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1. 发明授权

US06868347B2 System for real time, non-invasive metrology of microfluidic chips 有权
标题翻译：微流控芯片的实时，非侵入式计量系统
公开(公告)号：US06868347B2
公开(公告)日：2005-03-15
申请号：US10393109
申请日：2003-03-19
申请人： Guann-Pyng Li , Mark Bachman , Zhongping Chen
发明人： Guann-Pyng Li , Mark Bachman , Zhongping Chen
IPC分类号： G01B9/02 , G01N11/00
CPC分类号： G06F19/00 , G01B9/0201 , G01B9/02027 , G01B9/02045 , G01B9/02072 , G01B9/02091 , G01B2290/35 , G01B2290/45 , G01B2290/70
摘要： A system integration of multicomponent technologies includes an automated microfluidic probe station and the use of that station for the systematic study of nonideal, nonhomogeneous biological fluids such as blood in microfluidic chips. The probe station provides for real-time, non-invasive metrology of microfluidic chips employing optical coherence tomography and optical Doppler tomography to allow for collection of flow data at any location or depth within a microfluidics chip. Also included is a programmable fluidic loader and actuator platform as part of the probe station, and a semi-automated rapid prototyping tool used to fabricate the microfluidic chips measured on the probe station. The resulting data library produced by measurements on the probe station contains all the necessary information needed to develop mature, accurate microfluidic modeling and simulation CAD tools.
摘要翻译：多组分技术的系统集成包括自动化微流体探针站和该站的用途，用于系统研究非流体，非均质生物流体，如微流控芯片中的血液。探针台提供使用光学相干断层扫描和光学多普勒层析成像的微流控芯片的实时非侵入式计量，以允许在微流体芯片内的任何位置或深度收集流量数据。还包括作为探测台的一部分的可编程流体装载器和致动器平台，以及用于制造在探针台上测量的微流体芯片的半自动化快速成型工具。通过探针台上的测量产生的结果数据库包含开发成熟，精确的微流体建模和仿真CAD工具所需的全部必要信息。

2. 发明授权

US08617143B2 Therapeutic agent delivery systems and devices 有权
标题翻译：治疗剂递送系统和装置
公开(公告)号：US08617143B2
公开(公告)日：2013-12-31
申请号：US11952626
申请日：2007-12-07
申请人： Mark Bachman , Baruch Kuppermann , Asheesh Divetia , Guann Pyng Li
发明人： Mark Bachman , Baruch Kuppermann , Asheesh Divetia , Guann Pyng Li
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61F9/0017 , A61K9/025
摘要： Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided. In various embodiments, a device for controlled release of an active ingredient is provided, including a release aperture operably associated with a deflectable member, a base with a porous membrane substrate layer, and at least one chamber juxtaposed between the release aperture and the porous membrane layer. The chamber may contain a matrix including one or more active ingredients and an agent that expands when contacted with an aqueous solution. The device is suitable for implantation in a biological system and can be used for delayed and/or time release of specific drug dosages for various indications.
摘要翻译：提供了将预定量的活性成分输送到生物系统的装置，系统和方法。在各种实施例中，提供了用于控制释放活性成分的装置，包括与可偏转构件可操作地相关联的释放孔，具有多孔膜基底层的基底和并置在释放孔和多孔膜之间的至少一个腔室层。该室可以含有包含一种或多种活性成分的基质和当与水溶液接触时膨胀的试剂。该装置适于植入生物系统中，并且可用于各种适应症的特定药物剂量的延迟和/或时间释放。

3. 发明申请

US20120097636A1 ACOUSTIC SUBSTRATE 有权
标题翻译：声学基底
公开(公告)号：US20120097636A1
公开(公告)日：2012-04-26
申请号：US13340240
申请日：2011-12-29
申请人： Mark Bachman , Guann-Pyng Li
发明人： Mark Bachman , Guann-Pyng Li
IPC分类号： H04R31/00
CPC分类号： H04R19/005 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2924/01079 , H01L2924/10253 , H01L2924/1461 , H01L2924/19041 , H01L2924/00014 , H01L2924/00
摘要： A micromachined microphone or speaker embedded within, or positioned on top of, a substrate suitable for carrying microelectronic chips and components. The acoustic element converts sound energy into electrical energy which is then amplified by electronic components positioned on the surface of the substrate. Alternatively, the acoustic element may be driven by electronics to produce sound. The substrate can be used in standard microelectronic packaging applications.
摘要翻译：嵌入在适于承载微电子芯片和部件的基板内或位于其上的微机械麦克风或扬声器。声学元件将声能转换成电能，然后由位于基板表面上的电子部件放大。或者，声学元件可以由电子器件驱动以产生声音。该基板可用于标准微电子封装应用。

4. 发明授权

US07695954B2 Micropatterned plate with micro-pallets for addressable biochemical analysis 有权
标题翻译：具有微型托盘的微图案板，用于可寻址的生化分析
公开(公告)号：US07695954B2
公开(公告)日：2010-04-13
申请号：US11243926
申请日：2005-10-04
申请人： Mark Bachman , Guann-Pyng Li , Nancy Allbritton , Christopher Sims
发明人： Mark Bachman , Guann-Pyng Li , Nancy Allbritton , Christopher Sims
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5027 , B01L3/5025 , B01L3/5085 , B01L2200/0647 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2400/0454
摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.
摘要翻译：制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。

5. 发明授权

US07541898B2 High isolation tunable MEMS capacitive switch 有权
标题翻译：高隔离可调MEMS电容开关
公开(公告)号：US07541898B2
公开(公告)日：2009-06-02
申请号：US11849914
申请日：2007-09-04
申请人： Jiangyuan Qian , Hung-Pin Chang , Bedri A. Cetiner , Mark Bachman , Franco DeFlaviis , Guann-Pyng Li
发明人： Jiangyuan Qian , Hung-Pin Chang , Bedri A. Cetiner , Mark Bachman , Franco DeFlaviis , Guann-Pyng Li
IPC分类号： H01P1/10 , B81B5/00
CPC分类号： H01H59/0009 , H01G5/16 , H01G5/40 , H01H2001/0084 , Y10T29/49002 , Y10T29/49105 , Y10T29/49117 , Y10T29/49128 , Y10T29/49155 , Y10T29/49156
摘要： The systems and methods described herein provide for a radio frequency micro-electromechanical systems switch having two or more resonant frequencies. The switch can be configured as a capacitive shunt switch having a deflectable member coupled between two electrodes over a transmission line. A first insulator can be located between one of the electrodes and the deflectable member to form a capacitive element. The deflectable member can be deflectable between an up-state and a down-state, the down-state capacitively coupling the deflectable member with the transmission line. The degree by which the deflectable member overlaps the first insulator can be adjusted to adjust the capacitance of the capacitive element and the resulting resonant frequency.
摘要翻译：本文所述的系统和方法提供具有两个或更多个谐振频率的射频微机电系统开关。开关可以被配置为具有通过传输线耦合在两个电极之间的可偏转构件的电容分流开关。第一绝缘体可以位于电极之间和可偏转构件之间，以形成电容元件。可偏转构件可以在上升状态和下降状态之间偏转，下降状态将可偏转构件与传输线电容耦合。可以调节可偏转构件与第一绝缘体重叠的程度，以调整电容元件的电容和所得到的谐振频率。

6. 发明申请

US20080177153A1 THERAPEUTIC AGENT DELIVERY SYSTEMS AND DEVICES 有权
标题翻译：治疗剂递送系统和设备
公开(公告)号：US20080177153A1
公开(公告)日：2008-07-24
申请号：US11952626
申请日：2007-12-07
申请人： Mark Bachman , Baruch Kupperman , Asheesh Divetia , Guann Pyng Li
发明人： Mark Bachman , Baruch Kupperman , Asheesh Divetia , Guann Pyng Li
IPC分类号： A61K9/22 , A61B5/00 , A61F9/00
CPC分类号： A61K9/0024 , A61F9/0017 , A61K9/025
摘要： Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided.
摘要翻译：提供了将预定量的活性成分输送到生物系统的装置，系统和方法。

7. 发明申请

US20070292312A1 METHOD OF MANUFACTURE OF A PLATE OF RELEASABLE ELEMENTS AND ITS ASSEMBLY INTO A CASSETTE 审中-公开
标题翻译：可释放元素板的制造方法及其组装于CASSETTE
公开(公告)号：US20070292312A1
公开(公告)日：2007-12-20
申请号：US11742006
申请日：2007-04-30
申请人： Mark Bachman , Yuli Wang , Christopher Sims , Nancy Allbritton , Guann-Pyng Li
发明人： Mark Bachman , Yuli Wang , Christopher Sims , Nancy Allbritton , Guann-Pyng Li
IPC分类号： B01L3/02 , G01N35/00 , G03F7/038
CPC分类号： B01L3/502707 , B01L3/5085 , B01L3/5088 , B01L2200/0647 , B01L2300/0636 , B01L2300/0822 , B01L2300/0829 , B01L2300/089 , B01L2400/0454 , G01N2035/00158
摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.
摘要翻译：制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。

8. 发明申请

US20060042959A1 Microfluidic dynamic vapor control system 有权
标题翻译：微流控动态蒸汽控制系统
公开(公告)号：US20060042959A1
公开(公告)日：2006-03-02
申请号：US10967913
申请日：2004-10-18
申请人： Mark Bachman , Guann-Pyng Li , Liang Wu
发明人： Mark Bachman , Guann-Pyng Li , Liang Wu
IPC分类号： C02F1/461
CPC分类号： B01D19/0073 , B01D1/14 , B01D3/009 , B01D3/12 , B01D5/0027 , B01L3/502792 , B01L3/5088 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2300/10 , B01L2300/1822 , B01L2300/1861
摘要： A microfluidic dynamic vapor control system adapted to change the chemistry of small drops by dynamically controlling the vapor content surrounding the drops. The small volume surface area ratio makes this an efficient mechanism for controlling chemistry in nanovolumes. The system uses small reservoirs of material that can produce vapor on demand, and microfluidic channels that direct the vapor into a small chamber that holds a drop of the solution of interest. By changing the vapors that enter the chamber, the chemical composition of the drop can be modified.
摘要翻译：一种微流体动态蒸汽控制系统，其适于通过动态地控制液滴周围的蒸气含量来改变小液滴的化学性质。体积小的表面积比使其成为控制纳米体系化学的有效机制。该系统使用可以根据需要产生蒸气的小储层材料，以及将蒸汽引导到保持一滴感兴趣的溶液的小室的微流体通道。通过改变进入室的蒸气，可以改变液滴的化学成分。

9. 发明申请

US20050248423A1 High isolation tunable MEMS capacitive switch 有权
标题翻译：高隔离可调MEMS电容开关
公开(公告)号：US20050248423A1
公开(公告)日：2005-11-10
申请号：US11080112
申请日：2005-03-14
申请人： Jiangyuan Qian , Hung-Pin Chang , Bedri Cetiner , Mark Bachman , Franco DeFlaviis , Guann-Pyng Li
发明人： Jiangyuan Qian , Hung-Pin Chang , Bedri Cetiner , Mark Bachman , Franco DeFlaviis , Guann-Pyng Li
IPC分类号： H01H59/00 , H01P1/10
CPC分类号： H01H59/0009 , H01G5/16 , H01G5/40 , H01H2001/0084 , Y10T29/49002 , Y10T29/49105 , Y10T29/49117 , Y10T29/49128 , Y10T29/49155 , Y10T29/49156
摘要： The systems and methods described herein provide for a radio frequency micro-electromechanical systems switch having two or more resonant frequencies. The switch can be configured as a capacitive shunt switch having a deflectable member coupled between two electrodes over a transmission line. A first insulator can be located between one of the electrodes and the deflectable member to form a capacitive element. The deflectable member can be deflectable between an up-state and a down-state, the down-state capacitively coupling the deflectable member with the transmission line. The degree by which the deflectable member overlaps the first insulator can be adjusted to adjust the capacitance of the capacitive element and the resulting resonant frequency.
摘要翻译：本文所述的系统和方法提供具有两个或更多个谐振频率的射频微机电系统开关。开关可以被配置为具有通过传输线耦合在两个电极之间的可偏转构件的电容分流开关。第一绝缘体可以位于电极之间和可偏转构件之间，以形成电容元件。可偏转构件可以在上升状态和下降状态之间偏转，下降状态将可偏转构件与传输线电容耦合。可以调节可偏转构件与第一绝缘体重叠的程度，以调整电容元件的电容和所得到的谐振频率。

10. 发明授权

US08383378B2 Micro-bubble plate for patterning biological and non-biological materials 有权
标题翻译：用于生物和非生物材料图案的微泡板
公开(公告)号：US08383378B2
公开(公告)日：2013-02-26
申请号：US11539695
申请日：2006-10-09
申请人： Yuli Wang , Mark Bachman , Christopher E. Sims , Guann-Pyng Li , Nancy Allbritton
发明人： Yuli Wang , Mark Bachman , Christopher E. Sims , Guann-Pyng Li , Nancy Allbritton
IPC分类号： C12N11/02 , C12Q1/68 , C12M1/34
CPC分类号： B01L3/5085 , B01L3/5088 , B01L2200/0642 , B01L2200/12 , B01L2300/0819 , C12M25/06 , C12M29/20
摘要： Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.
摘要翻译：提供了系统和方法，用于在板上的特定位置图案化生物和非生物材料，以及生长三维结构。优选实施例包括具有区域的板，当板被浸没在液体中时，其具有通常以气泡形式捕获气体的区域。本发明的其它实施方案包括通过使用捕获的气体将材料放置在预定位置处的材料的方法，以防止材料在不需要的区域收集。该板对于在特定位置（例如阵列）上的电镀细胞和组织具有很大的用途。所公开的方法还可以用于在具有特定位置的涂层涂覆板的表面以用于图案化涂布应用，并且建立材料以产生三维结构，包括微机械结构，其中结构可以由活的或非 - 生物材料，组织或非组织，有机或无机物等。

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