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1. 发明授权

US08765669B2 Glycosylated GLP-1 peptide 有权
标题翻译：糖基化GLP-1肽
公开(公告)号：US08765669B2
公开(公告)日：2014-07-01
申请号：US12999654
申请日：2009-06-15
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/605 , A61K38/00
摘要： Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
摘要翻译：添加糖链的GLP-1肽在血液中更稳定，并且在没有添加低聚糖的情况下比GLP-1肽更有效地控制血糖水平。具有GLP-1活性的添加糖链的GLP-1肽包括GLP-1中由糖链连接的氨基酸取代的至少一个或至少两个氨基酸; 具有GLP-1的氨基酸序列的肽，其具有缺失，取代或添加一个或几个氨基酸; 或GLP-1类似物。具有至少一个被寡糖链添加的氨基酸取代的氨基酸的添加糖链的GLP-1肽包括具有寡聚透明质酸的寡糖链。寡糖链添加的氨基酸包括通过接头连接到氨基酸的寡糖链。

2. 发明申请

US20110195897A1 GLYCOSYLATED GLP-1 PEPTIDE 有权
公开(公告)号：US20110195897A1
公开(公告)日：2011-08-11
申请号：US12999654
申请日：2009-06-15
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
IPC分类号： A61K38/26 , C07K14/605 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00
摘要： Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
摘要翻译：添加糖链的GLP-1肽在血液中更稳定，并且在没有添加低聚糖的情况下比GLP-1肽更有效地控制血糖水平。具有GLP-1活性的添加糖链的GLP-1肽包括GLP-1中由糖链连接的氨基酸取代的至少一个或至少两个氨基酸; 具有GLP-1的氨基酸序列的肽，其具有缺失，取代或添加一个或几个氨基酸; 或GLP-1类似物。具有至少一个被寡糖链添加的氨基酸取代的氨基酸的添加糖链的GLP-1肽包括具有寡聚透明质酸的寡糖链。寡糖链添加的氨基酸包括通过接头连接到氨基酸的寡糖链。

3. 发明授权

US08993536B2 Low-molecular polysulfated hyaluronic acid derivative and medicine containing same 有权
标题翻译：低分子多硫酸化透明质酸衍生物及其含有药物
公开(公告)号：US08993536B2
公开(公告)日：2015-03-31
申请号：US13143129
申请日：2010-02-01
申请人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
发明人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
IPC分类号： A61K31/728 , A61P11/06 , A61P17/00 , A61P37/08 , C08B37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SO3H group etc.
摘要翻译：用于治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。用于治疗选自以下通式（IA）或（IB）表示的花粉病，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的药剂; 其中n表示0〜15的数; R各自独立地表示氢原子或SO 3 H基等

4. 发明申请

US20110281819A1 LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME 有权
标题翻译：低分子量聚羟基丙酸衍生物和含有其的药物
公开(公告)号：US20110281819A1
公开(公告)日：2011-11-17
申请号：US13143129
申请日：2010-02-01
申请人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
发明人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
IPC分类号： A61K31/728 , A61P11/06 , A61P17/00 , C08B37/08 , A61P37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： A low-molecular-weight polysulfated hyaluronic acid derivative useful for prevention and/or treatment of an allergic disease. An agent for prevention and/or treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R′s each independently represent a hydrogen atom or an SO3H group etc.
摘要翻译：用于预防和/或治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。由以下通式（IA）或（IB）表示的预防和/或治疗选自传粉炎，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的药剂; 其中n表示0〜15的数; R各自独立地表示氢原子或SO 3 H基等

5. 发明授权

US09010390B2 Pneumatic tire with sipe having bidirectional ridge portion rows and bidirectional valley portion rows 有权
标题翻译：具有刀槽花纹的气动轮胎具有双向脊部排和双向谷部分行
公开(公告)号：US09010390B2
公开(公告)日：2015-04-21
申请号：US12989588
申请日：2009-04-23
申请人： Naohiro Hayashi
发明人： Naohiro Hayashi
IPC分类号： B60C11/12 , B60C11/11
CPC分类号： B60C11/12 , B60C11/11 , B60C11/1218 , B60C2011/1213
摘要： It is a problem to provide a pneumatic tire where disengagement between sipe wall surfaces is suppressed.In a sipe formed in a block of a tread portion, two ridge portions (32) and (34) are formed in one sipe wall surface (29P), and two valley portions that engage with the ridge portions (32) and (34) are formed in another sipe wall surface. The two ridge portions (32) and (34) form a merged portion (30) where they merge together in the center of a sipe lengthwise direction and at their tire radial direction outside ends, and the two ridge portions (32) and (34) extend linearly from the merged portion (30) toward both sipe-lengthwise-direction end sides (F) and (K) so as to gradually move apart inward in the tire radial direction. Because of this configuration, the contact length of the adjacent sipe wall surfaces in a sipe depth direction (R) becomes longer.
摘要翻译：提供一种抑制刀槽花纹壁面之间的分离的充气轮胎是一个问题。在形成在胎面部的块体中的刀槽花纹中，在一个刀槽花纹壁面（29P）上形成有两个脊部（32）和（34），与脊部（32）和（34）接合的两个谷部，形成在另一个刀槽花纹壁表面。两个脊部（32）和（34）形成合并部分（30），它们在刀槽花纹长度方向的中心并且在其轮胎径向外侧端部处合并在一起，并且两个脊部（32）和（34 ）从合并部（30）向两个刀槽花纹长度方向端侧（F）和（K）延伸，以便在轮胎径向方向上逐渐向内移动。由于这种构造，相邻刀槽花纹壁表面在刀槽花纹深度方向（R）上的接触长度变长。

6. 外观设计

USD723454S1 Tread portion of an automobile tire 有权
公开(公告)号：USD723454S1
公开(公告)日：2015-03-03
申请号：US29409408
申请日：2011-12-22
申请人： Naohiro Hayashi
设计人： Naohiro Hayashi

7. 外观设计

USD677617S1 Tread portion of an automobile tire 有权
公开(公告)号：USD677617S1
公开(公告)日：2013-03-12
申请号：US29397543
申请日：2011-07-18
申请人： Naohiro Hayashi
设计人： Naohiro Hayashi

8. 外观设计

USD687371S1 Tread portion of an automobile tire 有权
公开(公告)号：USD687371S1
公开(公告)日：2013-08-06
申请号：US29412737
申请日：2012-02-07
申请人： Naohiro Hayashi
设计人： Naohiro Hayashi

9. 发明申请

US20110048602A1 PNEUMATIC TIRE 有权
标题翻译：气动轮胎
公开(公告)号：US20110048602A1
公开(公告)日：2011-03-03
申请号：US12989588
申请日：2009-04-23
申请人： Naohiro Hayashi
发明人： Naohiro Hayashi
IPC分类号： B60C11/12
CPC分类号： B60C11/12 , B60C11/11 , B60C11/1218 , B60C2011/1213
摘要： It is a problem to provide a pneumatic tire where disengagement between sipe wall surfaces is suppressed.In a sipe formed in a block of a tread portion, two ridge portions (32) and (34) are formed in one sipe wall surface (29P), and two valley portions that engage with the ridge portions (32) and (34) are formed in another sipe wall surface. The two ridge portions (32) and (34) form a merged portion (30) where they merge together in the center of a sipe lengthwise direction and at their tire radial direction outside ends, and the two ridge portions (32) and (34) extend linearly from the merged portion (30) toward both sipe-lengthwise-direction end sides (F) and (K) so as to gradually move apart inward in the tire radial direction. Because of this configuration, the contact length of the adjacent sipe wall surfaces in a sipe depth direction (R) becomes longer.
摘要翻译：提供一种抑制刀槽花纹壁面之间的分离的充气轮胎是一个问题。在形成在胎面部的块体中的刀槽花纹中，在一个刀槽花纹壁面（29P）上形成有两个脊部（32）和（34），与脊部（32）和（34）接合的两个谷部，形成在另一个刀槽花纹壁表面。两个脊部（32）和（34）形成合并部分（30），它们在刀槽花纹长度方向的中心并且在其轮胎径向外侧端部处合并在一起，并且两个脊部（32）和（34 ）从合并部（30）向两个刀槽花纹长度方向端侧（F）和（K）延伸，以便在轮胎径向方向上逐渐向内移动。由于这种构造，相邻刀槽花纹壁表面在刀槽花纹深度方向（R）上的接触长度变长。

10. 发明申请

US20160102591A1 CATALYTIC CONVERTER 审中-公开
标题翻译：催化转换器
公开(公告)号：US20160102591A1
公开(公告)日：2016-04-14
申请号：US14786341
申请日：2014-04-23
申请人： Ryosuke Kayanuma , Takahiko Fujiwara , Yuki Aoki , Hiroyuki Matsubara , Naohiro Hayashi , Yuji Yabuzaki
发明人： Ryosuke Kayanuma , Takahiko Fujiwara , Yuki Aoki , Hiroyuki Matsubara , Naohiro Hayashi , Yuji Yabuzaki
IPC分类号： F01N3/20
CPC分类号： F01N3/20 , F01N3/24 , F01N3/28 , F01N3/2803 , F01N2260/06 , F01N2260/14 , F01N2330/48 , F01N2330/60 , F01N2340/00
摘要： A catalytic converter (10) includes i) an outer tube (1) that includes a cylindrical portion (1a), an upstream-side cone portion (1b), and a downstream-side cone portion (1c), and ii) a substrate (2) having a cell structure that is arranged in the cylindrical portion (1a) of the outer tube (1). The substrate (2) has a center region (2a) where a cell density is relatively high and a peripheral region (2b) where the cell density is relatively low, in a cross-section that is orthogonal to a length direction of the substrate (2). A projection portion when a connecting portion (5) of the exhaust duct (4) and the downstream-side cone portion (1c) is projected onto the substrate (2) is within the center region (2a).
摘要翻译：催化转化器（10）包括i）包括圆筒部分（1a），上游侧锥形部分（1b）和下游侧锥形部分（1c）的外管（1），以及ii）基底（2）具有布置在外管（1）的圆筒部分（1a）中的单元结构。基板（2）具有细胞密度相对较高的中心区域（2a）和细胞密度相对较低的周边区域（2b），其与基板的长度方向正交的截面 2）。当排气管道（4）和下游侧锥形部分（1c）的连接部分（5）突出到基板（2）上时，突出部分在中心区域（2a）内。

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