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1. 发明申请

US20110152208A1 Use of Compounds Extracted from Momordica Charantia L. in the Manufacture of Medicaments for Prevention and Treatment of Diabetes and Obesity 有权
标题翻译：使用从苦瓜提取的化合物在糖尿病和肥胖的预防和治疗药物制造中的应用
公开(公告)号：US20110152208A1
公开(公告)日：2011-06-23
申请号：US12865843
申请日：2009-01-14
申请人： Yang Ye , David E. James , Minjia Tan , Gregory J. Cooney , Changqiang Ke , Edward W. Kraegen , Tong Chen , Jiming Ye , Xiqiang Li
发明人： Yang Ye , David E. James , Minjia Tan , Gregory J. Cooney , Changqiang Ke , Edward W. Kraegen , Tong Chen , Jiming Ye , Xiqiang Li
IPC分类号： A61K31/7032 , C07J9/00 , C07H15/00 , A61K31/575 , A61P3/04 , A61P3/10
CPC分类号： A61K31/575 , A61K31/704
摘要： The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4(GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
摘要翻译：本发明公开了葫芦科三萜类化合物的医学用途，其由葫芦科科的苦瓜属分离，用于制备预防和治疗糖尿病和肥胖症的药物。上述葫芦巴三萜类化合物可以作为葡萄糖吸收刺激剂，用于将葡萄糖转运蛋白4（GLUT4）转运至细胞膜的激动剂和腺苷一磷酸酯活化蛋白激酶（AMPK）的激活剂。他们可能有预防和治疗糖尿病和肥胖的潜力。

2. 发明申请

US20100113494A1 13,13a-Dihydroberberine Derivatives For Use In Pharmaceutical Compositions 审中-公开
标题翻译： 13,13a-Dihydroberberine衍生物用于药物组合物
公开(公告)号：US20100113494A1
公开(公告)日：2010-05-06
申请号：US12443401
申请日：2007-09-30
申请人： Lihong Hu , Jia Li , Jingya Li , Hankun Zhang , Zhe Cheng , Jiming Ye , David E. James , Edward W. Kraegen
发明人： Lihong Hu , Jia Li , Jingya Li , Hankun Zhang , Zhe Cheng , Jiming Ye , David E. James , Edward W. Kraegen
IPC分类号： A61K31/4375
CPC分类号： C07D455/03
摘要： The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.
摘要翻译：本发明提供由下式表示的13,13a-二氢小檗碱衍生物或其生理学上可接受的盐，其包含其的药物组合物及其用途。 13,13a-二氢小檗碱衍生物具有促进肌肉细胞中葡萄糖吸收的活性，整个动物实验表明，本发明化合物具有改善葡萄糖耐量和胰岛素抵抗，促进体重减轻，减轻脂肪肝等作用。因此，本发明化合物可用于治疗由胰岛素抵抗引起的糖尿病，肥胖，脂肪肝及其并发症。

3. 发明授权

US4782181A Process for removal of high molecular weight impurities in the manufacture of purified terephthalic acid 失效
标题翻译：在制备纯对苯二甲酸中除去高分子量杂质的方法
公开(公告)号：US4782181A
公开(公告)日：1988-11-01
申请号：US58142
申请日：1987-06-04
申请人： David E. James
发明人： David E. James
IPC分类号： C07C51/487 , C07C51/42
CPC分类号： C07C51/487
摘要： A process for producing fiber grade terephthalic acid is disclosed. In this process impurities having high molecular weight are eliminated by hydrogenation comprising the following steps: (a) treating an aqueous solution containing at least about 1 percent of said impure terephthalic acid with hydrogen at a temperature in the range of about 300.degree. F. to about 450.degree. F. and at a pressure sufficient to maintain the solution in the liquid phase in the presence of a supported or unsupported metallic Group VIII noble metal catalyst wherein both the metal and support components are insoluble in the solution at the temperature and at a hydrogen partial pressure of from about 30 to about 300 pounds per square inch; (b) separating the treated solution from the catalyst; (c) crystallizing terephthalic acid from the separated solution while retaining impurities and the reduced aromatic compounds dissolved in the resulting mother liquor at a temperature in the range of about 100.degree. F. to about 450.degree. F.; and (d) separating the mother liquor as a liquid phase containing dissolved impurities and reduction products from said crystals while continuing to maintain a temperature in the range of about 100.degree. F. to about 450.degree. F. whereby purified crystals of fiber grade terephthalic acid are recovered. Purified terephthalic acid is useful as a starting material in the manufacture of polyethylene terephthalate which is the principal polymer for polyester fibers, films, and resins for bottles.
摘要翻译：公开了一种生产纤维级对苯二甲酸的方法。在该方法中，通过氢化除去具有高分子量的杂质，包括以下步骤：（a）在约300°F的温度范围内用氢处理含有至少约1％的所述不纯对苯二甲酸的水溶液至在足够的压力下，在负载或未负载的金属VIII族贵金属催化剂存在下将溶液保持在液相中，其中金属和载体组分在温度下不溶于溶液，并且在氢分压为约30至约300磅/平方英寸; （b）将处理过的溶液与催化剂分离; （c）从分离的溶液中结晶对苯二甲酸，同时保留杂质和溶解在所得母液中的还原芳族化合物在约100°F至约450°F的温度范围内; 和（d）将母液从含有溶解的杂质和还原产物的液相中分离出来，同时继续保持在约100°F至约450°F范围内的温度，从而将纤维级对苯二甲酸被收回。纯化的对苯二甲酸可用作制造聚对苯二甲酸乙二醇酯的原料，聚对苯二甲酸乙二醇酯是聚酯纤维，膜和树脂树脂的主要聚合物。

4. 发明授权

US4652674A Method for monitoring the fluorescence of 4-carboxy-p-terphenyl in crude terephthalic acid 失效
标题翻译：用于监测粗对苯二甲酸中4-羧基 - 对三联苯的荧光的方法
公开(公告)号：US4652674A
公开(公告)日：1987-03-24
申请号：US800726
申请日：1985-11-22
申请人： David E. James , Neal R. Nowicki , Robert W. McCoy
发明人： David E. James , Neal R. Nowicki , Robert W. McCoy
IPC分类号： G01N21/78 , C07C51/265 , C07C63/26 , C09K11/06 , G01N21/64 , G01N21/76 , G01N30/74 , C07C51/42 , G01N30/02
CPC分类号： G01N21/64 , C07C51/265 , Y10T436/201666
摘要： A method is disclosed for separating and measuring the fluorescence of 4-carboxy-p-terphenyl in crude terephthalic acid formed by the liquid-phase oxidation of p-xylene in a solvent.
摘要翻译：公开了一种用于分离和测量在溶剂中通过对二甲苯的液相氧化形成的粗对苯二甲酸中4-羧基 - 对三联苯的荧光的方法。

5. 发明授权

US4467111A Process for purification of crude terephthalic acid 失效
标题翻译：纯对苯二甲酸粗品的方法
公开(公告)号：US4467111A
公开(公告)日：1984-08-21
申请号：US515796
申请日：1983-07-21
申请人： Imre Puskas , David E. James
发明人： Imre Puskas , David E. James
IPC分类号： B01J23/44 , C07C51/487 , C07C51/42
CPC分类号： B01J23/44 , C07C51/487 , B01J35/006
摘要： A catalyst and process for purifying crude terephthalic acid wherein the catalyst is prepared by contacting a carbonaceous support with an aqueous solution of sodium tetranitropalladate.
摘要翻译：用于纯化粗对苯二甲酸的催化剂和方法，其中催化剂通过使碳质载体与四硝酸铵的水溶液接触来制备。

6. 发明授权

US07487744B1 Multi-species animal caging modules 失效
标题翻译：多物种动物笼养模块
公开(公告)号：US07487744B1
公开(公告)日：2009-02-10
申请号：US11247055
申请日：2005-10-11
申请人： Michael L. Goldberg , Dwight L. Souder , Cindy M. Adamson , David E. James
发明人： Michael L. Goldberg , Dwight L. Souder , Cindy M. Adamson , David E. James
IPC分类号： A01K31/07 , A01K1/03
CPC分类号： A01K1/031 , A01K1/032 , A01K31/07
摘要： Configurable animal housing (caging) is arranged from an assortment of modules consisting of interchangeable frame cores, interstages, walls and divider panels that address a broad spectrum of animal housing needs. Various configurations include both open living and enrichment areas as well as isolation housing and are easily achieved using a quick-disconnect approach to assembly. Animal resistant lock assemblies hold modules together and use a common key to permit rapid changes of configuration without tools. Systems can address configurations for wall mounting, mobile racking, individual, and group housing, and almost any other configuration animal caregivers would want.
摘要翻译：可配置的动物房屋（笼子）由各种模块组成，包括可互换的框架芯，间隔件，墙壁和分隔板，可满足广泛的动物需求。各种配置包括开放生活和富集区域以及隔离住房，并且可以使用快速断开的组装方式轻松实现。动物抵抗锁定组件将模块保持在一起，并使用公共密钥来允许快速更改配置而无需工具。系统可以处理墙壁安装，移动式货架，个人和组件外壳以及几乎任何其他配置动物护理人员想要的配置。

7. 发明授权

US06284920B1 Aromatic acid monomers, polymers, products and processes for their manufacture 有权
标题翻译：芳香族酸单体，聚合物，产品及其制造方法
公开(公告)号：US06284920B1
公开(公告)日：2001-09-04
申请号：US09412458
申请日：1999-10-04
申请人： Edward E. Paschke , Bruce I. Rosen , David A. Peterson , David E. James , Melvin L. Luetkens, Jr. , Charles W. Bauer , Gary T. Brooks
发明人： Edward E. Paschke , Bruce I. Rosen , David A. Peterson , David E. James , Melvin L. Luetkens, Jr. , Charles W. Bauer , Gary T. Brooks
IPC分类号： C07C5109
CPC分类号： C08G63/189 , C07C51/265 , C07C51/42 , C07C63/38 , Y10T428/1352 , Y10T428/29 , Y10T428/2913
摘要： Processes for producing aromatic monomers useful for forming polyesters are disclosed. Cost effective steps employed in the processes permit small amounts of process-related materials typically removed from monomer to remain in an aromatic monomer product. In many cases, the presence of the process-related materials left in the monomer product by the cost effective process steps can enhance the performance of the monomer in certain applications. Aromatic monomer products and polymers produced therefrom having these advantages also are disclosed, as well as products such as pasteurizable bottles made from these polymers.
摘要翻译：公开了用于制备用于形成聚酯的芳族单体的方法。在该方法中使用的成本有效的步骤允许通常从单体中除去残留在芳族单体产物中的少量与工艺相关的材料。在许多情况下，通过成本有效的工艺步骤留在单体产品中的工艺相关材料的存在可以在某些应用中提高单体的性能。还公开了具有这些优点的芳族单体产物和由其制备的聚合物，以及由这些聚合物制成的诸如可巴氏消毒瓶的产品。

8. 发明授权

US5809940A Indirect cooling of primary impact type solids separator elements in a CFB reactor 失效
标题翻译：在CFB反应器中间接冷却主冲击型固体分离器元件
公开(公告)号：US5809940A
公开(公告)日：1998-09-22
申请号：US864233
申请日：1997-05-23
申请人： David E. James , David J. Walker , Felix Belin
发明人： David E. James , David J. Walker , Felix Belin
IPC分类号： B01D45/08 , B09B3/00
CPC分类号： B01D45/08
摘要： An improved CFB reactor or combustor arrangement has at least a first and a second group of impact type particle separators or U-beams with cooling surfaces located adjacent and immediately upstream of the second group of U-beams which serve to cool flue gas/solids flowing through the CFB before it reaches the second group of U-beams. By reducing the gas temperature in the vicinity of and entering the second group of U-beams, the U-beams can be made of less expensive materials and are thus less expensive to produce and maintain. The heat absorbed by the local cooling surfaces can be applied to heat a working fluid supplied to a turbine or other process.
摘要翻译：改进的CFB反应器或燃烧器装置具有至少第一组和第二组冲击型颗粒分离器或U形梁，其中冷却表面位于第二组U形梁的邻近并紧邻上游，用于冷却烟道气/固体流动通过CFB到达第二组U型梁前。通过降低第二组U形梁附近和进入第二组U形梁的气体温度，U形梁可以由较便宜的材料制成，因此生产和维护成本较低。由局部冷却表面吸收的热量可用于加热供应给涡轮机或其他工艺的工作流体。

9. 发明授权

US4892972A Purification of crude terephthalic acid 失效
标题翻译：纯对苯二甲酸粗品
公开(公告)号：US4892972A
公开(公告)日：1990-01-09
申请号：US344657
申请日：1989-04-27
申请人： Hobe Schroeder , David E. James
发明人： Hobe Schroeder , David E. James
IPC分类号： C07C51/487
CPC分类号： C07C51/487
摘要： Aqueous solutions of crude terephthalic acid are purified by hydrogenation in the presence of plural noble metal catalysts in separate layers. Initially, the solution to be purified is passed through a layer of ruthenium-on-carbon catalyst, rhodium-on-carbon catalyst, or platinum-on-carbon catalyst, and thereafter through a layer of palladium-on-carbon catalyst. Optionally, the purified aqueous terephthalic acid solution can be treated further to decrease the 4-carboxybenzaldehyde content thereof by passing it through a layer of rhodium-on-carbon catalyst downstream from the palladium-on-carbon catalyst layer.
摘要翻译：在多层贵金属催化剂存在下，通过氢化纯化粗对苯二甲酸的水溶液。最初，待纯化的溶液通过一层碳酸钌催化剂，铑 - 碳催化剂或铂 - 碳催化剂，然后通过一层钯 - 碳催化剂。任选地，可以进一步处理纯化的对苯二甲酸水溶液，以使其通过使其通过碳 - 钯催化剂层下游的铑 - 碳催化剂层来降低其4-羧基苯甲醛含量。

10. 发明授权

US4822527A Process for preparation of anthraquinones and fluorenones 失效
标题翻译：制备蒽醌和芴酮的方法
公开(公告)号：US4822527A
公开(公告)日：1989-04-18
申请号：US134839
申请日：1987-12-14
申请人： David E. James , Neal R. Nowicki
发明人： David E. James , Neal R. Nowicki
IPC分类号： C07C50/18 , C07C45/00
CPC分类号： C07C50/18 , Y02P20/584
摘要： A process is disclosed for producing cyclized aromatic compounds by the liquid-phase air oxidation of 2-methyl-substituted biphenyls and diphenylmethanes in an acetic acid medium in the presence of a cobalt-manganese-bromine catalyst or a zirconium-cobalt-manganese-bromine catalyst wherein the mole ratio of cobalt-to-manganese is about 1.0:0.1 to about 1.0:10.0 and the ratio of zirconium-to-cobalt is about 0.005:1.0 to about 0.20:1.0, and mole ratio of bromine to total metals of said cobalt-manganese-bromine catalyst or zirconium-cobalt-manganese-bromine catalyst is from about 0.2:1.0 to about 20.0:1.0, which process comprises conducting the reaction in a batch process at a temperature of from 75.degree. C. to about 250.degree. C. at a pressure of from 1 to 100 atmospheres, or continuously in two stages comprising a first-stage reaction at a temperature of about 75.degree. C. to about 200.degree. C. and a second-stage reaction at a temperature of about 150.degree. C. to about 250.degree. C. and recycling the cobalt-manganese catalyst or the zircnium-cobalt-manganese catalyst by oxalate precipitation of the catalyst at temperatures of about 110.degree. C. to about 200.degree. C. prior to the separation of mother liquor and using about 0.25 to about 2.5 moles of oxalic acid per mole of cobalt and manganese or mole of zirconium-cobalt-manganese and continuously recycling the recovered catalyst metals to the oxidation stages. The products of this novel process, anthraquinones and fluorenones, are useful for the manufacture of dyestuffs and pharmaceuticals.
摘要翻译：公开了在钴锰溴催化剂或锆 - 钴 - 锰 - 溴存在下，通过在乙酸介质中通过2-甲基取代的联苯和二苯基甲烷的液相空气氧化来生产环化芳族化合物的方法催化剂，其中钴与锰的摩尔比为约1.0:0.1至约1.0:10.0，锆与钴的摩尔比为约0.005:1.0至约0.20:1.0，溴与总金属的摩尔比为所述钴 - 锰 - 溴催化剂或锆 - 钴 - 锰 - 溴催化剂的量为约0.2:1.0至约20.0:1.0，该方法包括在75℃至约250℃的间歇过程中进行反应在1〜100个大气压的压力下，或者在约75℃至约200℃的温度下包括第一阶段反应的两个阶段的连续两个阶段，以及在约 150℃至约250℃并回收钴锰催化剂或锆 - 钴 - 锰催化剂，在母液分离之前，在约110℃至约200℃的温度下草酸盐沉淀催化剂，并使用约0.25至约2.5摩尔的草酸每摩尔钴和锰或摩尔的锆 - 钴 - 锰，并将回收的催化剂金属连续循环到氧化阶段。该新方法的产物，蒽醌和芴酮可用于制造染料和药物。

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