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1. 发明授权

US5549642A Atrial defibrillator and method of use 失效
标题翻译：心房除颤器及使用方法
公开(公告)号：US5549642A
公开(公告)日：1996-08-27
申请号：US293769
申请日：1994-08-19
申请人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson , Paul J. DeGroot , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson , Paul J. DeGroot , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/3962 , A61N1/395
摘要： A method and apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes located in the right atrium/SVC, the right ventricle and the coronary sinus/great vein, with the right ventricular and coronary sinus/great vein electrodes connected in common. Optionally a subcutaneous electrode, preferably located in the left pectoral area may also be employed, coupled in common to the right atrial/SVC electrode.
摘要翻译：一种治疗房性快速性心律失常的方法和装置，特别是房颤。高能量脉冲在位于右心房/ SVC，右心室和冠状窦/大静脉的电极之间传递，右心室和冠状窦/大静脉电极共同连接。任选地，也可以使用优选位于左胸部区域的皮下电极，共同连接到右心房/ SVC电极。

2. 发明授权

US5690686A Atrial defibrillation method 失效
标题翻译：心房除颤方法
公开(公告)号：US5690686A
公开(公告)日：1997-11-25
申请号：US640380
申请日：1996-04-30
申请人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson
发明人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3918 , A61N1/395
摘要： A method and apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes located in the right atrium/SVC, the left pectoral region and the coronary sinus/great vein, with the left pectoral and coronary sinus/great vein electrodes connected in common. Optionally a ventricular electrode may also be employed in conjunction with one or more of the other listed electrodes to accomplish ventricular cardioversion or defibrillation.
摘要翻译：一种治疗房性快速性心律失常的方法和装置，特别是房颤。在位于右心房/ SVC，左胸部区域和冠状窦/大静脉的电极之间传递高能量脉冲，左胸部和冠状窦/大静脉电极共同连接。任选地，心室电极还可以与一个或多个其它列出的电极结合使用以完成心室复律或除颤。

3. 发明授权

US5836976A Cardioversion energy reduction system 失效
标题翻译：心律转换能量减少系统
公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译：在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。复发疗法与心室感觉事件（如果存在）同步传递。如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

4. 发明授权

US5713924A Defibrillation threshold reduction system 失效
标题翻译：除颤门限降低系统
公开(公告)号：US5713924A
公开(公告)日：1998-02-03
申请号：US495251
申请日：1995-06-27
申请人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.
摘要翻译：一种用于治疗纤维性颤动，特别是心房颤动的装置的方法。响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。

5. 发明授权

US06949097B2 Ablation catheter and method for isolating a pulmonary vein 失效
标题翻译：消融导管和隔离肺静脉的方法
公开(公告)号：US06949097B2
公开(公告)日：2005-09-27
申请号：US10414800
申请日：2003-04-16
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B17/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter body of a catheter assembly includes a proximal portion, an intermediate portion extending from the proximal portion, a distal portion extending from the intermediate portion, and a locating device including a distal tip extending from the distal portion of the catheter body. The intermediate portion defines a longitudinal axis and the distal portion forms a loop including one or more loop segments formed around a central loop axis. The central loop axis is substantially parallel with the longitudinal axis and the one or more loop segments include at least one ablation electrode coupled thereto and adapted to create a lesion, the lesion electrically isolating a vessel from a chamber for treatment of a cardiac arrhythmia. The distal tip of the locating device is substantially parallel with the central loop axis.
摘要翻译：导管组件的导管主体包括近端部分，从近侧部分延伸的中间部分，从中间部分延伸的远侧部分和定位装置，该定位装置包括从导管主体的远端部分延伸的远侧末端。中间部分限定纵向轴线，并且远侧部分形成包括围绕中心环轴线形成的一个或多个环形部分的环。中心回路轴线基本上与纵向轴线平行，并且一个或多个环路段包括耦合到其上的适于产生病变的至少一个消融电极，所述损伤使血管与腔室电隔离以治疗心律失常。定位装置的远端基本上与中心环轴平行。

6. 发明授权

US06572612B2 Ablation catheter and method for isolating a pulmonary vein 有权
公开(公告)号：US06572612B2
公开(公告)日：2003-06-03
申请号：US09975789
申请日：2001-10-11
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.

7. 发明授权

US06325797B1 Ablation catheter and method for isolating a pulmonary vein 有权
标题翻译：消融导管和隔离肺静脉的方法
公开(公告)号：US06325797B1
公开(公告)日：2001-12-04
申请号：US09286048
申请日：1999-04-05
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.
摘要翻译：一种用于治疗心律失常（例如心房颤动）的导管组件和方法，通过诸如左心房的腔室电隔离血管（例如肺静脉）。导管组件包括导管主体和至少一个电极。导管主体包括近端部分，中间部分和远端部分。中间部分从近端部分延伸并且限定纵向轴线。远侧部分从中间部分延伸并且形成横向于纵向轴线的基本上闭合的环。沿着环设置至少一个电极。利用这种构造，环路被轴向地指向与容器孔周围的室壁接触。在通电时，电极消除围绕血管口的连续病变图案，从而将容器与腔室电隔离。

8. 发明授权

US07186247B2 Apparatus and system for delivery of drug therapies 失效
标题翻译：用于药物治疗的装置和系统
公开(公告)号：US07186247B2
公开(公告)日：2007-03-06
申请号：US10407996
申请日：2003-04-04
申请人： Michael R. Ujhelyi , Rahul Mehra , Xiaoyi Min
发明人： Michael R. Ujhelyi , Rahul Mehra , Xiaoyi Min
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M5/14276 , A61M5/14244 , A61M5/16813 , A61M2205/0266 , A61N1/0568
摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.
摘要翻译：一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

9. 发明申请

US20070203473A1 APPARATUS AND SYSTEM FOR DELIVERY OF DRUG THERAPIES 有权
标题翻译：用于输送药物治疗的装置和系统
公开(公告)号：US20070203473A1
公开(公告)日：2007-08-30
申请号：US11675693
申请日：2007-02-16
申请人： Michael Ujhelyi , Rahul Mehra , Xiaoyi Min
发明人： Michael Ujhelyi , Rahul Mehra , Xiaoyi Min
IPC分类号： A61M25/00
CPC分类号： A61M5/14276 , A61M5/14244 , A61M5/16813 , A61M2205/0266 , A61N1/0568
摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.
摘要翻译：一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

10. 发明授权

US07722598B2 Apparatus and system for delivery of drug therapies 有权
标题翻译：用于药物治疗的装置和系统
公开(公告)号：US07722598B2
公开(公告)日：2010-05-25
申请号：US11675693
申请日：2007-02-16
申请人： Michael R. Ujhelyi , Rahul Mehra , Xiaoyi Min
发明人： Michael R. Ujhelyi , Rahul Mehra , Xiaoyi Min
IPC分类号： A61K9/22
CPC分类号： A61M5/14276 , A61M5/14244 , A61M5/16813 , A61M2205/0266 , A61N1/0568
摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.
摘要翻译：一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

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