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1. 发明授权

US09096878B2 Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof 有权
标题翻译：用于使用动物细胞大量生产来自外来基因的蛋白质的表达载体及其用途
公开(公告)号：US09096878B2
公开(公告)日：2015-08-04
申请号：US13140905
申请日：2009-12-22
申请人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C12P21/02 , C12N15/85
CPC分类号： C12P21/02 , C12N15/85 , C12N2830/00
摘要： The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人进行了专门研究并成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的二氢叶酸还原酶基因顺反子，其表达已通过将密码子改变为最少常用的哺乳动物密码子以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

2. 发明授权

US08470555B2 Protein substance having triple helix structure and manufacturing method therefor 有权
标题翻译：具有三螺旋结构的蛋白质物质及其制造方法
公开(公告)号：US08470555B2
公开(公告)日：2013-06-25
申请号：US13141138
申请日：2009-12-22
申请人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C12P21/06 , C12N15/00 , C07H21/02 , C07K14/00
CPC分类号： C07K14/78 , C07K14/4726 , C07K2319/00 , C07K2319/02
摘要： As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.
摘要翻译：作为专门研究的结果，本发明人已经成功地发明了一种胶原基因构建体，其可以容易地纯化并保持与天然存在的胶原蛋白相当的三重螺旋结构，同时具有低分子量。具体地，通过亲和纯化进行一步纯化，因为CR-D（信号肽）具有碳水化合物识别结构域。通过将本发明的人胶原结构基因的一部分用MBL的胶原样结构基因部分代替，可以以高纯度获得维持三螺旋结构并且是热稳定的低分子量胶原，大批量。

3. 发明申请

US20120122083A1 EXPRESSION VECTOR FOR PRODUCING PROTEIN DERIVED FROM FOREIGN GENE IN LARGE QUANTITY USING ANIMAL CELLS, AND USE THEREOF 有权
标题翻译：用动物细胞生产大量外源基因衍生蛋白的表达载体及其用途
公开(公告)号：US20120122083A1
公开(公告)日：2012-05-17
申请号：US13140905
申请日：2009-12-22
申请人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Hiroshi Tahara , Yusuke Suzuki , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C12P21/00 , C12Q1/68 , C12N15/85
CPC分类号： C12P21/02 , C12N15/85 , C12N2830/00
摘要： The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人进行了专门研究并成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的二氢叶酸还原酶基因顺反子，其表达已通过将密码子改变为最少常用的哺乳动物密码子以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

4. 发明申请

US20120059152A1 PROTEIN SUBSTANCE HAVING TRIPLE HELIX STRUCTURE AND MANUFACTURING METHOD THEREFOR 有权
标题翻译：具有三重螺旋结构的蛋白质物质及其制造方法
公开(公告)号：US20120059152A1
公开(公告)日：2012-03-08
申请号：US13141138
申请日：2009-12-22
申请人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
发明人： Yusuke Suzuki , Hiroshi Tahara , Keiichi Yamamoto , Yuzuru Kitahara , Yasuhiko Suzuki
IPC分类号： C07K14/78 , C12P21/06
CPC分类号： C07K14/78 , C07K14/4726 , C07K2319/00 , C07K2319/02
摘要： As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.
摘要翻译：作为专门研究的结果，本发明人已经成功地发明了一种胶原基因构建体，其可以容易地纯化并保持与天然存在的胶原蛋白相当的三重螺旋结构，同时具有低分子量。具体地，通过亲和纯化进行一步纯化，因为CR-D（信号肽）具有碳水化合物识别结构域。通过将本发明的人胶原结构基因的一部分用MBL的胶原样结构基因部分代替，可以以高纯度获得维持三螺旋结构并且是热稳定的低分子量胶原，大批量。

5. 发明申请

US20110123993A1 EXPRESSION VECTOR FOR MASS PRODUCTION OF FOREIGN GENE-DERIVED PROTEIN USING ANIMAL CELL AND USE THEREOF 有权
标题翻译：使用动物细胞大量生产外源基因衍生蛋白的表达载体及其用途
公开(公告)号：US20110123993A1
公开(公告)日：2011-05-26
申请号：US12918776
申请日：2009-02-27
申请人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
发明人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
IPC分类号： C12N15/85 , C12P21/02 , C12Q1/68
CPC分类号： C12N15/85 , C12N9/1205 , C12N2830/50 , C12N2840/102 , C12Y207/01095
摘要： The present inventors successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired drug resistance gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的药物抗性基因顺反子，其表达已通过将密码子改变为最不常用的密码子而被减弱哺乳动物以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

6. 发明授权

US08653249B2 Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof 有权
标题翻译：用于使用动物细胞大规模生产外源基因衍生蛋白质的表达载体及其用途
公开(公告)号：US08653249B2
公开(公告)日：2014-02-18
申请号：US12918776
申请日：2009-02-27
申请人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
发明人： Yasuhiko Suzuki , Keiichi Yamamoto , Hiroshi Tahara , Yusuke Suzuki
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12N15/85 , C12N9/1205 , C12N2830/50 , C12N2840/102 , C12Y207/01095
摘要： The present inventors successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired drug resistance gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
摘要翻译：本发明人成功构建了能够在哺乳动物宿主细胞中高水平生产外源基因衍生蛋白质的表达载体，其包含翻译受损的药物抗性基因顺反子，其表达已通过将密码子改变为最不常用的密码子而被减弱哺乳动物以及具有用于在高转录活性启动子和高度稳定的聚腺苷酸化信号之间引入外源基因的克隆位点的基因盒。

7. 发明授权

US08258361B2 Transition metal complex compounds, olefin oligomerization catalysts including the compounds, and processes for producing olefin oligomers using the catalysts 有权
标题翻译：过渡金属络合物，包括该化合物的烯烃低聚催化剂，以及使用该催化剂生产烯烃低聚物的方法
公开(公告)号：US08258361B2
公开(公告)日：2012-09-04
申请号：US12452438
申请日：2008-06-27
申请人： Yasuhiko Suzuki , Shinsuke Kinoshita , Atsushi Shibahara , Naritoshi Yoshimura , Isao Hara , Tetsuya Hamada , Kazumori Kawamura , Kou Tsurugi , Yasunori Saito , Seiichi Ishii , Yasushi Nakayama , Naoto Matsukawa , Susumu Murata
发明人： Yasuhiko Suzuki , Shinsuke Kinoshita , Atsushi Shibahara , Naritoshi Yoshimura , Isao Hara , Tetsuya Hamada , Kazumori Kawamura , Kou Tsurugi , Yasunori Saito , Seiichi Ishii , Yasushi Nakayama , Naoto Matsukawa , Susumu Murata
IPC分类号： C07C2/22 , C07F7/28 , B01J31/18
CPC分类号： C08F10/00 , B01J31/143 , B01J31/1616 , B01J31/2243 , B01J2231/122 , B01J2231/20 , B01J2531/46 , B01J2531/62 , C07C2/32 , C07C251/24 , C07C2521/08 , C07C2521/16 , C07C2531/14 , C07C2531/22 , C07F7/003 , C08F110/02 , C07C11/107 , C08F4/64048 , C08F2500/02 , C08F4/64124 , C08F4/6931 , C08F4/64117 , C08F4/02
摘要： The invention provides transition metal complex compounds, high-activity olefin oligomerization catalysts containing the compounds, and olefin oligomerization processes using the catalysts.A transition metal complex compound [A] according to the invention is represented by Formula (I) or Formula (I′) below. An olefin oligomerization catalyst includes the transition metal complex compound [A]. In an olefin oligomerization process of the invention, an olefin is oligomerized in the presence of the catalyst.
摘要翻译：本发明提供了过渡金属络合物，含有这些化合物的高活性烯烃低聚催化剂和使用该催化剂的烯烃低聚方法。根据本发明的过渡金属络合物[A]由下式（I）或式（I'）表示。烯烃低聚催化剂包括过渡金属络合物[A]。在本发明的烯烃低聚方法中，烯烃在催化剂存在下被低聚。

8. 发明授权

US07972582B2 Method and apparatus for treating exhaust gas 有权
标题翻译：废气处理方法及装置
公开(公告)号：US07972582B2
公开(公告)日：2011-07-05
申请号：US10482683
申请日：2002-11-29
申请人： Toyoji Shinohara , Yoichi Mori , Yasuhiko Suzuki , Hiroshi Aono , Yuji Shirao
发明人： Toyoji Shinohara , Yoichi Mori , Yasuhiko Suzuki , Hiroshi Aono , Yuji Shirao
IPC分类号： B01D53/00 , B01D53/34 , B01D53/68 , B01D53/92 , B01D53/94
CPC分类号： F23J15/08 , B01D53/1456 , B01D53/62 , B01D53/68 , B01D53/70 , B01D53/864 , B01D53/8659 , F23G7/063 , F23J15/006 , F23J2215/301 , F23J2215/40 , F23J2219/10 , F23J2219/30 , F23J2219/40 , F23J2219/60 , Y02A50/2341
摘要： An apparatus for treating an exhaust gas that includes a pre-treatment section that removes a powdery component, a water-soluble component or a hydrolytic component from the exhaust gas. The exhaust gas contains a fluorine compound and CO. A heating oxidative decomposing section performs heating oxidative decomposition of at least one of the fluorine compound and CO to detoxify the exhaust gas. The apparatus also has a post-treatment section for post-treating an acid gas such as HF which has been produced by the heating oxidative decomposition.
摘要翻译：一种废气处理装置，其特征在于，包括从废气中除去粉状成分，水溶性成分或水解成分的预处理部。排气中含有氟化合物和CO，加热氧化分解部进行至少一种氟化合物和CO的加热氧化分解，对废气进行解毒。该设备还具有用于后处理由加热氧化分解产生的诸如HF的酸性气体的后处理部分。

9. 发明申请

US20080108160A1 Semiconductor Light Emitting Device, Its Manufacturing Method, Semiconductor Device and Its Manufacturing Method 有权
标题翻译：半导体发光器件及其制造方法，半导体器件及其制造方法
公开(公告)号：US20080108160A1
公开(公告)日：2008-05-08
申请号：US11969088
申请日：2008-01-03
申请人： Osamu Goto , Takeharu Asano , Yasuhiko Suzuki , Motonobu Takeya , Katsuyoshi Shibuya , Takashi Mizuno , Tsuyoshi Tojo , Shiro Uchida , Masao Ikeda
发明人： Osamu Goto , Takeharu Asano , Yasuhiko Suzuki , Motonobu Takeya , Katsuyoshi Shibuya , Takashi Mizuno , Tsuyoshi Tojo , Shiro Uchida , Masao Ikeda
IPC分类号： H01L33/00
CPC分类号： H01L33/0075 , B82Y20/00 , H01L33/04 , H01L33/06 , H01L33/32 , H01S5/0425 , H01S5/2004 , H01S5/2013 , H01S5/3201 , H01S5/34333 , H01S2301/173 , H01S2304/12
摘要： A semiconductor light emitting device made of nitride III-V compound semiconductors is includes an active layer made of a first nitride III-V compound semiconductor containing In and Ga, such as InGaN; an intermediate layer made of a second nitride III-V compound semiconductor containing In and Ga and different from the first nitride III-V compound semiconductor, such as InGaN; and a cap layer made of a third nitride III-V compound semiconductor containing Al and Ga, such as p-type AlGaN, which are deposited in sequential contact.
摘要翻译：由氮化物III-V化合物半导体制成的半导体发光器件包括由In和Ga等InGaN的第一氮化物III-V化合物半导体构成的有源层; 由包含In和Ga的不同于第一氮化物III-V化合物半导体的第二氮化物III-V化合物半导体制成的中间层，例如InGaN; 以及由含有Al和Ga的第三氮化物III-V化合物半导体（例如p型AlGaN）制成的覆盖层，其以顺序接触沉积。

10. 发明申请

US20060239854A1 Electrical contact and electrical equipment including the same 审中-公开
标题翻译：电气接触和电气设备包括相同
公开(公告)号：US20060239854A1
公开(公告)日：2006-10-26
申请号：US10564951
申请日：2004-07-16
申请人： Noboru Uenishi , Norihito Goma , Yasuhiko Suzuki
发明人： Noboru Uenishi , Norihito Goma , Yasuhiko Suzuki
IPC分类号： C22C5/06
CPC分类号： C22C5/06 , B32B15/018 , H01H1/0231 , H01H1/02376
摘要： An electric contact of high performance that is constituted of a Cd-free Ag alloy posing no toxic problem, excels in insulating capability and can ensure stability of brazing and consumption characteristics and that can be used in a breaker or high-load electromagnetic switch; and electrical equipment including the electric contact. In particular, an electric contact comprised of an Ag alloy containing 1 to 9 mass % of Sn in which the amount of Cd as impurity is 0 or less than 0.01 mass %, the electric contact having a double layer structure composed of a surface-side first layer and an interior second layer wherein the first layer has a thickness of 10 μm or greater and has an average hardness of 150 or higher on the microvickers scale stipulated in JIS while the second layer has an average hardness of higher than 130 on the same scale.
摘要翻译：高性能的电接触由无Cd的Ag合金构成，不会产生毒性问题，绝缘性能优异，可确保钎焊和消耗特性的稳定性，可用于断路器或高负载电磁开关; 以及包括电接触器的电气设备。特别是包含含有1〜9质量％Sn的杂质的Cd合金含量为0以下0.01以下的电接触体，具有由表面侧构成的双层结构的电接点第一层和内部第二层，其中第一层具有10μm以上的厚度，并且在JIS上规定的微观尺度上具有150或更高的平均硬度，而第二层具有高于130的平均硬度。规模。

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