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1. 发明授权

US06926884B2 GPIb-lipid bond construct and use thereof 失效
标题翻译： GPIb-脂质结合构型及其用途
公开(公告)号：US06926884B2
公开(公告)日：2005-08-09
申请号：US10220610
申请日：2001-03-02
申请人： Yasuo Ikeda , Hiroshi Saito , Hiromichi Mukai , Yoshiyuki Mori , Mitsuru Murata
发明人： Yasuo Ikeda , Hiroshi Saito , Hiromichi Mukai , Yoshiyuki Mori , Mitsuru Murata
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , A61K49/14 , A61K51/08 , A61P7/02 , A61P7/04 , A61P9/00 , A61P29/00 , C07K14/705 , A61K38/14 , A61K47/34 , C07K14/475
CPC分类号： C07K14/705 , A61K38/00 , A61K47/544 , A61K47/60 , A61K47/64 , A61K47/6911 , A61K49/0002 , A61K49/085 , A61K49/14
摘要： The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing this conjugate and a free lipid. The GPIb lipid complex is expected to have a potential for practical application in a wide range, as a platelet substitute, a pharmaceutical agent for the prophylaxis or treatment of angiopathy, vascular damage and thrombosis, a diagnostic for vWF deficiency and the like, a biological or medical reagent, a reagent for screening platelet aggregation suppressant or antithrombosis, and the like. The GPIb lipid complex of the present invention is also useful as a diagnostic for finding the location of vascular lesion or thrombus formation, or a therapeutic agent thereof. Moreover, the GPIb lipid complex of the present invention is also superior in retention property in blood, which enables continuous expression of a pharmacological action. The conjugate of the present invention is highly utilizable as an active ingredient of the GPIb lipid complex of the present invention.
摘要翻译：本发明提供了通过聚环氧烷键合GP（糖蛋白）1b和脂质的结合物。本发明还提供了含有该缀合物和游离脂质的复合物（GPIb脂质复合物）。预期GPIb脂质复合物在广泛范围内具有实际应用的潜力，作为血小板替代物，用于预防或治疗血管病，血管损伤和血栓形成的药剂，对vWF缺乏症的诊断等，生物或医用试剂，用于筛选血小板聚集抑制剂或抗血栓形成的试剂等。本发明的GPIb脂质复合物也可用作诊断血管损伤或血栓形成的位置，或其治疗剂。此外，本发明的GPIb脂质复合物在血液中的保留性也优异，能够连续表达药理作用。本发明的缀合物作为本发明的GPIb脂质复合物的活性成分是高度可利用的。

2. 发明授权

US06177059B1 GPIb-lipid complex and uses thereof 失效
标题翻译： GPIb-脂质复合物及其用途
公开(公告)号：US06177059B1
公开(公告)日：2001-01-23
申请号：US09117746
申请日：1998-12-03
申请人： Hiroshi Matsuda , Kaeko Kamide , Yasuo Amatsuji , Takashi Imagawa , Yasuo Ikeda , Mitsuru Murata
发明人： Hiroshi Matsuda , Kaeko Kamide , Yasuo Amatsuji , Takashi Imagawa , Yasuo Ikeda , Mitsuru Murata
IPC分类号： A61K9127
CPC分类号： A61K9/1271 , A61K38/00 , A61K47/62 , A61K47/6911 , C07K14/705 , C07K14/70596
摘要： A complex comprising a lipid and a conjugate of GPIb and lipid having a functional group, and use thereof. The GPIb-lipid complex of the present invention is extremely useful as a platelet substitute, a pharmaceutical agent for the prophylaxis and treatment of angiopathy, vascular damages and thrombosis, a diagnostic for vWF deficiency and the like, a biological or medical reagent, a reagent for screening platelet aggregation suppressant or antithrombosis, and the like. The GPIb-lipid complex of the present invention is also useful as a diagnostic for finding the location of vascular lesion or thrombus formation, or a therapeutic agent therefor, since it accumulates at vascular lesions.
摘要翻译：包含脂质和GPIb和具有官能团的脂质的缀合物的复合物及其用途。本发明的GPIb-脂质复合物作为血小板替代物，预防和治疗血管病，血管损伤和血栓形成的药剂，vWF缺乏症的诊断等，生物或医学试剂，试剂用于筛选血小板聚集抑制剂或抗血栓形成等。本发明的GPIb-脂质复合物也可用作诊断血管损伤或血栓形成的位置，或其治疗剂，因为它在血管损伤中积聚。

3. 发明申请

US20090291439A1 PHOSPHATASES INVOLVED IN THE REGULATION OF CARDIOMYOCYTE DIFFERENTIATION 失效
标题翻译：参与调节心肌细胞分化的磷酸酶
公开(公告)号：US20090291439A1
公开(公告)日：2009-11-26
申请号：US12296407
申请日：2007-04-12
申请人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
发明人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/16 , C12N15/63 , C12N5/10 , C12P13/04 , C07K16/00
CPC分类号： C12N9/99 , A61K38/00 , C07K16/40 , C12N5/0657 , C12N9/16 , C12N2501/70 , G01N2500/10
摘要： An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use thereof. A protein or the like consisting of any one of the following amino acid sequences (A) to (C) is used:(A) the amino acid sequence of SEQ ID NO:2; (B) an amino acid sequence wherein one or several amino acids except for cysteine at position 138 are deleted, substituted or added in the amino acid sequence of SEQ ID NO:2, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity; and (C) an amino acid sequence having at least 60% or more homology to the amino acid sequence of SEQ ID NO:2 and having cysteine at position 138, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity.
摘要翻译：本发明的目的是提供调节心肌细胞分化的脱磷酸酶，其显性失活酶，编码酶蛋白的基因及其用途。使用由下列氨基酸序列（A）至（C）中任一项构成的蛋白质：（A）SEQ ID NO：2的氨基酸序列; （B）氨基酸序列，其中138位的半胱氨酸以外的一个或几个氨基酸被缺失，取代或加入到SEQ ID NO：2的氨基酸序列中，其中由氨基酸序列组成的蛋白具有双重特异性磷酸酶活性; 和（C）与SEQ ID NO：2的氨基酸序列具有至少60％以上同源性并且在138位具有半胱氨酸的氨基酸序列，其中由氨基酸序列组成的蛋白具有双特异性磷酸酶活性。

4. 发明授权

US08105803B2 Phosphatases involved in the regulation of cardiomyocyte differentiation 失效
标题翻译：参与调节心肌细胞分化的磷酸酶
公开(公告)号：US08105803B2
公开(公告)日：2012-01-31
申请号：US12296407
申请日：2007-04-12
申请人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
发明人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
IPC分类号： C12P21/06 , C07K14/00
CPC分类号： C12N9/99 , A61K38/00 , C07K16/40 , C12N5/0657 , C12N9/16 , C12N2501/70 , G01N2500/10
摘要： An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use thereof. A protein or the like consisting of any one of the following amino acid sequences (A) to (C) is used: (A) the amino acid sequence of SEQ ID NO:2; (B) an amino acid sequence wherein one or several amino acids except for cysteine at position 138 are deleted, substituted or added in the amino acid sequence of SEQ ID NO:2, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity; and (C) an amino acid sequence having at least 60% or more homology to the amino acid sequence of SEQ ID NO:2 and having cysteine at position 138, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity.
摘要翻译：本发明的目的是提供调节心肌细胞分化的脱磷酸酶，其显性失活酶，编码酶蛋白的基因及其用途。使用由下列氨基酸序列（A）至（C）中任一项构成的蛋白质：（A）SEQ ID NO：2的氨基酸序列; （B）氨基酸序列，其中138位的半胱氨酸以外的一个或几个氨基酸被缺失，取代或加入到SEQ ID NO：2的氨基酸序列中，其中由氨基酸序列组成的蛋白具有双重特异性磷酸酶活性; 和（C）与SEQ ID NO：2的氨基酸序列具有至少60％以上同源性并且在138位具有半胱氨酸的氨基酸序列，其中由氨基酸序列组成的蛋白具有双特异性磷酸酶活性。

5. 发明申请

US20120200364A1 OSCILLATOR AND SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE 有权
标题翻译：振荡器和半导体集成电路器件
公开(公告)号：US20120200364A1
公开(公告)日：2012-08-09
申请号：US13364903
申请日：2012-02-02
申请人： Yoichi Iizuka , Yasuo Ikeda , Satoshi Inishi
发明人： Yoichi Iizuka , Yasuo Ikeda , Satoshi Inishi
IPC分类号： H03B5/12
CPC分类号： H03B5/1212 , H03B1/00 , H03B5/1228 , H03B5/1253 , H03L1/026
摘要： An oscillator and a semiconductor integrated circuit device with an internal oscillator capable of compensating the temperature characteristics even when there is a large parasitic capacitance too large to ignore directly between the output terminals of the oscillator. In an oscillator containing an inductance element L, and a capacitive element C, and an amplifier each coupled in parallel across a first and second terminal, the amplifier amplifies the resonance generated by the inductance element and capacitive element and issues an output from the first terminal and the second terminal, and in which a first resistance element with a larger resistance value than the parasitic resistance of the inductance element between the first terminal and the second terminal, is coupled in serial with the capacitive element between the first terminal and the second terminal.
摘要翻译：具有能够补偿温度特性的内部振荡器的振荡器和半导体集成电路器件，即使存在大的寄生电容也不能直接忽略振荡器的输出端子之间。在包含电感元件L和电容元件C的振荡器以及各自并联跨越第一和第二端子的放大器中，放大器放大由电感元件和电容元件产生的谐振，并从第一端子发出输出并且其中具有比第一端子和第二端子之间的电感元件的寄生电阻更大的电阻值的第一电阻元件与第一端子和第二端子之间的电容元件串联耦合。

6. 发明申请

US20100004117A1 METAL OXIDE CATALYST CARRIER PARTICLE AND EXHAUST GAS PURIFICATION CATALYST 失效
标题翻译：金属氧化物催化剂载体颗粒和排气净化催化剂
公开(公告)号：US20100004117A1
公开(公告)日：2010-01-07
申请号：US12295454
申请日：2007-03-30
申请人： Masahide Miura , Nobuyuki Takagi , Shinichi Matsumoto , Toshitaka Tanabe , Yasutaka Nagai , Kazuhiko Dohmae , Yasuo Ikeda
发明人： Masahide Miura , Nobuyuki Takagi , Shinichi Matsumoto , Toshitaka Tanabe , Yasutaka Nagai , Kazuhiko Dohmae , Yasuo Ikeda
IPC分类号： B01J20/34 , B01J23/42 , B01J23/10
CPC分类号： B01J37/0221 , B01D53/945 , B01D2255/206 , B01J23/63 , B01J35/008 , B01J35/026 , B01J35/10 , B01J35/1014 , B01J37/0234 , Y02T10/22 , Y10T428/2991
摘要： A metal oxide catalyst carrier particle has a center portion and an outer skin portion each containing a first metal oxide and a second metal oxide. The center portion and the outer skin portion are different in composition. The mole fraction of the metal of the first metal oxide is higher in the center portion than in the outer skin portion and the mole fraction of the metal of the second metal oxide is higher in the outer skin portion than in the center portion. The second metal oxide is selected from the group consisting of rare earth oxides, except for ceria, and alkali earth metal oxides. In addition, platinum is supported on the metal oxide catalyst carrier particle, thus forming an exhaust gas purification catalyst.
摘要翻译：金属氧化物催化剂载体颗粒具有分别含有第一金属氧化物和第二金属氧化物的中心部分和外皮部分。中心部分和外皮部分的组成不同。第一金属氧化物的金属的摩尔分数在中心部分高于外皮部分，并且第二金属氧化物的金属的摩尔分数在外皮部分比在中心部分高。第二金属氧化物选自除二氧化铈以外的稀土氧化物和碱土金属氧化物。此外，铂负载在金属氧化物催化剂载体颗粒上，从而形成废气净化催化剂。

7. 发明授权

US07294154B2 Microorganism staining agent and use thereof 有权
标题翻译：微生物染色剂及其用途
公开(公告)号：US07294154B2
公开(公告)日：2007-11-13
申请号：US10554285
申请日：2004-04-08
申请人： Koji Nashimoto , Kazuya Ishida , Yasuo Ikeda , Yoshiaki Hanaoka
发明人： Koji Nashimoto , Kazuya Ishida , Yasuo Ikeda , Yoshiaki Hanaoka
IPC分类号： D06P1/00 , D06P1/12 , C09B23/14
CPC分类号： G01N1/30 , C09B67/0083
摘要： A microorganism staining agent characterized in that an alkali substance and a diazo dye or xanthene dye are contained therein; and a method of detecting microorganisms with the use of the agent. There are provided a microorganism staining agent which resolves the problem of pretreatment posed by the conventional direct speculum method, being capable of staining microorganisms in shorter time; and a method of detecting microorganisms with the use of the agent.
摘要翻译：一种微生物染色剂，其特征在于，含有碱物质和重氮染料或呫吨染料; 以及使用该试剂检测微生物的方法。提供了一种微生物染色剂，其解决了常规直接窥器法预处理的问题，能够在较短时间内对微生物进行染色; 以及使用该试剂检测微生物的方法。

8. 发明申请

US20050186161A1 Antifungal and/or antimycotic external preparation for nail 审中-公开
标题翻译：用于指甲的抗真菌和/或抗真菌外用剂
公开(公告)号：US20050186161A1
公开(公告)日：2005-08-25
申请号：US10781908
申请日：2004-02-20
申请人： Ichiro Kawase , Yasuo Ikeda , Kousuke Hara , Takashi Narui , Tetsuo Kaneko
发明人： Ichiro Kawase , Yasuo Ikeda , Kousuke Hara , Takashi Narui , Tetsuo Kaneko
IPC分类号： A61K31/4164 , A61K8/49 , A61K9/00 , A61K31/4174 , A61K31/4178 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/26 , A61P31/10 , A61Q3/00 , A61K7/04
CPC分类号： A61K8/4946 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61Q3/00
摘要： An antifungal and/or antimycotic external preparation for nail, which comprises neticonazole or a salt thereof and a basic substance.
摘要翻译：用于指甲的抗真菌和/或抗真菌外用制剂，其包含苯环康唑或其盐和碱性物质。

9. 发明授权

US06461579B1 Catalyst for purifying exhaust gas and exhaust gas purifying method 失效
标题翻译：废气净化催化剂和废气净化方法
公开(公告)号：US06461579B1
公开(公告)日：2002-10-08
申请号：US09555384
申请日：2000-07-21
申请人： Ichiro Hachisuka , Yasuo Ikeda
发明人： Ichiro Hachisuka , Yasuo Ikeda
IPC分类号： B01D5394
CPC分类号： B01D53/945 , B01D53/8628 , B01J23/002 , B01J23/464 , B01J23/58 , B01J23/63 , B01J35/0006 , B01J35/023 , B01J37/0248 , B01J2523/00 , Y02T10/22 , B01J2523/11 , B01J2523/13 , B01J2523/23 , B01J2523/25 , B01J2523/31 , B01J2523/47 , B01J2523/48 , B01J2523/822 , B01J2523/828 , B01J2523/3706
摘要： A catalyst for purifying exhaust of an internal combustion engine is prepared by mixing first powders in which at least Pt is loaded on a first support and second powders in which at least Rh is loaded on a second support and loading NOx occluding material, for example an alkaline-earth metal, alkali metal or rare-earth metal, at least on the first support. In such catalyst, the second support is made of a stabilized zirconia stabilized by alkaline-earth metal or rare-earth element. The second support, having been become alkaline by the alkaline-earth metal or the rare-earth element, is excellent in absorbing performance of the steam (H2O), so that the steam reforming reaction by Rh advances sufficiently. Therefore, the created hydrogen greatly contributes to the reduction of NOx and to the sulfur poisoning prevention of the NOx occluding material. Also, the oxidizing ability of Pt is maintained high, Rh sufficiently exhibits the steam reforming reaction activity and the sulfur poisoning of NOx occluding material is restrained. An exhaust gas from an internal combustion engine is combusted where mixed gas of rich atmosphere containing excessive fuel is supplied to mixed gas of lean atmosphere containing excessive oxygen like a pulse. The exhaust gas is then introduced to the catalyst wherein the exhaust gas is purified.
摘要翻译：用于净化内燃机的排气的催化剂是通过混合其中至少将Pt装载在第一载体上的第一种粉末和其中至少将Rh装载在第二载体上的第二种粉末和装载NO x吸留材料，例如碱土金属，碱金属或稀土金属，至少在第一载体上。在这种催化剂中，第二载体由稳定的由碱土金属或稀土元素稳定的氧化锆制成。通过碱土金属或稀土元素变成碱性的第二载体具有优异的蒸气（H 2 O）吸收性能，使得Rh的蒸汽重整反应充分进行。因此，所产生的氢气大大有助于NOx的还原和防止NOx吸留材料的硫中毒。此外，Pt的氧化能力保持较高，Rh充分显示出蒸汽重整反应活性，并且抑制了NOx吸留材料的硫中毒。在含有过量燃料的富含气体的混合气体被供给到含有过量的氧气的稀薄气体的混合气体中的情况下，来自内燃机的废气燃烧。然后将废气引入催化剂，其中净化废气。

10. 发明授权

US06455053B1 Quickly soluble solid preparations 失效
标题翻译：快速溶解固体制剂
公开(公告)号：US06455053B1
公开(公告)日：2002-09-24
申请号：US09509988
申请日：2000-05-24
申请人： Minoru Okada , Yasuo Ikeda , Kenji Ono , Toshiaki Kurazumi , Syuichi Kasai , Katsumi Imamori
发明人： Minoru Okada , Yasuo Ikeda , Kenji Ono , Toshiaki Kurazumi , Syuichi Kasai , Katsumi Imamori
IPC分类号： A61K900
CPC分类号： A61K9/2095 , A61K9/0056
摘要： An orally administrable uncompressed rapidly dissolving molded dosage form comprises a drug and either one or more saccharides or one saccharide and polyvinylpyrrolidone. Saccarides are chosen and used in proportion based on their solubilities. Methods for producing uncompressed rapidly dissolving solid preparations comprise mixing a drug and carriers according to the present invention and charging the mixture in a mold. Rapidly dissolving oral dosage forms facilitate administration of drugs to patients having a difficulty in swallowing such as children and the elderly.
摘要翻译：口服给药的未压缩的快速溶解的模塑剂型包含药物和一种或多种糖或一种糖和聚乙烯吡咯烷酮。根据其溶解度选择和使用Saccarides成比例地使用。用于生产未压缩的快速溶解固体制剂的方法包括混合根据本发明的药物和载体，并将混合物装入模具中。快速溶解的口服剂型有助于向吞咽困难的患者（如儿童和老人）投放药物。

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