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    • 1. 发明授权
    • Carbostyril derivatives
    • 卡波他汀衍生物
    • US6143763A
    • 2000-11-07
    • US849664
    • 1997-05-29
    • Yasuo KogaYoshito KiharaMinoru OkadaTakao NishiYoshihiro InoueYukio KimuraHiroyoshi HidakaNorio Fukuda
    • Yasuo KogaYoshito KiharaMinoru OkadaTakao NishiYoshihiro InoueYukio KimuraHiroyoshi HidakaNorio Fukuda
    • C07D215/22C07D215/227A61K31/4704
    • C07D215/227
    • A carbostyril derivative of the formula (1): ##STR1## wherein A is lower alkylene, R is H, halogen or lower alkoxy, R.sup.1 and R.sup.2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl, R.sup.3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that when R and R.sup.3 are H, R.sup.1 and R.sup.2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.
    • PCT No.PCT / JP96 / 02892 Sec。 371日期:1998年5月29日 102(e)日期1998年5月29日PCT提交1996年10月4日PCT公布。 公开号WO97 / 12869 日期:1997年04月10日式(1)的喹诺酮衍生物:其中A为低级亚烷基,R为H,卤素或低级烷氧基,R1和R2各自为低级烷基,任选被OH,低级烷氧基,苯基 - 低级烷氧基 或低级烷酰氧基; 任选被OH,羟基 - 低级烷氧基或低级烷酰氧基取代的环烷基; 或氨基任选被低级烷基或环烷基取代,R 3是H,低级烷基,低级烯基或羟基 - 低级烷基,并且喹诺酮环的3-和4-位之间的键是单或双,条件是当R和 R3是H,R1和R2不应该是未取代的低级烷基或未取代的环烷基或其盐,其显示抗血栓形成活性,内膜增厚抑制活性,血小板质量分解活性和增加脑中血流的活性, 外周血管,因此可用作预防或治疗各种缺血性疾病的药物。
    • 3. 发明授权
    • Optical information recording disk
    • 光信息记录盘
    • US4847827A
    • 1989-07-11
    • US218765
    • 1988-06-28
    • Ryutaro HayashiYukio KimuraToshikazu Yoshino
    • Ryutaro HayashiYukio KimuraToshikazu Yoshino
    • B29C65/00B29C67/00G11B7/24G11B7/26
    • B29C66/342B29C65/02B29C67/004G11B7/24015G11B7/26B29C66/73921B29L2017/005
    • An optical information recording disk is formed by a pair of disk-like substrates with an inner and an outer annular spacer member disposed therebetween. The inner spacer member supports an inner circumferential portion of each of the disk-like substrates, and the outer spacer member supports an outer circumferential portion of each of the disk-like substrates. The spacer members and substrates thus define an interior space. The spacer members and substrates are fixed together by means of a thermosetting adhesive agent. A notched portion is formed in at least one of the space members so as to communicate the interior of the disk with the ambient atmosphere. Thus, during heating of the disk for purposes of joining the substrates and spacers by hardening the adhesive agent, air in the interior space in the disk can escape through the notched portion. After heating, the notched portion is filled with a sealing member such as a solid member or another adhesive agent.
    • 光信息记录盘由一对盘状基板形成,内部和外部环形间隔件设置在其间。 内隔离构件支撑各盘状基板的内周部,外隔离构件支承各盘状基板的外周部。 间隔构件和基底因此限定了内部空间。 间隔件和基底通过热固性粘合剂固定在一起。 在空间构件中的至少一个中形成切口部,以将盘的内部与环境气氛连通。 因此,为了通过硬化粘合剂来连接基板和间隔物,在盘的加热期间,盘中的内部空间中的空气可以通过切口部分逸出。 加热后,切口部分填充有固体部件或其他粘合剂等密封部件。