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1. 发明授权

US06209879B1 Sealing apparatus 有权
标题翻译：密封装置
公开(公告)号：US06209879B1
公开(公告)日：2001-04-03
申请号：US09177489
申请日：1998-10-23
申请人： Koichi Mizunoya , Ken Yoshikawa , Satoshi Yamanaka , Tatuhiko Watanabe , Shinobu Munekata , Yasuhiro Ikeda
发明人： Koichi Mizunoya , Ken Yoshikawa , Satoshi Yamanaka , Tatuhiko Watanabe , Shinobu Munekata , Yasuhiro Ikeda
IPC分类号： F16J1532
CPC分类号： F16J15/3268 , F16J15/3232
摘要： A sealing apparatus has a metal ring having a cylindrical portion and an inward flange portion bending from the open-air side end of the cylindrical portion radially inward; a first sealing member formed integral with the metal ring, and having a first rubber-like sealing lip, and a flange-shaped interposed portion held between the inward flange position of the metal ring and the radial portion of the first sealing member. A second sealing member made of a resin material, extends from the inside-diameter end of the interposed portion axially toward the sealing liquid side, and is located in a gap between the open-air side surface of the first sealing lip and a rotary member, having the inner periphery thereof in slidable close contact with the surface of the rotary member, and regulates radial deformation of the first sealing lip. A screw pumping portion is provided to transport the liquid between the sliding surfaces to the sealing liquid side on rotation of the rotary member.
摘要翻译：密封装置具有金属环，其具有从圆筒部的露天侧端径向向内弯曲的圆筒部和向内凸缘部，与所述金属环一体形成的第一密封构件，具有第一橡胶状密封唇和保持在所述金属环的向内凸缘位置与所述第一密封构件的径向部分之间的凸缘状插入部。由树脂材料制成的第二密封构件从插入部分的内径端向轴向朝向密封液侧延伸，并且位于第一密封唇的露天侧表面和旋转构件之间的间隙中其内周与旋转体的表面滑动紧密接触，并调节第一密封唇的径向变形。提供螺杆抽吸部分，用于在旋转构件旋转时将液体在滑动表面之间输送到密封液体侧。

2. 发明授权

US06279914B1 Sealing apparatus 有权
标题翻译：密封装置
公开(公告)号：US06279914B1
公开(公告)日：2001-08-28
申请号：US09177490
申请日：1998-10-23
申请人： Satoshi Yamanaka , Yasuhiro Ikeda , Shinobu Munekata
发明人： Satoshi Yamanaka , Yasuhiro Ikeda , Shinobu Munekata
IPC分类号： F16J1532
CPC分类号： F16J15/3232 , F16J15/3268
摘要： The present invention relates to a lip-type seal of the outer periphery rubber type having a stationary sealing portion made of rubber on the outer periphery of a reinforcing ring. In view of the fact that there is produced a gap corresponding to the rubber thickness of the stationary sealing portion between the outer periphery of the reinforcing ring and inner periphery of the seal attachment hole, the invention has an object to permit certain supporting of the reinforcing ring by means of a stop functional member by expanding the engagement area engaging with the stop functional member. More specifically, in the sealing apparatus of the invention, the engagement portion with the housing is sealed by a stationary sealing portion made of rubber attached to the outer periphery of the cylindrical portion of the reinforcing ring; the sliding portion with the shaft is sealed by sealing lips and supported by the reinforcing ring; and the reinforcing ring axially engages with the stop functional member such as a stop ring fixed to the inner periphery of the housing. In this sealing apparatus thus prevented from coming off, the reinforcing ring is provided with an engagement area expanding section which is arranged on the open-air side of the cylindrical portion, having a larger diameter than the cylindrical portion, arranged near the inner periphery of the housing, and expands the engagement area with the stop ring.
摘要翻译：本发明涉及一种外周橡胶型的唇型密封件，其具有在加强环的外周上由橡胶制成的固定密封部。考虑到在加强环的外周和密封附接孔的内周之间产生与固定密封部分的橡胶厚度相对应的间隙的事实，本发明的目的是允许加固件的某些支撑通过扩大与停止功能部件接合的接合区域，通过止动功能部件环。更具体地说，在本发明的密封装置中，与外壳的接合部由附着在加强环的圆筒部的外周的由橡胶构成的固定密封部密封，与轴的滑动部分由密封唇密封并由加强环支撑; 并且加强环与止动功能部件轴向地接合，例如固定到壳体的内周的止动环。在该封闭装置中防止脱落的情况下，加强环设置有配置在圆筒部的露天侧的接合区域扩大部，该部分的直径大于圆筒部的直径，壳体，并且与止动环扩张接合区域。

3. 发明授权

US10047346B2 Method of treating heart tissue using induced pluripotent stem cells 有权
公开(公告)号：US10047346B2
公开(公告)日：2018-08-14
申请号：US13058154
申请日：2009-08-10
申请人： Yasuhiro Ikeda , Andre Terzic , Timothy J. Nelson , Amber A. Mael , Almudena J. Martinez Fernandez , Satsuki Yamada
发明人： Yasuhiro Ikeda , Andre Terzic , Timothy J. Nelson , Amber A. Mael , Almudena J. Martinez Fernandez , Satsuki Yamada
IPC分类号： A01N63/00 , A61K48/00 , C12N5/074 , A61K35/12
摘要： This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

4. 发明授权

US08866282B2 Semiconductor apparatus, signal transmission system and signal transmission method 有权
标题翻译：半导体装置，信号传输系统和信号传输方法
公开(公告)号：US08866282B2
公开(公告)日：2014-10-21
申请号：US13586104
申请日：2012-08-15
申请人： Yasuhiro Ikeda , Yutaka Uematsu , Satoshi Muraoka
发明人： Yasuhiro Ikeda , Yutaka Uematsu , Satoshi Muraoka
IPC分类号： H01L23/52 , H04L25/02 , H05K1/02 , H01L49/02 , H01L23/12
CPC分类号： H01L28/20 , H01L23/12 , H01L23/5228 , H01L2224/16225 , H04L25/02 , H04L25/0272 , H04L25/0288 , H05K1/02 , H05K1/0234 , H05K1/0246 , H05K1/025 , H05K2201/10022 , H05K2201/10159
摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.
摘要翻译：在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器）负载电容，预加重不执行或略微执行。由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃数据传输速率提高。

5. 发明申请

US20130207234A1 SEMICONDUCTOR APPARATUS, SIGNAL TRANSMISSION SYSTEM AND SIGNAL TRANSMISSION METHOD 有权
标题翻译：半导体装置，信号传输系统和信号传输方法
公开(公告)号：US20130207234A1
公开(公告)日：2013-08-15
申请号：US13586104
申请日：2012-08-15
申请人： Yasuhiro Ikeda , Yutaka Uematsu , Satoshi Muraoka
发明人： Yasuhiro Ikeda , Yutaka Uematsu , Satoshi Muraoka
IPC分类号： H01L49/02
CPC分类号： H01L28/20 , H01L23/12 , H01L23/5228 , H01L2224/16225 , H04L25/02 , H04L25/0272 , H04L25/0288 , H05K1/02 , H05K1/0234 , H05K1/0246 , H05K1/025 , H05K2201/10022 , H05K2201/10159
摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.
摘要翻译：在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器）负载电容，预加重不执行或略微执行。由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃数据传输速率提高。

6. 发明授权

US08278284B2 Therapeutic agents for diseases associated with apoptotic degeneration in ocular tissue cells that use SIV-PEDF vectors 有权
标题翻译：与使用SIV-PEDF载体的眼组织细胞凋亡变性相关疾病的治疗剂
公开(公告)号：US08278284B2
公开(公告)日：2012-10-02
申请号：US11884738
申请日：2006-02-21
申请人： Masanori Miyazaki , Yoshikazu Yonemitsu , Yasuhiro Ikeda , Katsuo Sueishi , Toshiaki Tabata , Akihiro Iida , Yasuji Ueda , Mamoru Hasegawa
发明人： Masanori Miyazaki , Yoshikazu Yonemitsu , Yasuhiro Ikeda , Katsuo Sueishi , Toshiaki Tabata , Akihiro Iida , Yasuji Ueda , Mamoru Hasegawa
IPC分类号： A61K48/00 , A01N63/00 , C12P19/34
CPC分类号： A61K48/005 , A61K48/00 , C07K14/475 , C12N15/86 , C12N2740/15043 , C12N2740/15045 , C12N2810/6081
摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.
摘要翻译：本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

7. 发明授权

US08052153B2 Seal device 有权
标题翻译：密封装置
公开(公告)号：US08052153B2
公开(公告)日：2011-11-08
申请号：US12096600
申请日：2006-12-20
申请人： Hiroshi Ebihara , Yasuhisa Arita , Yasuhiro Ikeda
发明人： Hiroshi Ebihara , Yasuhisa Arita , Yasuhiro Ikeda
IPC分类号： F16J15/32
CPC分类号： F16J15/3232
摘要： [PROBLEMS] A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be sealed and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer.[MEANS FOR SOLVING PROBLEMS] A backup ring (2) has a tapered section (23) continuously extending from a fixation section (21) of the backup ring (2) and also has a forward end section (24). A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary (26) where a surface (D) of the tapered section (23) changes to a surface (F) of the forward end section (24). A portion of the surface (D) of the tapered surface (23), which portion is in contact with the rounded surface (E) at the boundary (26), is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary (26).
摘要翻译：一种密封装置，其中密封唇相对于待密封的高压流体可靠地保持轴密封，并且其中在密封唇中发生的等效米塞斯应力减小，以延长密封唇的耐用期。解决问题的手段备用环（2）具有从支撑环（2）的固定部（21）连续延伸的锥形部（23），并且还具有前端部（24）。至少在锥形部分（23）的表面（D）变化到前端部分的表面（F）的边界（26）处形成具有曲率半径（R-1）的圆形表面（E）（24）。锥形表面（23）的表面（D）的一部分在边界（26）处与圆形表面（E）接触的是曲率半径大于曲率半径的投影曲率表面（D） R-1）。

8. 发明申请

US20110226676A1 CYLINDRICAL SIEVE AND CYLINDRICAL SIFTER 有权
标题翻译：圆柱形和圆柱形
公开(公告)号：US20110226676A1
公开(公告)日：2011-09-22
申请号：US13131916
申请日：2010-05-31
申请人： Yasuhiro Ikeda
发明人： Yasuhiro Ikeda
IPC分类号： B07B1/22 , B07B1/46 , B07B1/20
CPC分类号： B07B1/22 , B07B1/24 , B07B1/4654 , B07B1/469 , B07B13/16
摘要： An integrally-rotating cylindrical sieve 1 includes a hollow rotating shaft 2, which a driveshaft 21 is inserted into and fixed to, support members 3 radially extended from the rotating shaft 2, a cylindrical sieve body 4 made from a thin plate with a large number of apertures 5 formed therein, such as punching metal, and coupled with the support members 3, and sieve frames 6a and 6b attached to axial ends of the sieve body 4. The rotating shaft 2, the support members 3, the sieve body 4, the sieve frames 6a and 6b, and the driveshaft 21 are coaxially rotated together. The sieve body 4 is a cylindrical corrugated plate having wave crests and wave troughs arranged along its circumference and has a large number of apertures 5 formed in the corrugated plate. This arrangement improves the sieving efficiency of the granular material and effectively prevents potential destruction and cracking of the granular material, thus enhancing the commercial value of the sieved granular material.
摘要翻译：一体旋转的圆筒筛1包括中空旋转轴2，驱动轴21插入并固定到从旋转轴2径向延伸的支撑构件3，圆柱形筛体4由具有大量的薄板制成形成在其中的孔5，例如冲孔金属，并且与支撑构件3相连，以及安装在筛体4的轴向端部的筛架6a和6b。旋转轴2，支撑构件3，筛体4，筛架6a和6b以及驱动轴21同时旋转。筛体4是具有沿着其圆周布置的波峰和波谷的圆柱形波纹板，并且在波纹板中形成有大量的孔5。由此，能够提高粒状材料的筛分效率，有效地防止颗粒状物的潜在的破坏和破裂，从而提高筛分粒状材料的商业价值。

9. 发明申请

US20090233988A1 Therapeutic Agents for Diseases Associated With Apoptotic Degeneration in Ocular Tissue Cells That Use SIV-PEDF Vectors 有权
标题翻译：与使用SIV-PEDF载体的组织细胞凋亡相关的疾病治疗剂
公开(公告)号：US20090233988A1
公开(公告)日：2009-09-17
申请号：US11884738
申请日：2006-02-21
申请人： Masanori Miyazaki , Yoshikazu Yonemitsu , Yasuhiro Ikeda , Katsuo Sueishi , Toshiaki Tabata , Akihiro Iida , Yasuji Ueda , Mamoru Hasegawa
发明人： Masanori Miyazaki , Yoshikazu Yonemitsu , Yasuhiro Ikeda , Katsuo Sueishi , Toshiaki Tabata , Akihiro Iida , Yasuji Ueda , Mamoru Hasegawa
IPC分类号： A61K31/711 , C12N15/63 , C12N7/01
CPC分类号： A61K48/005 , A61K48/00 , C07K14/475 , C12N15/86 , C12N2740/15043 , C12N2740/15045 , C12N2810/6081
摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.
摘要翻译：本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

10. 发明授权

US07344140B2 Lip-type seal 有权
标题翻译：唇型密封
公开(公告)号：US07344140B2
公开(公告)日：2008-03-18
申请号：US10542751
申请日：2004-01-30
申请人： Yasuhiro Ikeda
发明人： Yasuhiro Ikeda
IPC分类号： F16J15/32
CPC分类号： F16J15/3268 , F16J15/3228 , F16J15/3276
摘要： The lip-type seal of the present invention is a lip-type seal with which the outer periphery of a rotational shaft (S) supported by a predetermined housing (H) is sealed. The lip-type seal is made up of a first annular reinforcing member (11) and a first sealing member (12). The first reinforcing member (11) includes a wall surface part (11a) defining a hole through which the rotational shaft (S) is passed and a cylindrical part (11b) bent from the outer edge of the wall surface part (11a). The first sealing member (12) includes an annular base (12a) that is joined to the housing (H), a first lip part (12b) that extends almost conical from the base (12a) inwardly in the radial direction and that comes into contact with the rotational shaft (S), and an annular concave part (11c) formed on the base (12a) so as to detachably fit the cylindrical part (11b). Accordingly, a desired sealing capability can be secured, and the components can be easily assembled, disassembled, and recycled.
摘要翻译：本发明的唇形密封件是密封由预定壳体（H）支撑的旋转轴（S）的外周的唇型密封件。唇形密封件由第一环形加强件（11）和第一密封件（12）构成。第一加强构件（11）包括限定旋转轴（S）穿过的孔的壁表面部分（11a）和从壁表面部分（11a）的外边缘弯曲的圆柱形部分（11b））。第一密封构件（12）包括连接到壳体（H）的环形基部（12a），从基部（12a）沿径向向内延伸大致圆锥形的第一唇部（12b）与所述旋转轴（S）接触的环形凹部（11c），以及形成在所述基部（12a）上的环状凹部（11c），以便可拆卸地装配所述圆筒部（11b）。因此，可以确保期望的密封能力，并且可以容易地组装，拆卸和再循环组件。

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