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1. 发明授权

US5081112A Method for treating hyperlipidemia 失效
标题翻译：治疗高脂血症的方法
公开(公告)号：US5081112A
公开(公告)日：1992-01-14
申请号：US375632
申请日：1989-07-05
申请人： Kazuhiko Tsutsumi , Tagui Sugimoto , Yoshihiko Tsuda , Eiji Uesaka , Kayoko Shinomiya , Yasuo Shoji , Atsushi Shima
发明人： Kazuhiko Tsutsumi , Tagui Sugimoto , Yoshihiko Tsuda , Eiji Uesaka , Kayoko Shinomiya , Yasuo Shoji , Atsushi Shima
IPC分类号： C12N9/99 , A61K31/66 , A61K31/675 , A61P3/06 , A61P43/00
CPC分类号： A61K31/675 , A61K31/66 , Y10S514/824
摘要： A pharmaceutical composition for treating hyperlipidemia containing, as the active ingredient, at least one carboxamide compounds represented by the formula (1) which possess excellent activities in lowering serum lipid, as well as having low toxicity with high safety.Said carboxamide compounds represented by the formula (1) are known compounds developed by the present inventors, but the pharmacological activities for treating hyperlipidemia have not been found yet.

2. 发明授权

US4971957A Carboxamide compounds, processes for preparing the same and a pharmaceutical composition containing the same 失效
标题翻译：羧酰胺化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US4971957A
公开(公告)日：1990-11-20
申请号：US373837
申请日：1989-06-29
申请人： Kazuhiko Tsutsumi , Eiji Uesaka , Kayoko Shinomiya , Yoshihiko Tsuda , Yauso Shoji , Atsushi Shima
发明人： Kazuhiko Tsutsumi , Eiji Uesaka , Kayoko Shinomiya , Yoshihiko Tsuda , Yauso Shoji , Atsushi Shima
IPC分类号： C07F9/40 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/6506 , C07F9/6509 , C07F9/653 , C07F9/6533 , C07F9/6547
CPC分类号： C07F9/4056 , C07F9/5728 , C07F9/588 , C07F9/591 , C07F9/60 , C07F9/62 , C07F9/65067 , C07F9/650947 , C07F9/650958 , C07F9/653 , C07F9/65335 , C07F9/6547
摘要： Novel carboxamide compounds represented by the general formula (I) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases (hyperlipidemia) such as hypercholesterolemia, hypertriglyceridemia, hyperphospholipidemia, hyperlipacidemia, and the like.
摘要翻译：由通式（I）表示的新型羧酰胺化合物具有优异的脂质降低活性，因此可用作治疗和预防各种疾病（高脂血症）如高胆固醇血症，高甘油三酯血症，高磷脂血症，高脂血症等的药剂。

3. 发明授权

US5376665A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5376665A
公开(公告)日：1994-12-27
申请号：US182145
申请日：1994-01-14
申请人： Kazuyoshi Miyata , Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Naba , Yasuhisa Kurogi
发明人： Kazuyoshi Miyata , Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Naba , Yasuhisa Kurogi
IPC分类号： A61K31/675 , C07F9/6506 , C07F9/653 , C07F9/6541 , C07F9/6561 , C07D235/04 , A61K31/415 , A61K31/44 , C07D221/04
CPC分类号： C07F9/6561 , C07F9/65068 , C07F9/65324 , C07F9/6541
摘要： The invention provides a phosphonic diester derivative of the general formula ##STR1## The phosphonic diester derivative of the invention has hypoglycemic and hypolipidemic activities, for instance, and is of value as an antidiabetic or anti-hyperlipidemic agent.

4. 发明授权

US5480874A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5480874A
公开(公告)日：1996-01-02
申请号：US318860
申请日：1995-01-12
申请人： Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue
发明人： Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue
IPC分类号： A61K31/00 , A61K31/675 , C07F9/6506 , C07F9/6541 , C07F9/6561 , C07F9/28
CPC分类号： C07F9/6561 , C07F9/6541
摘要： The invention provides a phosphonic diester derivative of the formula: ##STR1## wherein the variables are as defined in the specification. The derivative of the invention has excellent hypolipidemic and hypoglycemic activities and little side effects and hence is useful as therapeutic and prophylactic agents for hyperlipidemic diseases and diabetes and as a therapeutic agent for cataract.
摘要翻译：本发明提供下式的膦酸二酯衍生物：其中变量如说明书中所定义。本发明的衍生物具有优异的降血脂和降血糖活性，副作用小，因此可用作高脂血症和糖尿病的治疗和预防剂，并且作为白内障治疗剂。

5. 发明授权

US5618801A Composition for preventing and treating cataract 失效
标题翻译：用于预防和治疗白内障的组合物
公开(公告)号：US5618801A
公开(公告)日：1997-04-08
申请号：US178829
申请日：1994-01-07
申请人： Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Yoshida , Yoshihiko Tsuda
发明人： Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Yoshida , Yoshihiko Tsuda
IPC分类号： A61K31/195 , A61K31/66
CPC分类号： A61K31/683 , Y10S514/912
摘要： The present invention provides an agent for preventing and treating cataract comprising, as an active ingredient, a carboxylic acid amide derivative represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X are as defined above. The present invention has a marked preventive and therapeutic effect on the cataract belonging to various classifications and particularly on the diabetic cataract.
摘要翻译：本发明提供了用于预防和治疗白内障的药剂，其包含作为活性成分的由以下通式表示的羧酸酰胺衍生物：其中R 1，R 2，R 3，R 4和X如上所定义。本发明对属于各种分类，特别是糖尿病性白内障的白内障具有明显的预防和治疗作用。

6. 发明授权

US5527786A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5527786A
公开(公告)日：1996-06-18
申请号：US424345
申请日：1995-04-19
申请人： Kazuyoshi Miyata , Yasuhisa Kurogi , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Takeshi Iwamoto , Chieko Naba
发明人： Kazuyoshi Miyata , Yasuhisa Kurogi , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Takeshi Iwamoto , Chieko Naba
IPC分类号： C07F9/655 , A61K31/675 , A61K31/665 , C07F9/28
CPC分类号： C07F9/65522
摘要： The present invention provides a phosphonic diester derivative of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and they each represent a hydrogen atom, a lower alkyl group, a halogen atom, a cyano group, a hydroxyl group, or a lower alkoxy group optionally having a halogen atom, a phenyl group or a hydroxypiperidino group as a substituent; R.sup.4 represents a hydrogen atom, a lower alkoxy group, a halogen atom, or a lower alkyl group optionally having a halogen atom or a cyano group as a substituent; and R.sup.5 and R.sup.6 are the same or different and they each represent a hydrogen atom or a lower alkyl group.The derivative of the present invention has excellent hypolipidemic, vasodepressor and hypoglycemic activities and is useful as therapeutic and preventive agents for hyperlipidemic diseases, hypertension and diabetes.
摘要翻译： PCT No.PCT / JP94 / 01307 Sec。 371日期1995年04月19日 102（e）1995年4月19日PCT PCT 1994年8月8日PCT公布。出版物WO95 / 06051 日本3月2日公开本发明提供下式的膦酸二酯衍生物：其中R 1，R 2和R 3相同或不同，它们各自表示氢原子，低级烷基，卤素原子，氰基，羟基或任选具有卤素原子的低级烷氧基，苯基或羟基哌啶子基作为取代基; R4表示氢原子，低级烷氧基，卤素原子或任选具有卤素原子或氰基作为取代基的低级烷基; R 5和R 6相同或不同，它们各自表示氢原子或低级烷基。本发明的衍生物具有优异的降血脂，血管抑制剂和降血糖活性，可用作高脂血症和高血压病和糖尿病的治疗和预防剂。

7. 发明申请

US20080186413A1 Video display apparatus 有权
标题翻译：视频显示装置
公开(公告)号：US20080186413A1
公开(公告)日：2008-08-07
申请号：US12003176
申请日：2007-12-20
申请人： Jun Someya , Kazuo Kyuma , Kazuhiko Tsutsumi , Hiroaki Sugiura , Hironobu Yasui
发明人： Jun Someya , Kazuo Kyuma , Kazuhiko Tsutsumi , Hiroaki Sugiura , Hironobu Yasui
IPC分类号： H04N5/66
CPC分类号： H04N5/20 , H04N5/147 , H04N9/68
摘要： A video display apparatus generates luminance information for individual frames of a video signal from histograms of the luminance component of the video signal, and classifies the content of the video signal on the basis of this information. Color saturation information is also generated from color saturation histograms, and scene changes are detected. Video correction parameters and display control parameters are derived from the content classification and color saturation information. The video signal is corrected according to the video correction parameters, and displayed according to the display control parameters. Display characteristics suitable for the video content are thereby obtained. The parameters are changed when a scene change is detected, so that the viewer is not disturbed by the change in video display characteristics.
摘要翻译：视频显示装置从视频信号的亮度分量的直方图生成视频信号的各个帧的亮度信息，并根据该信息对视频信号的内容进行分类。颜色饱和度信息也是从颜色饱和度直方图生成的，并且检测到场景变化。视频校正参数和显示控制参数是从内容分类和色彩饱和度信息中得出的。视频信号根据视频校正参数进行校正，并根据显示控制参数进行显示。从而获得适合于视频内容的显示特性。当检测到场景变化时，参数被改变，使得观看者不受视频显示特征的变化的干扰。

8. 发明授权

US06426620B1 Magnetic field sensing element and device having magnetoresistance element and integrated circuit formed on the same substrate 有权
标题翻译：具有形成在同一衬底上的磁阻元件和集成电路的磁场感测元件和器件
公开(公告)号：US06426620B1
公开(公告)日：2002-07-30
申请号：US09307751
申请日：1999-05-10
申请人： Motohisa Taguchi , Izuru Shinjo , Yuji Kawano , Tatsuya Fukami , Kazuhiko Tsutsumi , Yuuichi Sakai , Naoki Hiraoka , Yasuyoshi Hatazawa
发明人： Motohisa Taguchi , Izuru Shinjo , Yuji Kawano , Tatsuya Fukami , Kazuhiko Tsutsumi , Yuuichi Sakai , Naoki Hiraoka , Yasuyoshi Hatazawa
IPC分类号： G01B700
CPC分类号： G01R33/09
摘要： A magnetic field sensing element comprises an underlayer formed on a substrate, a giant magnetoresistance element formed on the underlayer for detecting a change in a magnetic field, and an integrated circuit formed on the substrate for carrying out predetermined arithmetic processing based on a change in a magnetic field detected by the giant magnetoresistance element, wherein the giant magnetoresistance element and the integrated circuit are formed on the same surface.
摘要翻译：磁场感测元件包括形成在基板上的底层，形成在用于检测磁场变化的底层上的巨磁阻元件，以及形成在基板上的集成电路，用于基于基板上的变化执行预定的算术处理由巨磁阻元件检测的磁场，其中巨磁电阻元件和集成电路形成在同一表面上。

9. 发明授权

US06274571B1 Agent for preventing and curing fatty liver and method for curing thereof 失效
标题翻译：用于预防和治疗脂肪肝的药剂及其固化方法
公开(公告)号：US06274571B1
公开(公告)日：2001-08-14
申请号：US09582765
申请日：2000-06-30
申请人： Kazuhiko Tsutsumi , Yasuhide Inoue
发明人： Kazuhiko Tsutsumi , Yasuhide Inoue
IPC分类号： A61K31662
CPC分类号： A61K31/683
摘要： The present invention provides an agent for preventing and curing fatty liver containing, as the effective ingredient compound, a carboxylic acid amide derivative represented by the general formula (1), (wherein R is a lower alkyl group; and X is a halogen atom), and a method for curing fatty liver by administering said agent.
摘要翻译：本发明提供含有作为有效成分化合物的通式（1）表示的羧酸酰胺衍生物（其中，R为低级烷基，X为卤素原子）的脂肪肝的预防和治疗剂，以及通过施用所述药剂来治疗脂肪肝的方法。

10. 发明授权

US6031231A Infrared focal plane array 失效
标题翻译：红外焦平面阵列
公开(公告)号：US6031231A
公开(公告)日：2000-02-29
申请号：US927407
申请日：1997-09-10
申请人： Masafumi Kimata , Tomohiro Ishikawa , Kazuhiko Tsutsumi , Hisatoshi Hata
发明人： Masafumi Kimata , Tomohiro Ishikawa , Kazuhiko Tsutsumi , Hisatoshi Hata
IPC分类号： G01J1/02 , G01J5/02 , G01J5/10 , G01J5/12 , H01L27/14 , H01L27/146 , H01L35/32 , H01L37/02 , H04N5/33 , G01J5/20
CPC分类号： H01L27/14649 , G01J5/08 , G01J5/0853 , G01J5/10 , H01L37/02
摘要： A two-dimensional infrared focal plane array of temperature detecting units is provided with the temperature detecting units being arranged for every pixel in a two-dimensional arrangement on a semiconductor substrate. Each temperature detecting unit is formed integrally with readout circuitry. Each temperature detecting unit further has a temperature detecting portion which is supported by support legs made of a high thermal resistance material to reduce heat flow to the semiconductor substrate. Each temperature detecting unit also has a temperature detecting element with an infrared ray absorbing portion which is spliced by at least one splicing pillar with the temperature detecting element.
摘要翻译：温度检测单元的二维红外焦平面阵列设置有温度检测单元，其布置在半导体基板上的二维布置中的每个像素。每个温度检测单元与读出电路整体形成。每个温度检测单元还具有温度检测部分，其由由高热阻材料制成的支撑腿支撑，以减少对半导体基板的热流。每个温度检测单元还具有温度检测元件，其具有通过至少一个具有温度检测元件的拼接柱拼接的红外线吸收部分。

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