of electrodes functioning as both a drive electrode and a sensing electrode for directly applying voltage and measuring impedance between the electrodes. An operation control unit measures variation in electrical pulses generated in the first and second electrode groups, thus detecting motion characteristics of the particles. The present invention is advantageous in that it does not require complicated optical measuring instruments or analyzing instruments, and in that it can be used to easily detect the motion characteristics of particles in a flow channel merely by analyzing variation in electrical pulses without requiring preliminary information.
    • 本文公开了一种用于检测流动通道中的颗粒的运动特性的装置和方法。 本发明的装置包括第一和第二电极组,每个包括一对电极,它们被布置为在流动通道中彼此间隔开,该对电极用作驱动电极和用于 直接施加电压和测量电极之间的阻抗。 操作控制单元测量在第一和第二电极组中产生的电脉冲的变化,从而检测颗粒的运动特性。 本发明的优点在于它不需要复杂的光学测量仪器或分析仪器,并且其仅仅通过分析电脉冲的变化而不需要初步信息就可以用于容易地检测流动通道中的颗粒的运动特性。
    • 5. 发明授权
    • Infrared sensor and method for compensating temperature thereof
    • 红外传感器及其温度补偿方法
    • US6043493A
    • 2000-03-28
    • US10513
    • 1998-01-21
    • In Sik KimTae Yoon KimYoung Cho ShimJun Bae Lee
    • In Sik KimTae Yoon KimYoung Cho ShimJun Bae Lee
    • G01J5/00G01J5/06G01J5/08G01J5/10G01J5/16
    • G01J5/16G01J5/06G01J5/08G01J5/0815G01J5/0846G01J5/0862G01J5/0893G01J2005/068G01J5/026
    • Infrared sensor that can make a temperature compensation by itself, and method for compensating a temperature thereof, are disclosed. The infrared sensor preferably includes a substrate, a diaphragm formed on the substrate, and a first thermopile sensor formed on a region of the diaphragm for sensing an infrared radiation emitted from a measured object and infrared radiations emitted from regions other than the measured object. A second thermopile sensor is formed on a region of the diaphragm and connected to the first thermopile sensor for sensing the infrared radiations emitted from the regions other than the measured object. A housing protects a front face of the substrate including the first, and second thermopile sensors includes an infrared filter in the housing over the first and second thermopile sensors for transmission of infrared radiations, and a reflector reflects the infrared radiation emitted from the measured object toward the first thermopile sensor. The method for temperature compensation can include the steps of letting an infrared radiation from a measured object be directed to the first thermopile sensor and letting infrared radiations from regions other than the measured object be directed to the first and second thermopile sensors, respectively, sensing the infrared radiations in the first and second thermopile sensors directed thereto, and making a temperature compensation for the infrared radiations from regions other than the measured object using the first and second thermopile sensors to provide a temperature component of the measured object only.
    • 公开了能够自行进行温度补偿的红外线传感器及其温度补偿方法。 红外线传感器优选地包括基板,形成在基板上的光阑和形成在光阑的区域上的第一热电堆传感器,用于感测从测量对象发射的红外辐射和从测量对象以外的区域发射的红外辐射。 第二热电堆传感器形成在隔膜的一个区域上并连接到第一热电堆传感器,用于感测从测量对象以外的区域发射的红外辐射。 壳体保护基板的前表面,包括第一和第二热电堆传感器在壳体中包括在第一和第二热电堆传感器上的红外滤光器,用于传输红外辐射,并且反射器将从测量对象发射的红外辐射反射到 第一个热电堆传感器。 用于温度补偿的方法可以包括以下步骤:将来自测量对象的红外辐射引导到第一热电堆传感器并且使来自被测物体以外的区域的红外辐射分别被引导到第一和第二热电堆传感器,感测 第一和第二热电堆传感器中的红外辐射被引导到其上,并且使用第一和第二热电堆传感器对来自除被测物体之外的区域的红外辐射进行温度补偿,以仅提供被测物体的温度分量。
    • 7. 发明申请
    • NOVEL USE OF EC-SOD AND METHOD FOR PREPARING THEREOF
    • EC-SOD的新用途及其制备方法
    • US20120093796A1
    • 2012-04-19
    • US12532539
    • 2008-03-24
    • Dong Heon ShinTae Yoon Kim
    • Dong Heon ShinTae Yoon Kim
    • A61K38/44A61P3/10A61P29/00A61P27/06A61P9/10A61P27/02A61P27/14A61P17/10A61P37/08A61P17/06A61P11/06C12N9/02C12N15/63A61K48/00A61P11/02A61P17/00A61P35/00
    • A61K38/446A61K38/00C12N9/0089C12Y115/01001
    • The present invention relates to compositions for preventing or treating angiogenesis-mediated diseases or allergic diseases which contain, as an active ingredient, an EC-SOD protein or a vector having a polynucleotide encoding thereof. The EC-SOD protein or the vector having a polynucleotide encoding the EC-SOD protein has the effect on inhibiting angiogenesis by inhibiting the expression of VEGF and MMP-9 which induce angiogenesis. Therefore, the EC-SOD protein or the vector may be useful for preventing or treating angiogenesis-mediated diseases. And the EC-SOD protein or the vector having a polynucleotide encoding said EC-SOD protein also has the effect on inhibiting over-differentiation of Th2 cells which cause allergic diseases, inhibiting transcription factor (NF-κ B), and reducing degranulation of human mast cells. Accordingly, the EC-SOD protein or the vector may be useful for preventing or treating allergy diseases. In addition, the inventive method for preparing an EC-SOD protein may be used in preparing an EC-SOD protein having the activity on a large scale. Therefore, the inventive method may be useful industrially.
    • 本发明涉及用于预防或治疗血管生成介导的疾病或过敏性疾病的组合物,其含有作为活性成分的EC-SOD蛋白或其编码多核苷酸的载体。 EC-SOD蛋白或具有编码EC-SOD蛋白的多核苷酸的载体通过抑制诱导血管发生的VEGF和MMP-9的表达,具有抑制血管发生的作用。 因此,EC-SOD蛋白或载体可用于预防或治疗血管生成介导的疾病。 并且具有编码所述EC-SOD蛋白质的多核苷酸的EC-SOD蛋白或载体也具有抑制Th2细胞过度分化的作用,所述Th2细胞引起过敏性疾病,抑制转录因子(NF-κB)和减少脱颗粒 人体肥大细胞。 因此,EC-SOD蛋白或载体可用于预防或治疗过敏性疾病。 此外,本发明的制备EC-SOD蛋白的方法可用于制备具有大规模活性的EC-SOD蛋白。 因此,本发明的方法在工业上可能是有用的。
    • 9. 发明授权
    • Automatic cooking controlling apparatus and method employing a narrow
viewing angle of an infrared absorptive thermopile sensor
    • 采用红外吸收式热电堆传感器的窄视角的自动烹调控制装置和方法
    • US5702626A
    • 1997-12-30
    • US567847
    • 1995-12-06
    • Tae Yoon Kim
    • Tae Yoon Kim
    • H05B6/68
    • H05B6/6411H05B6/6455
    • In an automatic cooking controlling apparatus and method for a cooker, the apparatus includes a turntable installed within a chamber of the cooker for placing a to-be-cooked object thereon, an infrared filter for filtering only the infrared wavelength bands reflected from the to-be-cooked object, an infrared adjusting lens means for adjusting the wavelength filtered by the infrared filter, a magnetron for heating the to-be-cooked object, a driving motor for rotating the turntable, a thermopile sensor for detecting an infrared signal generated from the to-be-cooked object, a signal processor for processing the signal detected from the infrared sensor, and a controller for controlling the oscillation mode of the magnetron. In the controlling method, a defrost mode control is performed such that periodicity of output signals input from the sensor according to a constant period is checked to determine the size of the to-be-cooked object, the periodic signals are analyzed based on the presence of the periodicity, and then a cooking reference value suitable for the defrost mode is taken, thereby controlling the oscillation of the magnetron. A general cooking mode control is performed such that periodicity of detection signals input from the sensor according to a constant period is checked to determine the size of the to-be-cooked object, the periodic signals are analyzed based on the presence of the periodicity, and then a cooking reference value suitable for the general cooking mode is taken, thereby controlling the oscillation of the magnetron.
    • 在一种用于炊具的自动烹饪控制装置和方法中,该装置包括安装在炊具的腔室内的转盘,用于将被烹饪物体放置在其上,红外线滤光器仅用于过滤从炊具中反射的红外波长带, 红外调节透镜装置,用于调节由红外滤光器滤波的波长,用于加热被烹饪物体的磁控管,用于旋转转台的驱动电机,用于检测从 被烹饪物体,用于处理从红外传感器检测的信号的信号处理器,以及用于控制磁控管的振荡模式的控制器。 在控制方法中,执行除霜模式控制,使得检测从传感器输入的输出信号的周期性,以确定待烹饪对象的大小,根据存在的情况分析周期信号 的周期性,然后采用适合于除霜模式的烹饪参考值,从而控制磁控管的振荡。 执行通用烹调模式控制,使得检测从传感器输入的恒定周期的检测信号的周期性来确定被烹饪对象的大小,根据周期性的存在来分析周期信号, 然后拍摄适合于一般烹饪模式的烹调参考值,从而控制磁控管的振荡。
    • 10. 发明授权
    • Pharmaceutical composition used in treatment of hyperproliferative skin conditions and malignant melanomas comprising pachastrissamine as active ingredient
    • 用于治疗过度增生性皮肤病和用恶性黑素瘤治疗的药物组合物,其包括蓬曲沙胺作为活性成分
    • US08609718B2
    • 2013-12-17
    • US13236080
    • 2011-09-19
    • Dong Heon ShinTae Yoon Kim
    • Dong Heon ShinTae Yoon Kim
    • A61K31/34
    • A61K31/341
    • Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle. Accordingly, the disclosed composition, a use, and the method can be used for preventing or treating various hyper-proliferative skin diseases such as skin cancer or psoriasis.
    • 披露了植物鞘氨醇的新用途。 更具体地,公开了一种用于预防或治疗高增殖性皮肤疾病的组合物,其包括作为活性成分的蓬曲沙胺,用于制备高增殖性皮肤疾病的预防/治疗剂的波多沙胺或其药学上可接受的盐的方法, 用于治疗对有需要的受试者施用有效量的多沙普坦或其药学上可接受的盐的增殖性皮肤病。 帕沙星可抑制FoxO3a蛋白的降解,增加FoxO3a蛋白的表达。 因此,本发明的药物组合物通过诱导高增殖细胞的细胞凋亡和抑制细胞周期来防止治疗对增殖性疾病的作用。 因此,所公开的组合物,用途和方法可用于预防或治疗各种高增殖性皮肤疾病如皮肤癌或牛皮癣。