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1. 发明申请

US20110282166A1 System and Method for Efficient Coherence Anti-Stokes Raman Scattering Endoscopic and Intravascular Imaging and Multimodal Imaging 有权
标题翻译：高效相干反斯托克斯拉曼散射内镜和血管内成像和多模态成像的系统和方法
公开(公告)号：US20110282166A1
公开(公告)日：2011-11-17
申请号：US12969295
申请日：2010-12-15
申请人： Zhongping Chen , Gangjun Liu , Mihael Balu , Bruce Tromberg , Eric Olaf Potma
发明人： Zhongping Chen , Gangjun Liu , Mihael Balu , Bruce Tromberg , Eric Olaf Potma
IPC分类号： A61B5/1455 , A61B6/00 , G01J3/44
CPC分类号： G01J3/44 , A61B1/00165 , A61B1/043 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/441 , G01J3/02 , G01J3/0218 , G01J3/0297 , G01N21/65 , G01N2021/653 , G01N2201/08 , G01N2201/0866
摘要： A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.
摘要翻译：适用于厚组织CARS成像的纤维输送探针是实用的。所公开的设计基于两个进展。首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。该方案可生成高品质的CARS图像，无需检测器孔径效果。该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。

2. 发明授权

US5287168A Sensor for monitoring solute in a liquid stream 失效
标题翻译：用于在液体流中监测溶质的传感器
公开(公告)号：US5287168A
公开(公告)日：1994-02-15
申请号：US72668
申请日：1993-06-07
申请人： David Poucher , Chilengi Madhusudhan , Joaquin M. Otero
发明人： David Poucher , Chilengi Madhusudhan , Joaquin M. Otero
IPC分类号： G01N21/27 , G01N21/59 , G01N21/85 , G01N21/53 , G01N21/09
CPC分类号： G01N21/8507 , G01N2201/086 , G01N2201/0866
摘要： The sensor system monitors solutes in a liquid stream by analyzing the amount of light absorbed in a liquid in a particular wavelength band. The sensor system is arranged for selectability of the type of fiber used for transmission and adjustability of the liquid gap length in the liquid so that individual installations can be arranged with optimum characteristics for sensing particular chemical species in solution by absorption spectroscopy.
摘要翻译：传感器系统通过分析在特定波长带中的液体中吸收的光量来监测液体流中的溶质。传感器系统被布置用于可选择性的用于传输的纤维类型和液体间隙长度在液体中的可调节性，使得各个装置可以布置成具有用于通过吸收光谱检测溶液中的特定化学物质的最佳特性。

3. 发明授权

US08582096B2 System and method for efficient coherence anti-stokes raman scattering endoscopic and intravascular imaging and multimodal imaging 有权
标题翻译：系统和方法用于有效的一致性反kes散射内镜和血管内成像和多模态成像
公开(公告)号：US08582096B2
公开(公告)日：2013-11-12
申请号：US12969295
申请日：2010-12-15
申请人： Zhongping Chen , Gangjun Liu , Mihael Balu , Bruce Tromberg , Eric Olaf Potma
发明人： Zhongping Chen , Gangjun Liu , Mihael Balu , Bruce Tromberg , Eric Olaf Potma
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , A61B1/00165 , A61B1/043 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/441 , G01J3/02 , G01J3/0218 , G01J3/0297 , G01N21/65 , G01N2021/653 , G01N2201/08 , G01N2201/0866
摘要： A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.
摘要翻译：适用于厚组织CARS成像的纤维输送探针是实用的。所公开的设计基于两个进展。首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。该方案可生成高品质的CARS图像，无需检测器孔径效果。该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。

4. 发明申请

US20120242992A1 GRADIENT INDEX (GRIN)-BASED ABSORPTION SPECTROSCOPY APPARATUS, METHOD, AND APPLICATIONS 有权
标题翻译：梯度指数（GRIN） - 吸收光谱仪器，方法和应用
公开(公告)号：US20120242992A1
公开(公告)日：2012-09-27
申请号：US13425670
申请日：2012-03-21
申请人： Alfons Schulte , Silki Arora
发明人： Alfons Schulte , Silki Arora
IPC分类号： G01N21/59
CPC分类号： G01N21/31 , G01N2201/08 , G01N2201/0866
摘要： Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a GRIN-based detection path in place of a typical confocal microscope. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, cytology, and other areas.
摘要翻译：用微米尺度测量空间分辨率的光吸收光谱的装置和方法。示例性设置将透射几何中的连续白光激发光束与基于GRIN的检测路径代替典型的共焦显微镜组合。该装置和方法能够研究微量级小样品的光密度的空间变化以及单细胞水平的生物装配的研究，从而在光学诊断，微流体学，细胞学和其他领域的应用。

5. 发明申请

US20160357008A1 FIBER-OPTIC METHODS AND DEVICES ENABLING MULTIPHOTON IMAGING WITH IMPROVED SIGNAL-TO-NOISE RATIO 有权
标题翻译：光纤方法和设备实现具有改进的信号噪声比的多光子成像
公开(公告)号：US20160357008A1
公开(公告)日：2016-12-08
申请号：US15169917
申请日：2016-06-01
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： Xingde Li , Yicong Wu , Wenxuan Liang
IPC分类号： G02B23/26 , G02B21/16 , G02B21/00 , A61B1/07 , G01N33/483 , A61B1/00 , A61B1/04 , A61B1/06 , G02B23/24 , G01N21/64
CPC分类号： G02B23/26 , A61B1/0017 , A61B5/0068 , A61B5/0084 , G01N21/636 , G01N21/6458 , G01N33/4833 , G01N2021/6478 , G01N2021/6484 , G01N2201/0866 , G01N2201/10 , G02B3/0087 , G02B21/0008 , G02B23/243 , G02B23/2469 , G02B26/103
摘要： The present invention is directed to a fiber optic device that enables multiphoton imaging with improved signal-to-noise ratio having a single piece of double-clad fiber (DCF). The device also includes all components for focusing, scanning and signal collection within an endomicroscope probe of 2.1 mm outer diameter (OD). The unprecedented imaging capability of this miniature endomicroscope is demonstrated herein via both ex vivo and in vivo experiments.
摘要翻译：本发明涉及一种光纤装置，其能够实现具有单片双包层光纤（DCF）的具有改善的信噪比的多光子成像。该器件还包括用于在2.1 mm外径（OD）的内窥镜探头内聚焦，扫描和信号采集的所有组件。本文通过离体和体内实验证明了该微型内窥镜的前所未有的成像能力。

6. 发明申请

US20150087902A1 Phase Contrast Microscopy With Oblique Back-Illumination 审中-公开
标题翻译：相对对比度显微镜与斜背照明
公开(公告)号：US20150087902A1
公开(公告)日：2015-03-26
申请号：US14388847
申请日：2013-03-15
申请人： Trustees of Boston University
发明人： Jerome Charles Mertz , Timothy Nehiley Ford , Kengyeh Ken Chu
IPC分类号： G06T5/00 , G02B21/00 , A61B1/00 , G01N21/25 , A61B1/04 , G02B21/06 , G01N21/27
CPC分类号： G06T5/009 , A61B1/00009 , A61B1/00172 , A61B1/04 , G01N21/255 , G01N21/27 , G01N21/4795 , G01N2021/4797 , G01N2201/062 , G01N2201/0866 , G02B21/0012 , G02B21/06 , G02B21/14 , G06T2207/10068 , G06T2207/20208 , G06T2207/20221
摘要： A method of creating a phase contrast image is provided. In some embodiments the method comprises illuminating the target region of a sample with a first light source to provide a first oblique back illumination of the target region of the sample, and detecting a first phase contrast image from light originating from the first light source and back illuminating the target region of the sample. In some embodiments the method further comprises illuminating the sample with a second light source to provide a second oblique back illumination of the target region of the sample, and detecting a second phase contrast image from light originating from the second light source and back illuminating the target region of the sample. In some embodiments a difference image of the target region of the sample is created by subtracting the second phase contrast image of the target region of the sample from the first phase contrast image of the target region of the sample. Apparatus for carrying out the methods are also provided. The methods and apparatus find use, for example, in endoscopy.
摘要翻译：提供了创建相位对比图像的方法。在一些实施例中，该方法包括用第一光源照射样品的目标区域，以提供样品的目标区域的第一倾斜背照射，以及从源自第一光源和背部的光检测第一相位对比图像照亮样品的目标区域。在一些实施例中，该方法还包括用第二光源照亮样品以提供样品的目标区域的第二倾斜背照射，以及从源自第二光源的光检测第二相位对比图像，并且反射照射目标样品区域。在一些实施例中，通过从样本的目标区域的第一相位对比图像中减去样本的目标区域的第二相位对比图像来创建样本的目标区域的差异图像。还提供了用于执行方法的装置。该方法和装置可用于例如内窥镜检查。

7. 发明授权

US09557154B2 Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions 有权
标题翻译：用于提供结构和组合物的光学成像的系统，装置，方法，装置和计算机可访问介质
公开(公告)号：US09557154B2
公开(公告)日：2017-01-31
申请号：US13114845
申请日：2011-05-24
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
IPC分类号： A61B5/00 , G01B9/02 , G01N21/47 , G01N21/64 , G01N21/65
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译：描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。例如，一种布置可以向解剖结构提供至少一个电磁辐射。这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

8. 发明授权

US09110009B2 Gradient index (GRIN)-based absorption spectroscopy apparatus, method, and applications 有权
标题翻译：基于梯度指数（GRIN）的吸收光谱仪，方法和应用
公开(公告)号：US09110009B2
公开(公告)日：2015-08-18
申请号：US13425670
申请日：2012-03-21
申请人： Alfons Schulte , Silki Arora
发明人： Alfons Schulte , Silki Arora
IPC分类号： G01N21/31
CPC分类号： G01N21/31 , G01N2201/08 , G01N2201/0866
摘要： Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a GRIN-based detection path in place of a typical confocal microscope. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, cytology, and other areas.
摘要翻译：用微米尺度测量空间分辨率的光吸收光谱的装置和方法。示例性设置将透射几何中的连续白光激发光束与基于GRIN的检测路径代替典型的共焦显微镜组合。该装置和方法能够研究微量级小样品的光密度的空间变化以及单细胞水平的生物装配的研究，从而在光学诊断，微流体学，细胞学和其他领域的应用。

9. 发明授权

US06740865B1 Imaging system for luminescence assays 失效
标题翻译：用于发光测定的成像系统
公开(公告)号：US06740865B1
公开(公告)日：2004-05-25
申请号：US09743132
申请日：2001-01-03
申请人： John Gordon Rushbrook , Claire Elizabeth Hooper
发明人： John Gordon Rushbrook , Claire Elizabeth Hooper
IPC分类号： G01I300
CPC分类号： G01N21/6452 , G01N21/76 , G01N2021/6421 , G01N2021/6484 , G01N2201/0826 , G01N2201/0833 , G01N2201/0866
摘要： Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fiber bundle. The cross-sectional area of the optical fiber bundle corresponds to the area of the sample, the end of which is located close to the sample for detecting any light emitted therefrom, and selected fibers (30) of those making up the bundle are separated from the remainder and extend to a source of excitation radiation (76) and serve to convey excitation radiation (if required) directly to a corresponding plurality of points distributed over the are of the end face of the bundle and therefore over the area of the sample. The remaining fibers (32, 38) of the bundle serve to collect emitted light (whether generated by fluorescence caused by excitation or otherwise) and provide a light path to the change coupled device camera, wherein the ends of the excitation fibers and the ends of the emitted light collecting fibers area distributed uniformly over the area of the fiber bundle presented to the reaction site.
摘要翻译：提供了用于检测由测定样品发射的光的装置，其中由样品发射的光被收集以通过光纤束传输到电荷耦合器件照相机（74）。光纤束的横截面积对应于样品的面积，其端部靠近样品，用于检测从其发出的任何光，并且构成束的那些选定的纤维（30）从剩余部分并延伸到激发辐射源（76）并且用于将激发辐射（如果需要）直接传递到分布在束的端面上并因此在样品的区域上的对应的多个点。束的剩余纤维（32,38）用于收集发射的光（无论是由通过激发还是其他方式产生的荧光产生），并且向变换耦合器件照相机提供光路，其中激发光纤的端部和发射的光收集纤维区域均匀分布在纤维束的呈现给反应部位的区域上。

10. 发明申请

WO00005569A1 IMAGING SYSTEM FOR LUMINESCENCE ASSAYS 审中-公开
标题翻译：成像系统用于发光测定
公开(公告)号：WO00005569A1
公开(公告)日：2000-02-03
申请号：PCT/GB1999/002348
申请日：1999-07-20
IPC分类号： G01N21/64 , G01N21/76
CPC分类号： G01N21/6452 , G01N21/76 , G01N2021/6421 , G01N2021/6484 , G01N2201/0826 , G01N2201/0833 , G01N2201/0866
摘要： Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fibre bundle. The cross-sectional area of the optical fibre bundle corresponds to the area of the sample, the end of which is located close to the sample for detecting any light emitted therefrom, and selected fibres (30) of those making up the bundle are separated from the remainder and extend to a source of excitation radiation (76) and serve to convey excitation radiation (if required) directly to a corresponding plurality of points distributed over the area of the end face of the bundle and therefore over the area of the sample. The remaining fibres (32, 38) of the bundle serve to collect emitted light (whether generated by fluorescence caused by excitation or otherwise) and provide a light path to the charge coupled device camera, wherein the ends of the excitation fibres and the ends of the emitted light collecting fibres are distributed uniformly over the area of the fibre bundle presented to the reaction site.
摘要翻译：提供了用于检测由测定样品发射的光的装置，其中由样品发射的光被收集以通过光纤束传输到电荷耦合器件照相机（74）。光纤束的横截面积对应于样品的面积，其端部靠近样品，用于检测从其发出的任何光，并且构成束的那些选定的纤维（30）从剩余部分并延伸到激发辐射源（76）并且用于将激发辐射（如果需要）直接传送到分布在束的端面的区域上并因此在样品的区域上的对应的多个点。束的剩余纤维（32,38）用于收集发射的光（无论是由激发产生的还是由激发产生的），并且向电荷耦合器件照相机提供光路，其中激发光纤的端部和发射的聚光纤维均匀地分布在呈现给反应部位的纤维束的区域上。

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