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1. 发明授权

US08710209B2 Modulation of HSP47 expression 有权
标题翻译：调节HSP47表达
公开(公告)号：US08710209B2
公开(公告)日：2014-04-29
申请号：US12963600
申请日：2010-12-08
申请人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

2. 发明申请

US20110178157A1 MODULATION OF HSP47 EXPRESSION 有权
标题翻译： HSP47表达调控
公开(公告)号：US20110178157A1
公开(公告)日：2011-07-21
申请号：US12963600
申请日：2010-12-08
申请人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers
IPC分类号： A61K31/713 , C07H21/02 , A61P43/00 , C07H21/00
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

3. 发明申请

US20130030034A9 MODULATION OF TIMP1 AND TIMP2 EXPRESSION 审中-公开
标题翻译： TIMP1和TIMP2表达的调控
公开(公告)号：US20130030034A9
公开(公告)日：2013-01-31
申请号：US13246621
申请日：2011-09-27
申请人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
发明人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
IPC分类号： A61K31/7088 , A61P43/00 , C07H21/02
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C07K14/8146 , C12N2310/14 , C12N2310/3519 , C12N2320/30 , C12N2320/32
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是金属蛋白酶1的组织抑制剂和金属蛋白酶2的组织抑制剂（分别为TIMP1和TIMP2）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码TIMP1和TIMP2的基因，例如编码人TIMP1和TIMP2的基因。本文公开的组合物和方法也可用于治疗与TIMP1和TIMP2相关的病症和病症，包括纤维化疾病和病症，包括肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

4. 发明申请

US20120142754A1 MODULATION OF TIMP1 AND TIMP2 EXPRESSION 审中-公开
标题翻译： TIMP1和TIMP2表达的调控
公开(公告)号：US20120142754A1
公开(公告)日：2012-06-07
申请号：US13246621
申请日：2011-09-27
申请人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
发明人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
IPC分类号： A61K31/7088 , A61P43/00 , C07H21/02
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C07K14/8146 , C12N2310/14 , C12N2310/3519 , C12N2320/30 , C12N2320/32
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是金属蛋白酶1的组织抑制剂和金属蛋白酶2的组织抑制剂（分别为TIMP1和TIMP2）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码TIMP1和TIMP2的基因，例如编码人TIMP1和TIMP2的基因。本文公开的组合物和方法也可用于治疗与TIMP1和TIMP2相关的病症和病症，包括纤维化疾病和病症，包括肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

5. 发明申请

US20160333354A1 DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF 审中-公开
公开(公告)号：US20160333354A1
公开(公告)日：2016-11-17
申请号：US15228214
申请日：2016-08-04
申请人： Sharon Avkin-Nachum , Elena Feinstein , Hagar Kalinski , Igor Mett
发明人： Sharon Avkin-Nachum , Elena Feinstein , Hagar Kalinski , Igor Mett
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12Q1/6888
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.

6. 发明申请

US20160102313A1 DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF 审中-公开
公开(公告)号：US20160102313A1
公开(公告)日：2016-04-14
申请号：US14973388
申请日：2015-12-17
申请人： Sharon Avkin-Nachum , Elena Feinstein , Hagar Kalinski , Igor Mett
发明人： Sharon Avkin-Nachum , Elena Feinstein , Hagar Kalinski , Igor Mett
IPC分类号： C12N15/113
CPC分类号： C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12Q1/6888
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.

7. 发明授权

US09045755B2 Double stranded RNA compounds to RhoA and use thereof 有权
标题翻译： RhoA的双链RNA化合物及其用途
公开(公告)号：US09045755B2
公开(公告)日：2015-06-02
申请号：US13700942
申请日：2011-06-23
申请人： Sharon Avkin-Nachum , Elena Feinstein , Hagar Kalinski , Igor Mett
发明人： Sharon Avkin-Nachum , Elena Feinstein , Hagar Kalinski , Igor Mett
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12Q1/6888
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.
摘要翻译：本发明涉及化合物，包含其的药物组合物，其使用方法和用于下调RhoA基因的试剂盒。化合物，组合物，方法和试剂盒可用于治疗患有RhoA表达具有不良后果和赋予神经保护作用的疾病或病症和/或与疾病或病症相关的症状的受试者。

8. 发明申请

US20150018404A1 DOUBLE-STRANDED OLIGONUCLEOTIDE COMPOUNDS FOR TREATING HEARING AND BALANCE DISORDERS 审中-公开
标题翻译：用于治疗听觉和平衡障碍的双链寡核苷酸化合物
公开(公告)号：US20150018404A1
公开(公告)日：2015-01-15
申请号：US14235780
申请日：2012-08-03
申请人： Elena Feinstein , Sharon Avkin-Nachum , Igor Mett , Hagar Kalinski
发明人： Elena Feinstein , Sharon Avkin-Nachum , Igor Mett , Hagar Kalinski
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/332 , C12N2310/333 , C12N2310/3341 , C12N2310/335 , C12N2310/336 , C12N2310/337 , C12N2310/3521 , C12N2310/50
摘要： The present application relates to double stranded nucleic acid compounds, compositions comprising same and methods of use thereof for the treatment of hearing loss in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA molecules which inhibit expression of a gene expressed selected from the group consisting of HES1, HES5, HEY1, HEY2, ID1, ID2, ID3, CDKN1B, and NOTCH1.
摘要翻译：本申请涉及双链核酸化合物，包含其的组合物以及用于治疗有此需要的受试者的听力损失的方法。所述化合物优选化学合成并抑制表达选自HES1，HES5，HEY1，HEY2，ID1，ID2，ID3，CDKN1B和NOTCH1的基因表达的dsRNA分子。

9. 发明申请

US20140005253A1 COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 有权
标题翻译：用于治疗肺部疾病和伤害的组合物和方法
公开(公告)号：US20140005253A1
公开(公告)日：2014-01-02
申请号：US14002660
申请日：2012-03-01
申请人： Andrew E. Gelman , Elena Feinstein , Svetlana Adamsky , Igor Mett , Hagar Kalinski , Sharon Avkin-Nachum
发明人： Andrew E. Gelman , Elena Feinstein , Svetlana Adamsky , Igor Mett , Hagar Kalinski , Sharon Avkin-Nachum
IPC分类号： A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.
摘要翻译：本文公开了治疗哺乳动物肺疾病，病症和损伤的治疗方法，包括治疗急性呼吸窘迫综合征（ARDS），急性肺损伤，肺纤维化（特发性），博来霉素诱导的肺纤维化，机械通气机诱导的肺损伤，慢性阻塞性肺疾病（COPD），慢性支气管炎，肺气肿，肺移植后闭塞性细支气管炎和肺移植引起的急性移植物功能障碍，包括治疗，预防或预防原发性移植物衰竭，缺血再灌注损伤，再灌注损伤，再灌注水肿，同种异体移植功能障碍，肺再植入反应，肺移植后闭塞性细支气管炎和/或器官移植后特别是肺移植中的原发性移植物功能障碍（PGD），包括下调TLR2基因或TLR2基因和TLR4基因。本文提供了用于治疗肺部疾病，病症和损伤的组合物，方法和试剂盒。

10. 发明授权

US09487778B2 Oligonucleotide modulators of the toll-like receptor pathway 有权
标题翻译： toll样受体途径的寡核苷酸调节剂
公开(公告)号：US09487778B2
公开(公告)日：2016-11-08
申请号：US14002901
申请日：2012-03-01
申请人： Elena Feinstein , Svetlana Adamsky , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
发明人： Elena Feinstein , Svetlana Adamsky , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/321 , C12N2310/3521
摘要： Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (PGD) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA compounds, which down regulate or inhibit expression of a Toll like receptor genes.
摘要翻译：本文公开的是双链核酸分子和药物组合物，其包含用于治疗急性和慢性炎症，神经性疼痛，有需要的受试者肺移植后的原发性移植物功能障碍（PGD）的特征。化合物优选是化学合成和修饰的dsRNA化合物，其下调或抑制Toll样受体基因的表达。

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