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    • 8. 发明授权
    • System for real time, non-invasive metrology of microfluidic chips
    • 微流控芯片的实时,非侵入式计量系统
    • US06868347B2
    • 2005-03-15
    • US10393109
    • 2003-03-19
    • Guann-Pyng LiMark BachmanZhongping Chen
    • Guann-Pyng LiMark BachmanZhongping Chen
    • G01B9/02G01N11/00
    • G06F19/00G01B9/0201G01B9/02027G01B9/02045G01B9/02072G01B9/02091G01B2290/35G01B2290/45G01B2290/70
    • A system integration of multicomponent technologies includes an automated microfluidic probe station and the use of that station for the systematic study of nonideal, nonhomogeneous biological fluids such as blood in microfluidic chips. The probe station provides for real-time, non-invasive metrology of microfluidic chips employing optical coherence tomography and optical Doppler tomography to allow for collection of flow data at any location or depth within a microfluidics chip. Also included is a programmable fluidic loader and actuator platform as part of the probe station, and a semi-automated rapid prototyping tool used to fabricate the microfluidic chips measured on the probe station. The resulting data library produced by measurements on the probe station contains all the necessary information needed to develop mature, accurate microfluidic modeling and simulation CAD tools.
    • 多组分技术的系统集成包括自动化微流体探针站和该站的用途,用于系统研究非流体,非均质生物流体,如微流控芯片中的血液。 探针台提供使用光学相干断层扫描和光学多普勒层析成像的微流控芯片的实时非侵入式计量,以允许在微流体芯片内的任何位置或深度收集流量数据。 还包括作为探测台的一部分的可编程流体装载器和致动器平台,以及用于制造在探针台上测量的微流体芯片的半自动化快速成型工具。 通过探针台上的测量产生的结果数据库包含开发成熟,精确的微流体建模和仿真CAD工具所需的全部必要信息。