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1. 发明申请

US20110143950A1 Diagnosis/Treatment Option for Head-and-Neck Tumor Using Micro-RNA as Biomarker 有权
标题翻译：使用微RNA作为生物标志物的头颈部肿瘤的诊断/治疗选择
公开(公告)号：US20110143950A1
公开(公告)日：2011-06-16
申请号：US12996420
申请日：2009-06-10
申请人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Hideki Naganishi
发明人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Hideki Naganishi
IPC分类号： C40B30/00 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178
摘要： Disclosed are: a method for using a particular microRNA as a biomarker for head-and-neck tumor; a method for the determination of head-and-neck tumor; a kit for the determination of head-and-neck tumor, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21, miR-31, miR-133b, miR-145 and miR-375 is used as a biomarker for head-and-neck tumor.
摘要翻译：公开的是：使用特定的微RNA作为头颈部肿瘤的生物标志物的方法; 一种确定头颈部肿瘤的方法; 用于确定头颈部肿瘤的试剂盒等。本发明的特征在于，选自miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR- 21，miR-31，miR-133b，miR-145和miR-375用作头颈部肿瘤的生物标志物。

2. 发明授权

US08512949B2 Diagnosis/treatment option for head-and-neck tumor using micro-RNA as biomarker 有权
标题翻译：使用微RNA作为生物标志物的头颈部肿瘤的诊断/治疗选择
公开(公告)号：US08512949B2
公开(公告)日：2013-08-20
申请号：US12996420
申请日：2009-06-10
申请人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Hideki Naganishi
发明人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Hideki Naganishi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178
摘要： Disclosed are: a method for using a particular microRNA as a biomarker for head-and-neck tumor; a method for the determination of head-and-neck tumor; a kit for the determination of head-and-neck tumor, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21, miR-31, miR-133b, miR-145 and miR-375 is used as a biomarker for head-and-neck tumor.
摘要翻译：公开的是：使用特定的微RNA作为头颈部肿瘤的生物标志物的方法; 一种确定头颈部肿瘤的方法; 用于确定头颈部肿瘤的试剂盒等。本发明的特征在于，选自miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR- 21，miR-31，miR-133b，miR-145和miR-375用作头颈部肿瘤的生物标志物。

3. 发明授权

US08420800B2 Head-and-neck tumor proliferation inhibitor 失效
标题翻译：头颈肿瘤增生抑制剂
公开(公告)号：US08420800B2
公开(公告)日：2013-04-16
申请号：US13263800
申请日：2010-04-16
申请人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Koji Inagaki
发明人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Koji Inagaki
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： A61K31/7088 , A61K31/713 , C12N15/113 , C12N2310/113 , C12N2310/141
摘要： It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.
摘要翻译：它提供了一种新型的头颈部肿瘤增殖抑制剂，头颈部肿瘤转移抑制剂和用于治疗头颈部肿瘤的药物组合物。本发明的特征在于使用在头颈部肿瘤中其表达降低的头颈部肿瘤和/或其表达降低的促进物质的microRNA的抑制物质。在头颈部肿瘤中表达增加的微小RNA的优选实例包括miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR-21和 miR-31。在头颈部肿瘤中表达降低的微小RNA的优选实例包括miR-133b，miR-145和miR-375。

4. 发明授权

US08105803B2 Phosphatases involved in the regulation of cardiomyocyte differentiation 失效
标题翻译：参与调节心肌细胞分化的磷酸酶
公开(公告)号：US08105803B2
公开(公告)日：2012-01-31
申请号：US12296407
申请日：2007-04-12
申请人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
发明人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
IPC分类号： C12P21/06 , C07K14/00
CPC分类号： C12N9/99 , A61K38/00 , C07K16/40 , C12N5/0657 , C12N9/16 , C12N2501/70 , G01N2500/10
摘要： An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use thereof. A protein or the like consisting of any one of the following amino acid sequences (A) to (C) is used: (A) the amino acid sequence of SEQ ID NO:2; (B) an amino acid sequence wherein one or several amino acids except for cysteine at position 138 are deleted, substituted or added in the amino acid sequence of SEQ ID NO:2, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity; and (C) an amino acid sequence having at least 60% or more homology to the amino acid sequence of SEQ ID NO:2 and having cysteine at position 138, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity.
摘要翻译：本发明的目的是提供调节心肌细胞分化的脱磷酸酶，其显性失活酶，编码酶蛋白的基因及其用途。使用由下列氨基酸序列（A）至（C）中任一项构成的蛋白质：（A）SEQ ID NO：2的氨基酸序列; （B）氨基酸序列，其中138位的半胱氨酸以外的一个或几个氨基酸被缺失，取代或加入到SEQ ID NO：2的氨基酸序列中，其中由氨基酸序列组成的蛋白具有双重特异性磷酸酶活性; 和（C）与SEQ ID NO：2的氨基酸序列具有至少60％以上同源性并且在138位具有半胱氨酸的氨基酸序列，其中由氨基酸序列组成的蛋白具有双特异性磷酸酶活性。

5. 发明申请

US20120088816A1 Head-And-Neck Tumor Proliferation Inhibitor 失效
标题翻译：头颈肿瘤增生抑制剂
公开(公告)号：US20120088816A1
公开(公告)日：2012-04-12
申请号：US13263800
申请日：2010-04-16
申请人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Koji Inagaki
发明人： Takeru Zama , Koichiro Saito , Akira Hirasawa , Koji Inagaki
IPC分类号： A61K31/713 , A61P35/00 , A61P35/04 , C07H21/02
CPC分类号： A61K31/7088 , A61K31/713 , C12N15/113 , C12N2310/113 , C12N2310/141
摘要： It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.
摘要翻译：它提供了一种新型的头颈部肿瘤增殖抑制剂，头颈部肿瘤转移抑制剂和用于治疗头颈部肿瘤的药物组合物。本发明的特征在于使用在头颈部肿瘤中其表达降低的头颈部肿瘤和/或其表达降低的促进物质的微小RNA的抑制物质。在头颈部肿瘤中表达增加的微小RNA的优选实例包括miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR-21和 miR-31。在头颈部肿瘤中表达降低的微小RNA的优选实例包括miR-133b，miR-145和miR-375。

6. 发明申请

US20110166041A1 Diagnosis/Therapeutic Strategy For Gynecological Cancer by Utilizing Micro-RNA as Biomarker 审中-公开
标题翻译：通过利用微RNA作为生物标志物进行妇科癌症诊断/治疗策略
公开(公告)号：US20110166041A1
公开(公告)日：2011-07-07
申请号：US12999124
申请日：2009-06-25
申请人： Takeru Zama , Akira Hirasawa , Koichiro Saito , Tomoko Akahane
发明人： Takeru Zama , Akira Hirasawa , Koichiro Saito , Tomoko Akahane
IPC分类号： C40B40/06 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2330/10 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： Disclosed are: a method for using a particular microRNA as a biomarker for gynecological cancer; a method for the determination of gynecological cancer; a kit for the determination of gynecological cancer, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-592, miR-629*, miR-517a, miR-205, miR-184, miR-509-5p, miR-135a*, miR-137, miR-602, miR-186*, miR-181a-2*, miR-193b*, miR-377*, miR-449b, miR-449a, miR-369-3p, miR-323-3p, miR-329, miR-299-5p, miR-34b, miR-411, miR-34c-5p, miR-376b, miR-885-5p, miR-337-3p, miR-337-5p, miR-127-3p, miR-138, miR-203, miR-488, miR-489, miR-643, miR-888, miR-424, miR-432, miR-433, miR-450a, miR-503, miR-542-3p, miR-542-5p and miR-584 is used as a biomarker for gynecological cancer.
摘要翻译：公开的是：使用特定微小RNA作为妇科癌症生物标志物的方法; 确定妇科癌症的方法; 用于确定妇科癌症的试剂盒等。本发明的特征在于，至少一种选自miR-592，miR-629 *，miR-517a，miR-205，miR-184，miR-509-5p，miR-135a * ，miR-137，miR-602，miR-186 *，miR-181a-2 *，miR-193b *，miR-377 *，miR-449b，miR-449a，miR-369-3p，miR-323-3p ，miR-329，miR-299-5p，miR-34b，miR-411，miR-34c-5p，miR-376b，miR-885-5p，miR-337-3p，miR-337-5p，miR-127 -3p，miR-138，miR-203，miR-488，miR-489，miR-643，miR-888，miR-424，miR-432，miR-433，miR-450a，miR-503，miR-542 -3p，miR-542-5p和miR-584用作妇科癌症的生物标志物。

7. 发明申请

US20090291439A1 PHOSPHATASES INVOLVED IN THE REGULATION OF CARDIOMYOCYTE DIFFERENTIATION 失效
标题翻译：参与调节心肌细胞分化的磷酸酶
公开(公告)号：US20090291439A1
公开(公告)日：2009-11-26
申请号：US12296407
申请日：2007-04-12
申请人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
发明人： Takeru Zama , Mitsuru Murata , Yasuo Ikeda
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/16 , C12N15/63 , C12N5/10 , C12P13/04 , C07K16/00
CPC分类号： C12N9/99 , A61K38/00 , C07K16/40 , C12N5/0657 , C12N9/16 , C12N2501/70 , G01N2500/10
摘要： An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use thereof. A protein or the like consisting of any one of the following amino acid sequences (A) to (C) is used:(A) the amino acid sequence of SEQ ID NO:2; (B) an amino acid sequence wherein one or several amino acids except for cysteine at position 138 are deleted, substituted or added in the amino acid sequence of SEQ ID NO:2, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity; and (C) an amino acid sequence having at least 60% or more homology to the amino acid sequence of SEQ ID NO:2 and having cysteine at position 138, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity.
摘要翻译：本发明的目的是提供调节心肌细胞分化的脱磷酸酶，其显性失活酶，编码酶蛋白的基因及其用途。使用由下列氨基酸序列（A）至（C）中任一项构成的蛋白质：（A）SEQ ID NO：2的氨基酸序列; （B）氨基酸序列，其中138位的半胱氨酸以外的一个或几个氨基酸被缺失，取代或加入到SEQ ID NO：2的氨基酸序列中，其中由氨基酸序列组成的蛋白具有双重特异性磷酸酶活性; 和（C）与SEQ ID NO：2的氨基酸序列具有至少60％以上同源性并且在138位具有半胱氨酸的氨基酸序列，其中由氨基酸序列组成的蛋白具有双特异性磷酸酶活性。

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