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1. 发明授权

US06497127B2 Method for supplying rolling oil for cold rolling 有权
标题翻译：冷轧轧制油的方法
公开(公告)号：US06497127B2
公开(公告)日：2002-12-24
申请号：US09991793
申请日：2001-11-05
申请人： Nobuo Nishiura , Yasuhiro Sodani , Yukio Kimura , Hiroyoshi Sakai , Yoshiki Sakurai , Shigehiro Tomotsune
发明人： Nobuo Nishiura , Yasuhiro Sodani , Yukio Kimura , Hiroyoshi Sakai , Yoshiki Sakurai , Shigehiro Tomotsune
IPC分类号： B21B4502
CPC分类号： B21B45/0251 , B21B1/28 , B21B27/10 , B21B37/007 , B21B45/0296 , B21B2265/20 , Y02P70/135
摘要： A method for supplying rolling oil for cold rolling is provided wherein emulsion rolling oil is supplied using both: (i) a first rolling oil supply system for sypplying the emulsion rolling oil to a roll and a steel sheet being rolled in a recirculation mode, and (ii) a second rolling oil supply system for supplying the emulsion rolling oil to only the front and back surface of the stell sheet. The emulsion rolling oil supplied by the first and second supply systems comprise an emulsifier of a same type and concentration, and the second supply system is controlled so that an average particle diameter of emulsion is larger than an average particle diameter of emulsion of the first supply system. The emulsion of the second supply system, which has not stuck onto the steel sheet being rolled, is then joined to the emulsion of the first supply system.
摘要翻译：提供一种用于冷轧的轧制油的方法，其中使用以下两种方式供应乳液轧制油：（i）用于将乳液轧制油施加到辊的第一轧制油供应系统和以循环模式轧制的钢板，以及（ii）第二轧制油供给系统，用于仅将乳化轧制油供给到钢板的前表面和后表面。由第一和第二供应系统供应的乳液轧制油包括相同类型和浓度的乳化剂，并且控制第二供应系统使得乳液的平均粒径大于第一供应的乳液的平均粒径系统。然后，第二供给系统的未粘附在被轧制的钢板上的乳液与第一供给系统的乳液接合。

2. 发明授权

US4931453A Di phenylpyridazine compounds, processes for the preparation thereof and pharmaceutical compositions comprising the same 失效
标题翻译：二苯基哒嗪化合物，其制备方法和包含其的药物组合物
公开(公告)号：US4931453A
公开(公告)日：1990-06-05
申请号：US286169
申请日：1988-12-19
申请人： Hisashi Takasugi , Atsushi Kuno , Hiroyoshi Sakai , Yoshie Sugiyama , Takao Takaya
发明人： Hisashi Takasugi , Atsushi Kuno , Hiroyoshi Sakai , Yoshie Sugiyama , Takao Takaya
IPC分类号： C07D237/10 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/445 , A61K31/455 , A61K31/495 , A61K31/50 , A61K31/535 , A61K31/54 , A61P9/00 , A61P25/28 , C07D211/78 , C07D213/26 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/80 , C07D213/82 , C07D237/04 , C07D237/08 , C07D237/24 , C07D471/04
CPC分类号： C07D213/30 , C07D211/78 , C07D213/26 , C07D213/36 , C07D213/80 , C07D213/82 , C07D237/04 , C07D237/08 , C07D237/24 , C07D471/04
摘要： The invention relates to diphenylpyridazine compounds useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl,R.sup.2 is phenyl substituted with nitro, andR.sup.3 is hydrogen or halogen, or a pharmaceutically acceptable salt thereof.

3. 发明授权

US4990507A N-containing heterocyclic compounds, and composition comprising the same 失效
标题翻译：含氮杂环化合物及其组合物
公开(公告)号：US4990507A
公开(公告)日：1991-02-05
申请号：US294743
申请日：1989-01-09
申请人： Takao Takaya , Hisashi Takasugi , Kimio Esumi , Atsushi Kuno , Hiroyoshi Sakai , Kazuhiro Maeda , Yoshie Sakamoto
发明人： Takao Takaya , Hisashi Takasugi , Kimio Esumi , Atsushi Kuno , Hiroyoshi Sakai , Kazuhiro Maeda , Yoshie Sakamoto
IPC分类号： C07D213/26 , C07D213/30 , C07D213/36 , C07D213/75 , C07D213/80 , C07D213/82 , C07D237/08 , C07D237/24 , C07D413/12 , C07D471/04 , C07D401/12 , A61K31/44
CPC分类号： C07D213/30 , C07D213/26 , C07D213/36 , C07D213/75 , C07D213/80 , C07D213/82 , C07D237/08 , C07D237/24 , C07D413/12 , C07D471/04
摘要： The invention relates to a pharmaceutical composition as a therapeutic agent for ischemic disease comprising a compound of the formula ##STR1## wherein R.sup.1 is carbamoyl substituted with morpholino (lower) alkyl, thiomorpholino(lower)alkyl or lower alkylamino(lower)alkyl; or ureido substituted with lower alkylamino(lower)alkyl; andR.sup.2 is phenyl substituted with nitro, andR.sup.4 is lower alkyl; orR.sup.2 is lower alkyl, andR.sup.4 is phenyl substituted with nitro;with proviso that R.sup.1 is carbamoyl substituted with thiomorpholino(lower)alkyl or lower alkylamino(lower)alkyl; or ureido substituted with lower alkylamino(lower)alkyl when R.sup.4 is lower alkyl; or its salt, as an active ingredient, in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient.
摘要翻译：本发明涉及作为缺血性疾病治疗剂的药物组合物，其包含下式化合物其中R 1是被吗啉代（低级）烷基，硫代吗啉代（低级）烷基或低级烷基氨基（低级）烷基取代的氨基甲酰基）或被低级烷基氨基（低级）烷基取代的脲基; R2是被硝基取代的苯基，R4是低级烷基; 或R 2为低级烷基，R 4为被硝基取代的苯基; 条件是R1是被硫代吗啉代（低级）烷基或低级烷基氨基（低级）烷基取代的氨基甲酰基; 或当R 4为低级烷基时被低级烷基氨基（低级）烷基取代的脲基; 或其盐作为活性成分，与药学上可接受的，基本上无毒的载体或赋形剂结合。

4. 发明授权

US4831030A Diphenylpyridine compounds, processes for the preparation thereof and composition comprising the same 失效
标题翻译：二苯基吡啶化合物，其制备方法和包含其的组合物
公开(公告)号：US4831030A
公开(公告)日：1989-05-16
申请号：US940923
申请日：1986-12-12
申请人： Hisashi Takasugi , Atsushi Kuno , Hiroyoshi Sakai , Yoshie Sugiyama , Takao Takaya
发明人： Hisashi Takasugi , Atsushi Kuno , Hiroyoshi Sakai , Yoshie Sugiyama , Takao Takaya
IPC分类号： C07D237/10 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/445 , A61K31/455 , A61K31/495 , A61K31/50 , A61K31/535 , A61K31/54 , A61P9/00 , A61P25/28 , C07D211/78 , C07D213/26 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/80 , C07D213/82 , C07D237/04 , C07D237/08 , C07D237/24 , C07D471/04
CPC分类号： C07D213/30 , C07D211/78 , C07D213/26 , C07D213/36 , C07D213/80 , C07D213/82 , C07D237/04 , C07D237/08 , C07D237/24 , C07D471/04
摘要： The invention relates to compounds for treatment of hypertension, and cardiovascular and cerebrovascular diseases, which compounds are of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl, andR.sup.3 is hydrogen or halogen;R.sup.2 is phenyl substituted with nitro, andR.sup.4 is lower alkyl or halo(lower)alkyl; orR.sup.2 is lower alkyl, andR.sup.4 is phenyl substitured with nitro;and a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及用于治疗高血压和心血管和脑血管疾病的化合物，其化合物具有下式：其中R 1是哌嗪基（低级）烷基，被哌嗪基（低级）烷基或哌嗪基羰基取代的氨基甲酰基，哌嗪基可以被低级烷基取代，R3是氢或卤素; R2是被硝基取代的苯基，R4是低级烷基或卤代（低级）烷基; 或R2是低级烷基，R4是被硝基取代的苯基; 及其药学上可接受的盐。

5. 发明授权

US4386110A Electrical treatment method of soybean protein 失效
标题翻译：大豆蛋白的电处理方法
公开(公告)号：US4386110A
公开(公告)日：1983-05-31
申请号：US338575
申请日：1982-01-08
申请人： Minoru Komeyasu , Yoshisuke Miura , Hiroyoshi Sakai
发明人： Minoru Komeyasu , Yoshisuke Miura , Hiroyoshi Sakai
IPC分类号： A23J3/16 , C25B3/04
CPC分类号： A23J3/16
摘要： An electrical treatment method for soybean protein is performed in such a manner that a mixture of soybean protein and solvent is set in a first electrolytic tank having a cathode and solvent is set in a second electrolytic tank which is separated from above electrolytic tank by a diaphram or a salt bridge and is provided with an anode and DC voltage is given between the two electrodes for electrolytic treatment for soybean protein. The soybean protein's quality can be significantly improved.
摘要翻译：大豆蛋白的电处理方法是将大豆蛋白和溶剂的混合物置于具有阴极的第一电解槽和溶剂中的情况下，将其置于第二电解槽中，所述第二电解槽与上述电解槽分隔开，或盐桥，并且设置有阳极，并且在用于大豆蛋白质的电解处理的两个电极之间提供DC电压。大豆蛋白的质量可以显着提高。

6. 发明授权

US06380215B1 Beta-alanine derivative and a process for the preparation thereof 失效
标题翻译： β-丙氨酸衍生物及其制备方法
公开(公告)号：US06380215B1
公开(公告)日：2002-04-30
申请号：US08495572
申请日：1995-08-04
申请人： Mitsuru Ohkubo , Fumie Takahashi , Toshio Yamanaka , Hiroyoshi Sakai , Masayuki Kato
发明人： Mitsuru Ohkubo , Fumie Takahashi , Toshio Yamanaka , Hiroyoshi Sakai , Masayuki Kato
IPC分类号： A61K314545
CPC分类号： C07D401/06 , C07D211/56 , C07D211/60 , C07D405/14 , C07D413/06 , Y02P20/55
摘要： This invention relates to &bgr;-alanine derivatives represented by the following formula: wherein each symbol is as defined in the specification and pharmaceutically acceptable salt thereof which is glycoprotein IIb/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.
摘要翻译：本发明涉及由下式表示的β-丙氨酸衍生物：其中每个符号如说明书中所定义，其药学上可接受的盐是糖蛋白IIb / IIIa拮抗剂，血小板聚集抑制剂和纤维蛋白原与血液结合的抑制剂血小板，其制备方法，包含其的药物组合物以及用于预防和/或治疗本说明书中针对人或动物的疾病的方法。

7. 发明授权

US5574016A Peptide compound and a process for the preparation thereof 失效
标题翻译：肽化合物及其制备方法
公开(公告)号：US5574016A
公开(公告)日：1996-11-12
申请号：US446288
申请日：1995-05-22
申请人： Hisashi Takasugi , Akito Tanaka , Hiroyoshi Sakai , Takatoshi Ishikawa
发明人： Hisashi Takasugi , Akito Tanaka , Hiroyoshi Sakai , Takatoshi Ishikawa
IPC分类号： A61K38/00 , A61P7/02 , A61P35/00 , C07C237/22 , C07K1/02 , C07K1/06 , C07K1/113 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/11 , C07K14/75 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K5/06113 , C07K14/75 , C07K5/06104 , C07K5/0806 , C07K5/1019 , A61K38/00 , Y10S514/822
摘要： The present invention concerns glycoprotein IIa/IIIb antagonists and platelet aggregation inhibitors of the formula (I): ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s),R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is carboxy or protected carboxy,A.sup.1 is alkylene which may have one or more suitable substituent(s),A.sup.2 is a group of the formula: ##STR2## (wherein R is lower alkyl), or a group of the formula:--NHCH.sub.2 CH.sub.2 CO--,A.sup.3 is lower alkylene which may have one or more suitable substituent(s),l, m and n are each the same or different an integer of 0 or 1,with proviso that A.sup.2 is not a group of the formula:--NHCH.sub.2 CH.sub.2 CO--,when l is an integer of 0.
摘要翻译：本发明涉及式（I）的糖蛋白IIa / IIIb拮抗剂和血小板聚集抑制剂：其中R 1为可具有一个或多个合适取代基的芳基，R 2为羧基（低级）烷基或保护的羧基（低级）烷基，R3是羧基或保护的羧基，A1是可以具有一个或多个合适取代基的亚烷基，A2是下式的基团：其中R是低级烷基，或基团：-NHCH 2 CH 2 CO-，A3是可具有一个或多个合适取代基的低级亚烷基，l，m和n各自相同或不同，为0或1的整数，条件是A2不是基团：-NHCH 2 CH 2 CO-，当l是0的整数时。

8. 发明授权

US5037824A N-containing heterocyclic compounds, compositions and use 失效
标题翻译：含氮杂环化合物，组合物和用途
公开(公告)号：US5037824A
公开(公告)日：1991-08-06
申请号：US489536
申请日：1990-03-07
申请人： Hisashi Takasugi , Atsushi Kuno , Hiroyoshi Sakai
发明人： Hisashi Takasugi , Atsushi Kuno , Hiroyoshi Sakai
IPC分类号： C07D213/73 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D405/04 , C07D409/04 , C07D413/04
CPC分类号： C07D213/73 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D405/04 , C07D409/04 , C07D413/04
摘要： The invention relates to cardioprotective compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2 R.sup.3 and R.sup.4 are moieties as described in the specification.

9. 发明授权

US4857527A Morpholine containing pyridine compounds, compositions and use 失效
标题翻译：含有吡啶化合物的吗啉，组成和用途
公开(公告)号：US4857527A
公开(公告)日：1989-08-15
申请号：US184195
申请日：1988-04-21
申请人： Takao Takaya , Hisashi Takasugi , Kimio Esumi , Atsushi Kuno , Hiroyoshi Sakai , Kazuhiro Maeda , Yoshie Sakamoto
发明人： Takao Takaya , Hisashi Takasugi , Kimio Esumi , Atsushi Kuno , Hiroyoshi Sakai , Kazuhiro Maeda , Yoshie Sakamoto
IPC分类号： C07D213/82
CPC分类号： C07D213/82
摘要： An N-containing heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted with hydroxy, halogen or a heterocyclic group, carboxy, esterified carboxy, carbamoyl optionally substituted with heterocyclic(lower)alkyl or lower alkylamino(lower)alkyl, N-containing heterocycliccarbonyl optionally substituted with lower alkyl, or ureido optionally substituted with lower alkylamino(lower)alkyl, andR.sup.3 is hydrogen or halogen;R.sup.2 is phenyl substituted with nitro, andX is .dbd.N--or ##STR2## in which R.sup.4 is lower alkyl or halo(lower)alkyl, or is taken together with R.sup.1 to form an N-containing heterocyclic group optionally substituted with oxo and lower alkylamino(lower)alkyl; orR.sup.2 is lower alkyl, andX is ##STR3## in which R.sup.4 is phenyl substituted with nitro; and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical (e.g. antihypertension) compositions comprising the same.
摘要翻译：含有下式的杂环化合物：其中R 1为任选被羟基，卤素或杂环基取代的低级烷基，羧基，酯化羧基，任选被杂环（低级）烷基或低级烷基氨基（低级）烷基取代的氨基甲酰基，任选被低级烷基取代的含N杂环羰基或任选被低级烷基氨基（低级）烷基取代的脲基，R 3为氢或卤素; R 2为被硝基取代的苯基，X为= N-或其中R 4为低级烷基或卤代（低级）烷基），或与R 1一起形成任选被氧代取代的含氮杂环基烷基氨基（低级）烷基; 或R2是低级烷基，X是其中R4是被硝基取代的苯基; 和其药学上可接受的盐，其制备方法和包含其的药物（例如抗高血压）组合物。

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