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1. 发明授权

US07741027B2 Amplification of HIV-1 sequences for detection of sequences associated with drug-resistance mutations 有权
标题翻译：扩增用于检测与耐药性突变相关的序列的HIV-1序列
公开(公告)号：US07741027B2
公开(公告)日：2010-06-22
申请号：US12100350
申请日：2008-04-09
申请人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
发明人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
IPC分类号： C07H21/00 , C12N15/49 , C12Q1/70
CPC分类号： C07H21/02 , C12Q1/703 , H01L2924/014 , H01L2924/14 , Y10S435/974
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
摘要翻译：公开了用于扩增HIV-1的gag和pol基因的不同部分的核酸寡核苷酸的序列和用于检测这种扩增的核酸序列的序列。公开了使用特异于gag和pol靶序列的扩增寡核苷酸来扩增和检测生物样品中HIV-1核酸的方法。

2. 发明授权

US07374877B2 Amplification of HIV-1 gag sequences for detection of sequences associated with drug-resistance mutations 有权
标题翻译：扩增用于检测与耐药突变相关的序列的HIV-1 gag序列
公开(公告)号：US07374877B2
公开(公告)日：2008-05-20
申请号：US11145272
申请日：2005-06-03
申请人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
发明人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
IPC分类号： C07H21/00 , C12N15/49
CPC分类号： C07H21/02 , C12Q1/703 , H01L2924/014 , H01L2924/14 , Y10S435/974
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
摘要翻译：公开了用于扩增HIV-1的gag和pol基因的不同部分的核酸寡核苷酸的序列和用于检测这种扩增的核酸序列的序列。公开了使用特异于gag和pol靶序列的扩增寡核苷酸来扩增和检测生物样品中HIV-1核酸的方法。

3. 发明申请

US20090047659A1 AMPLIFICATION OF HIV-1 SEQUENCES FOR DETECTION OF SEQUENCES ASSOCIATED WITH DRUG-RESISTANCE MUTATIONS 有权
标题翻译：用于检测与药物耐药突变相关的序列的HIV-1序列的扩增
公开(公告)号：US20090047659A1
公开(公告)日：2009-02-19
申请号：US12100350
申请日：2008-04-09
申请人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
发明人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
IPC分类号： C12Q1/70 , C07H21/04
CPC分类号： C07H21/02 , C12Q1/703 , H01L2924/014 , H01L2924/14 , Y10S435/974
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
摘要翻译：公开了用于扩增HIV-1的gag和pol基因的不同部分的核酸寡核苷酸的序列和用于检测这种扩增的核酸序列的序列。公开了使用特异于gag和pol靶序列的扩增寡核苷酸来扩增和检测生物样品中HIV-1核酸的方法。

4. 发明授权

US06946254B2 Amplification of HIV-1 gag sequences for detection of sequences associated with drug-resistance mutations 有权
标题翻译：扩增用于检测与耐药突变相关的序列的HIV-1 gag序列
公开(公告)号：US06946254B2
公开(公告)日：2005-09-20
申请号：US10425975
申请日：2003-04-28
申请人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
发明人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
IPC分类号： C07H21/02 , C12Q1/68 , C12Q1/70
CPC分类号： C07H21/02 , C12Q1/703 , H01L2924/014 , H01L2924/14 , Y10S435/974
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
摘要翻译：公开了用于扩增HIV-1的gag和pol基因的不同部分的核酸寡核苷酸的序列和用于检测这种扩增的核酸序列的序列。公开了使用特异于gag和pol靶序列的扩增寡核苷酸来扩增和检测生物样品中HIV-1核酸的方法。

5. 发明授权

US06582920B2 Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations 有权
标题翻译：扩增HIV-1 RT序列用于检测与耐药性突变相关的序列
公开(公告)号：US06582920B2
公开(公告)日：2003-06-24
申请号：US09944036
申请日：2001-08-31
申请人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
发明人： Yeasing Y. Yang , Steven T. Brentano , Odile Babola , Nathalie Tran , Guy Vernet
IPC分类号： C12Q168
CPC分类号： C07H21/02 , C12Q1/703 , H01L2924/014 , H01L2924/14 , Y10S435/974
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
摘要翻译：公开了用于扩增HIV-1的gag和pol基因的不同部分的核酸寡核苷酸的序列和用于检测这种扩增的核酸序列的序列。公开了使用特异于gag和pol靶序列的扩增寡核苷酸来扩增和检测生物样品中HIV-1核酸的方法。

6. 发明申请

US20050227227A1 Amplification of HIV-1 gag sequences for detection of sequences associated with drug-resistance mutations 有权
公开(公告)号：US20050227227A1
公开(公告)日：2005-10-13
申请号：US11145272
申请日：2005-06-03
申请人： Yeasing Yang , Steven Brentano , Odile Babola , Nathalie Tran , Guy Vernet
发明人： Yeasing Yang , Steven Brentano , Odile Babola , Nathalie Tran , Guy Vernet
IPC分类号： C07H21/02 , C12Q1/68 , C12Q1/70
CPC分类号： C07H21/02 , C12Q1/703 , H01L2924/014 , H01L2924/14 , Y10S435/974
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.

7. 发明授权

US08168387B2 Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus 有权
标题翻译：寡核苷酸，其用途，用于诊断甲型流感病毒H5和N1基因存在的检测方法和试剂盒
公开(公告)号：US08168387B2
公开(公告)日：2012-05-01
申请号：US12084704
申请日：2006-11-23
申请人： Aurélie Lefeuvre , Jean-Noel Telles , Guy Vernet
发明人： Aurélie Lefeuvre , Jean-Noel Telles , Guy Vernet
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/701
摘要： The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said oligonucleotides being of a length ranging between 10 and 50 nucleotides and comprising at least one fragment of 10 consecutive nucleotides derived from the following sequences: SEQ ID No. 1:TGTATGTTGTGGAATGGCA, SEQ ID No. 2:GCCGAATGATGCCATCAA, SEQ ID No. 3:CGTGGATTGTCTCCGAAA, and SEQ ID No. 4:GGAATGCTCCTGTTATCCTGA or the sequence complementary thereto. The invention also relates to oligonucleotides for detecting amplicons, to the use of all these sequences, and to a method for detecting and a kit for diagnosing the presence of the H5 and N1 genes of the Influenza A virus.The invention is particularly applicable in the field of diagnosis.
摘要翻译：本发明涉及用于扩增分别位于甲型流感病毒基因组的H5和N1基因中的两个靶序列的双重寡核苷酸，所述寡核苷酸的长度范围在10至50个核苷酸之间并且至少包含衍生自以下序列的10个连续核苷酸的一个片段：SEQ ID No.1：TGTATGTTGTGGAATGGCA，SEQ ID No.2：GCCGAATGATGCCATCAA，SEQ ID No.3：CGTGGATTGTCTCCGAAA和SEQ ID No.4：GGAATGCTCCTGTTATCCTGA或其互补序列。本发明还涉及用于检测扩增子的寡核苷酸，所有这些序列的使用以及用于检测的方法和用于诊断甲型流感病毒的H5和N1基因的存在的试剂盒。本发明特别适用于诊断领域。

8. 发明申请

US20090305243A1 Oligonucleotides, Use Thereof, Detecting Method and Kit for Diagnosing the Presence of H5 and N1 Genes of the Influenza a Virus 有权
标题翻译：寡核苷酸，其用途，用于诊断流感病毒H5和N1基因存在的检测方法和试剂盒
公开(公告)号：US20090305243A1
公开(公告)日：2009-12-10
申请号：US12084704
申请日：2006-11-23
申请人： Aurélie Lefeuvre , Jean-Noel Telles , Guy Vernet
发明人： Aurélie Lefeuvre , Jean-Noel Telles , Guy Vernet
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/701
摘要： The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said oligonucleotides being of a length ranging between 10 and 50 nucleotides and comprising at least one fragment of 10 consecutive nucleotides derived from the following sequences: SEQ ID No. 1:TGTATGTTGTGGAATGGCA, SEQ ID No. 2:GCCGAATGATGCCATCAA, SEQ ID No. 3:CGTGGATTGTCTCCGAAA, and SEQ ID No. 4:GGAATGCTCCTGTTATCCTGA or the sequence complementary thereto. The invention also relates to oligonucleotides for detecting amplicons, to the use of all these sequences, and to a method for detecting and a kit for diagnosing the presence of the H5 and N1 genes of the Influenza A virus.The invention is particularly applicable in the field of diagnosis.
摘要翻译：本发明涉及用于扩增分别位于甲型流感病毒基因组的H5和N1基因中的两个靶序列的双重寡核苷酸，所述寡核苷酸的长度范围在10至50个核苷酸之间并且至少包含衍生自以下序列的10个连续核苷酸的一个片段：SEQ ID No.1：TGTATGTTGTGGAATGGCA，SEQ ID No.2：GCCGAATGATGCCATCAA，SEQ ID No.3：CGTGGATTGTCTCCGAAA和SEQ ID No.4：GGAATGCTCCTGTTATCCTGA或其互补序列。本发明还涉及用于检测扩增子的寡核苷酸，所有这些序列的使用以及用于检测的方法和用于诊断甲型流感病毒的H5和N1基因的存在的试剂盒。本发明特别适用于诊断领域。

9. 发明申请

US20080171314A1 Method for controlling the microbiological quality of an aqueous medium and kit therefor 审中-公开
标题翻译：用于控制水性介质的微生物质量的方法及其试剂盒
公开(公告)号：US20080171314A1
公开(公告)日：2008-07-17
申请号：US12010716
申请日：2008-01-29
申请人： Patricia Renaud , Emmanuelle Guillot , Claude Mabilat , Carole Vachon , Bruno Lacroix , Guy Vernet , Marie-Astrid Armand , Philippe Laffaire
发明人： Patricia Renaud , Emmanuelle Guillot , Claude Mabilat , Carole Vachon , Bruno Lacroix , Guy Vernet , Marie-Astrid Armand , Philippe Laffaire
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/70
CPC分类号： C12Q1/701 , C12Q1/689 , C12Q1/6893
摘要： Disclosed is a method for controlling the microbiological quality of an environmental aqueous medium, suspected of containing various micro-organisms, having the following steps: selecting a reference set, having at least three micro-organisms, representing jointly or separately a microbiological quality level; providing a microbiological detection kit, having at least three probes specifically and respectively identifying said three micro-organisms; after treating the medium to be analyzed, contacting said micro-organisms, or any fraction thereof derived from the medium to be analyzed therefrom, with said detection kit, whereby a multiple determination of the micro-organisms is carried out, the determination representing the microbiological quality level of the medium.
摘要翻译：公开了一种用于控制怀疑含有各种微生物的环境水性介质的微生物质量的方法，具有以下步骤：选择具有至少三种微生物的参考文献，共同或分别表示微生物质量水平; 提供微生物检测试剂盒，具有特异性和分别鉴定所述三种微生物的至少三种探针; 在处理要分析的培养基之后，将所述微生物或其衍生自待分析培养基的任何部分与所述检测试剂盒接触，由此进行微生物的多重测定，所述微生物质量水平的介质。

10. 发明申请

US20080085284A1 Construction of a Comparative Database and Identification of Virulence Factors Comparison of Polymorphic Regions in Clinical Isolates of Infectious Organisms 审中-公开
标题翻译：构建比较数据库和确定感染生物临床分离株中多态性区域的毒力因子比较
公开(公告)号：US20080085284A1
公开(公告)日：2008-04-10
申请号：US11632108
申请日：2007-04-09
申请人： Villoo Patell , K.R. Rajyashri , Marc Rodrigue , Guy Vernet
发明人： Villoo Patell , K.R. Rajyashri , Marc Rodrigue , Guy Vernet
IPC分类号： A61K31/70 , A61K39/00 , A61P43/00 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases more particularly tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence' and/or infectivity in infectious diseases more particularly in tuberculosis by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of M. tuberculosis strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence. Although the present invention has been illustrated with specific reference to the polymorphic region in the Mycobacterium tuberculosis, the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.
摘要翻译：本发明涉及新的核苷酸序列，用于诊断，鉴定菌株，分型和赋予其潜在的毒力程度，感染性和/或所有感染性疾病特别是结核病的潜伏期的方向。本发明还包括通过对不同临床分离株/感染生物菌株的序列的比较基因组分析来鉴定和选择与感染性疾病相关的多态性和/或感染性疾病更特别地在结核病中的方法。多态性区域也可以作为潜在的药物靶点和疫苗靶点。更具体地说，本发明还涉及鉴定要包括在诊断DNA芯片中的结核分枝杆菌菌株和其他感染性生物体的毒力因子，其允许鉴定菌株，分型并最终赋予其潜在的毒力程度。虽然已经具体参考结核分枝杆菌中的多态性区域来说明了本发明，但是本发明不被理解为并且被解释为限于结核病，而是适用于所有感染性疾病。

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