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1. 发明申请

US20080085284A1 Construction of a Comparative Database and Identification of Virulence Factors Comparison of Polymorphic Regions in Clinical Isolates of Infectious Organisms 审中-公开
标题翻译：构建比较数据库和确定感染生物临床分离株中多态性区域的毒力因子比较
公开(公告)号：US20080085284A1
公开(公告)日：2008-04-10
申请号：US11632108
申请日：2007-04-09
申请人： Villoo Patell , K.R. Rajyashri , Marc Rodrigue , Guy Vernet
发明人： Villoo Patell , K.R. Rajyashri , Marc Rodrigue , Guy Vernet
IPC分类号： A61K31/70 , A61K39/00 , A61P43/00 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases more particularly tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence' and/or infectivity in infectious diseases more particularly in tuberculosis by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of M. tuberculosis strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence. Although the present invention has been illustrated with specific reference to the polymorphic region in the Mycobacterium tuberculosis, the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.
摘要翻译：本发明涉及新的核苷酸序列，用于诊断，鉴定菌株，分型和赋予其潜在的毒力程度，感染性和/或所有感染性疾病特别是结核病的潜伏期的方向。本发明还包括通过对不同临床分离株/感染生物菌株的序列的比较基因组分析来鉴定和选择与感染性疾病相关的多态性和/或感染性疾病更特别地在结核病中的方法。多态性区域也可以作为潜在的药物靶点和疫苗靶点。更具体地说，本发明还涉及鉴定要包括在诊断DNA芯片中的结核分枝杆菌菌株和其他感染性生物体的毒力因子，其允许鉴定菌株，分型并最终赋予其潜在的毒力程度。虽然已经具体参考结核分枝杆菌中的多态性区域来说明了本发明，但是本发明不被理解为并且被解释为限于结核病，而是适用于所有感染性疾病。

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