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1. 发明申请

US20100113494A1 13,13a-Dihydroberberine Derivatives For Use In Pharmaceutical Compositions 审中-公开
标题翻译： 13,13a-Dihydroberberine衍生物用于药物组合物
公开(公告)号：US20100113494A1
公开(公告)日：2010-05-06
申请号：US12443401
申请日：2007-09-30
申请人： Lihong Hu , Jia Li , Jingya Li , Hankun Zhang , Zhe Cheng , Jiming Ye , David E. James , Edward W. Kraegen
发明人： Lihong Hu , Jia Li , Jingya Li , Hankun Zhang , Zhe Cheng , Jiming Ye , David E. James , Edward W. Kraegen
IPC分类号： A61K31/4375
CPC分类号： C07D455/03
摘要： The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.
摘要翻译：本发明提供由下式表示的13,13a-二氢小檗碱衍生物或其生理学上可接受的盐，其包含其的药物组合物及其用途。 13,13a-二氢小檗碱衍生物具有促进肌肉细胞中葡萄糖吸收的活性，整个动物实验表明，本发明化合物具有改善葡萄糖耐量和胰岛素抵抗，促进体重减轻，减轻脂肪肝等作用。因此，本发明化合物可用于治疗由胰岛素抵抗引起的糖尿病，肥胖，脂肪肝及其并发症。

2. 发明授权

US08183383B2 Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof 失效
标题翻译：蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途
公开(公告)号：US08183383B2
公开(公告)日：2012-05-22
申请号：US12530281
申请日：2008-02-26
申请人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
发明人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
IPC分类号： C07D277/30 , C07D263/34 , C07D233/00 , C07D233/61 , C07D417/10 , C07D413/10 , C07D401/10 , A61K31/445 , A61K31/44 , A61K31/425 , A61K31/42 , A61K31/415
CPC分类号： C07D277/30 , C07D417/12
摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
摘要翻译：具有以下结构的PTP1B抑制剂（式I）。实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。它们可以用作胰岛素敏化剂。它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。本发明还提供了制备这些抑制剂的方法。

3. 发明申请

US20100197927A1 Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof 失效
标题翻译：蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途
公开(公告)号：US20100197927A1
公开(公告)日：2010-08-05
申请号：US12530281
申请日：2008-02-26
申请人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
发明人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
IPC分类号： C07D277/30 , C07D417/12
CPC分类号： C07D277/30 , C07D417/12
摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
摘要翻译：具有以下结构的PTP1B抑制剂（式I）。实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。它们可以用作胰岛素敏化剂。它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。本发明还提供了制备这些抑制剂的方法。

4. 发明授权

US09788975B2 Method of estimating soft tissue balance for knee arthroplasty 有权
公开(公告)号：US09788975B2
公开(公告)日：2017-10-17
申请号：US13283879
申请日：2011-10-28
申请人： Jia Li
发明人： Jia Li
IPC分类号： A61B17/15 , A61F2/46 , A61B34/10 , B33Y80/00 , A61B5/107
CPC分类号： A61F2/4657 , A61B5/1071 , A61B5/1075 , A61B17/155 , A61B17/157 , A61B34/10 , A61B2034/105 , A61B2034/108 , A61F2002/4666 , B33Y80/00
摘要： A method is provided for evaluating the tension or laxity of the soft tissue surrounding a patient's knee joint. Based on this evaluation, a surgeon may determine a desired resection depth for a knee arthroplasty procedure that will achieve an appropriate spacing between adjacent, articulating components of the knee joint.

5. 发明申请

US20170221272A1 LOCAL AUGMENTED REALITY PERSISTENT STICKER OBJECTS 审中-公开
公开(公告)号：US20170221272A1
公开(公告)日：2017-08-03
申请号：US15010847
申请日：2016-01-29
申请人： Jia Li , Linjie Luo , Rahul Sheth , Ning Xu , Jianchao Yang
发明人： Jia Li , Linjie Luo , Rahul Sheth , Ning Xu , Jianchao Yang
IPC分类号： G06T19/20 , G06T7/20 , H04L12/58 , G06T19/00
CPC分类号： G06T19/20 , G06T7/204 , G06T7/248 , G06T19/006 , G06T2207/20104 , H04L51/32
摘要： Systems and methods for local augmented reality (AR) tracking of an AR object are disclosed. In one example embodiment a device captures a series of video image frames. A user input is received at the device associating a first portion of a first image of the video image frames with an AR sticker object and a target. A first target template is generated to track the target across frames of the video image frames. In some embodiments, global tracking based on a determination that the target is outside a boundary area is used. The global tracking comprises using a global tracking template for tracking movement in the video image frames captured following the determination that the target is outside the boundary area. When the global tracking determines that the target is within the boundary area, local tracking is resumed along with presentation of the AR sticker object on an output display of the device.

6. 发明授权

US08781175B2 On-site composition and aesthetics feedback through exemplars for photographers 有权
公开(公告)号：US08781175B2
公开(公告)日：2014-07-15
申请号：US13493564
申请日：2012-06-11
申请人： James Z. Wang , Jia Li , Lei Yao , Poonam Suryanarayan , Mu Qiao
发明人： James Z. Wang , Jia Li , Lei Yao , Poonam Suryanarayan , Mu Qiao
IPC分类号： G06K9/00
CPC分类号： G06K9/6267 , G06K9/00624 , G06K9/46 , G06K9/4652 , G06K9/4671 , G06K9/6228 , H04N5/23222
摘要： A comprehensive system to enhance the aesthetic quality of the photographs captured by mobile consumers provides on-site composition and aesthetics feedback through retrieved examples. Composition feedback is qualitative in nature and responds by retrieving highly aesthetic exemplar images from the corpus which are similar in content and composition to the snapshot. Color combination feedback provides confidence on the snapshot to contain good color combinations. Overall aesthetics feedback predicts the aesthetic ratings for both color and monochromatic images. An algorithm is used to provide ratings for color images, while new features and a new model are developed to treat monochromatic images. This system was designed keeping the next generation photography needs in mind and is the first of its kind. The feedback rendered is guiding and intuitive in nature. It is computed in situ while requiring minimal input from the user.

7. 发明授权

US08470763B2 Alpha-amino-N-substituted amides, pharmaceutical composition containing them and uses thereof 有权
标题翻译： α-氨基-N-取代的酰胺，含有它们的药物组合物及其用途
公开(公告)号：US08470763B2
公开(公告)日：2013-06-25
申请号：US12747485
申请日：2008-12-11
申请人： Fajun Nan , Jia Li , Jian Ding , Gang Liu , Chuanming Xie , Zehong Miao , Wanyi Tai
发明人： Fajun Nan , Jia Li , Jian Ding , Gang Liu , Chuanming Xie , Zehong Miao , Wanyi Tai
IPC分类号： C07D345/00
CPC分类号： C07C237/22 , C07C247/12 , C07C271/22 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D209/14 , C07D209/20 , C07D233/54 , C07D307/24 , C07D307/94
摘要： Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
摘要翻译：公开了一系列具有下式结构的α-氨基-N-取代酰胺化合物及其药学上可接受的盐，以及包含它们的药物组合物。根据本发明的α-氨基-N-取代的酰胺化合物或其药学上可接受的盐在体内和体外具有抗肿瘤和/或抗癌活性，可以有效抑制各种肿瘤细胞的生长和/或癌细胞，因此可用于制备用于治疗肿瘤和/或癌症的药物。

8. 发明申请

US20130010286A1 METHOD AND DEVICE OF DIFFERENTIAL CONFOCAL AND INTERFERENCE MEASUREMENT FOR MULTIPLE PARAMETERS OF AN ELEMENT 审中-公开
标题翻译：差分协调的方法和设备和干扰测量对于元素的多个参数
公开(公告)号：US20130010286A1
公开(公告)日：2013-01-10
申请号：US13636123
申请日：2011-11-09
申请人： Weiqian Zhao , Jiamiao Yang , Lirong Qiu , Yun Wang , Jia Li
发明人： Weiqian Zhao , Jiamiao Yang , Lirong Qiu , Yun Wang , Jia Li
IPC分类号： G01B11/24 , G01N21/41 , G01B11/06 , G01B11/255 , G01B11/02
CPC分类号： G01M11/025 , G01B11/06 , G01B11/14 , G01B11/2441 , G01B11/255 , G01M11/0271
摘要： The present invention relates to the field of optical precision measurement technologies, and in particular, to a method and a device of differential confocal (confocal) and interference measurement for multiple parameters of an element. The core concept of the invention lies in that: the concurrent high-precision measurement of multiple parameters of an element may be realized by measuring the surface curvature radius of an element with spherical surface, the back focal length of a lens, the refractive index of a lens, the thickness of a lens and the axial spaces of an assembled lenses by using a differential confocal (confocal) measuring system and measuring the surface profile of the element by using a figure interference measuring system. In the invention, a differential confocal (confocal) detection system and a figure interference measuring system are combined for the first time, the method covers more measured parameters, and during the measurement of multiple parameters of an element, it is not essential to readjust the optical path or disassemble the test element, thus no damage will be caused on the test element, and the measurement speed will be fast.
摘要翻译：本发明涉及光学精密测量技术领域，特别涉及用于元件的多个参数的差分共焦（共焦）和干涉测量的方法和装置。本发明的核心思想在于：通过测量具有球形表面的元件的表面曲率半径，透镜的后焦距，折射率的折射率，可以实现元件的多个参数的并行高精度测量通过使用差分共焦（共焦）测量系统，透镜，透镜的厚度和组装的透镜的轴向空间，并通过使用图形干涉测量系统测量元件的表面轮廓。在本发明中，首次组合了差分共焦（共焦）检测系统和图形干扰测量系统，该方法涵盖更多的测量参数，并且在测量元件的多个参数期间，重要的是不必重新调整光路或拆卸测试元件，因此不会对测试元件造成损坏，测量速度将会很快。

9. 发明申请

US20120085306A1 STARTER MOTOR 有权
标题翻译：起动马达
公开(公告)号：US20120085306A1
公开(公告)日：2012-04-12
申请号：US13269162
申请日：2011-10-07
申请人： Jun-Jie Chu , Jia Li
发明人： Jun-Jie Chu , Jia Li
IPC分类号： F02N11/00
CPC分类号： F02N15/063 , F02N11/00 , F02N15/006 , F02N15/02 , F02N15/04 , F02N15/065 , F02N15/066 , Y10T74/131
摘要： A starter motor for an internal combustion engine has an electric motor, a shaft driven by the motor, and a pinion assembly arranged to engage a flywheel of the engine. The pinion assembly has a drive collar mounted to a helical spline of the shaft, an output gear and an elastic member disposed between the drive collar and the output gear. A connection shell prevents axial separation between the drive collar and the output gear. The elastic member prevents direct contact between the connection shell and at least one and possibly both of the drive collar and the output gear.
摘要翻译：用于内燃机的起动电动机具有电动机，由电动机驱动的轴和布置成接合发动机的飞轮的小齿轮组件。小齿轮组件具有安装到轴的螺旋花键的驱动轴环，输出齿轮和布置在驱动轴环和输出齿轮之间的弹性构件。连接壳防止驱动套环与输出齿轮之间的轴向分离。弹性构件防止连接壳体与驱动套环和输出齿轮中的至少一个以及可能的两个直接接触。

10. 发明申请

US20110215151A1 Method and Apparatus for Correcting Decoding Errors in Machine-Readable Symbols 有权
标题翻译：用于校正机器可读符号中的解码错误的方法和装置
公开(公告)号：US20110215151A1
公开(公告)日：2011-09-08
申请号：US12719379
申请日：2010-03-08
申请人： Jia Li , Mikhail Brusnitsyn , Eunice Poon , Seungsik Kwak
发明人： Jia Li , Mikhail Brusnitsyn , Eunice Poon , Seungsik Kwak
IPC分类号： G06K7/10
CPC分类号： G06K7/10
摘要： The present invention is a system and method for decoding an image of a bar code. Decoding the barcode includes tokenizing a plurality of pixels in the image of the barcode based upon a plurality of thresholds to form a first set of tokens. Decoding the barcode also includes re-tokenizing the plurality of pixels in the image of the barcode based upon the intensity of the pixels in the plurality of tokens, and the relativity intensity of neighboring tokens, to form a second set of tokens.
摘要翻译：本发明是用于对条形码图像进行解码的系统和方法。对条形码进行解码包括基于多个阈值对条形码图像中的多个像素进行标记，以形成第一组令牌。条形码的解码还包括基于多个令牌中的像素的强度和相邻令牌的相对强度重新标记条形码图像中的多个像素，以形成第二组令牌。

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