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1. 发明申请

US20060135542A1 GTPase inhibitors and use thereof for controlling platelet hyperactivity 失效
公开(公告)号：US20060135542A1
公开(公告)日：2006-06-22
申请号：US11283556
申请日：2005-11-18
申请人： Yi Zheng , Huzoor Akbar , David Williams , Wieslaw Mazur
发明人： Yi Zheng , Huzoor Akbar , David Williams , Wieslaw Mazur
IPC分类号： A61K31/506
CPC分类号： A61K31/506
摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

2. 发明授权

US07612080B2 GTPase inhibitors and use thereof for controlling platelet hyperactivity 失效
标题翻译： GTP酶抑制剂及其用于控制血小板多动症的用途
公开(公告)号：US07612080B2
公开(公告)日：2009-11-03
申请号：US11283556
申请日：2005-11-18
申请人： Yi Zheng , Huzoor Akbar , David A. Williams , Wieslaw Adam Mazur
发明人： Yi Zheng , Huzoor Akbar , David A. Williams , Wieslaw Adam Mazur
IPC分类号： A61K31/506
CPC分类号： A61K31/506
摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.
摘要翻译：优选的实施方案通常涉及影响Rho家族GTP酶，优选Rac（Rac1，Rac2和/或Rac3）成员的GTP结合活性的方法和组合物，所述组合物包括沿着GTP / GDP交换活性调节GTP / GDP交换活性的化合物用于化合物的用途，包括筛选识别Rac GTP酶的化合物，以及治疗与Rho家族GTP酶（包括Rac）相关或相关的病理状况的方法。优选实施方案还涉及使用这些化合物或其衍生物的方法，例如在治疗学，诊断学和研究工具中。

3. 发明申请

US20060004032A1 GTPase inhibitors and methods of use 有权
公开(公告)号：US20060004032A1
公开(公告)日：2006-01-05
申请号：US10994165
申请日：2004-11-19
申请人： Yi Zheng , Jie Zheng , Yuan Gao , John Dickerson , Wieslaw Mazur
发明人： Yi Zheng , Jie Zheng , Yuan Gao , John Dickerson , Wieslaw Mazur
IPC分类号： A61K31/506
CPC分类号： A61K31/506 , A61K31/47 , A61K31/505 , Y02A50/409
摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

4. 发明申请

US20050142103A1 Mobilization of hematopoietic cells 有权
标题翻译：动员造血细胞
公开(公告)号：US20050142103A1
公开(公告)日：2005-06-30
申请号：US10918328
申请日：2004-08-12
申请人： David Williams , Yi Zheng
发明人： David Williams , Yi Zheng
IPC分类号： A61K31/04 , A61K31/522 , A61K31/7088 , A61K35/12 , A61K35/28 , A61K38/19 , A61K38/20 , C07K14/47 , C12N5/0775 , A61K38/10 , A61K38/08
CPC分类号： A61K31/522 , A61K31/04 , A61K31/7088 , A61K35/28 , A61K38/193 , C07K14/4706 , C07K2319/01 , C12N5/0647 , C12N2500/40 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26
摘要： Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.
摘要翻译：本文提供了改进的方法和药物组合物，用于将造血祖细胞从骨髓移入外周血中，包括单独或组合施用有效量的GTP酶抑制剂，例如Rac1和Rac2。具体地，公开了将造血干细胞移入受试者的外周血中的方法。特别地，该方法的实施方案涉及抑制Rac1和Rac2GTP酶以将造血干细胞的数量增加到受试者的受试者的外周血中。受试者的血液可以被处理并用于重建受体的破坏的淋巴造血系统，并且将来可以用于修复各种非造血组织。因此，通过本发明的方法动员到受试者的外周血中的造血干细胞可用作骨髓移植中的供体细胞来源，用于治疗各种疾病，包括癌症，贫血，自身免疫和免疫缺陷。它们也可用于增加白细胞的存活和化疗。

5. 发明申请

US20050069553A1 Chimeric peptides for the regulation of GTPases 审中-公开
标题翻译：嵌合肽用于调节GTP酶
公开(公告)号：US20050069553A1
公开(公告)日：2005-03-31
申请号：US10918648
申请日：2004-08-12
申请人： Yi Zheng , David Williams
发明人： Yi Zheng , David Williams
IPC分类号： C07K14/47 , C12N9/14 , A61K39/395 , C07K16/44
CPC分类号： C07K14/4706 , C07K2319/01 , C07K2319/02 , C07K2319/03 , C12N9/14 , C12Y306/05002
摘要： Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene. Methods are provided for constructing and for using such compounds to regulate transcription of a selected gene.
摘要翻译：公开了嵌合肽或融合蛋白，其包括RhoGAP活性结构域和至少一个靶向特异性Rho蛋白的特异性结构域。融合蛋白可用于抑制细胞内的任何GTP酶活性。融合蛋白对癌症的治疗特别有利。本发明一般涉及本发明一般涉及能够调节GTP酶的嵌合肽，更具体地，涉及通过使用GTP酶活化蛋白靶向各个GTP酶的方法。这些蛋白质可用于治疗癌症和其它与GTP酶有关的疾病。本发明涉及核酸分子和编码的GTP酶活化蛋白及其变体，以及这些分子在表征，诊断，预防和治疗细胞信号传导，免疫和细胞增殖性疾病，特别是癌症中的用途。本文公开了用于调节所选基因转录的化合物和方法。提供了构建和使用这些化合物调节所选基因转录的方法。

6. 发明申请

US20190031567A1 Beta-SiAlON Wavelength Converters and Methods of Making the Same 审中-公开
公开(公告)号：US20190031567A1
公开(公告)日：2019-01-31
申请号：US15661183
申请日：2017-07-27
申请人： Zhengbo Yu , Madis Raukas , Yi Zheng
发明人： Zhengbo Yu , Madis Raukas , Yi Zheng
IPC分类号： C04B35/597 , F21V9/16
摘要： Methods for producing wavelength converters are described. The methods include sintering a mixture consisting essentially of first particles and second particles to form a sintered article. In embodiments the first particles consist essentially of particles of β-SiAlON or precursors thereof, and the second particles consist essentially one or more sintering aids or precursors thereof. In embodiments the sintered article has a density that is greater than or equal to about 90% of a theoretical bulk density of the mixture, and is configured to convert primary light incident thereon to secondary light, wherein the secondary light exhibits a peak with a full width half maximum of greater than 0 to about 60 nanometers (nm) within a wavelength range of about 495 nm to about 600 nm.

7. 发明授权

US09082523B2 Transparent conductor 有权
标题翻译：透明导体
公开(公告)号：US09082523B2
公开(公告)日：2015-07-14
申请号：US13882451
申请日：2011-11-10
申请人： Barbaros Özyilmaz , Guang Xin Ni , Yi Zheng
发明人： Barbaros Özyilmaz , Guang Xin Ni , Yi Zheng
IPC分类号： B32B9/00 , H01B1/04 , C01B31/04 , H01L51/44 , H01B13/00 , H01L51/52
CPC分类号： H01B1/04 , C01B32/182 , C01B2204/00 , H01B13/0033 , H01L51/442 , H01L51/5206 , H01L51/5215 , Y02E10/549 , Y10T428/2911 , Y10T428/30
摘要： A transparent conductor comprising: a graphene layer and a permanent dipole layer on the graphene layer configured to electrostatically dope the graphene layer.
摘要翻译：一种透明导体，包括：石墨烯层和石墨烯层上的永久偶极子层，被配置为静电掺杂石墨烯层。

8. 发明授权

US08786146B2 Electric machine and oil cooling method for electrical machine 有权
标题翻译：电机电机油冷却方式
公开(公告)号：US08786146B2
公开(公告)日：2014-07-22
申请号：US13513019
申请日：2010-01-26
申请人： Wei Cai , Yi Zheng , Xinglian Yuan
发明人： Wei Cai , Yi Zheng , Xinglian Yuan
IPC分类号： H02K9/20
CPC分类号： H02K9/19 , H02K9/197
摘要： An electrical machine including a casing (1), an oil inlet hole (7), an oil passage (2), oil outlet holes (3), a stator retainer (8), a casing end cover (10), a stator iron core (5), winding coils (6), slot insulations (12) and oil-guides (4). The oil passage (2) is located inside the casing (1) and links with the oil inlet hole (7) of the casing (1) and the oil outlet holes (3) of the stator retainer (8). The oil outlet holes (3) are located above the winding coils (6) and the oil-guides (4) are located between the oil outlet holes (3) and the winding coils (6). Oil entering from the oil inlet hole (7) pours onto the winding coils (6) by the guidance of the oil-guides (4) after flowing through the oil passage (2) and flowing out of the oil outlet holes (3). The winding coils of the electrical machine can be effectively cooled and the electrical machine can achieve higher thermal durability. An oil cooling method for the electrical machine is also provided.
摘要翻译：一种电机，包括壳体（1），进油孔（7），油路（2），出油孔（3），定子保持架（8），壳体端盖（10），定子铁（5），绕组线圈（6），槽绝缘（12）和导油器（4）。油路（2）位于壳体（1）的内部，与壳体（1）的进油孔（7）和定子保持架（8）的排油孔（3）连结。出油孔（3）位于绕组线圈（6）的上方，导油件（4）位于排油孔（3）和绕组线圈（6）之间。从进油孔（7）进入的油在流经油路（2）并从出油孔（3）流出之后，通过导油件（4）的引导而在卷绕线圈（6）上倾倒。可以有效地冷却电机的绕组线圈，并且电机可以实现更高的耐热性。还提供了一种用于电机的油冷却方法。

9. 发明授权

US08547660B2 Magnetic write head manufactured by an enhanced damascene process producing a tapered write pole with a non-magnetic spacer and non-magnetic bump 有权
标题翻译：通过增强的镶嵌工艺制造的磁性写头，其产生具有非磁性间隔物和非磁性凸块的锥形写柱
公开(公告)号：US08547660B2
公开(公告)日：2013-10-01
申请号：US12641251
申请日：2009-12-17
申请人： Donald G. Allen , Amanda Baer , Yingjian Chen , Andrew Chiu , Liubo Hong , Wen-Chien D. Hsiao , Edward H. P. Lee , Fenglin Liu , Aron Pentek , Katalin Pentek , Kyusik Shin , Yi Zheng , Qiping Zhong , Honglin Zhu
发明人： Donald G. Allen , Amanda Baer , Yingjian Chen , Andrew Chiu , Liubo Hong , Wen-Chien D. Hsiao , Edward H. P. Lee , Fenglin Liu , Aron Pentek , Katalin Pentek , Kyusik Shin , Yi Zheng , Qiping Zhong , Honglin Zhu
IPC分类号： G11B5/127
CPC分类号： G11B5/3163 , G11B5/112 , G11B5/1278 , G11B5/3116 , G11B5/314 , G11B5/3143 , G11B5/3146 , G11B5/315 , Y10T428/11 , Y10T428/1171
摘要： A magnetic write head having a tapered trailing edge and having a magnetic layer formed over a trailing edge of the write pole at a location recessed from the ABS, the magnetic layer being separated from the trailing edge of the write pole by a thin non-magnetic layer. The thin non-magnetic layer is preferably sufficiently thin that the magnetic layer can function as a portion of the write pole in a region removed from the ABS. A trailing magnetic shield is formed over the write pole and is separated from the write pole by a non-magnetic trailing gap layer. A non-magnetic spacer layer can be formed over the magnetic layer to provide additional separation between the magnetic layer and the trailing magnetic shield.
摘要翻译：一种具有锥形后缘并具有磁性层的磁性写头，该磁性层形成在从ABS的凹陷处的写入极的后缘上，该磁性层通过薄的非磁性的方式与写入极的后缘分离层。薄的非磁性层优选地足够薄，使得磁性层可以在从ABS去除的区域中用作写入极的一部分。尾磁屏蔽形成在写极上，并且通过非磁性拖尾间隙层与写极分离。可以在磁性层之上形成非磁性间隔层，以在磁性层和尾部磁屏蔽之间提供额外的间隔。

10. 发明申请

US20130104388A1 NOVEL HIGH BEVEL ANGLE MAGNETIC WRITER POLE FABRICATION PROCESS 有权
标题翻译：新型高水平角度磁性写入器制造工艺
公开(公告)号：US20130104388A1
公开(公告)日：2013-05-02
申请号：US13285688
申请日：2011-10-31
申请人： Guomin Mao , Yi Zheng
发明人： Guomin Mao , Yi Zheng
IPC分类号： G11B5/84
CPC分类号： G11B5/1278 , G11B5/3116 , G11B5/3163 , Y10T29/49043 , Y10T29/49044 , Y10T29/49046 , Y10T29/49048 , Y10T29/49052 , Y10T29/49067
摘要： Methods of making write poles for perpendicular magnetic recording write heads. The bevel angle of the write pole for a perpendicular magnetic recording write head affects the performance of the write head. By forming reinforcement layer on the polymeric underlayer mask to enhance the mask durability during ion mill and tapering the polymeric underlayer above the non-magnetic mill mask layer using oxygen and nitrogen based reactive ion etch process, the bevel angle of the magnetic write pole can be increased greatly to meet the demands of the next and future generations of magnetic recording write heads.
摘要翻译：制作垂直磁记录写磁头写磁极的方法。用于垂直磁记录写头的写入极的斜角影响写入头的性能。通过在聚合物底层掩模上形成增强层，以增强离子研磨过程中的掩模耐久性，并使用基于氧和氮的反应离子蚀刻工艺使非磁性研磨掩模层上方的聚合物底层逐渐变细，磁性写入极的斜角可以为大大增加，以满足下一代和下一代磁记录头的要求。

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