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1. 发明授权

US07218960B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07218960B1
公开(公告)日：2007-05-15
申请号：US10606299
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/7242 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

2. 发明授权

US07643872B2 System and method for detecting cardiac ischemia based on T-Waves using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07643872B2
公开(公告)日：2010-01-05
申请号：US11686784
申请日：2007-03-15
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452 , A61N1/36
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

3. 发明授权

US07225015B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
公开(公告)号：US07225015B1
公开(公告)日：2007-05-29
申请号：US10603398
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0468
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

4. 发明申请

US20080215127A1 Medical Electrical Lead Providing Far-Field Signal Attenuation 审中-公开
标题翻译：医疗电气铅提供远场信号衰减
公开(公告)号：US20080215127A1
公开(公告)日：2008-09-04
申请号：US12122458
申请日：2008-05-16
申请人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
发明人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573
摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.
摘要翻译：双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减不想要的信号的幅度，例如远场R波，远场P波和T波。

5. 发明授权

US07925343B1 Subcutaneous implantable cardiac device system with low defibrillation thresholds and improved sensing 有权
标题翻译：具有低除颤阈值和改进感测的皮下植入式心脏装置系统
公开(公告)号：US07925343B1
公开(公告)日：2011-04-12
申请号：US11539576
申请日：2006-10-06
申请人： Xiaoyi Min , Scott Salys , Yougandh Chitre , Eric Falkenberg , Gene A. Bornzin
发明人： Xiaoyi Min , Scott Salys , Yougandh Chitre , Eric Falkenberg , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61B5/04014 , A61B5/046 , A61B5/7203 , A61N1/0563 , A61N1/37288
摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.
摘要翻译：皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。在一个实施方案中，一个或多个皮下传感器检测心室颤动。皮下传感器的定位和过滤导致改进的感测，噪音降低。与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。皮下补片可以包括执行感测和除颤的一个或多个电极。皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

6. 发明授权

US07383091B1 Medical electrical lead providing far-field signal attenuation 有权
标题翻译：医用电源提供远场信号衰减
公开(公告)号：US07383091B1
公开(公告)日：2008-06-03
申请号：US10656649
申请日：2003-09-04
申请人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
发明人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573
摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.
摘要翻译：双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减不想要的信号的幅度，例如远场R波，远场P波和T波。

7. 发明授权

US07155282B1 Automatic sensitivity control and method for use in an implantable cardiac stimulation device 有权
标题翻译：自动灵敏度控制和用于可植入心脏刺激装置的方法
公开(公告)号：US07155282B1
公开(公告)日：2006-12-26
申请号：US10719307
申请日：2003-11-21
申请人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
发明人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
IPC分类号： A61N1/362
CPC分类号： A61N1/3704 , A61B5/0452 , A61B5/0456
摘要： A threshold sensing control for use in an implantable cardiac stimulation device controls the sensing of cardiac activity during a current cardiac cycle of a heart while avoiding sensing a T wave. The system includes a sensing circuit that senses cardiac activity of the heart during a cardiac cycle preceding the current cardiac cycle, a detector that measures selected T wave and R wave characteristics of the cardiac activity and a control circuit that varies the sensing threshold based upon the measured selected R wave and T wave characteristics. The sensing threshold control may be implemented for both intrinsic and paced beats.
摘要翻译：用于可植入心脏刺激装置的阈值感测控制器控制在心脏的当前心动周期期间对心脏活动的感测，同时避免感测T波。该系统包括感测电路，该感测电路在当前心动周期之前的心动周期期间感测心脏的心脏活动，测量心脏活动的所选T波和R波特征的检测器以及基于测量选定的R波和T波特性。感测阈值控制可以针对内部节奏和节奏节拍实现。

8. 发明授权

US07881810B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US07881810B1
公开(公告)日：2011-02-01
申请号：US11753484
申请日：2007-05-24
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

9. 发明授权

US07797059B1 System and method for lead implantation in a pericardial space 有权
标题翻译：在心包空间引导植入的系统和方法
公开(公告)号：US07797059B1
公开(公告)日：2010-09-14
申请号：US11560297
申请日：2006-11-15
申请人： Gene A. Bornzin , Yougandh Chitre , John W. Poore
发明人： Gene A. Bornzin , Yougandh Chitre , John W. Poore
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： A system for pericardial lead implantation is disclosed herein. The system includes an implantation tool and a stimulation lead. The implantation tool includes a tubular body, a first lumen, a second lumen, a stylet or guidewire, a first port, and a second port. The first and second lumens longitudinally extend through tubular body. The first port is in communication with the first lumen, and the second port is in communication with the second lumen. The stylet or guidewire is longitudinally displaceable in the first lumen and across the first port. A tissue adhesive is selectively administrable through the second port via the second lumen. The stimulation lead includes a distal end and an engagement feature. Placing the engagement feature in the first port and causing the stylet or guidewire to displace in a first direction across the first port causes the lead to attach to the implantation tool. Displacing the stylet or guidewire in a second direction opposite the first direction allows the lead to detach from the implantation tool.
摘要翻译：本文公开了用于心包线植入的系统。该系统包括植入工具和刺激引线。植入工具包括管状体，第一腔，第二腔，探针或导丝，第一端口和第二端口。第一和第二管腔纵向延伸穿过管状体。第一端口与第一管腔连通，第二端口与第二管腔连通。探针或导丝可在第一管腔中纵向移动并穿过第一端口。组织粘合剂可经由第二内腔通过第二端口选择性地施用。刺激引线包括远端和接合特征。将接合特征放置在第一端口中并且导致探针或导丝沿第一方向跨越第一端口移位导致引线附着到植入工具。在与第一方向相反的第二方向上置换探针或导丝允许引线从植入工具脱离。

10. 发明授权

US07711437B1 Lead fixation device 失效
标题翻译：铅固定装置
公开(公告)号：US07711437B1
公开(公告)日：2010-05-04
申请号：US11562725
申请日：2006-11-22
申请人： Gene A. Bornzin , Yougandh Chitre
发明人： Gene A. Bornzin , Yougandh Chitre
IPC分类号： A61N1/00
CPC分类号： A61N1/0573
摘要： A lead fixation device that includes a helix having a surface, and a layer of electrically insulating material that covers one or more selected regions of the surface leaving one or more additional regions of the surface exposed. The insulating material defines one of a plurality of individual exposed portions along the length of the helix having a plurality of different configurations, e.g. shapes and sizes, or an insulating strip that wraps around the helix while advancing along the length of the helix.
摘要翻译：一种引导固定装置，其包括具有表面的螺旋和覆盖所述表面的一个或多个选定区域的电绝缘材料层，留下暴露的表面的一个或多个附加区域。绝缘材料限定沿着螺旋长度的多个单个暴露部分中的一个具有多个不同的构造，例如，形状和尺寸，或者在沿着螺旋的长度方向前进的情况下围绕螺旋缠绕的绝缘条。

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