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1. 发明授权

US09096878B2 Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof 有权
标题翻译：用于使用动物细胞大量生产来自外来基因的蛋白质的表达载体及其用途
公开(公告)号：US09096878B2
公开(公告)日：2015-08-04
申请号：US13140905
申请日：2009-12-22
申请人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C12P21/02 , C12N15/85
CPC分类号： C12P21/02 , C12N15/85 , C12N2830/00
摘要： The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人进行了专门研究并成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的二氢叶酸还原酶基因顺反子，其表达已通过将密码子改变为最少常用的哺乳动物密码子以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

2. 发明申请

US20110123993A1 EXPRESSION VECTOR FOR MASS PRODUCTION OF FOREIGN GENE-DERIVED PROTEIN USING ANIMAL CELL AND USE THEREOF 有权
标题翻译：使用动物细胞大量生产外源基因衍生蛋白的表达载体及其用途
公开(公告)号：US20110123993A1
公开(公告)日：2011-05-26
申请号：US12918776
申请日：2009-02-27
申请人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
发明人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
IPC分类号： C12N15/85 , C12P21/02 , C12Q1/68
CPC分类号： C12N15/85 , C12N9/1205 , C12N2830/50 , C12N2840/102 , C12Y207/01095
摘要： The present inventors successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired drug resistance gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的药物抗性基因顺反子，其表达已通过将密码子改变为最不常用的密码子而被减弱哺乳动物以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

3. 发明授权

US08653249B2 Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof 有权
标题翻译：用于使用动物细胞大规模生产外源基因衍生蛋白质的表达载体及其用途
公开(公告)号：US08653249B2
公开(公告)日：2014-02-18
申请号：US12918776
申请日：2009-02-27
申请人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
发明人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12N15/85 , C12N9/1205 , C12N2830/50 , C12N2840/102 , C12Y207/01095
摘要： The present inventors successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired drug resistance gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的药物抗性基因顺反子，其表达已通过将密码子改变为最不常用的密码子而被减弱哺乳动物以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

4. 发明申请

US20120122083A1 EXPRESSION VECTOR FOR PRODUCING PROTEIN DERIVED FROM FOREIGN GENE IN LARGE QUANTITY USING ANIMAL CELLS, AND USE THEREOF 有权
标题翻译：用动物细胞生产大量外源基因衍生蛋白的表达载体及其用途
公开(公告)号：US20120122083A1
公开(公告)日：2012-05-17
申请号：US13140905
申请日：2009-12-22
申请人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C12P21/00 , C12Q1/68 , C12N15/85
CPC分类号： C12P21/02 , C12N15/85 , C12N2830/00
摘要： The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人进行了专门研究并成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的二氢叶酸还原酶基因顺反子，其表达已通过将密码子改变为最少常用的哺乳动物密码子以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

5. 发明申请

US20120059152A1 PROTEIN SUBSTANCE HAVING TRIPLE HELIX STRUCTURE AND MANUFACTURING METHOD THEREFOR 有权
标题翻译：具有三重螺旋结构的蛋白质物质及其制造方法
公开(公告)号：US20120059152A1
公开(公告)日：2012-03-08
申请号：US13141138
申请日：2009-12-22
申请人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C07K14/78 , C12P21/06
CPC分类号： C07K14/78 , C07K14/4726 , C07K2319/00 , C07K2319/02
摘要： As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.
摘要翻译：作为专门研究的结果，本发明人已经成功地发明了一种胶原基因构建体，其可以容易地纯化并保持与天然存在的胶原蛋白相当的三重螺旋结构，同时具有低分子量。具体地，通过亲和纯化进行一步纯化，因为CR-D（信号肽）具有碳水化合物识别结构域。通过将本发明的人胶原结构基因的一部分用MBL的胶原样结构基因部分代替，可以以高纯度获得维持三螺旋结构并且是热稳定的低分子量胶原，大批量。

6. 发明授权

US08470555B2 Protein substance having triple helix structure and manufacturing method therefor 有权
标题翻译：具有三螺旋结构的蛋白质物质及其制造方法
公开(公告)号：US08470555B2
公开(公告)日：2013-06-25
申请号：US13141138
申请日：2009-12-22
申请人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C12P21/06 , C12N15/00 , C07H21/02 , C07K14/00
CPC分类号： C07K14/78 , C07K14/4726 , C07K2319/00 , C07K2319/02
摘要： As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.
摘要翻译：作为专门研究的结果，本发明人已经成功地发明了一种胶原基因构建体，其可以容易地纯化并保持与天然存在的胶原蛋白相当的三重螺旋结构，同时具有低分子量。具体地，通过亲和纯化进行一步纯化，因为CR-D（信号肽）具有碳水化合物识别结构域。通过将本发明的人胶原结构基因的一部分用MBL的胶原样结构基因部分代替，可以以高纯度获得维持三螺旋结构并且是热稳定的低分子量胶原，大批量。

7. 发明申请

US20130155030A1 DISPLAY SYSTEM AND DETECTION METHOD 审中-公开
标题翻译：显示系统和检测方法
公开(公告)号：US20130155030A1
公开(公告)日：2013-06-20
申请号：US13820584
申请日：2011-07-13
申请人： Michihiro Kawai , Keiichi Yamamoto
发明人： Michihiro Kawai , Keiichi Yamamoto
IPC分类号： G06F3/042
CPC分类号： G06F3/042 , G06F3/0428
摘要： A display system displays objects in a display region in a manner arranged in a predetermined orientation. One light-emitting element of a sensor array emits light to the objects in the predetermined orientation. The display system prestores data which associates numerical value ranges different from each other with the objects, respectively. When light reflected by a finger is received by light-receiving elements of the sensor array, the display system calculates the number of the light-receiving elements that have received the reflected light, identifies one object associated with the numerical value range including the calculated number of the light-receiving elements, from among the objects, based on the calculated number of the light-receiving elements and the stored data, and performs processing corresponding to the identified object.
摘要翻译：显示系统以预定方向布置的方式在显示区域中显示对象。传感器阵列的一个发光元件以预定取向向对象发光。显示系统预先分别将数据值彼此不同的数据与对象相关联。当由手指反射的光被传感器阵列的光接收元件接收时，显示系统计算已经接收到反射光的光接收元件的数量，识别与包括计算出的数字的数值范围相关联的一个对象的光接收元件，基于计算出的光接收元件数量和存储的数据，并且执行与所识别的对象相对应的处理。

8. 发明授权

US08456854B2 Method of repair of electronic device and repair system 失效
公开(公告)号：US08456854B2
公开(公告)日：2013-06-04
申请号：US12285632
申请日：2008-10-09
申请人： Shigeo Iriguchi , Kiyoyuki Hatanaka , Satoshi Watanabe , Nobuo Taketomi , Keiichi Yamamoto , Masaru Sugie
发明人： Shigeo Iriguchi , Kiyoyuki Hatanaka , Satoshi Watanabe , Nobuo Taketomi , Keiichi Yamamoto , Masaru Sugie
IPC分类号： H05K7/02 , H05K7/06 , H05K7/08 , H05K7/10
CPC分类号： H05K3/3494 , H05K1/0212 , H05K3/225 , H05K2203/101 , H05K2203/176 , Y10T29/49137
摘要： A repair system which prevents heating of weakly heat resistant devices together and causing deterioration of the quality when preheating a first surface of the circuit board, wherein an electromagnetic induction material is buried in advance inside the circuit board near a specific electronic device envisioned as needed repair when becoming a defective electronic device in a production process and an electromagnetic coil emitting electromagnetic waves to an electromagnetic induction member in the vicinity of the repair device is provided and the heat generated by the electromagnetic induction member due to the electromagnetic waves enables the repair device to be heated and detached from the circuit board.

9. 发明授权

US08278794B2 Axial gap type motor and method of manufacturing rotor of motor 有权
标题翻译：轴向间隙式马达及其制造方法
公开(公告)号：US08278794B2
公开(公告)日：2012-10-02
申请号：US12918638
申请日：2009-10-29
申请人： Satoshi Ishikawa , Keiichi Yamamoto , Shoei Abe
发明人： Satoshi Ishikawa , Keiichi Yamamoto , Shoei Abe
IPC分类号： H02K1/27
CPC分类号： H02K1/30 , H02K1/2793 , H02K15/02 , H02K15/03 , H02K21/24 , Y10T29/49012
摘要： The rotor 11 of an axial gap type motor 10 is provided with a plurality of main magnets 41 respectively magnetized in an axial direction of a rotational axis and disposed at predetermined intervals in a peripheral direction, a plurality of yokes 42 structured by a laminated member 71 produced by winding a tape-shaped electromagnetic steel plate 60 and respectively disposed on both sides of the main magnets 41 in the axial direction, and a rotor frame 30 made of a die-cast alloy and including a plurality of ribs 31 respectively interposed between the main magnets 41 adjoining each other in the peripheral direction and extending in the radial direction, and an inner cylindrical portion 32 and an outer cylindrical portion 33 respectively formed on the radially inner side of the ribs 31 and on the radially outer side of the ribs 31. According to this structure, the yokes structured by the wound laminated member and the rotor frame can be firmly unified with each other, thereby being able to secure such rigidity that can withstand a centrifugal force generated due to the rotation of the rotor and a magnetic suction force given from the stator.
摘要翻译：轴向间隙型电动机10的转子11具有分别沿旋转轴的轴向磁化并沿周向以规定间隔设置的多个主磁体41，由层叠部件71构成的多个磁轭42 通过缠绕分别设置在主磁体41的轴向两侧的带状电磁钢板60和由压铸合金制成的转子架30制成，转子架30分别插入在压铸合金中主磁体41在圆周方向上彼此邻接并沿径向延伸，以及分别形成在肋31的径向内侧上和肋31的径向外侧上的内圆柱形部分32和外圆柱形部分33 根据该结构，由缠绕层叠构件和转子架构成的轭可以彼此牢固地一体化，从而能够 o确保能够承受由于转子的旋转产生的离心力和从定子给出的磁吸力的刚性。

10. 发明申请

US20120229408A1 DISPLAY DEVICE 审中-公开
标题翻译：显示设备
公开(公告)号：US20120229408A1
公开(公告)日：2012-09-13
申请号：US13508654
申请日：2010-11-05
申请人： Keiichi Yamamoto
发明人： Keiichi Yamamoto
IPC分类号： G06F3/041
CPC分类号： G06F3/0412 , G02F1/13338 , G06F3/0416 , G06F3/047 , G06F2203/04104 , G09G3/3648 , H01L27/1214
摘要： A display device includes detection sections each of which is arranged in an associated one of a plurality of pixels, and is configured to detect a pressed position; scan lines and detection lines formed on a first substrate; and a detection driver connected to the detection lines. When the first substrate or a second substrate is pressed, and the detection section in the pressed area is scanned with the scan line, the detection driver detects a voltage applied to the detection section via the detection line. An inspection line to which at least the scan lines or the detection lines are connected in parallel is further formed on the first substrate.
摘要翻译：显示装置包括检测部，每个检测部分被布置在多个像素中的相关联的一个中，并且被配置为检测按压位置; 扫描线和形成在第一基板上的检测线; 以及连接到检测线的检测驱动器。当按下第一基板或第二基板，并且用扫描线扫描按压区域中的检测部分时，检测驱动器通过检测线检测施加到检测部分的电压。至少扫描线或检测线并联连接的检查线进一步形成在第一基板上。

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