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1. 发明授权

US5376665A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5376665A
公开(公告)日：1994-12-27
申请号：US182145
申请日：1994-01-14
申请人： Kazuyoshi Miyata , Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Naba , Yasuhisa Kurogi
发明人： Kazuyoshi Miyata , Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Naba , Yasuhisa Kurogi
IPC分类号： A61K31/675 , C07F9/6506 , C07F9/653 , C07F9/6541 , C07F9/6561 , C07D235/04 , A61K31/415 , A61K31/44 , C07D221/04
CPC分类号： C07F9/6561 , C07F9/65068 , C07F9/65324 , C07F9/6541
摘要： The invention provides a phosphonic diester derivative of the general formula ##STR1## The phosphonic diester derivative of the invention has hypoglycemic and hypolipidemic activities, for instance, and is of value as an antidiabetic or anti-hyperlipidemic agent.

2. 发明授权

US5480874A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5480874A
公开(公告)日：1996-01-02
申请号：US318860
申请日：1995-01-12
申请人： Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue
发明人： Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue
IPC分类号： A61K31/00 , A61K31/675 , C07F9/6506 , C07F9/6541 , C07F9/6561 , C07F9/28
CPC分类号： C07F9/6561 , C07F9/6541
摘要： The invention provides a phosphonic diester derivative of the formula: ##STR1## wherein the variables are as defined in the specification. The derivative of the invention has excellent hypolipidemic and hypoglycemic activities and little side effects and hence is useful as therapeutic and prophylactic agents for hyperlipidemic diseases and diabetes and as a therapeutic agent for cataract.
摘要翻译：本发明提供下式的膦酸二酯衍生物：其中变量如说明书中所定义。本发明的衍生物具有优异的降血脂和降血糖活性，副作用小，因此可用作高脂血症和糖尿病的治疗和预防剂，并且作为白内障治疗剂。

3. 发明授权

US5081112A Method for treating hyperlipidemia 失效
标题翻译：治疗高脂血症的方法
公开(公告)号：US5081112A
公开(公告)日：1992-01-14
申请号：US375632
申请日：1989-07-05
申请人： Kazuhiko Tsutsumi , Tagui Sugimoto , Yoshihiko Tsuda , Eiji Uesaka , Kayoko Shinomiya , Yasuo Shoji , Atsushi Shima
发明人： Kazuhiko Tsutsumi , Tagui Sugimoto , Yoshihiko Tsuda , Eiji Uesaka , Kayoko Shinomiya , Yasuo Shoji , Atsushi Shima
IPC分类号： C12N9/99 , A61K31/66 , A61K31/675 , A61P3/06 , A61P43/00
CPC分类号： A61K31/675 , A61K31/66 , Y10S514/824
摘要： A pharmaceutical composition for treating hyperlipidemia containing, as the active ingredient, at least one carboxamide compounds represented by the formula (1) which possess excellent activities in lowering serum lipid, as well as having low toxicity with high safety.Said carboxamide compounds represented by the formula (1) are known compounds developed by the present inventors, but the pharmacological activities for treating hyperlipidemia have not been found yet.

4. 发明授权

US5985858A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5985858A
公开(公告)日：1999-11-16
申请号：US91946
申请日：1998-06-26
申请人： Kazuyoshi Miyata , Yasuhiro Sakai , Yasuo Shoji , Yoshihiko Tsuda , Yasuhide Inoue , Keigo Sato , Shinya Miki
发明人： Kazuyoshi Miyata , Yasuhiro Sakai , Yasuo Shoji , Yoshihiko Tsuda , Yasuhide Inoue , Keigo Sato , Shinya Miki
IPC分类号： C07F9/6509 , C07F9/6539 , C07F9/6553 , C07F9/6558 , C07F9/6561 , A61K31/67 , A61K31/675
CPC分类号： C07F9/650964 , C07F9/6539 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： A phosphonic diester derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group; a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent; a thiazolyl group; a pyridyl group which may be substituted by a halogen atom; a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring; or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group; R.sup.2 represents a hydrogen atom or a phenyl lower alkyl group; R.sup.3 and R.sup.4 each represents a lower alkyl group; and A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring; the derivative being of value as an agent for treating and preventing hyperlipidemia, diabetes and cataract, or as an antitumor agent.
摘要翻译： PCT No.PCT / JP96 / 03775第 371日期：1998年6月26日 102（e）日期1998年6月26日PCT 1996年12月24日PCT公布。公开号WO97 / 24360 PCT 日期：1997年7月10日由下式（1）表示的膦酸二酯衍生物：其中R1表示环烷基; 可以具有1〜3个选自低级烷氧基，低级烷基，卤素原子，卤素取代的低级烷基，低级烷酰基，硝基，苯甲酰基的取代基的苯基，氰基，N-低级烷基氨基甲酰基，N-苯基 - 低级烷基氨基甲酰基，N-（卤素取代的苯基）氨基甲酰基和N，N-二低级烷基氨基甲酰基; 具有卤素取代的低级烷基作为取代基的1,3,4-噻二唑-2-基; 噻唑基可被卤素原子取代的吡啶基; 在苯环上具有1至2个低级烷氧基的苯并噻唑-2-基; 或4,5-二氢噻吩并[3,2-e]苯并噻唑-2-基; R2表示氢原子或苯基低级烷基; R3和R4各自表示低级烷基; A表示选自吡嗪环，噻吩环和苯基取代的噻唑环的杂环; 该衍生物作为治疗和预防高脂血症，糖尿病和白内障或作为抗肿瘤剂的药剂是有价值的。

5. 发明授权

US5985882A Pyrazolo[1,5-a]pyrimidine derivatives 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物
公开(公告)号：US5985882A
公开(公告)日：1999-11-16
申请号：US930974
申请日：1997-10-10
申请人： Makoto Inoue , Takashi Okamura , Yasuo Shoji , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
发明人： Makoto Inoue , Takashi Okamura , Yasuo Shoji , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
IPC分类号： C07D487/04 , A61K31/505 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention provides pyrazolo[1,5-a]pyrimidine derivatives which are useful as potent analgesics and represented by the formula ##STR1## wherein R.sup.1 is lower alkenyl, hydroxy(lower)alkyl, (lower)alkylthio(lower)alkyl, (lower)alkanoyloxy(lower)alkyl, (lower)alkoxy(lower)alkyl, furyl or thienyl, R.sup.2 is pyridyl, 1-oxide-pyridyl, lower alkyl-substituted pyrazinyl, lower alkyl-substituted pyrimidinyl, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy and halogen, R.sup.3 is hydrogen or halogen, and A is a single bond or lower alkylene.
摘要翻译： PCT No.PCT / JP96 / 00955 Sec。 371日期：1997年10月10日 102（e）1997年10月10日PCT PCT 1996年4月5日PCT公布。公开号WO96 / 32394 日期：1996年10月17日本发明提供了吡唑并[1,5-a]嘧啶衍生物，其可用作强力止痛剂并由下式表示：其中R1为低级烯基，羟基（低级）烷基，（低级）烷硫基（低级）烷基，（低级）烷酰氧基（低级）烷基，（低级）烷氧基（低级）烷基，呋喃基或噻吩基，R2是吡啶基，1-氧化物 - 吡啶基，低级烷基取代的吡嗪基，低级烷基取代的嘧啶基或苯基，至3个选自低级烷基，低级烷氧基和卤素的取代基，R3为氢或卤素，A为单键或低级亚烷基。

6. 发明授权

US5707997A Pyrazolo�1,5-a!pyrimidine derivative 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物
公开(公告)号：US5707997A
公开(公告)日：1998-01-13
申请号：US602824
申请日：1996-02-21
申请人： Yasuo Shoji , Makoto Inoue , Takashi Okamura , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
发明人： Yasuo Shoji , Makoto Inoue , Takashi Okamura , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
IPC分类号： C07D487/04 , A61K31/505 , C07D403/02
CPC分类号： C07D487/04
摘要： The invention provides a pyrazolo�1,5-a!pyrimidine derivative of the following formula (1): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, Q, A and n are defined in the description; and R.sup.2 is naphthyl, cycloalkyl, furyl, thienyl, optionally halogen-substituted pyridyl, optionally halogen-substituted phenoxy, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro, halogen-substituted lower alkyl, halogen-substituted lower alkoxy, lower alkoxycarbonyl, hydroxyl, phenyl(lower)alkoxy, amino, cyano, lower alkanoyloxy, phenyl and di(lower)alkoxyphos-phoryl(lower)alkyl. This derivative is useful as a potent analgesic.
摘要翻译： PCT No.PCT / JP95 / 01104 Sec。 371日期1996年2月21日 102（e）日期1996年2月21日PCT提交1995年6月5日PCT公布。出版物WO95 / 35298 日期：1995年12月28日本发明提供下述通式（1）的吡唑并[1,5-a]嘧啶衍生物：d n在说明书中定义; R 2为萘基，环烷基，呋喃基，噻吩基，任选卤素取代的吡啶基，任选卤素取代的苯氧基，或可具有1至3个选自低级烷基，低级烷氧基，卤素，硝基，取代的低级烷基，卤素取代的低级烷氧基，低级烷氧基羰基，羟基，苯基（低级）烷氧基，氨基，氰基，低级烷酰氧基，苯基和二（低级）烷氧基磷酰基（低级）烷基。该衍生物作为有效的止痛剂是有用的。

7. 发明授权

US5303263A Transmission channel characteristic equalizer 失效
标题翻译：传输通道特性均衡器
公开(公告)号：US5303263A
公开(公告)日：1994-04-12
申请号：US904337
申请日：1992-06-24
申请人： Yasuo Shoji , Haruhiro Shiino , Norio Yamaguchi , Masami Abe
发明人： Yasuo Shoji , Haruhiro Shiino , Norio Yamaguchi , Masami Abe
IPC分类号： H03H21/00 , H04L25/02 , H04L25/03 , H03H7/30
CPC分类号： H03H21/0012 , H04L25/03292 , H04L25/025
摘要： An equalizer including a channel estimator allowing a Viterbi algorithm processor to estimate transmitted symbols accurately, so that the impulse response of a transmission channel may not deviate from the correct one. The equalizer outputs an transmitted symbol sequence estimate having the largest path metric by correcting the channel impulse response by parameter coefficients of the LMS (Least Mean Square) or RLS (Recursive Least Square) algorithm, by compensating for phase fluctuations due to the frequency offset and phase jitter of received signals, or by using a sequence included in an intermediate portion of a TDMA (Time Division Multiple Access) frame format.
摘要翻译：包括允许维特比算法处理器精确估计发射符号的信道估计器的均衡器，使得传输信道的脉冲响应可能不偏离正确的。均衡器通过通过补偿由于频率偏移引起的相位波动来校正由LMS（最小均方）或RLS（递归最小二乘法）算法的参数系数的信道脉冲响应而输出具有最大路径度量的发送符号序列估计，以及接收信号的相位抖动，或通过使用TDMA（时分多址）帧格式的中间部分所包含的序列。

8. 发明授权

US5055685A Infrared detecting apparatus 失效
标题翻译：红外线检测装置
公开(公告)号：US5055685A
公开(公告)日：1991-10-08
申请号：US444755
申请日：1989-12-01
申请人： Tadashi Sugimoto , Masashi Iwasawa , Yasuo Shoji
发明人： Tadashi Sugimoto , Masashi Iwasawa , Yasuo Shoji
IPC分类号： G01J5/08 , G08B13/193
CPC分类号： G01J5/08 , G01J5/0806 , G01J5/0846 , G01J5/0862 , G01J5/0875 , G01J5/089 , G01J5/0893 , G08B13/193 , Y10S250/01
摘要： An infrared detecting apparatus which includes an infrared filter which intercepts visible light and transmits infrared rays having at least two infrared detecting elements for receiving infrared rays transmitted through the filter and converting the received infrared rays into an electric signal and an electronic circuit which amplifies the difference signal supplied from the infrared detecting elements so that the relative positional relationship between the infrared detecting elements and the infrared filter which allows for the solid angle extending from an arbitrary point on the infrared filter to the peripheral edge of the infrared detecting element's receiving surface to be not greater or less than a specific range.
摘要翻译：一种红外线检测装置，其包括：红外线滤光器，其截取可见光并透射具有至少两个红外线检测元件的红外线，用于接收通过滤光器透射的红外线，并将接收的红外线转换为电信号;以及电子电路，信号，使得红外线检测元件和红外线滤光器之间的相对位置关系允许从红外线滤波器上的任意点到红外线检测元件的接收表面的周边边缘的立体角度为不大于或小于特定范围。

9. 发明授权

US4961160A Linear predictive coding analysing apparatus and bandlimiting circuit therefor 失效
标题翻译：线性预测编码分析装置及其限幅电路
公开(公告)号：US4961160A
公开(公告)日：1990-10-02
申请号：US186576
申请日：1988-04-27
申请人： Shinichi Sato , Atsushi Fukasawa , Takuro Sato , Yasuo Shoji , Haruhiro Shiino , Yukio Suzuki , Hiromi Ando
发明人： Shinichi Sato , Atsushi Fukasawa , Takuro Sato , Yasuo Shoji , Haruhiro Shiino , Yukio Suzuki , Hiromi Ando
IPC分类号： G10L19/04 , G10L19/08
CPC分类号： G10L19/08
摘要： An LPC analyser calculates LPC coefficients using signals bandlimited to half the sampling frequency of the LPC coefficients to be calculated. Thef calculated LPC coefficients are continuous in time scale and free from aliasing distortion. A bandlimiting circuit suitable for use in the LPC analyser is also disclosed.

10. 发明授权

US4772871A Delta sigma modulator circuit for an analog-to-digital converter 失效
标题翻译：用于模数转换器的ΔΣ调制器电路
公开(公告)号：US4772871A
公开(公告)日：1988-09-20
申请号：US46783
申请日：1987-05-07
申请人： Takao Suzuki , Yasuo Shoji , Yuichi Shiraki
发明人： Takao Suzuki , Yasuo Shoji , Yuichi Shiraki
IPC分类号： H03M3/04 , H03M3/02 , H03M1/00
CPC分类号： H03M3/42
摘要： In a delta-sigma modulator for an A/D converter for modulating an analog input signal to produce a modulated signal of a digital form, a first integrator produces a first integral signal indicative of an integral of the difference between the analog input signal and feedback signal, a first delay element delays the first integral signal by one sampling period, a second integrator produces a second integral signal indicative of an integral of the difference between the output of the first delay element and the feedback signal, a first quantizer produces a two-level signal "1" or "0" depending on whether or not the second integral signal is greater than a predetermined reference, and a second quantizer produces a two-level signal "1" or "0" depending on whether or not the first integral signal is greater than a predetermined reference. An output digital signal is produced in accordance with the outputs of the first and the second quantizers. The feedback signal is also produced in accordance with the outputs of the first and the second quantizers.
摘要翻译：在用于调制模拟输入信号以产生数字形式的调制信号的A / D转换器的Δ-Σ调制器中，第一积分器产生指示模拟输入信号和反馈之间的差的积分的第一积分信号信号，第一延迟元件将第一积分信号延迟一个采样周期，第二积分器产生指示第一延迟元件的输出与反馈信号之间的差的积分的第二积分信号，第一量化器产生二 - 根据第二积分信号是否大于预定参考值，第二量化器根据第一和第二信号“1”或“0”是否产生两级信号“1”或“0” 积分信号大于预定参考值。根据第一和第二量化器的输出产生输出数字信号。还根据第一和第二量化器的输出产生反馈信号。

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