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1. 发明授权

US5985899A Selective thrombin inhibitors 失效
标题翻译：选择性凝血酶抑制剂
公开(公告)号：US5985899A
公开(公告)日：1999-11-16
申请号：US967661
申请日：1997-11-10
申请人： Yeong Soo Oh , Sang Soo Kim , Sang Yeul Hwang , Mi Kyung Yun , Seong Ryul Hwang , Seong Won Hong , Yong Hee Lee , Yi Na Jeong , Koo Lee , You Seung Shin
发明人： Yeong Soo Oh , Sang Soo Kim , Sang Yeul Hwang , Mi Kyung Yun , Seong Ryul Hwang , Seong Won Hong , Yong Hee Lee , Yi Na Jeong , Koo Lee , You Seung Shin
IPC分类号： C07C257/22 , C07C311/19 , C07C311/29 , C07C311/42 , C07D211/60 , C07D295/185 , C07D295/205 , C07D295/26 , A61K31/445 , C07D211/34
CPC分类号： C07C257/22 , C07C311/19 , C07C311/29 , C07C311/42 , C07D211/60 , C07D295/185 , C07D295/205 , C07D295/26 , C07C2101/02 , C07C2101/10 , C07C2101/14
摘要： The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group,X represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, orR.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl,R.sup.4 represents hydrogen, lower alkyl or lower alkoxy,R.sup.5 represents alkanesulfonyl; alkoxycarbonyl; alkylcarbonyl; formyl; lower alkyl; aryl substituted or unsubstituted with alkoxy or haloalkyl; or hydroxy-substituted lower alkyl, andR.sup.6 and R.sup.7 independently of one another represent hydrogen, lower alkyl or amino,and to a process for preparation thereof and a pharmaceutical composition for thrombin inhibition which comprises the compound of formula (I) as an active ingredient.
摘要翻译：本发明涉及一种新型的具有下列通式（I）的选择性凝血酶抑制剂，其也可通过口服给药有效：其中R1表示被芳基或芳氧基取代的乙酰基，或表示被取代或未取代的芳基或含N 杂环基，X表示式R 2的基团，R 3彼此独立地表示氢; 被羧基或烷氧基羰基取代或未取代的环烷基; 芳基烷氧基; 羟基; 或与羧基，烷氧基羰基或羟基取代或未取代的低级烷基，或R 2和R 3与它们所连接的氮原子一起形成被羧基或烷氧基羰基取代的哌啶基，R 4表示氢，低级烷基或低级烷氧基，R 5表示烷磺酰基 ; 烷氧基羰基烷基羰基; 甲酰基低级烷基被烷氧基或卤代烷基取代或未取代的芳基; 或羟基取代的低级烷基，R 6和R 7彼此独立地表示氢，低级烷基或氨基，以及其制备方法和用于凝血酶抑制的药物组合物，其包含式（I）化合物作为活性成分。

2. 发明授权

US5977114A Selective thrombin inhibitors 失效
标题翻译：选择性凝血酶抑制剂
公开(公告)号：US5977114A
公开(公告)日：1999-11-02
申请号：US967018
申请日：1997-11-10
申请人： Yeong Soo Oh , Sang Soo Kim , Sang Yeul Hwang , Mi Kyung Yun , Seong Ryul Hwang , Seong Won Hong , Yong Hee Lee , Yi Na Jeong , Koo Lee , You Seung Shin
发明人： Yeong Soo Oh , Sang Soo Kim , Sang Yeul Hwang , Mi Kyung Yun , Seong Ryul Hwang , Seong Won Hong , Yong Hee Lee , Yi Na Jeong , Koo Lee , You Seung Shin
IPC分类号： C07C257/22 , C07C311/19 , C07C311/29 , C07C311/42 , C07D211/60 , C07D295/185 , C07D295/205 , C07D295/26 , A61K31/495 , C07D241/04
CPC分类号： C07C257/22 , C07C311/19 , C07C311/29 , C07C311/42 , C07D211/60 , C07D295/185 , C07D295/205 , C07D295/26 , C07C2101/02 , C07C2101/10 , C07C2101/14
摘要： The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group,x represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, orR.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl,R.sup.4 represents hydrogen, lower alkyl or lower alkoxy,R.sup.5 represents alkanesulfonyl; alkoxycarbonyl; alkylcarbonyl; formyl; lower alkyl; aryl substituted or unsubstituted with alkoxy or haloalkyl; or hydroxy-substituted lower alkyl, andR.sup.6 and R.sup.7 independently of one another represent hydrogen, lower alkyl or amino,and to a process for preparation thereof and a pharmaceutical composition for thrombin inhibition which comprises the compound of formula (I) as an active ingredient.
摘要翻译：本发明涉及一种新型的具有下列通式（I）的选择性凝血酶抑制剂，其也可通过口服给药有效：其中R1表示被芳基或芳氧基取代的乙酰基，或表示被取代或未取代的芳基或含N 杂环基，x代表式R2和R3彼此独立地表示氢; 被羧基或烷氧基羰基取代或未取代的环烷基; 芳基烷氧基; 羟基; 或与羧基，烷氧基羰基或羟基取代或未取代的低级烷基，或R 2和R 3与它们所连接的氮原子一起形成被羧基或烷氧羰基取代的哌啶基，R 4表示氢，低级烷基或低级烷氧基，R 5表示烷磺酰基 ; 烷氧基羰基烷基羰基; 甲酰基低级烷基被烷氧基或卤代烷基取代或未取代的芳基; 或羟基取代的低级烷基，R 6和R 7彼此独立地表示氢，低级烷基或氨基，以及其制备方法和用于凝血酶抑制的药物组合物，其包含式（I）化合物作为活性成分。

3. 发明授权

US5747535A Selective thrombin inhibitors 失效
标题翻译：选择性凝血酶抑制剂
公开(公告)号：US5747535A
公开(公告)日：1998-05-05
申请号：US586208
申请日：1996-01-16
申请人： Yeong Soo Oh , Sang Soo Kim , Sang Yeul Hwang , Mi Kyung Yun , Seong Ryul Hwang , Seong Won Hong , Yong Hee Lee , Yi Na Jeong , Koo Lee , You Seung Shin
发明人： Yeong Soo Oh , Sang Soo Kim , Sang Yeul Hwang , Mi Kyung Yun , Seong Ryul Hwang , Seong Won Hong , Yong Hee Lee , Yi Na Jeong , Koo Lee , You Seung Shin
IPC分类号： C07C257/18 , A61K31/155 , A61K31/165 , A61K31/18 , A61K31/445 , A61K31/495 , A61P7/02 , A61P43/00 , C07C257/22 , C07C311/19 , C07C311/29 , C07C311/42 , C07C311/45 , C07D211/34 , C07D211/60 , C07D241/04 , C07D295/10 , C07D295/16 , C07D295/185 , C07D295/205 , C07D295/26 , C07C311/18
CPC分类号： C07D295/185 , C07C257/22 , C07C311/19 , C07C311/29 , C07C311/42 , C07D211/60 , C07D295/205 , C07D295/26 , C07C2101/02 , C07C2101/10 , C07C2101/14
摘要： The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group, X represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, or R.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl, R.sup.4 represents hydrogen, lower alkyl or lower alkoxy, R.sup.5 represents alkanesulfonyl; alkoxycarbonyl; alkylcarbonyl; formyl; lower alkyl; aryl substituted or unsubstituted with alkoxy or haloalkyl; or hydroxy-substituted lower alkyl, and R.sup.6 and R.sup.7 independently of one another represent hydrogen, lower alkyl or amino, and to a process for preparation thereof and a pharmaceutical composition for thrombin inhibition which comprises the compound of formula (I) as an active ingredient.
摘要翻译：本发明涉及具有下式（I）的新型选择性凝血酶抑制剂，其也可通过口服给药有效：其中R1表示被芳基或芳氧基取代的乙酰基，或表示被取代或取代的磺酰基取代的磺酰基未取代的芳基或含N的杂环基，X表示式的基团，R 2和R 3彼此独立地表示氢; 被羧基或烷氧基羰基取代或未取代的环烷基; 芳基烷氧基; 羟基; 或与羧基，烷氧基羰基或羟基取代或未取代的低级烷基，或R 2和R 3与它们所连接的氮原子一起形成被羧基或烷氧基羰基取代的哌啶基，R 4表示氢，低级烷基或低级烷氧基，R 5表示烷磺酰基 ; 烷氧基羰基烷基羰基; 甲酰基低级烷基被烷氧基或卤代烷基取代或未取代的芳基; 或羟基取代的低级烷基，R 6和R 7彼此独立地表示氢，低级烷基或氨基，以及其制备方法和用于凝血酶抑制的药物组合物，其包含式（I）化合物作为活性成分。

4. 发明授权

US06449674B1 Internal command signal generator and method therefor 有权
标题翻译：内部指令信号发生器及其方法
公开(公告)号：US06449674B1
公开(公告)日：2002-09-10
申请号：US09471486
申请日：1999-12-23
申请人： Mi Kyung Yun , Jong Hee Han
发明人： Mi Kyung Yun , Jong Hee Han
IPC分类号： G06F1324
CPC分类号： G11C7/22 , G11C7/1072
摘要： An internal command signal generator and a method therefor generate internal command signal for an internal circuit operation after receiving external control signal in a synchronous memory device. Particularly, the internal command signal generator and a method therefor previously decode external input control signals for generating an internal command signal during a time required to generate an internal clock signal by buffering the external clock signal, thus produce an internal command signal, and synchronize the internal command signal to the internal clock signal. As a result, all time required to a decoding operation is reduced so that a data access time is greatly reduced.
摘要翻译：内部命令信号发生器及其方法在同步存储器件中接收到外部控制信号之后产生用于内部电路操作的内部命令信号。特别地，内部命令信号发生器及其方法先前解码外部输入控制信号，以在通过缓冲外部时钟信号产生内部时钟信号所需的时间内产生内部命令信号，从而产生内部命令信号，并使内部命令信号到内部时钟信号。结果，减少解码操作所需的所有时间，从而大大减少数据访问时间。

5. 外观设计

USD1039612S1 Character sticker 有权
公开(公告)号：USD1039612S1
公开(公告)日：2024-08-20
申请号：US29889902
申请日：2023-04-18
申请人： Mi Kyung Yun
设计人： Mi Kyung Yun
摘要： The file of this patent contains at least one drawing executed in color. Copies of this patent with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
The FIGURE is a front view of a character sticker, showing my design.
The broken lines represent the boundaries of the claimed design and form no part of the claimed design.

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