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1. 发明授权

US07789210B2 Sealing device 有权
标题翻译：密封装置
公开(公告)号：US07789210B2
公开(公告)日：2010-09-07
申请号：US11661559
申请日：2005-06-06
申请人： Yasunari Hamaya , Kiichiro Goto , Ken Yoshikawa , Shinji Nagasawa , Yoshiyuki Kanzaki , Yasushi Sugiyama , Hiroyuki Nikamoto
发明人： Yasunari Hamaya , Kiichiro Goto , Ken Yoshikawa , Shinji Nagasawa , Yoshiyuki Kanzaki , Yasushi Sugiyama , Hiroyuki Nikamoto
IPC分类号： F16D25/0638 , F16D25/12 , F16D13/70
CPC分类号： F16D25/0638 , F16D2250/00 , F16D2300/12
摘要： To make it unnecessary to insert a plate spring as a separate part between a metal ring (2) and a mating member (11) to be coupled therewith such as a clutch plate, and reduce the number of parts and the assembly manhours, the sealing device (1) includes the metal ring (2) and seal sections (3) such as packings supported by the metal ring (2), and the metal ring (2) is provided with a intimate-contact region (4) for intimately contacting to the mating member (11) to be coupled, wherein the sealing device (1) is characterized in that the intimate-contact region (4) of the metal ring (2) is integrally formed with pawl-like intimate-contact sections (6) which are in the form of a pawl and which exert spring force on the mating member (11) to be coupled, and is used, for example, as a bonded piston seal (BPS) in an automatic transmission.
摘要翻译：为了不需要将金属环（2）和匹配构件（11）之间的分离部件插入以与离合器板相连接，并且减少零件数量和组装工时，密封件装置（1）包括金属环（2）和密封部分（3），例如由金属环（2）支撑的填料，并且金属环（2）设置有紧密接触区域（4），用于紧密接触所述密封装置（1）的特征在于，金属环（2）的紧密接触区域（4）与棘爪状紧密接触部分（6）整体形成），其形式为棘爪，并且在配合构件（11）上施加弹簧力以联接，并且例如用作自动变速器中的粘结活塞密封件（BPS）。

2. 发明申请

US20070256557A1 Sealing Device 有权
标题翻译：密封装置
公开(公告)号：US20070256557A1
公开(公告)日：2007-11-08
申请号：US11661559
申请日：2005-06-06
申请人： Yasunari Hamaya , Kiichiro Goto , Ken Yoshikawa , Shinji Nagasawa , Yoshiyuki Kanzaki , Yasushi Sugiyama , Hiroyuki Nikamoto
发明人： Yasunari Hamaya , Kiichiro Goto , Ken Yoshikawa , Shinji Nagasawa , Yoshiyuki Kanzaki , Yasushi Sugiyama , Hiroyuki Nikamoto
IPC分类号： F16J1/06
CPC分类号： F16D25/0638 , F16D2250/00 , F16D2300/12
摘要： To make it unnecessary to insert a plate spring as a separate part between a metal ring (2) and a mating member (11) to be coupled therewith such as a clutch plate, and reduce the number of parts and the assembly manhours, the sealing device (1) includes the metal ring (2) and seal sections (3) such as packings supported by the metal ring (2), and the metal ring (2) is provided with a intimate-contact region (4) for intimately contacting to the mating member (11) to be coupled, wherein the sealing device (1) is characterized in that the intimate-contact region (4) of the metal ring (2) is integrally formed with pawl-like intimate-contact sections (6) which are in the form of a pawl and which exert spring force on the mating member (11) to be coupled, and is used, for example, as a bonded piston seal (BPS) in an automatic transmission.
摘要翻译：为了不需要将金属环（2）和匹配构件（11）之间的分离部件插入以与离合器板相连接，并且减少零件数量和组装工时，密封件装置（1）包括金属环（2）和密封部分（3），例如由金属环（2）支撑的填料，并且金属环（2）设置有紧密接触区域（4），用于紧密接触所述密封装置（1）的特征在于，金属环（2）的紧密接触区域（4）与棘爪状紧密接触部分（6）整体形成），其形式为棘爪，并且在配合构件（11）上施加弹簧力以联接，并且例如用作自动变速器中的粘结活塞密封件（BPS）。

3. 发明授权

US07576129B2 Carboxylic acid compounds 失效
标题翻译：羧酸化合物
公开(公告)号：US07576129B2
公开(公告)日：2009-08-18
申请号：US10544646
申请日：2004-02-06
申请人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
发明人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
IPC分类号： A61K31/195 , A61K31/34 , C07D317/44 , C07D335/00 , C07C63/00
CPC分类号： C07D213/65 , C07C235/42 , C07C235/44 , C07C235/46 , C07C237/30 , C07D209/18 , C07D209/30 , C07D213/55 , C07D309/14 , C07D317/64 , C07D317/66 , C07D405/12 , C07D407/04 , C07D409/04
摘要： The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要翻译：本发明涉及式（I）的羧酸化合物：其中R 1是H，烷基; m为2,3; n为0-2; R2是苯基，萘基，苯并呋喃，苯并噻吩; Q是-CH2-O-Cyc1，-CH2-Cyc2，-L-Cyc3; R3a和R3b各自独立地为氢，烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐，其制备方法的制备方法和包含其的药剂作为活性成分。式（I）化合物对PGE2受体具有拮抗作用，特别是作为其亚型的EP3受体，可用于预防和/或治疗瘙痒，疼痛，尿失调或应激疾病。

4. 发明授权

US07262393B2 Releasably sealable, air and liquid impermeable bags and methods for low temperature food preparation using the same 有权
标题翻译：可密封的空气和液体不可渗透袋及使用其的低温食品制备方法
公开(公告)号：US07262393B2
公开(公告)日：2007-08-28
申请号：US10292234
申请日：2002-11-12
申请人： Tatsuya Ishii , Yuka Ishii , Satoru Hatano , Ken Yoshikawa , Kumiko Shirai , John William Toussant
发明人： Tatsuya Ishii , Yuka Ishii , Satoru Hatano , Ken Yoshikawa , Kumiko Shirai , John William Toussant
IPC分类号： H05B6/80 , B65D65/40
CPC分类号： B65D65/14 , B65D33/20 , B65D81/3415
摘要： Disclosed is a releasably sealable bag for low temperature cooking comprising a film material, wherein the film material does not deform at temperatures of up to about 125° C., and wherein the bag is air and liquid impermeable when sealed. Also disclosed are such bags wherein at least a portion of the film material is comprised of a composite film material provided with a pressure sensitive adhesive protected from inadvertent adherence. Further disclosed are methods for food preparation and cooking using any of the embodiments of the bag of the present invention.
摘要翻译：公开了一种用于低温烹饪的可释放密封的袋，其包括膜材料，其中所述膜材料在高达约125℃的温度下不变形，并且其中所述袋在密封时不透气。还公开了这样的袋，其中至少一部分薄膜材料由设置有防止无意粘附的压敏粘合剂的复合膜材料组成。进一步公开的是使用本发明的袋的任何实施例的食物制备和烹饪的方法。

5. 发明申请

US20070167498A1 Carboxylic acid compounds 失效
标题翻译：羧酸化合物
公开(公告)号：US20070167498A1
公开(公告)日：2007-07-19
申请号：US10544646
申请日：2004-02-06
申请人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
发明人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
IPC分类号： A61K31/44 , A61K31/35 , A61K31/343 , A61K31/195
CPC分类号： C07D213/65 , C07C235/42 , C07C235/44 , C07C235/46 , C07C237/30 , C07D209/18 , C07D209/30 , C07D213/55 , C07D309/14 , C07D317/64 , C07D317/66 , C07D405/12 , C07D407/04 , C07D409/04
摘要： The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要翻译：本发明涉及式（I）的羧酸化合物：其中R 1是H，烷基; m为2,3; n为0-2; R 2是苯基，萘基，苯并呋喃，苯并噻吩; Q是-CH 2 -O-Cyc 1，-CH 2 -Cyc2，-L-Cyc 3; R 3a和R 3b各自独立地是氢，烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐，其制备方法的制备方法和包含其的药剂作为活性成分。式（I）化合物对PGE2受体具有拮抗作用，特别是作为其亚型的EP 3受体，可用于预防和/或治疗瘙痒，疼痛，尿失禁或压力疾病。

6. 发明授权

US08993543B2 Diphenyl sulfide derivative and pharmaceutical product which contains same as active ingredient 有权
标题翻译：二苯硫醚衍生物和含有与活性成分相同的药物
公开(公告)号：US08993543B2
公开(公告)日：2015-03-31
申请号：US13883847
申请日：2011-12-20
申请人： Kumi Ishikawa , Shigeru Koga , Yasushi Kohno , Kiyoshi Fujii , Ken Yoshikawa
发明人： Kumi Ishikawa , Shigeru Koga , Yasushi Kohno , Kiyoshi Fujii , Ken Yoshikawa
IPC分类号： C07F9/38 , C07F9/09 , C07F9/40
CPC分类号： C07F9/38 , C07F9/091 , C07F9/3808 , C07F9/4006 , C07F9/4015
摘要： [Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.
摘要翻译： [问题]提供可用作具有优异的S1P3拮抗剂活性的药物的二苯硫醚衍生物。发明人已经发现，通式（1）表示的二苯硫醚衍生物（其中，R1表示碳原子数1〜6的烷氧基，R2表示丙基或烯丙基，X表示亚甲基或氧原子，Z表示卤素原子）作为具有S1P3拮抗剂活性的化合物的生产的广泛研究的结果，具有优异的S1P3拮抗剂活性。

7. 发明授权

US07231230B2 Mobile telephone set capable of altering key layout thereof and mobile telephone system including the same 有权
标题翻译：能够改变其键布局的移动电话机和包括其的移动电话系统
公开(公告)号：US07231230B2
公开(公告)日：2007-06-12
申请号：US10160110
申请日：2002-06-04
申请人： Ken Yoshikawa
发明人： Ken Yoshikawa
IPC分类号： H04B1/38 , H04M1/00 , G09G5/00
CPC分类号： H04M1/72525 , G06F1/1626 , G06F3/0216 , G06F3/04886 , H04M1/7258 , H04M2250/22
摘要： A mobile telephone switching network 3, a server 5, and a terminal equipment 7 are connected to a network 4. A portable telephone set 2 manufactured by a manufacturer 1 is connected to the mobile telephone switching network 3. Not only a service application fabricated by an application maker 6 but also a key application determining a key layout based on API published by the manufacturer 1 are uploaded to the server 5. The service and the key applications are downloaded to the portable telephone set 2 in response to a requirement from the portable telephone set 2. In the portable telephone set 2, the service application is analyzed by using the key application downloaded as mentioned above. The key layout is then determined by analyzing the service application. The key layout is displayed on the liquid crystal display of the portable telephone set 2.
摘要翻译：移动电话交换网3，服务器5和终端设备7连接到网络4。由制造商1制造的便携式电话机2连接到移动电话交换网络3。不仅由制造商6制作的服务应用程序，而且还基于由制造商1发布的API确定密钥布局的关键应用程序被上传到服务器5。响应于来自便携式电话机2的要求，将服务和密钥应用程序下载到便携式电话机2。在便携式电话机2中，通过使用如上所述下载的密钥应用来分析服务应用。然后通过分析服务应用程序确定关键布局。键布局显示在便携式电话机2的液晶显示器上。

8. 发明授权

US06209879B1 Sealing apparatus 有权
标题翻译：密封装置
公开(公告)号：US06209879B1
公开(公告)日：2001-04-03
申请号：US09177489
申请日：1998-10-23
申请人： Koichi Mizunoya , Ken Yoshikawa , Satoshi Yamanaka , Tatuhiko Watanabe , Shinobu Munekata , Yasuhiro Ikeda
发明人： Koichi Mizunoya , Ken Yoshikawa , Satoshi Yamanaka , Tatuhiko Watanabe , Shinobu Munekata , Yasuhiro Ikeda
IPC分类号： F16J1532
CPC分类号： F16J15/3268 , F16J15/3232
摘要： A sealing apparatus has a metal ring having a cylindrical portion and an inward flange portion bending from the open-air side end of the cylindrical portion radially inward; a first sealing member formed integral with the metal ring, and having a first rubber-like sealing lip, and a flange-shaped interposed portion held between the inward flange position of the metal ring and the radial portion of the first sealing member. A second sealing member made of a resin material, extends from the inside-diameter end of the interposed portion axially toward the sealing liquid side, and is located in a gap between the open-air side surface of the first sealing lip and a rotary member, having the inner periphery thereof in slidable close contact with the surface of the rotary member, and regulates radial deformation of the first sealing lip. A screw pumping portion is provided to transport the liquid between the sliding surfaces to the sealing liquid side on rotation of the rotary member.
摘要翻译：密封装置具有金属环，其具有从圆筒部的露天侧端径向向内弯曲的圆筒部和向内凸缘部，与所述金属环一体形成的第一密封构件，具有第一橡胶状密封唇和保持在所述金属环的向内凸缘位置与所述第一密封构件的径向部分之间的凸缘状插入部。由树脂材料制成的第二密封构件从插入部分的内径端向轴向朝向密封液侧延伸，并且位于第一密封唇的露天侧表面和旋转构件之间的间隙中其内周与旋转体的表面滑动紧密接触，并调节第一密封唇的径向变形。提供螺杆抽吸部分，用于在旋转构件旋转时将液体在滑动表面之间输送到密封液体侧。

9. 发明申请

US20130261089A1 DIPHENYL SULFIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT WHICH CONTAINS SAME AS ACTIVE INGREDIENT 有权
标题翻译：含硫酸盐衍生物和药物产品含有活性成分
公开(公告)号：US20130261089A1
公开(公告)日：2013-10-03
申请号：US13883847
申请日：2011-12-20
申请人： Kumi Ishikawa , Shigeru Koga , Yasushi Kohno , Kiyoshi Fujii , Ken Yoshikawa
发明人： Kumi Ishikawa , Shigeru Koga , Yasushi Kohno , Kiyoshi Fujii , Ken Yoshikawa
IPC分类号： C07F9/38
CPC分类号： C07F9/38 , C07F9/091 , C07F9/3808 , C07F9/4006 , C07F9/4015
摘要： [Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.
摘要翻译： [问题]提供可用作具有优异的S1P3拮抗剂活性的药物的二苯硫醚衍生物。发明人已经发现，通式（1）表示的二苯硫醚衍生物（其中，R1表示碳原子数1〜6的烷氧基，R2表示丙基或烯丙基，X表示亚甲基或氧原子，Z表示卤素原子）作为具有S1P3拮抗剂活性的化合物的生产的广泛研究的结果，具有优异的S1P3拮抗剂活性。

10. 发明授权

US08413995B2 Oil seal 有权
标题翻译：油封
公开(公告)号：US08413995B2
公开(公告)日：2013-04-09
申请号：US12595417
申请日：2008-02-22
申请人： Hiroki Matsui , Masayuki Tanida , Hirotaka Mizuta , Hideyuki Furuyama , Ken Yoshikawa , Yuki Sato
发明人： Hiroki Matsui , Masayuki Tanida , Hirotaka Mizuta , Hideyuki Furuyama , Ken Yoshikawa , Yuki Sato
IPC分类号： F16J15/32
CPC分类号： F16J15/324 , F16J15/3244
摘要： For an oil seal (1) having a seal lip (6) with a slope (7) at the side of sealed fluid and a slope (8) at the side opposite to the sealed fluid, and a screw section (9) provided on the slope (8) for pushing back sealed fluid by a pumping effect at a time of rotation, in order to achieve low torque characteristics based on fluid lubrication by increasing the thickness of an oil film on sliding surfaces, an intermediate surface (10) is provided between the slopes (7, 8), and an oppositely threaded screw section (11) for sucking the sealed fluid by a pumping effect is provided on the intermediate surface (10) without reaching the boundary (13) between the intermediate surface (10) and the slope (8), so that a threadless region is provided in the entire circumference between the screw section (11) and the boundary (13).
摘要翻译：对于具有在密封流体侧具有斜面（7）的密封唇（6）和与密封流体相对的一侧上的斜面（8）的油封（1）和设置在密封件用于在旋转时通过泵送效果推回密封流体的斜面（8），以便通过增加滑动表面上的油膜的厚度来实现基于流体润滑的低扭矩特性，中间表面（10）是设置在所述斜面（7,8）之间，并且在所述中间表面（10）上设置用于通过泵送效果吸附所述密封流体的相对螺纹的螺纹部（11），而不到达所述中间表面（10））和斜面（8），使得在螺杆部分（11）和边界（13）之间的整个圆周上设置无螺纹区域。

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