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1. 发明授权

US07576129B2 Carboxylic acid compounds 失效
标题翻译：羧酸化合物
公开(公告)号：US07576129B2
公开(公告)日：2009-08-18
申请号：US10544646
申请日：2004-02-06
申请人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
发明人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
IPC分类号： A61K31/195 , A61K31/34 , C07D317/44 , C07D335/00 , C07C63/00
CPC分类号： C07D213/65 , C07C235/42 , C07C235/44 , C07C235/46 , C07C237/30 , C07D209/18 , C07D209/30 , C07D213/55 , C07D309/14 , C07D317/64 , C07D317/66 , C07D405/12 , C07D407/04 , C07D409/04
摘要： The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要翻译：本发明涉及式（I）的羧酸化合物：其中R 1是H，烷基; m为2,3; n为0-2; R2是苯基，萘基，苯并呋喃，苯并噻吩; Q是-CH2-O-Cyc1，-CH2-Cyc2，-L-Cyc3; R3a和R3b各自独立地为氢，烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐，其制备方法的制备方法和包含其的药剂作为活性成分。式（I）化合物对PGE2受体具有拮抗作用，特别是作为其亚型的EP3受体，可用于预防和/或治疗瘙痒，疼痛，尿失调或应激疾病。

2. 发明申请

US20070167498A1 Carboxylic acid compounds 失效
标题翻译：羧酸化合物
公开(公告)号：US20070167498A1
公开(公告)日：2007-07-19
申请号：US10544646
申请日：2004-02-06
申请人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
发明人： Masaki Asada , Kaoru Kobayashi , Masami Narita , Kazutoyo Sato , Atsushi Kinoshita , Toshihiko Nagase , Ken Yoshikawa
IPC分类号： A61K31/44 , A61K31/35 , A61K31/343 , A61K31/195
CPC分类号： C07D213/65 , C07C235/42 , C07C235/44 , C07C235/46 , C07C237/30 , C07D209/18 , C07D209/30 , C07D213/55 , C07D309/14 , C07D317/64 , C07D317/66 , C07D405/12 , C07D407/04 , C07D409/04
摘要： The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.
摘要翻译：本发明涉及式（I）的羧酸化合物：其中R 1是H，烷基; m为2,3; n为0-2; R 2是苯基，萘基，苯并呋喃，苯并噻吩; Q是-CH 2 -O-Cyc 1，-CH 2 -Cyc2，-L-Cyc 3; R 3a和R 3b各自独立地是氢，烷基或一起形成四氢-2H-吡喃; 其药学上可接受的盐，其制备方法的制备方法和包含其的药剂作为活性成分。式（I）化合物对PGE2受体具有拮抗作用，特别是作为其亚型的EP 3受体，可用于预防和/或治疗瘙痒，疼痛，尿失禁或压力疾病。

3. 发明申请

US20060258728A1 Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient 失效
标题翻译：羧酸衍生物化合物和包含这些化合物作为活性成分的药物
公开(公告)号：US20060258728A1
公开(公告)日：2006-11-16
申请号：US10486220
申请日：2002-08-08
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： A61K31/4178 , A61K31/4172 , A61K31/4152 , A61K31/192 , A61K31/4035 , A61K31/325
CPC分类号： C07D231/12 , C07C59/68 , C07C69/734 , C07C69/736 , C07C69/738 , C07C229/34 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/29 , C07C311/51 , C07C317/18 , C07C317/22 , C07C317/40 , C07C317/50 , C07C323/19 , C07C323/42 , C07C323/59 , C07C323/60 , C07D233/56 , C07D249/08
摘要： A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.
摘要翻译：式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R 2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。式（I）化合物与PGE2受体结合，特别是亚型EP 3和/或EP 4，并显示出拮抗活性，用于预防和/或治疗疾病引起的疼痛，瘙痒，荨麻疹，过敏，尿频，尿失调，阿尔茨海默病，癌症，痛经，子宫内膜异位症等。

4. 发明申请

US20050026908A1 Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient 审中-公开
标题翻译：羧酸衍生物，其制备方法和包含其作为活性成分的药物组合物
公开(公告)号：US20050026908A1
公开(公告)日：2005-02-03
申请号：US10924924
申请日：2004-08-25
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： A61P1/12 , A61P3/12 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/12 , A61P15/00 , A61P15/06 , A61P17/00 , A61P17/02 , A61P17/04 , A61P19/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P37/08 , C07C233/44 , C07C233/55 , C07C235/38 , C07C255/60 , C07C311/51 , C07C323/52 , C07C323/60 , C07D209/18 , C07D213/75 , C07D261/10 , C07D319/18 , C07D333/60 , A61K31/55 , A61K31/40 , A61K31/445
CPC分类号： C07D213/75 , C07B2200/07 , C07C233/44 , C07C233/55 , C07C235/38 , C07C255/60 , C07C311/51 , C07C323/52 , C07C323/60 , C07C2601/02 , C07C2601/10 , C07C2602/10 , C07D209/18 , C07D261/10 , C07D319/18 , C07D333/60
摘要： A carboxylic acid derivative of formula (I) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; R6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.
摘要翻译：式（I）的羧酸衍生物，其中R 1是COOH，COOR 6等; A是亚烷基等; R 2是烷基，烯基，炔基等; B是碳环或杂环; R 4是烷基，环烷基等; R 6是碳环或杂环; 或其无毒盐，其制备方法和包含其作为活性成分的药剂。式（I）化合物可以结合前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，并且可用于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病疾病，癌症。

5. 发明授权

US07786161B2 Carboxylic acid derivatives and pharmaceutical agent comprising the same as active ingredient 有权
标题翻译：羧酸衍生物和包含与活性成分相同的药剂
公开(公告)号：US07786161B2
公开(公告)日：2010-08-31
申请号：US12259012
申请日：2008-10-27
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07C59/68 , C07C69/734 , C07C69/736 , C07C69/738 , C07C229/34 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/29 , C07C311/51 , C07C317/18 , C07C317/22 , C07C317/40 , C07C317/50 , C07C323/19 , C07C323/42 , C07C323/59 , C07C323/60 , C07D233/56 , C07D249/08
摘要： A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.
摘要翻译：式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。式（I）化合物与PGE2受体结合，特别是亚型EP3和/或EP4并显示拮抗活性，可用于预防和/或治疗疾病诱发的疼痛，瘙痒，荨麻疹，过敏，尿频，尿紊乱，阿尔茨海默病，癌症，痛经，子宫内膜异位症等

6. 发明授权

US07491748B2 Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient 失效
标题翻译：羧酸衍生物化合物和包含这些化合物作为活性成分的药物
公开(公告)号：US07491748B2
公开(公告)日：2009-02-17
申请号：US10486220
申请日：2002-08-08
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： A61K31/195 , C07C229/02
CPC分类号： C07D231/12 , C07C59/68 , C07C69/734 , C07C69/736 , C07C69/738 , C07C229/34 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/29 , C07C311/51 , C07C317/18 , C07C317/22 , C07C317/40 , C07C317/50 , C07C323/19 , C07C323/42 , C07C323/59 , C07C323/60 , C07D233/56 , C07D249/08
摘要： A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.
摘要翻译：式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。式（I）化合物与PGE2受体结合，特别是亚型EP3和/或EP4并显示拮抗活性，可用于预防和/或治疗疾病诱发的疼痛，瘙痒，荨麻疹，过敏，尿频，尿紊乱，阿尔茨海默病，癌症，痛经，子宫内膜异位症等

7. 发明申请

US20090318703A1 CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：羧酸衍生物和包含它们的药物代谢作为活性成分
公开(公告)号：US20090318703A1
公开(公告)日：2009-12-24
申请号：US12259012
申请日：2008-10-27
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： C07D213/62 , C07C229/34 , C07D307/02 , C07D231/10
CPC分类号： C07D231/12 , C07C59/68 , C07C69/734 , C07C69/736 , C07C69/738 , C07C229/34 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/29 , C07C311/51 , C07C317/18 , C07C317/22 , C07C317/40 , C07C317/50 , C07C323/19 , C07C323/42 , C07C323/59 , C07C323/60 , C07D233/56 , C07D249/08
摘要： A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.
摘要翻译：式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。式（I）化合物与PGE2受体结合，特别是亚型EP3和/或EP4并显示拮抗活性，可用于预防和/或治疗疾病诱发的疼痛，瘙痒，荨麻疹，过敏，尿频，尿紊乱，阿尔茨海默病，癌症，痛经，子宫内膜异位症等

8. 发明授权

US06835752B2 Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient 失效
标题翻译：羧酸衍生物，其制备方法和包含其作为活性成分的药剂
公开(公告)号：US06835752B2
公开(公告)日：2004-12-28
申请号：US10344989
申请日：2003-02-20
申请人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
发明人： Kousuke Tani , Masaki Asada , Kaoru Kobayashi , Masami Narita , Mikio Ogawa
IPC分类号： C07C23343
CPC分类号： C07D213/75 , C07B2200/07 , C07C233/44 , C07C233/55 , C07C235/38 , C07C255/60 , C07C311/51 , C07C323/52 , C07C323/60 , C07C2601/02 , C07C2601/10 , C07C2602/10 , C07D209/18 , C07D261/10 , C07D319/18 , C07D333/60
摘要： A carboxylic acid derivative of formula (1) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; R6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.
摘要翻译：式（1）的羧酸衍生物，其中R 1是COOH，COOR 6等; A是亚烷基等; R 2是烷基，烯基，炔基等; B是碳环或杂环; R 4是烷基，环烷基等; R 6是碳环或杂环;或其无毒盐，其制备方法和包含与活性成分相同的药剂。式（I）化合物可与前列腺素E2受体结合，特别是EP3受体和/或EP4受体，并显示拮抗活性，并且可用于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症。

9. 发明申请

US20080033033A1 8-AZAPROSTAGLANDIN DERIVATIVES AND MEDICAL USE THEREOF 审中-公开
标题翻译： 8-AZAPROSTAGLANDIN衍生物及其医疗用途
公开(公告)号：US20080033033A1
公开(公告)日：2008-02-07
申请号：US11749531
申请日：2007-05-16
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/41 , A61K31/4015 , C07D207/18 , C07D257/04
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：包含本发明化合物的盐，其盐，其溶剂合物或环糊精包合物，其具有由式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）或其前药，并且它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，静脉炎，川崎病，烧伤，系统性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。此外，化合物还具有促进骨形成的作用，因此预期可用于预防和/或治疗与骨量丧失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

10. 发明授权

US07256211B1 8-azaprostaglandin derivatives and medical use thereof 失效
标题翻译： 8-氮杂普罗兰前列腺素衍生物及其医疗用途
公开(公告)号：US07256211B1
公开(公告)日：2007-08-14
申请号：US10542724
申请日：2004-01-20
申请人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
发明人： Tohru Kambe , Toru Maruyama , Kaoru Kobayashi , Kousuke Tani , Yoshihiko Nakai , Toshihiko Nagase , Takayuki Maruyama , Kiyoto Sakata , Hideyuki Yoshida , Shinsei Fujimura , Akio Nishiura , Nobutaka Abe
IPC分类号： A61K31/40 , A61K31/426 , C07D207/12 , C07D207/36
CPC分类号： C07D417/12 , C07D417/14
摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.
摘要翻译：该药物组合物包含本发明化合物，其具有式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义）其盐，其溶剂合物或环糊精包合物，或其前药和它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，Still氏病，川崎病，烧伤，全身性肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。该化合物还具有加速骨形成的作用，因此预期可用于预防和/或治疗与骨质量损失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

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