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1. 发明申请

US20070147727A1 Optical waveguide bio-sensing device 有权
标题翻译：光波导生物传感器
公开(公告)号：US20070147727A1
公开(公告)日：2007-06-28
申请号：US11540972
申请日：2006-10-02
申请人： Yen-Chieh Mao , Jian-Shian Lin , Lai-Sheng Chen , Wei-Han Wang
发明人： Yen-Chieh Mao , Jian-Shian Lin , Lai-Sheng Chen , Wei-Han Wang
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , G01N21/553 , G01N2021/7773
摘要： An optical waveguide bio-sensing device, comprising: a monochromatic light source, a beam splitter, a grating chip with a sub-wavelength grating structure and a sensor. Moreover, in order to enhance the sensitivity of the system using the optical waveguide bio-sensing device, a light concentrating element or a quarter waveplate (¼λ) is arranged in the optical path during detection. When the grating chip is not coated with a layer of biochemical substance corresponding to a monochrome light emitted from the monochromatic light source, a reflected light of a specific narrow wavelength is reflected by a specific angle as a surface plasmon resonant effect caused by waveguide coupling is excited by the incidence of the monochrome light to the grating chip through the beam splitter; otherwise, there will be little or no reflection. Accordingly, the optical waveguide bio-sensing device can detect bio-molecular interactions, reaction rate and/or molecular dynamics without any labeling in real time. Optical systems using the present invention are simplified and capable of being portable. Thus a high sensitivity detection technique is achieved.
摘要翻译：一种光波导生物感测装置，包括：单色光源，分束器，具有亚波长光栅结构的光栅芯片和传感器。此外，为了提高使用光波导生物感测装置的系统的灵敏度，在检测期间在光路中布置光聚集元件或四分之一波片（λ=λ）。当光栅芯片没有涂覆与从单色光源发射的单色光相对应的生物化学物质层时，由于波导耦合引起的表面等离子体共振效应，特定窄波长的反射光被反射特定角度由单色光通过分束器激发到光栅芯片; 否则，会有很少或没有反映。因此，光波导生物传感装置可以实时检测生物分子相互作用，反应速率和/或分子动力学，而无需任何标记。使用本发明的光学系统被简化并能够便携。因此实现了高灵敏度检测技术。

2. 发明授权

US07636502B2 Optical waveguide bio-sensing device 有权
标题翻译：光波导生物传感器
公开(公告)号：US07636502B2
公开(公告)日：2009-12-22
申请号：US11540972
申请日：2006-10-02
申请人： Yen-Chieh Mao , Jian-Shian Lin , Lai-Sheng Chen , Wei-Han Wang
发明人： Yen-Chieh Mao , Jian-Shian Lin , Lai-Sheng Chen , Wei-Han Wang
IPC分类号： G02B6/00 , G02B6/34
CPC分类号： G01N21/7703 , G01N21/553 , G01N2021/7773
摘要： An optical waveguide bio-sensing device, comprising: a monochromatic light source, a beam splitter, a grating chip with a sub-wavelength grating structure and a sensor. Moreover, in order to enhance the sensitivity of the system using the optical waveguide bio-sensing device, a light concentrating element or a quarter waveplate (¼λ) is arranged in the optical path during detection. When the grating chip is not coated with a layer of biochemical substance corresponding to a monochrome light emitted from the monochromatic light source, a reflected light of a specific narrow wavelength is reflected by a specific angle as a surface plasmon resonant effect caused by waveguide coupling is excited by the incidence of the monochrome light to the grating chip through the beam splitter; otherwise, there will be little or no reflection. Accordingly, the optical waveguide bio-sensing device can detect bio-molecular interactions, reaction rate and/or molecular dynamics without any labeling in real time. Optical systems using the present invention are simplified and capable of being portable. Thus a high sensitivity detection technique is achieved.
摘要翻译：一种光波导生物感测装置，包括：单色光源，分束器，具有亚波长光栅结构的光栅芯片和传感器。此外，为了提高使用光波导生物感测装置的系统的灵敏度，在检测期间在光路中布置光聚集元件或四分之一波片（λ-λ）。当光栅芯片没有涂覆与从单色光源发射的单色光相对应的生物化学物质层时，由于波导耦合引起的表面等离子体共振效应，特定窄波长的反射光被反射特定角度由单色光通过分束器激发到光栅芯片; 否则，会有很少或没有反映。因此，光波导生物传感装置可以实时检测生物分子相互作用，反应速率和/或分子动力学，而无需任何标记。使用本发明的光学系统被简化并能够便携。因此实现了高灵敏度检测技术。

3. 发明申请

US20060238767A1 Coupled waveguide-surface plasmon resonance biosensor 有权
标题翻译：耦合波导表面等离子体共振生物传感器
公开(公告)号：US20060238767A1
公开(公告)日：2006-10-26
申请号：US11448098
申请日：2006-06-07
申请人： Shean-Jen Chen , Yen-Chieh Mao , Jenq-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
发明人： Shean-Jen Chen , Yen-Chieh Mao , Jenq-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/7743
摘要： The present invention discloses a coupled waveguide-surface plasmon resonance biosensor, comprising: a grating layer formed of a transparent material, the grating layer comprising a first periodic grating structure; a waveguide layer formed on the first periodic grating structure, the refractive index of the waveguide layer being larger than the refractive index of the grating layer; a plasmon resonance layer formed on the waveguide layer, capable of being optically excited to cause a plasmon resonance wave; and a ligand layer formed on the plasmon resonance layer; capable of being bound to react with receptors of a sample to be tested.
摘要翻译：本发明公开了一种耦合的波导表面等离子体共振生物传感器，包括：由透明材料形成的光栅层，所述光栅层包括第一周期性光栅结构; 形成在所述第一周期性光栅结构上的波导层，所述波导层的折射率大于所述光栅层的折射率; 形成在波导层上的等离子体共振层，能够被光学激发以产生等离子体共振波; 和形成在等离子体共振层上的配体层; 能够与待测样品的受体反应。

4. 发明授权

US07679748B2 Coupled waveguide-surface plasmon resonance biosensor 有权
标题翻译：耦合波导表面等离子体共振生物传感器
公开(公告)号：US07679748B2
公开(公告)日：2010-03-16
申请号：US11448098
申请日：2006-06-07
申请人： Shean-Jen Chen , Yen-Chieh Mao , Jeng-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
发明人： Shean-Jen Chen , Yen-Chieh Mao , Jeng-Nan Yih , Fan-Ching Chien , Chun-Yu Lin , Yi-Ming Chu , Lai-Sheng Chen , Wei-Han Wang , Chao-Chi Wu , Yen-Chun Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/7743
摘要： The present invention discloses a coupled waveguide-surface plasmon resonance biosensor, comprising: a grating layer formed of a transparent material, the grating layer comprising a first periodic grating structure; a waveguide layer formed on the first periodic grating structure, the refractive index of the waveguide layer being larger than the refractive index of the grating layer; a plasmon resonance layer formed on the waveguide layer, capable of being optically excited to cause a plasmon resonance wave; and a ligand layer formed on the plasmon resonance layer; capable of being bound to react with receptors of a sample to be tested.
摘要翻译：本发明公开了一种耦合的波导表面等离子体共振生物传感器，包括：由透明材料形成的光栅层，所述光栅层包括第一周期性光栅结构; 形成在所述第一周期性光栅结构上的波导层，所述波导层的折射率大于所述光栅层的折射率; 形成在波导层上的等离子体共振层，能够被光学激发以产生等离子体共振波; 和形成在等离子体共振层上的配体层; 能够与待测样品的受体反应。

5. 发明授权

US07114692B2 Vibration isolation device 有权
标题翻译：隔振装置
公开(公告)号：US07114692B2
公开(公告)日：2006-10-03
申请号：US11075724
申请日：2005-03-10
申请人： Yann-Shuoh Sun , Wei-Han Wang , Jen-Hua Wu , Yen-Chieh Mao
发明人： Yann-Shuoh Sun , Wei-Han Wang , Jen-Hua Wu , Yen-Chieh Mao
IPC分类号： A47B97/00
CPC分类号： F16F15/02
摘要： A vibration isolation device for isolating a vibration source from a carried member, includes: a carrier for carrying the carried member; a housing positioned on the vibration source, and formed with an accommodating space; a cover for sealing an open end of the housing; a base mounted in the accommodating space, and extended through the cover to be connected to the carrier; a plurality of connecting members mounted in the accommodating space and around the base, wherein each of the connecting members is connected to the base and the cover; and a plurality of actuators provided in the connecting members respectively, for changing vibration of the connecting members and the base when the vibration source vibrates, so as to minimize vibration of the carrier, thereby achieving the effect of isolating vertical and horizontal vibrations.
摘要翻译：一种用于将振动源与承载构件隔离的隔振装置，包括：承载所承载的构件的载体; 定位在振动源上的壳体，并形成有容纳空间; 用于密封壳体的开口端的盖; 安装在所述容纳空间中并且延伸穿过所述盖以连接到所述载体的基座; 多个连接构件安装在容纳空间中并围绕基座，其中每个连接构件连接到基座和盖子; 以及分别设置在连接构件中的多个致动器，用于当振动源振动时改变连接构件和基座的振动，从而最小化载体的振动，从而实现隔离垂直和水平振动的效果。

6. 发明申请

US20060131471A1 Vibration isolation device 有权
公开(公告)号：US20060131471A1
公开(公告)日：2006-06-22
申请号：US11075724
申请日：2005-03-10
申请人： Yann-Shuoh Sun , Wei-Han Wang , Jen-Hua Wu , Yen-Chieh Mao
发明人： Yann-Shuoh Sun , Wei-Han Wang , Jen-Hua Wu , Yen-Chieh Mao
IPC分类号： F16M13/00
CPC分类号： F16F15/02
摘要： A vibration isolation device for isolating a vibration source from a carried member, includes: a carrier for carrying the carried member; a housing positioned on the vibration source, and formed with an accommodating space; a cover for sealing an open end of the housing; a base mounted in the accommodating space, and extended through the cover to be connected to the carrier; a plurality of connecting members mounted in the accommodating space and around the base, wherein each of the connecting members is connected to the base and the cover; and a plurality of actuators provided in the connecting members respectively, for changing vibration of the connecting members and the base when the vibration source vibrates, so as to minimize vibration of the carrier, thereby achieving the effect of isolating vertical and horizontal vibrations.

7. 发明授权

US07473088B2 Microimprint/nanoimprint device 有权
标题翻译：微印/纳米压印装置
公开(公告)号：US07473088B2
公开(公告)日：2009-01-06
申请号：US11242067
申请日：2005-10-04
申请人： Yu-Lun Ho , Lai-Sheng Chen , Wei-Han Wang , Jen-Hua Wu , Chuan-Feng Chen , Shou-Ren Chen
发明人： Yu-Lun Ho , Lai-Sheng Chen , Wei-Han Wang , Jen-Hua Wu , Chuan-Feng Chen , Shou-Ren Chen
IPC分类号： B29C43/02
CPC分类号： G03F7/0002 , B29C35/02 , B29C59/022 , B29C2035/0827 , B29C2059/023 , B82Y10/00 , B82Y40/00
摘要： A microimprint/nanoimprint device includes a mold, a substrate and an energy transferring module. The substrate is disposed oppositely to the mold and at least has a molding material layer. The energy transferring module includes an energy transferring member and at least one energy source, wherein the energy transferring member is connected to the substrate or the mold, and the energy source provides imprint energy to the substrate or the mold, such that at least part of the imprint energy goes through the energy transferring member to the substrate or the mold for performing imprint molding.
摘要翻译：微压印/纳米压印装置包括模具，基底和能量转移模块。基板与模具相对地设置，并且至少具有模制材料层。能量传递模块包括能量传递构件和至少一个能量源，其中能量传递构件连接到衬底或模具，并且能量源向衬底或模具提供压印能量，使得至少部分压印能量通过能量传递构件到达用于进行压印成型的基板或模具。

8. 发明申请

US20070092594A1 Method and device for demolding 有权
标题翻译：用于脱模的方法和装置
公开(公告)号：US20070092594A1
公开(公告)日：2007-04-26
申请号：US11291853
申请日：2005-12-02
申请人： Yu-Lun Ho , Jen-Hua Wu , Wei-Han Wang , Shou-Ren Chen , Lai-Sheng Chen
发明人： Yu-Lun Ho , Jen-Hua Wu , Wei-Han Wang , Shou-Ren Chen , Lai-Sheng Chen
IPC分类号： B29C45/40
CPC分类号： B29C37/0007 , B29C33/44 , B29C43/003 , B29C43/021 , B29C43/40 , B29C43/50 , B29C59/022 , B29C2043/025 , B29C2043/5038 , B29C2043/5069 , B29C2059/023
摘要： The present invention relates to a demolding method and device, being used for detaching a mold and a substrate after completing an imprinting process, in which the mold is forced to detach from the substrate partially and form a gap therebetween by inserting at least a blade module between the two, and thus, as air is sucked into the gap and the adhesion force of vacuum effect exerting between the mold and the substrate is eliminated, the blade module is further applied to detach the mold from the substrate completely.
摘要翻译：脱模方法和装置技术领域本发明涉及一种脱模方法和装置，其用于在完成压印过程之后分离模具和基材，其中模具被迫部分地从基板上分离并通过至少插入一个叶片模块在两者之间，因此当空气被吸入到间隙中并且消除了在模具和基板之间施加的真空效应的粘附力时，进一步施加叶片模块以将模具完全分离。

9. 发明申请

US20060198917A1 Microimprint/nanoimprint device 有权
公开(公告)号：US20060198917A1
公开(公告)日：2006-09-07
申请号：US11242067
申请日：2005-10-04
申请人： Yu-Lun Ho , Lai-Sheng Chen , Wei-Han Wang , Jen-Hua Wu , Chuan-Feng Chen , Shou-Ren Chen
发明人： Yu-Lun Ho , Lai-Sheng Chen , Wei-Han Wang , Jen-Hua Wu , Chuan-Feng Chen , Shou-Ren Chen
IPC分类号： B29C35/08
CPC分类号： G03F7/0002 , B29C35/02 , B29C59/022 , B29C2035/0827 , B29C2059/023 , B82Y10/00 , B82Y40/00
摘要： A microimprint/nanoimprint device includes a mold, a substrate and an energy transferring module. The substrate is disposed oppositely to the mold and at least has a molding material layer. The energy transferring module includes an energy transferring member and at least one energy source, wherein the energy transferring member is connected to the substrate or the mold, and the energy source provides imprint energy to the substrate or the mold, such that at least part of the imprint energy goes through the energy transferring member to the substrate or the mold for performing imprint molding.

10. 发明授权

US07462320B2 Method and device for demolding 有权
标题翻译：用于脱模的方法和装置
公开(公告)号：US07462320B2
公开(公告)日：2008-12-09
申请号：US11291853
申请日：2005-12-02
申请人： Yu-Lun Ho , Jen-Hua Wu , Wei-Han Wang , Shou-Ren Chen , Lai-Sheng Chen
发明人： Yu-Lun Ho , Jen-Hua Wu , Wei-Han Wang , Shou-Ren Chen , Lai-Sheng Chen
IPC分类号： B28B7/10 , B29C43/50
CPC分类号： B29C37/0007 , B29C33/44 , B29C43/003 , B29C43/021 , B29C43/40 , B29C43/50 , B29C59/022 , B29C2043/025 , B29C2043/5038 , B29C2043/5069 , B29C2059/023
摘要： The present invention relates to a demolding method and device, being used for detaching a mold and a substrate after completing an imprinting process, in which the mold is forced to detach from the substrate partially and form a gap therebetween by inserting at least a blade module between the two, and thus, as air is sucked into the gap and the adhesion force of vacuum effect exerting between the mold and the substrate is eliminated, the blade module is further applied to detach the mold from the substrate completely.
摘要翻译：脱模方法和装置技术领域本发明涉及一种脱模方法和装置，其用于在完成压印过程之后分离模具和基材，其中模具被迫部分地从基板上分离并通过至少插入一个叶片模块在两者之间，因此当空气被吸入到间隙中并且消除了在模具和基板之间施加的真空效应的粘附力时，进一步施加叶片模块以将模具完全分离。

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