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1. 发明申请

US20090036788A1 SYSTEMS AND METHODS FOR DETECTION OF VT AND VF FROM REMOTE SENSING ELECTRODES 有权
标题翻译：用于从远程感测电极检测VT和VF的系统和方法
公开(公告)号：US20090036788A1
公开(公告)日：2009-02-05
申请号：US12244607
申请日：2008-10-02
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
IPC分类号： A61B5/0456
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.
摘要翻译：提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。然后使用所选择的监测模式进行室性心律失常监测。

2. 发明授权

US07403813B1 Systems and methods for detection of VT and VF from remote sensing electrodes 有权
公开(公告)号：US07403813B1
公开(公告)日：2008-07-22
申请号：US10998026
申请日：2004-11-24
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Anders Bjorling , Yelena Nabutovsky , Kjell Noren
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Anders Bjorling , Yelena Nabutovsky , Kjell Noren
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61N1/3621 , A61N1/36535 , A61N1/36542 , A61N1/36564
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

3. 发明授权

US07970473B2 Systems and methods for detection of VT and VF from remote sensing electrodes 有权
标题翻译：从遥感电极检测VT和VF的系统和方法
公开(公告)号：US07970473B2
公开(公告)日：2011-06-28
申请号：US12244607
申请日：2008-10-02
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
IPC分类号： A61N1/00
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.
摘要翻译：提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。然后使用所选择的监测模式进行室性心律失常监测。

4. 发明授权

US07447540B1 Systems and methods for detection of VT and VF from remote sensing electrodes 有权
标题翻译：从遥感电极检测VT和VF的系统和方法
公开(公告)号：US07447540B1
公开(公告)日：2008-11-04
申请号：US10998027
申请日：2004-11-24
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
IPC分类号： A61B5/0452
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。然后使用所选择的监测模式进行室性心律失常监测。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

5. 发明授权

US07546159B1 Subcutaneous cardiac stimulation device, system, and method providing accelerated arrhythmia detection verification and transient rate compensation 有权
标题翻译：皮下心脏刺激装置，系统和方法提供加速心律失常检测验证和瞬时率补偿
公开(公告)号：US07546159B1
公开(公告)日：2009-06-09
申请号：US11080215
申请日：2005-03-14
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/0504
摘要： A subcutaneous cardiac stimulation system verifies accelerated arrhythmia detection before delivering accelerated arrhythmia therapy to the heart. The stimulation system includes a verification circuit that verifies detection of the accelerated arrhythmia with each of first and second sense channels utilizing first and second electrode configurations. The therapy circuit delivers the stimulation therapy to the heart if the accelerated arrhythmia detection is verified with each of the first and second electrode configurations. The system also compensates for transient rate changes during the detection of the accelerated arrhythmia.
摘要翻译：皮下心脏刺激系统在对心脏进行加速心律失常治疗之前验证加速心律失常检测。刺激系统包括验证电路，其使用第一和第二电极配置来验证第一和第二感测通道中的每一个的加速心律失常的检测。如果通过第一和第二电极配置中的每个验证加速的心律不齐检测，治疗电路将刺激治疗递送到心脏。该系统还补偿了在检测加速心律失常期间的瞬时速率变化。

6. 发明授权

US08170664B1 Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
标题翻译：使用由其确定的可植入传感器和斜坡来监测心脏病
公开(公告)号：US08170664B1
公开(公告)日：2012-05-01
申请号：US11931165
申请日：2007-10-31
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.
摘要翻译：本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。确定斜率，其中斜率表示在一段时间内生理特性的变化。基于斜率的大小来监测心脏病。在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。根据斜率的变化监测患者心脏病变化。

7. 发明授权

US08385999B1 Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
标题翻译：在植入式传感器中处理静脉血氧饱和度和血细胞比容信息
公开(公告)号：US08385999B1
公开(公告)日：2013-02-26
申请号：US12028261
申请日：2008-02-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/00
CPC分类号： A61N1/39 , A61B5/0031 , A61B5/14535 , A61B5/14551 , A61B5/4836 , A61N1/362
摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.
摘要翻译：提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。对光检测器的输出进行采样以测量透射光的强度。对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

8. 发明授权

US07920913B1 Systems and methods for increasing implantable sensor accuracy 有权
标题翻译：增加植入式传感器精度的系统和方法
公开(公告)号：US07920913B1
公开(公告)日：2011-04-05
申请号：US11771514
申请日：2007-06-29
申请人： Yelena Nabutovsky , Gene A. Bornzin , Kyungmoo Ryu , Taraneh Ghaffari Farazi
发明人： Yelena Nabutovsky , Gene A. Bornzin , Kyungmoo Ryu , Taraneh Ghaffari Farazi
IPC分类号： A61B5/04
CPC分类号： A61B5/14551 , A61B2560/02
摘要： Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.
摘要翻译：本文提供了可植入系统及其使用的方法，其增加使用植入式传感器产生的测量的精度，其中测量受周期性身体功能（例如心跳和/或呼吸）的周期的影响。根据系统的具体实施例，获得推测为准确的测量值。测量可以具有生理特性，例如但不限于血氧饱和度，血细胞比容或血糖浓度。另外，植入用于产生生理特性的多个测量。将使用植入的传感器产生的这种测量与推定为准确的测量进行比较，从而识别何时使用植入的传感器产生的测量是最准确的。此后，当使用植入的传感器产生的测量最准确时，植入系统被配置为使用植入的传感器来产生测量。

9. 发明授权

US07630078B1 Calibrating implantable optical sensors 失效
标题翻译：校准植入光学传感器
公开(公告)号：US07630078B1
公开(公告)日：2009-12-08
申请号：US11683521
申请日：2007-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： G01B9/08
CPC分类号： A61B5/14542 , A61B5/02028 , A61B5/14535 , A61B5/1459 , A61B2560/0223 , A61N1/36557
摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度光源。基于由校准光检测器产生的校准信号来补偿透射光强度的变化。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

10. 发明授权

US08175668B1 Implantable multi-wavelength venous oxygen saturation and hematocrit sensor and method 有权
标题翻译：可植入多波长静脉血氧饱和度和血细胞比容传感器及方法
公开(公告)号：US08175668B1
公开(公告)日：2012-05-08
申请号：US11877056
申请日：2007-10-23
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/1459 , A61N1/36557
摘要： An intravenous implantable optical sensor assesses the relative absorbance of multiple wavelengths of light in order to determine oxygen saturation. The calculation of oxygen saturation is enhanced by use of a function of hematocrit which is derived from the relative absorbance of light of an isobestic wavelength along two different length paths through the blood. The use of the hematocrit-dependent term and multiple wavelengths of light to calculate oxygen saturation provides results that are less susceptible to noise and variation in hematocrit and thus provides a more accurate measure of oxygen saturation over a wider range of conditions than previously possible. The optical sensor may form part of an implantable system which performs the calculation of oxygen saturation and uses the results for a diagnostic or therapeutic purpose.
摘要翻译：静脉注射光学传感器评估多个波长的光的相对吸光度以确定氧饱和度。通过使用血细胞比容的功能来提高氧饱和度的计算，血细胞比容的功能来源于通过血液的两条不同长度路径的异质波长的光的相对吸光度。使用血细胞比容相关术语和多个波长的光来计算氧饱和度提供的结果不太容易受噪声和血细胞比容的变化，因此在比以前可能的更宽的条件下提供更准确的氧饱和度测量。光学传感器可以形成可执行氧饱和度的计算的可植入系统的一部分，并将结果用于诊断或治疗目的。

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